Read by QxMD icon Read

Fasting Intermitent

Eva Pigna, Krizia Sanna, Dario Coletti, Zhenlin Li, Ara Parlakian, Sergio Adamo, Viviana Moresi
Physiological autophagy plays a crucial role in the regulation of muscle mass and metabolism, while the excessive induction or the inhibition of the autophagic flux contributes to the progression of several diseases. Autophagy can be activated by different stimuli, including cancer, exercise, caloric restriction and denervation. The latter leads to muscle atrophy through the activation of catabolic pathways, i.e. the ubiquitin-proteasome system and autophagy. However, the kinetics of autophagy activation and the upstream molecular pathways in denervated skeletal muscle have not been reported yet...
July 10, 2018: European Journal of Translational Myology
Xiaoya Wang, Qin Yu, Hongmei Yue, Shuang Zeng, Fenfen Cui
BACKGROUND: Obstructive sleep apnea (OSA) and its main feature, chronic intermit-tent hypoxia (IH) during sleep, is closely associated with insulin resistance (IR) and diabetes. Rimonabant can regulate glucose metabolism and improve IR. The present study aimed to assess the effect of IH and rimonabant on glucose metabolism and insulin sensitivity, and to explore the possible mechanisms. MATERIAL AND METHODS: Thirty-two rats were randomly assigned into 4 groups: Control group, subjected to intermittent air only; IH group, subjected to IH only; IH+NS group, subjected to IH and treated with normal saline; and IH+Rim group, subjected to IH and treated with 10 mg/kg/day of rimonabant...
October 27, 2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
M Pfeuffer, A Auinger, U Bley, I Kraus-Stojanowic, C Laue, P Winkler, C E Rüfer, J Frank, C Bösch-Saadatmandi, G Rimbach, J Schrezenmeir
BACKGROUND AND AIMS: The polyphenol quercetin may prevent cardiovascular diseases due to its vasorelaxant and anti-oxidative properties. We investigated the effects of quercetin on risk factors of atherosclerosis, biomarkers of inflammation and oxidative stress, depending on the apolipoprotein E (APOE) genotype. METHODS AND RESULTS: In a double-blind crossover study 49 healthy male subjects with APOE genotype 3/3 (n = 19), 3/4 (n = 22) and 4/4 (n = 8) consumed 150 mg/d quercetin or placebo for 8 weeks each, intermitted by a three-week washout phase...
May 2013: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Inmaculada Alonso, Pedro Valdivielso, María Josefa Zamudio, Miguel Angel Sánchez Chaparro, Francisca Pérez, Heliodoro Ramos, Pedro González Santos
BACKGROUND AND OBJECTIVE: Detection of asymptomatic peripheral arterial disease increases the risk of vascular morbibity and mortality. We aimed to estimate the prevalence of clinical and subclinical peripheral arterial disease using the ankle-arm index (AAI) as diagnostic tool in a working population. SUBJECTS AND METHOD: We included 450 workers, older than 50 years old, attending voluntary regular health check-up at Centro de Prevención de Riesgos Laborales de la Junta de Andalucía in Málaga (Spain)...
January 17, 2009: Medicina Clínica
Y Pospísilová, Z Adam
A deterioration of glucose tolerance is one of the most important side-effects ofglucocorticoid therapy. Disorders of glucose metabolism are present in almost all patients treated with glucocorticoids and 25% of these develop manifest diabetes mellitus. Glucocorticoids increase gluconeogenesis in hepatis and decrease insulinosensitivity in peripheral tissues and probably also decrease the release of insulin from pancreatic beta cells. The deterioration of glucose tolerance leads to worsening of morbidity and mortality of seriously ill patients...
January 2007: Vnitr̆ní Lékar̆ství
B Koudela, J Vítovec
The clinical, pathological and parasitological features of giardiasis resulting from experimental inoculation with 3 x 10(6) Giardia cysts were studied in goat kids. All experimentally inoculated goat kids given Giardia cysts became infected. Three of the eight inoculated kids had decreased appetite, formless feces and become slightly depressed beginning 7 or 8 days post inoculation. The mean duration of the appearance of abnormal feces was 6 days. Irregular and intermitted cysts shedding started after prepatent periods of 6-10 days and lasted throughout this study (10 weeks)...
January 15, 1998: Veterinary Parasitology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"