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Keywords Photothermal therapy with immu...

Photothermal therapy with immune nanoparticles

https://read.qxmd.com/read/38522491/surface-modification-of-hollow-gold-nanoparticles-conducted-by-incorporating-cancer-cell-membrane-and-as1411-aptamer-aiming-to-achieve-a-dual-targeted-therapy-for-colorectal-cancer
#1
JOURNAL ARTICLE
Sepideh Hassibian, Seyed Mohammad Taghdisi, Zahra Jamshidi, Ali Samie, Morteza Alinezhad Nameghi, Mersedeh Shayan, Naser Farrokhi, Mona Alibolandi, Mohammad Ramezani, Seyed Mohsen Dehnavi, Khalil Abnous
Due to its inherent membrane structure, a nanostructure enveloped by an active cell membrane possesses distinctive characteristics such as prolonged presence in the bloodstream, precise identification capabilities, and evasion of immune responses. This research involved the production of biomimetic nanoparticles, specifically hollow gold nanoparticles (HGNPs) loaded with methotrexate (MTX), which were further coated with cancer cell membrane. These nanoparticles were then adorned with AS1411 aptamer to serve as a targeting agent (Apt-CCM-HG@MTX)...
March 22, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38520338/immunoantitumor-activity-and-oxygenation-effect-based-on-iron-copper-doped-folic-acid-carbon-dots
#2
JOURNAL ARTICLE
Siqi Li, Hui Zhang, Yujun Bao, Huanli Zhang, Jingchun Wang, Mingyang Liu, Rui Yan, Zhiqiang Wang, Xiaodan Wu, Yingxue Jin
Cancer metastasis and recurrence are closely associated with immunosuppression and a hypoxic tumor microenvironment. Chemodynamic therapy (CDT) and photothermodynamic therapy (PTT) have been shown to induce immunogenic cell death (ICD), effectively inhibiting cancer metastasis and recurrence when combined with immune adjuvants. However, the limited efficacy of Fenton's reaction and suboptimal photothermal effect present significant challenges for successfully inducing ICD through CDT and PTT. This paper described the synthesis and immunoantitumor activity of the novel iron-copper-doped folic acid carbon dots (CFCFB)...
March 23, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38511548/pulsed-photothermal-therapy-of-solid-tumors-as-a-precondition-for-immunotherapy
#3
JOURNAL ARTICLE
Negin Farivar, Nastaran Khazamipour, Morgan E Roberts, Irina Nelepcu, Mona Marzban, Alireza Moeen, Htoo Zarni Oo, Nader Al Nakouzi, Casper Dolleris, Peter C Black, Mads Daugaard
Photothermal therapy (PTT) refers to the use of plasmonic nanoparticles to convert electromagnetic radiation in the near infrared region to heat and kill tumor cells. Continuous wave lasers have been used clinically to induce PTT, but the treatment is associated with heat-induced tissue damage that limits usability. Here, the engineering and validation of a novel long-pulsed laser device able to induce selective and localized mild hyperthermia in tumors while reducing the heat affected zone and unwanted damage to surrounding tissue are reported...
March 21, 2024: Small
https://read.qxmd.com/read/38503397/multifunctional-iron-apigenin-nanocomplex-conducting-photothermal-therapy-and-triggering-augmented-immune-response-for-triple-negative-breast-cancer
#4
JOURNAL ARTICLE
Ruijie Chen, Zewei Jiang, Yingfeng Cheng, Jinyao Ye, Shize Li, Yitianhe Xu, Zhanzheng Ye, Yifan Shi, Jie Ding, Yingyi Zhao, Hailun Zheng, Fugen Wu, Guangyong Lin, Congying Xie, Qing Yao, Longfa Kou
Triple negative breast cancer (TNBC) presents a formidable challenge due to its low sensitivity to many chemotherapeutic drugs and a relatively low overall survival rate in clinical practice. Photothermal therapy has recently garnered substantial interest in cancer treatment, owing to its swift therapeutic effectiveness and minimal impact on normal cells. Metal-polyphenol nanostructures have recently garnered significant attention as photothermal transduction agents due to their facile preparation and favorable photothermal properties...
March 17, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38496894/advancing-cancer-theranostics-through-biomimetics-a-comprehensive-review
#5
REVIEW
Kuttiappan Anitha, Santenna Chenchula, Vijayaraj Surendran, Bhatt Shvetank, Parameswar Ravula, Rhythm Milan, Radhika Chikatipalli, Padmavathi R
Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers a multidisciplinary avenue with potential in advancing cancer theranostics. This review comprehensively analyses recent progress in biomimetics-based cancer theranostics, emphasizing its role in overcoming current treatment challenges, with a focus on breast, prostate, and skin cancers...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38477852/spatiotemporal-controlled-nir-ii-immune-agonist-sensitizes-cancer-immunotherapy
#6
JOURNAL ARTICLE
Shuai Guo, Dongsheng Tang, Mengjie Zhang, Haiyin Yang, Tian Zhang, Bo Hu, Chun Xu, Yuhua Weng, Kun Shang, Yuanyu Huang
The integration of nanomedicine and immunotherapy has presented a promising opportunity for treatment of cancer and diverse diseases. However, achieving spatiotemporal controllable immunotherapy with excellent efficacy and safety performances remains a significant challenge. This study develops a biodegradable near-infrared-II (NIR-II) photothermal response polymer nanoparticle (PTEQ) system. This platform exhibits intrinsic immunostimulatory properties while concurrently delivering siRNA targeting the programmed death-ligand 1 gene (siPD-L1), leveraging enhanced immune responses and immune checkpoint blockade (ICB) for safe and effective cancer therapy...
