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JOURNAL ARTICLE
Nerea Martín Almazán, Afsar Rahbar, Marcus Carlsson, Tove Hoffman, Linda Kolstad, Bengt Rönnberg, Mattia Russel Pantalone, Ilona Lewensohn Fuchs, Anna Nauclér, Mats Ohlin, Mariusz Sacharczuk, Piotr Religa, Stefan Amér, Christian Molnár, Åke Lundkvist, Andres Susrud, Birger Sörensen, Cecilia Söderberg-Nauclér
Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is highly variable and could be mediated by a cross-protective pre-immunity. We identified 14 cross-reactive peptides between SARS-CoV-2 and influenza A H1N1, H3N2, and human herpesvirus (HHV)-6A/B with potential relevance. The H1N1 peptide NGVEGF was identical to a peptide in the most critical receptor binding motif in SARS-CoV-2 spike protein that interacts with the angiotensin converting enzyme 2 receptor. About 62%-73% of COVID-19-negative blood donors in Stockholm had antibodies to this peptide in the early pre-vaccination phase of the pandemic...
December 15, 2023: IScience
#22
JOURNAL ARTICLE
Qingqin Tao, Lingzi Wu, Jinying An, Zheng Liu, Kai Zhang, Lei Zhou, Xiaomin Zhang
Fuchs uveitis syndrome (FUS) is a commonly misdiagnosed uveitis syndromes often presenting as an asymptomatic mild inflammatory condition until complications arise. The diagnosis of this disease remains clinical because of the lack of specific laboratory tests. The aqueous humor (AH) is a complex fluid containing nutrients and metabolic wastes from the eye. Changes in the AH protein provide important information for diagnosing intraocular diseases. This study aimed to analyze the proteomic profile of AH in individuals diagnosed with FUS and to identify potential biomarkers of the disease...
December 18, 2023: Experimental Eye Research
#23
JOURNAL ARTICLE
Vanessa Wolfschluckner, Beate Obermüller, Angela Horvath, Giovanny Rodriguez-Blanco, Patricia Fuchs, Wolfram Miekisch, Barbara Mittl, Christina Flucher, Holger Till, Georg Singer
Pediatric short bowel syndrome (SBS) is a rare condition characterized by a massive loss of the small intestine, leading to the inability to meet nutritional requirements without the use of parenteral or enteral supplementation. SBS causes profound alterations in the intestinal microbiome and metabolome. The aim of this study was a detailed assessment of the intestinal microbiome and metabolome in a murine model of SBS. We performed a 60% proximal small bowel resection versus a sham operation in C57BL/6 mice...
November 29, 2023: Nutrients
#24
JOURNAL ARTICLE
Florent Fuchs, Alexis Rodriguez, Eve Mousty, Denis Morin, Agathe Roubertie, Constance F Wells, Olivier Prodhomme, Jean-François Benoist, Sophie Dreux, Jean-Michel Faure, Marjolaine Willems
OBJECTIVE: To evaluate the postnatal outcome of children with antenatal colonic hyperechogenicity, currently considered as a sign of lysinuria-cystinuria, but which may also be a sign of other disorders with a more severe prognosis. METHOD: We carried out a French multi-centric retrospective study via 15 Multidisciplinary Center for Prenatal Diagnosis from January 2011 to January 2021. We included pregnancies for which fetal colonic hyperechogenicity had been demonstrated...
December 6, 2023: Prenatal Diagnosis
#25
JOURNAL ARTICLE
Anne Rensing-Ehl, Myriam Ricarda Lorenz, Marita Führer, Wolfgang Willenbacher, Ella Willenbacher, Sieghart Sopper, Mario Abinun, Maria Elena Maccari, Christoph König, Pauline Haegele, Sebastian Fuchs, Carla Castro, Patrick Kury, Olivier Pelle, Christian Klemann, Maximilian Heeg, Julian Thalhammer, Oliver Wegehaupt, Marco Fischer, Sigune Goldacker, Björn Schulte, Saskia Biskup, Philippe Chatelain, Volker Schuster, Klaus Warnatz, Bodo Grimbacher, Andrea Meinhardt, Dirk Holzinger, Prasad Thomas Oommen, Tanja Hinze, Holger Hebart, Karlheinz Seeger, Kai Lehmberg, Timothy Ronan Leahy, Alexander Claviez, Simon Vieth, Freimut H Schilling, Ilka Fuchs, Miriam Groß, Frederic Rieux-Laucat, Aude Magerus, Carsten Speckmann, Klaus Schwarz, Stephan Ehl
BACKGROUND: Elevated TCRαβ+ CD4- CD8- double-negative T-cells (DNT) and serum biomarkers help identifying FAS mutant patients with autoimmune lymphoproliferative syndrome (ALPS). However, in some patients with clinical features and biomarkers consistent with ALPS, germline or somatic FAS mutations cannot be identified upon standard exon sequencing (ALPS-undetermined: ALPS-U). OBJECTIVE: We aimed to explore whether complex genetic alterations in the FAS gene escaping standard sequencing or mutations in other FAS pathway-related genes could explain these cases...
