Peng Qi, Ping Li, Lijiao Qiao, Huaqian Xue, Yanni Ma, Shijie Wei, Xiaoying Yang, Hao Zhang, Yuxin Zhang, Yifan Wang, Shaolong He, Hongfeng Quan, Wenping Zhang
Pirarubicin (THP), doxorubicin (DOX), cyclophosphamide (CTX), and vincristine (VCR) are widely used in the treatment of patients with non-Hodgkin's Lymphoma. Herein, a precise and sensitive method was developed for the determination of THP, DOX, CTX and VCR in human plasma by high-performance liquid-chromatography-tandem mass spectrometry (LC-MS/MS). Liquid-liquid extraction was applied to extract THP, DOX, CTX, VCR, and the internal standard (IS, Pioglitazone) in plasma. Agilent Eclipse XDB-C18 (3.0 mm × 100 mm) was utilized and chromatographic separation was obtained in eight minutes...
May 15, 2023: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences