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https://read.qxmd.com/read/30771336/clinical-manifestations-prognosis-and-vaccination-status-of-patients-with-rubella-virus-associated-uveitis
#1
Fahriye Groen-Hakan, Suzanne van de Laar, Annemiek A van der Eijk-Baltissen, Ninette Ten Dam van Loon, Joke de Boer, Aniki Rothova
PURPOSE: To assess the clinical and laboratory manifestations and vaccination status of uveitis patients positive for Rubella virus (RV) in aqueous humor and investigate its relationship to Fuchs Uveitis Syndrome (FUS). METHODS: Retrospective study of all uveitis patients, positive for RV in aqueous humor analysis (polymerase chain reaction (PCR) and/or Goldmann-Witmer coefficient (GWC)) between January 2010 and October 2016 at the ophthalmology departments in the Erasmus Medical Center (Rotterdam) and University Medical Center Utrecht...
February 13, 2019: American Journal of Ophthalmology
https://read.qxmd.com/read/30732563/a-case-report-of-severe-recurrent-varicella-in-an-ankylosing-spondylitis-patient-treated-with-adalimumab-a-new-side-effect-after-15-years-of-usage
#2
Tomislava Skuhala, Anita Atelj, Jelena Prepolec, Mahmoud Al-Mufleh, Andrija Stanimirović, Dalibor Vukelić
BACKGROUND: Tumor necrosis factor-α (TNF-α) antagonists, most of which are monoclonal antibodies, became a widespread treatment for autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, psoriasis, psoriatic arthritis, hidradenitis suppurativa and uveitis. Their use is based on the blockage of TNF-α, which plays an important role in granulomas formation, development of phagosomes, activation and differentiation of macrophages, immune response against viral pathogens...
February 7, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30704352/chronic-active-epstein-barr-virus-infection-a-bi-faceted-disease-with-inflammatory-and-neoplastic-elements
#3
Ayako Arai
Chronic active Epstein-Barr virus infection (CAEBV) is one of the Epstein-Barr virus (EBV)-positive T- or NK-cell lymphoproliferative diseases. It is characterized by clonal proliferation of EBV-infected T or NK cells and their infiltration into systemic organs, leading to their failure. Inflammatory symptoms, fever, lymphadenopathy and liver dysfunction are main clinical findings of CAEBV. EBV itself contributes to the survival of the host cells via induction of CD40 and CD137 expression and constitutive activation of NF-κB...
January 31, 2019: Immunological medicine
https://read.qxmd.com/read/30683065/coinfections-and-differential-diagnosis-in-immunocompetent-patients-with-uveitis-of-infectious-origin
#4
Alejandra de-la-Torre, Juanita Valdés-Camacho, Clara López de Mesa, Andrés Uauy-Nazal, Juan David Zuluaga, Lina María Ramírez-Páez, Felipe Durán, Elizabeth Torres-Morales, Jessica Triviño, Mateo Murillo, Alba Cristina Peñaranda, Juan Carlos Sepúlveda-Arias, Jorge Enrique Gómez-Marín
BACKGROUND: Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditional serologic-diagnostic tools. METHODS: Descriptive transversal study, in a Uveitis Service of an Ophthalmology Reference Center, in Bogotá, Colombia, from July 2014 to February 2016...
January 25, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30627195/the-role-of-human-t-lymphotropic-virus-htlv-in-cardiovascular-diseases-a-review-of-literature
#5
REVIEW
Samaneh Abolbashari, Majid Ghayour-Mobarhan, Mahmoud Ebrahimi, Zahra Meshkat
Cardiovascular diseases are a major cause of morbidity and mortality. Chronic inflammation is an important risk factor for atherosclerosis, and viral infections can cause cardiovascular disease by developing inflammation. Infection with human T-lymphotropic virus (HTLV) is endemic in some parts of the world such as Japan, Africa, Caribbean islands, South America, and Iran. HTLV-1 is an oncogenic retrovirus, and can cause adult T-cell leukemia/lymphoma (ATL or ATLL). It also causes HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
July 2018: ARYA Atherosclerosis
https://read.qxmd.com/read/30601389/retinal-findings-in-presumed-infectious-posterior-uveitis-and-correlation-with-polymerase-chain-reaction-results
#6
Sivan M Elyashiv, C Michael Samson, Douglas A Jabs
PURPOSE: To correlate demographics, retinal lesion characteristics, and host immune status with the pathogen found on polymerase chain reaction analysis of aqueous fluid in patients with suspected infectious posterior uveitis. METHODS: Medical records of patients who underwent anterior chamber paracentesis for suspected infectious posterior uveitis and had retinal photographs between 2014 and 2016 at a single institution were reviewed. Data collection included demographics, clinical appearance of the lesions, and polymerase chain reaction results...
December 27, 2018: Retina
https://read.qxmd.com/read/30589932/association-of-ocular-inflammation-and-rubella-virus-persistence
#7
John A Gonzales, Armin Hinterwirth, Jessica Shantha, Kaidi Wang, Lina Zhong, Susie L Cummings, Ying Qian, Michael R Wilson, Nisha R Acharya, Thuy Doan
Importance: Metagenomic deep sequencing (MDS) demonstrates that persistent and active rubella virus (RV) infection is associated with Fuchs heterochromic iridocyclitis (FHI). Objective: To assess the utility of MDS in identifying RV infection in patients with uveitis. Design, Setting, and Participants: This case series assessed 6 patients diagnosed by MDS with RV-associated uveitis at a tertiary uveitis referral center in the United States...
December 27, 2018: JAMA Ophthalmology
https://read.qxmd.com/read/30587876/a-pediatric-case-with-parvovirus-b19-associated-uveitis-without-autoantibody-formation
#8
Takuma Ito, Takayuki Hoshina, Kazuyoshi Mizuki, Tomofumi Fukuda, Shingo Ishibashi, Koichi Kusuhara
Acute parvovirus B19 (B19) infection is often accompanied by autoantibody formation, including antinuclear antibodies and rheumatoid factor, and the symptoms of the infection are similar to those of several autoimmune diseases. Uveitis is a representative manifestation of autoimmune diseases and is rarely caused by B19. Autoantibody formation was confirmed in 2 previously reported cases with B19-associated uveitis. However, whether B19-associated uveitis is caused by the direct invasion of the virus or the induction of autoimmunity remains unclear...
November 2018: Nagoya Journal of Medical Science
https://read.qxmd.com/read/30515585/syphilitic-uveitis-misdiagnosed-as-viral-retinitis-a-misleading-history
#9
Manisha Agarwal, Richa Ranjan, Lagan Paul, Deepa Sharma
BACKGROUND: Syphilitic uveitis is an infective uveitis and a great mimicker. Misdiagnosis can lead to delay in the specific treatment resulting in deterioration of uveitis and loss of vision. FINDINGS: A 38-year-old unmarried female presented with pain, redness, and blurring of vision in the left eye for the last 5 days. She denied history of any sexual exposure in the past. Anterior segment examination of the right eye was normal and the left eye showed keratic precipitates with anterior chamber cells and iris pigments on anterior lens capsule...