November 16, 2023: Journal of Allergy and Clinical Immunology
#26
JOURNAL ARTICLE
Olaf M Glueck, Xiaoling Liang, Irina Badell, Paul R Wratil, Alexander Graf, Stefan Krebs, Helmut Blum, Johannes C Hellmuth, Clemens Scherer, Alexandra Hollaus, Patricia M Spaeth, Burak Karakoc, Thimo Fuchs, Julia Zimmermann, Teresa Kauke, Andreas Moosmann, Oliver T Keppler, Christian Schneider, Maximilian Muenchhoff
PURPOSE: Lung transplant recipients are at increased risk of severe disease following infection with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) due to high-dose immunosuppressive drugs and the lung is the main organ affected by Coronavirus disease 2019 (COVID-19). Several studies have confirmed increased SARS-CoV-2-related mortality and morbidity in patients living with lung allografts; however, detailed immunological studies of patients with SARS-CoV-2 infection in the early phase following transplantation remain scarce...
November 3, 2023: Infection
#27
REVIEW
Madeline E Marks, Ramya Krishna Botta, Riichiro Abe, Thomas M Beachkofsky, Isabelle Boothman, Bruce C Carleton, Wen-Hung Chung, Ricardo R Cibotti, Roni P Dodiuk-Gad, Christian Grimstein, Akito Hasegawa, Jay H Hoofnagle, Shuen-Iu Hung, Benjamin Kaffenberger, Daniela Kroshinsky, Rannakoe J Lehloenya, Michelle Martin-Pozo, Robert G Micheletti, Maja Mockenhaupt, Keisuke Nagao, Suman Pakala, Amy Palubinsky, Helena B Pasieka, Jonathan Peter, Munir Pirmohamed, Melissa Reyes, Hajirah N Saeed, Jeffery Shupp, Chonlaphat Sukasem, Jhih Yu Syu, Mayumi Ueta, Li Zhou, Wan-Chun Chang, Patrice Becker, Teresa Bellon, Kemberlee Bonnet, Gianpiero Cavalleri, James Chodosh, Anna K Dewan, Arturo Dominguez, Xinzhong Dong, Elena Ezhkova, Esther Fuchs, Jennifer Goldman, Sonia Himed, Simon Mallal, Alina Markova, Kerry McCawley, Allison E Norton, David Ostrov, Michael Phan, Arthur Sanford, David Schlundt, Daniel Schneider, Neil Shear, Kanade Shinkai, Eric Tkaczyk, Jason A Trubiano, Simona Volpi, Charles S Bouchard, Sherrie J Divito, Elizabeth J Phillips
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a predominantly drug-induced disease, with a mortality rate of 15-20%, that engages the expertise of multiple disciplines: dermatology, allergy, immunology, clinical pharmacology, burn surgery, ophthalmology, urogynecology, and psychiatry. SJS/TEN has an incidence of 1-5/million persons per year in the United States, with even higher rates globally. One of the challenges of SJS/TEN has been developing the research infrastructure and coordination to answer questions capable of transforming clinical care and leading to improved patient outcomes...
2023: Frontiers in Medicine
#28
JOURNAL ARTICLE
John A Sauceda, Joseph Watabe, Lauren Sterling, Jonathan Fuchs, Audrey Parangan-Smith, Kelechi Uwaezuoke, Monica Gandhi, Carina Marquez
BACKGROUND: Investments early in the academic pathway are essential to increasing the diversity of the HIV research workforce. Applied mentored research experiences can advance research skills, self-efficacy, and retention in science among scholars considered to be underrepresented minorities. SETTING: The UCSF Center for AIDS Research Scholars Program is a 16-week program that pairs URM undergraduate and masters-level students from San Francisco State University with URM investigators from the UCSF...
October 1, 2023: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#29
REVIEW
Julieta Sabates, Wei-Hsuan Chiu, Samantha Loi, Amit Lampit, Hanna M Gavelin, Terence Chong, Nathalie Launder, Anita M Y Goh, Amy Brodtmann, Nicola Lautenschlager, Alex Bahar-Fuchs
Most people with dementia experience neuropsychiatric symptoms (NPS), including anxiety, depression or disinhibition. There is growing interest in the relationship between NPS and cognitive impairment, but data is still limited. This study aimed to investigate the specific associations between NPS and cognition in people with dementia. MEDLINE, EMBASE and PsycINFO were searched for published, peer-reviewed studies of associations between at least one NPS and one cognitive ability in people with dementia. The quality of the studies was assessed with the NIH National Heart, Lung and Blood Institute's quality assessment tools...
