Heather Dahlenburg, David Cameron, Sheng Yang, Angelica Bachman, Kari Pollock, Whitney Cary, Missy Pham, Kyle Hendrix, Jeannine White, Haley Nelson, Peter Deng, Joseph S Anderson, Kyle Fink, Jan Nolta
Huntington's disease (HD) is a fatal autosomal-dominant neurodegenerative disease caused by a trinucleotide CAG repeat expansion of the huntingtin gene (HTT) that affects 1 in every 10 000 individuals in the United States. Our lab developed a novel immune deficient HD mouse strain, the YACNSG, from a commonly used line, the YAC128 mouse, to enable transplantation studies using engineered human cells in addition to studying the impact of the immune system on disease progression. The primary goal of this project was to characterize this novel immune deQficient HD mouse model, using behavioral assays and histology to compare this new model to the immune competent YAC128 and immune deficient mice that had engraftment of a human immune system...
March 12, 2021: Stem Cells Translational Medicine