December 4, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30505865/a-review-of-antimicrobial-therapy-for-infectious-uveitis-of-the-posterior-segment
#10
REVIEW
Ahmed B Sallam, Kyle A Kirkland, Richard Barry, Mohamed Kamel Soliman, Tayyeba K Ali, Sue Lightman
Treatment of infectious posterior uveitis represents a therapeutic challenge for ophthalmologists. The eye is a privileged site, maintained by blood ocular barriers, which limits penetration of systemic antimicrobials into the posterior segment. In addition, topical and subconjunctival therapies are incapable of producing sufficient drug concentrations, intraocularly. Posterior infectious uveitis can be caused by bacteria, virus, fungi, or protozoa. Mode of treatment varies greatly based on the infectious etiology...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
https://read.qxmd.com/read/30489451/immune-recovery-uveitis-like-syndrome-mimicking-recurrent-t-cell-lymphoma-after-autologous-bone-marrow-transplant
#11
Jeremy A Lavine, Arun D Singh, Kimberly Baynes, Sunil K Srivastava
PURPOSE: To report the multimodal imaging findings of immune recovery uveitis mimicking recurrent T-cell lymphoma after autologous bone marrow transplant therapy. METHODS: A 71-year-old man presented with posterior uveitis 6 weeks after chemotherapy and autologous bone marrow transplant for angioimmunoblastic T-cell lymphoma. Multimodal imaging included fluorescein angiography, fundus autofluorescence, and optical coherence tomography. Diagnostic testing included ocular polymerase chain reaction and diagnostic vitrectomy...
November 26, 2018: Retinal Cases & Brief Reports
https://read.qxmd.com/read/30474222/emerging-infectious-uveitis-chikungunya-dengue-zika-ebola
#12
REVIEW
Genevieve F Oliver, Jillian M Carr, Justine R Smith
Recently recognised forms of uveitis include intraocular inflammations that occur during or following one of several emerging infectious diseases: chikungunya fever, dengue, Zika virus disease and Ebola virus disease. Anterior, intermediate, posterior and pan- uveitis have been described in individuals infected with chikungunya virus. Persons who contract dengue or Zika viruses also may develop different types of uveitis in the course of the infection: maculopathy is a common manifestation of dengue eye disease, and Zika eye disease may cause hypertensive anterior uveitis or mimic a white dot syndrome...
November 25, 2018: Clinical & Experimental Ophthalmology
https://read.qxmd.com/read/30411142/relevance-of-erythrocyte-sedimentation-rate-and-c-reactive-protein-in-patients-with-active-uveitis
#13
Fahriye Groen-Hakan, Laura Eurelings, Jan van Laar, Aniki Rothova
PURPOSE: To relate erythrocyte sedimentation rates (ESR) and C-reactive protein (CRP) values to different uveitis entisties. METHODS: A retrospective study of patients with a first episode of active uveitis visiting the Erasmus University Medical Center, uveitis clinic, Rotterdam, the Netherlands, was performed. Levels of ESR and CRP were determined within 2 weeks and 1 week after onset of uveitis, respectively. Uveitis had to be of unknown origin at that moment...
November 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/30386807/care-of-ebola-survivors-and-factors-associated-with-clinical-sequelae-monrovia-liberia
#14
A de St Maurice, E Ervin, R Orone, M Choi, E K Dokubo, P E Rollin, S T Nichol, D Williams, J Brown, R Sacra, J Fankhauser, B Knust
Background: The Eternal Love Winning Africa (ELWA) Clinic was the first clinic to provide free, comprehensive care to Ebola virus disease (EVD) survivors in Liberia. The objectives of this analysis were to describe the demographics and symptoms of EVD survivors at ELWA from January 2015 through March 2017 and to identify risk factors for development of sequelae. Methods: Patients' demographic and clinical information was collected by chart review in June 2016 and March 2017...
October 2018: Open Forum Infectious Diseases
https://read.qxmd.com/read/30358761/role-of-diagnostic-pars-plana-vitrectomy-in-determining-the-etiology-of-uveitis-initially-unknown
#15
Xin-Yu Zhao, Song Xia, You-Xin Chen
PURPOSE: To estimate the success and safety of diagnostic pars plana vitrectomy (PPV) in determining the etiology of uveitis initially unknown and analyze their characteristics. METHODS: The PubMed, Embase, and Ovid were searched up to October 2017 to identify relevant studies. The PRISMA guidelines were followed. Statistical analyses were performed with R version 3.3.1. Result in proportion were transformed by the Freeman-Tukey variant of arcsine square to attain symmetry of confidence intervals (CIs)...