July 21, 2023: Neuropsychology Review
#30
JOURNAL ARTICLE
Marcelo B Lucca, Juliano A Jorge, Fabio T Cichelero, Denis Martinez, Rogério B Borges, Vania N Hirakata, Flavio D Fuchs, Sandra C Fuchs
OBJECTIVE: To compare the effects of chlortalidone plus amiloride and amlodipine on blood pressure (BP) variability in patients with hypertension and obstructive sleep apnea syndrome (OSA). METHODS: A randomized, controlled, double-blind trial enrolled men and women aged 40 years or older with a diagnosis of OSA (apnea-hypopnea index 10-40 apneas/h of sleep) confirmed by overnight laboratory polysomnography and systolic BP 140-159 mmHg or diastolic BP 90-99 mmHg...
July 12, 2023: Blood Pressure Monitoring
#31
JOURNAL ARTICLE
Sontoria D King, Swathi Veliginti, Martijn C G J Brouwers, Zhewen Ren, Wei Zheng, Veronica Wendy Setiawan, Lynne R Wilkens, Xiao-Ou Shu, Alan A Arslan, Laura E Beane Freeman, Paige M Bracci, Federico Canzian, Mengmeng Du, Steven J Gallinger, Graham G Giles, Phyllis J Goodman, Christopher A Haiman, Manolis Kogevinas, Charles Kooperberg, Loic Le Marchand, Rachel E Neale, Kala Visvanathan, Emily White, Demetrius Albanes, Gabriella Andreotti, Ana Babic, Sonja I Berndt, Lauren K Brais, Paul Brennan, Julie E Buring, Kari G Rabe, William R Bamlet, Stephen J Chanock, Charles S Fuchs, J Michael Gaziano, Edward L Giovannucci, Thilo Hackert, Manal M Hassan, Verena Katzke, Robert C Kurtz, I-Min Lee, Nuria Malats, Neil Murphy, Ann L Oberg, Irene Orlow, Miquel Porta, Francisco X Real, Nathaniel Rothman, Howard D Sesso, Debra T Silverman, Ian M Thompson, Jean Wactawski-Wende, Xiaoliang Wang, Nicolas Wentzensen, Herbert Yu, Anne Zeleniuch-Jacquotte, Kai Yu, Brian M Wolpin, Eric J Duell, Donghui Li, Rayjean J Hung, Sandra Perdomo, Marjorie L McCullough, Neal D Freedman, Alpa V Patel, Ulrike Peters, Elio Riboli, Malin Sund, Anne Tjønneland, Jun Zhong, Stephen K Van Den Eeden, Peter Kraft, Harvey A Risch, Laufey T Amundadottir, Alison P Klein, Rachael Z Stolzenberg-Solomon, Samuel O Antwi
BACKGROUND: There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer (PC). Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for PC. METHODS: Data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium (PanScan; cases n=5090, controls n=8733) and the Pancreatic Cancer Case Control Consortium (PanC4; cases n=4,163, controls n=3,792) were analyzed...
June 23, 2023: Cancer Epidemiology, Biomarkers & Prevention
#32
REVIEW
Jiri Lindovsky, Zuzana Nichtova, Nathalia R V Dragano, David Pajuelo Reguera, Jan Prochazka, Helmut Fuchs, Susan Marschall, Valerie Gailus-Durner, Radislav Sedlacek, Martin Hrabě de Angelis, Jan Rozman, Nadine Spielmann
Cardiovascular diseases cause a high mortality rate worldwide and represent a major burden for health care systems. Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. In this review, we summarize the current advances of the IMPC in cardiac research and describe in detail the diagnostic requirements of high-throughput electrocardiography and transthoracic echocardiography capable of detecting cardiac arrhythmias and cardiomyopathies in mice...
June 16, 2023: Mammalian Genome: Official Journal of the International Mammalian Genome Society
#33
RANDOMIZED CONTROLLED TRIAL
Martina Schneider, Marivic Narciso-Abraham, Sandra Hadl, Robert McMahon, Sebastian Toepfer, Ulrike Fuchs, Romana Hochreiter, Annegret Bitzer, Karin Kosulin, Julian Larcher-Senn, Robert Mader, Katrin Dubischar, Oliver Zoihsl, Juan-Carlos Jaramillo, Susanne Eder-Lingelbach, Vera Buerger, Nina Wressnigg
BACKGROUND: VLA1553 is a live-attenuated vaccine candidate for active immunisation and prevention of disease caused by chikungunya virus. We report safety and immunogenicity data up to day 180 after vaccination with VLA1553. METHODS: This double-blind, multicentre, randomised, phase 3 trial was done in 43 professional vaccine trial sites in the USA. Eligible participants were healthy volunteers aged 18 years and older. Patients were excluded if they had history of chikungunya virus infection or immune-mediated or chronic arthritis or arthralgia, known or suspected defect of the immune system, any inactivated vaccine received within 2 weeks before vaccination with VLA1553, or any live vaccine received within 4 weeks before vaccination with VLA1553...
