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OBJECTIVE: The purpose of this evidence-based analysis is to examine the safety and efficacy of airway clearance devices (ACDs) for cystic fibrosis and attempt to differentiate between devices, where possible, on grounds of clinical efficacy, quality of life, safety and/or patient preference. BACKGROUND: Cystic fibrosis (CF) is a common, inherited, life-limiting disease that affects multiple systems of the human body. Respiratory dysfunction is the primary complication and leading cause of death due to CF...
2009: Ontario Health Technology Assessment Series
Lianne van der Giessen, Marije Bakker, Koen Joosten, Wim Hop, Harm Tiddens
BACKGROUND: Hypoxemia during sleep is a common finding in Cystic Fibrosis (CF) patients with more advanced lung disease. Nocturnal hypoxemia is associated with frequent awakenings and poor sleep quality. For children with CF, data of nocturnal oxygen saturation are sparse. OBJECTIVE: To assess the oxygen saturation profile during sleep in 25 clinically stable children with CF lung disease and to correlate these data with spirometry, cough frequency, sleep quality, and CT-scan scores...
November 2012: Pediatric Pulmonology
Nicole Beydon, Bruno Mahut, L Maingot, H Guillo, M C La Rocca, N Medjahdi, M Koskas, M Boulé, Christophe Delclaux
In children unable to perform reliable spirometry, the interrupter resistance (R(int) ) technique for assessing respiratory resistance is easy to perform. However, few data are available on the possibility to use R(int) as a surrogate for spirometry. We aimed at comparing R(int) and spirometry at baseline and after bronchodilator administration in a large population of asthmatic children. We collected retrospectively R(int) and spirometry results measured in 695 children [median age 7.8 (range 4.8-13.9) years] referred to our lab for routine assessment of asthma disease...
October 2012: Pediatric Pulmonology
Masato Muraki, Yusaku Nisikawa, Eri Naito, Ryuji Sato, Takashi Iwanaga, Yuji Tohda
BACKGROUND: Little is known regarding annual changes of respiratory functions among patients with asthma after asthma symptoms enter remission. OBJECTIVE: Annual changes of respiratory function and influence of patient characteristics and treatment variables on these changes were assessed in patients with adult asthma. METHODS: Respiratory function (pre- and postbronchodilator forced expiratory volume in one second [FEV₁] and reversibility by short-acting β₂-agonist) and their changes were retrospectively investigated and relationships between these changes, after symptomatic remission, and patient characteristics and treatments were analyzed in adult outpatients with asthma who had undergone spirometry (including a reversibility test) ≥5 times in >5 years...
November 2010: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Francine M Ducharme, Muireann Ni Chroinin, Ilana Greenstone, Toby J Lasserson
BACKGROUND: Long-acting inhaled ss(2)-adrenergic agonists (LABAs) are recommended as 'add-on' medication to inhaled corticosteroids (ICS) in the maintenance therapy of asthmatic adults and children aged two years and above. OBJECTIVES: To quantify in asthmatic patients the safety and efficacy of the addition of LABAs to ICS in patients insufficiently controlled on ICS alone. SEARCH STRATEGY: We identified randomised controlled trials (RCTs) through electronic database searches (the Cochrane Airways Group Specialised Register, MEDLINE, EMBASE and CINAHL), bibliographies of RCTs and correspondence with manufacturers until May 2008...
2010: Cochrane Database of Systematic Reviews
Angeliki M Tsimogianni, Spyros A Papiris, Georgios T Stathopoulos, Effrosyni D Manali, Charis Roussos, Anastasia Kotanidou
BACKGROUND: The outcome after hospitalization for an exacerbation of chronic obstructive pulmonary disease (COPD) is unfavorable and uncertainty exists about factors predicting short and long-term prognosis. OBJECTIVE: To identify clinical predictors of length of hospital stay (LOS) and three-year mortality after COPD exacerbations requiring hospitalization. DESIGN: Retrospective analysis of prospectively collected data. PARTICIPANTS AND METHODS: All consecutive patients hospitalized with COPD exacerbation were enrolled...
September 2009: Journal of General Internal Medicine
Masashi Kanehara, Akihito Yokoyama, Yoshitaka Tomoda, Naoki Shiota, Hiroshi Iwamoto, Nobuhisa Ishikawa, Yasuyuki Taooka, Yoshinori Haruta, Noboru Hattori, Nobuoki Kohno
BACKGROUND: The airway inflammation of chronic obstructive pulmonary disease (COPD) demonstrates a poor response to the anti-inflammatory actions of corticosteroids. However, long-acting beta(2)-agonists and low-dose theophylline are reported to have a possible anti-inflammatory effect in COPD. The aim of this study was to compare the effects of treatment between theophylline and the tulobuterol patch (transdermal patch preparation designed to yield sustained beta(2)-agonistic effects for 24h) on airway inflammation in addition to quality of life (QOL) and pulmonary function in mild-to-moderate COPD...
December 2008: Pulmonary Pharmacology & Therapeutics
Meir Kryger, Thomas Roth, Sherry Wang-Weigand, Jeffrey Zhang
BACKGROUND: Individuals with moderate to severe chronic obstructive pulmonary disease (COPD) have poor sleep quality. This study evaluated the effects of ramelteon, an MT(1)/MT(2) melatonin receptor agonist indicated for insomnia treatment on respiration in this population. MATERIALS AND METHODS: This double-blind, crossover study enrolled 25 subjects (>or=40 years) with moderate to severe COPD (FEV(1)/FVC <70% and FEV(1) between 50 and 80% of predicted value [moderate], or FEV(1)/FVC <70% and FEV(1) <50% of predicted value [severe])...
March 2009: Sleep & Breathing
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