Qing Zhang, Wenjun Hu, Mingxue Guo, Xinyu Zhang, Qin Zhang, Fengqi Peng, Liwen Yan, Zucheng Hu, Jakkree Tangthianchaichana, Yan Shen, Haiyan Hu, Shouying Du, Yang Lu
INTRODUCTION: Responsive drug delivery systems hold great promise for tumor treatment as they focus on therapeutic agents directly, thus minimizing systemic toxicities and drug leakage. In this study, we covalently bound a matrix metalloproteinases-2 (MMP-2) enzyme-sensitive peptide to a tissue-penetrating peptide to rationally design a MMP-2 responsive multifunctional peptide hydrogel platform (aP/IR@FMKB) for cancer photothermal-chemo-immunotherapy. The constructed aP/IR@FMKB with bufalin (BF) loaded in trimethyl chitosan nanoparticles (TB NPs), photothermal agent IR820, and immune checkpoint inhibitor aPD-L1 by self-assembly could be dissociated in the presence of MMP-2 enzyme, triggering content release...
2024: International Journal of Nanomedicine