June 24, 2023: Lancet
#34
REVIEW
Derrick P Smit, Dony K Mathew, Moncef Khairallah, Steven Yeh, Emmett T Cunningham
We provide an updated review of pre-selected RNA viruses causing ocular inflammation in humans. RNA viruses such as coronaviruses and arboviruses are reviewed elsewhere. A Google Scholar search was conducted to identify recent publications on ocular inflammation caused by the RNA viruses specified here. Human RNA viruses target a wide range of ocular tissues from the anterior to the posterior. Influenza, measles and mumps cause anterior segment manifestations including conjunctivitis and keratitis, while retinitis and optic neuritis may be seen posteriorly...
June 14, 2023: Ocular Immunology and Inflammation
#35
RANDOMIZED CONTROLLED TRIAL
Marina Leitman, Shmuel Fuchs, Vladimir Tyomkin, Amir Hadanny, Shani Zilberman-Itskovich, Shai Efrati
Post-COVID-19 condition refers to a range of persisting physical, neurocognitive, and neuropsychological symptoms following SARS-CoV-2 infection. Recent evidence revealed that post-COVID-19 syndrome patients may suffer from cardiac dysfunction and are at increased risk for a broad range of cardiovascular disorders. This randomized, sham-control, double-blind trial evaluated the effect of hyperbaric oxygen therapy (HBOT) on the cardiac function of post-COVID-19 patients with ongoing symptoms for at least three months after confirmed infection...
June 10, 2023: Scientific Reports
#36
RANDOMIZED CONTROLLED TRIAL
Fiona G Li, Talia Fuchs, Rebecca Deans, Lalla McCormack, Erin Nesbitt-Hawes, Jason Abbott, Annabelle Farnsworth
BACKGROUND: Postmenopausal vaginal symptoms affect over 60% of women and may substantially impact a woman's quality of life. Since 2012, fractional CO2 laser has been suggested as a treatment for this indication. Structural assessment of vaginal epithelium using microscopic biopsy examination has been used as a primary outcome measure and surrogate determinant of success of vaginal laser in previous clinical studies. OBJECTIVE: This study aimed to report the effects of laser compared with sham treatment on human vaginal epithelium from postmenopausal women using microscopic examination of tissue biopsies...
September 2023: American Journal of Obstetrics and Gynecology
#37
JOURNAL ARTICLE
Adrian Weber, Aja Reinhold, Konstantin Gugleta, Zisis Gatzioufas
No abstract text is available yet for this article.
April 2023: Klinische Monatsblätter Für Augenheilkunde
#38
JOURNAL ARTICLE
Samuel Sitbon, Phalla Ou, Caroline Nguyen, Carsten Ehmer, Eric Garbarz, Eric Brochet, Adeline Fuchs, Pierre Aubry, Jeremie Abtan
No abstract text is available yet for this article.
April 24, 2023: Circulation. Cardiovascular Imaging
#39
JOURNAL ARTICLE
Natalia Ivanivna Khramenko, Liudmyla Mikolaivna Velychko, Natalia Valerievna Konovalova, Oleksandra Viktorivna Bogdanova, Lilia Dumbrăveanu Gheorghe, Doina Vasile Bobescu
Introduction: Uveitis is a disease that manifests with increased vascular permeability and occlusion, with some ischemia and inflammatory mediators. It is characterized by a wide range of pathological processes, including inflammation, increased vascular permeability and occlusion, local ischemia and cell alteration by inflammatory mediators, and is characterized by the presence of complications. Aim: To study the state of ocular hemodynamics by rheoophthalmography, as well as the immune status in patients with idiopathic recurrent anterior uveitis complicated by intraocular hypertension, Fuchs heterochromic uveitis, Posner-Schlossman syndrome, during the relapse period...
2023: Romanian Journal of Ophthalmology
#40
Seham Alsulami, Malak Aldahasi, Hazem M Aljabri, Mazin Aljabri
Stevens-Johnson syndrome (SJS) typically involves a skin rash, mucositis, and conjunctivitis. Previous reports of SJS without skin manifestations affect children and are usually associated with Mycoplasma pneumoniae infection. We present a rare case of oral and ocular SJS without skin lesions in a healthy adult after exposure to azithromycin without mycoplasma pneumonia infection.
March 2023: Curēus
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