October 23, 2018: Retina
https://read.qxmd.com/read/30355888/real-time-polymerase-chain-reaction-for-diagnosis-and-management-of-hiv-induced-uveitis
#16
Jayapratha R Selvaraj, S Sudharshan, Lily K Therese, M K Janani, Poongulali Selvamuthu, Parveen Rewri, Jyotirmay Biswas
Intraocular (IO) inflammation in patients with Human immune deficiency virus (HIV) infection can be due to opportunistic infections, immune recovery uveitis, drugs used in the management or a primary manifestation of HIV itself. We studied the role of RT-PCR for HIV RNA in confirming the diagnosis of HIV induced uveitis and its useful in the management and follow-up of these patients.
November 2018: Indian Journal of Ophthalmology
https://read.qxmd.com/read/30355419/utility-of-routine-chest-radiography-in-ocular-tuberculosis-and-sarcoidosis
#17
J A Shaw, D P Smit, S Griffith-Richards, C F N Koegelenberg
BACKGROUND: Tuberculosis (TB) and sarcoidosis commonly present with pulmonary and ocular involvement. Routine chest radiography (CXR) is recommended in the workup for suspected intraocular TB (IOTB) or intraocular sarcoidosis (IOS); however, data on the utility of CXR in this setting are lacking. METHODS: A post-hoc analysis was performed of a prospectively collected data set comprising 104 patients with uveitis of unknown cause. A pulmonologist and thoracic radiologist, blinded to the final diagnosis, independently reported these CXRs as being in keeping with TB or sarcoidosis...
November 1, 2018: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30345620/demystifying-viral-anterior-uveitis-a-review
#18
REVIEW
Nicole Shu-Wen Chan, Soon-Phaik Chee
A viral aetiology should be suspected when anterior uveitis is accompanied by ocular hypertension, diffuse stellate keratic precipitates or the presence of iris atrophy. The most common viruses associated with anterior uveitis include herpes simplex virus, varicella-zoster virus, cytomegalovirus and rubella virus. They may present as the following: Firstly, granulomatous cluster of small and medium-sized keratic precipitates in Arlt's triangle, with or without corneal scars, suggestive of herpes simplex or varicella-zoster virus infection...
October 21, 2018: Clinical & Experimental Ophthalmology
https://read.qxmd.com/read/30274199/ocular-manifestations-of-emerging-flaviviruses-and-the-blood-retinal-barrier
#19
REVIEW
Sneha Singh, Ashok Kumar
Despite flaviviruses remaining the leading cause of systemic human infections worldwide, ocular manifestations of these mosquito-transmitted viruses are considered relatively uncommon in part due to under-reporting. However, recent outbreaks of Zika virus (ZIKV) implicated in causing multiple ocular abnormalities, such as conjunctivitis, retinal hemorrhages, chorioretinal atrophy, posterior uveitis, optic neuritis, and maculopathies, has rejuvenated a significant interest in understanding the pathogenesis of flaviviruses, including ZIKV, in the eye...
September 28, 2018: Viruses
https://read.qxmd.com/read/30239127/uveitis-causes-according-to-immune-status-of-patients
#20
Aniki Rothova, Anass Hajjaj, Joeri de Hoog, Alberta A H J Thiadens, Virgil A S H Dalm
PURPOSE: The advances in medicine have led to an increased number of people living with some form of immunodeficiency. Most ocular infections in immunocompromised patients may lead to irreversible blindness. We identify the causes of uveitis in immunocompetent and immunocompromised patients. METHODS: A retrospective cohort study of 1354 consecutive patients. All patients underwent a standard work-up for uveitis. RESULTS: An immunocompromised state was identified in 171/1354 patients (13%), of whom 40 had Human immunodeficiency virus (HIV) infection, 52 received immunosuppressive medications, 28 had concurrent malignant disorder and 20 had other causes for their immunosuppression...
September 21, 2018: Acta Ophthalmologica
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