March 13, 2024: Advanced Materials
https://read.qxmd.com/read/38474590/adjuvant-novel-nanocarrier-based-targeted-therapy-for-lung-cancer
#7
REVIEW
Kangkan Sarma, Md Habban Akther, Irfan Ahmad, Obaid Afzal, Abdulmalik S A Altamimi, Manal A Alossaimi, Mariusz Jaremko, Abdul-Hamid Emwas, Preety Gautam
Lung cancer has the lowest survival rate due to its late-stage diagnosis, poor prognosis, and intra-tumoral heterogeneity. These factors decrease the effectiveness of treatment. They release chemokines and cytokines from the tumor microenvironment (TME). To improve the effectiveness of treatment, researchers emphasize personalized adjuvant therapies along with conventional ones. Targeted chemotherapeutic drug delivery systems and specific pathway-blocking agents using nanocarriers are a few of them. This study explored the nanocarrier roles and strategies to improve the treatment profile's effectiveness by striving for TME...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38470224/nanomedicine-as-a-multimodal-therapeutic-paradigm-against-cancer-on-the-way-forward-in-advancing-precision-therapy
#8
REVIEW
Puja Sandbhor, Pranoti Palkar, Sakshi Bhat, Geofrey John, Jayant S Goda
Recent years have witnessed dramatic improvements in nanotechnology-based cancer therapeutics, and it continues to evolve from the use of conventional therapies (chemotherapy, surgery, and radiotherapy) to increasingly multi-complex approaches incorporating thermal energy-based tumor ablation ( e.g. magnetic hyperthermia and photothermal therapy), dynamic therapy ( e.g. photodynamic therapy), gene therapy, sonodynamic therapy ( e.g. ultrasound), immunotherapy, and more recently real-time treatment efficacy monitoring ( e...
March 12, 2024: Nanoscale
https://read.qxmd.com/read/38468940/intervaginal-space-injection-of-photothermal-chemotherapy-nanoparticles-for-facilitating-tumor-targeting-and-improving-outcomes-in-mice
#9
JOURNAL ARTICLE
Yuling Liu, Meng Su, Yinghan Wang, Yilong Du, Yan Wang, Nan Hu
Although numerous photothermal nanoparticles have been designed to improve the enhanced and permeability and retention (EPR) effect, the delivery of nanoparticles to the tumor site remains a major obstacle in cancer treatment. The interstital structure and its internal fluid that play an important role in material transmission, intercellular signal transduction, tissue morphology, immunity, tumor development, and disease diagnosis and treatment may be considered as a new route for drug delivery. Here, we prepared a nanoplatform composed of polydopamine (PDA), indocyanine green (ICG) as a photothermal agent, and paclitaxel (PTX) as a chemotherapeutic drug...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38463812/black-phosphorus-based-nanoparticles-induce-liver-cancer-cell-mitochondrial-apoptosis-and-immune-cell-tumor-infiltration-for-enhancing-dendritic-cell-therapy
#10
JOURNAL ARTICLE
Ke Liao, Shang Chen, Gun Yang, Xin Huang, Tianyuan Wang, Shoubin Long, Jing Wang, Lei Yin, Qingshuang Zou, Quan Liu, Zifen Guo
Cellular immunotherapy is a crucial aspect of current tumor immunotherapy, though it presents several challenges such as immune cell dysfunction, limited recognition of neoantigens, and inadequate lymphocyte infiltration into the tumor microenvironment. This study proposes a novel approach utilizing a combination of dendritic cell (DC)-based cellular immunotherapy and a photothermal nanoadjuvant black phosphorus (BP) nanoparticles to overcome these challenges. A new platform called PLGA@BP-R848, which consists of modifying poly-(lactic- co -glycolic acid) (PLGA) onto BP nanosheets loading the immune adjuvant R848...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38446095/multiple-treatment-of-triple-negative-breast-cancer-through-gambogic-acid-loaded-mesoporous-polydopamine
#11
JOURNAL ARTICLE
Jiaqi Liu, Hongmei Liu, Shan Huang, Hong Peng, Jiamei Li, Kerong Tu, Sumin Tan, Rou Xie, Lei Lei, Qin Yue, Huile Gao, Lulu Cai
Triple-negative breast cancer (TNBC) is a highly heterogeneous subtype of breast cancer, characterized by aggressiveness and high recurrence rate. As monotherapy provides limited benefit to TNBC patients, combination therapy emerges as a promising treatment approach. Gambogic acid (GA) is an exceedingly promising anticancer agent. Nonetheless, its application potential is hampered by low drug loading efficiency and associated toxic side effects. To overcome these limitations, using mesoporous polydopamine (MPDA) endowed with photothermal conversion capabilities is considered as a delivery vehicle for GA...
March 6, 2024: Small
https://read.qxmd.com/read/38441015/the-emerging-role-of-cell-membrane-coated-nanomaterials-in-cancer-therapy
#12
JOURNAL ARTICLE
Sankha Bhattacharya, Paul Beninger
This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within the embryonic landscape of nanotechnology. Nanoparticles, pivotal in cancer treatment, are systematically examined for their diverse physicochemical structures, categorized as organic (lipid-based, protein-based, and polymer-assisted) and inorganic (carbon-based and metal) varieties. A significant focus is placed on CMNPs, which serve as an innovative drug delivery vehicle, overcoming limitations associated with conventional nanoparticle therapies...
March 1, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38409920/-three-in-one-a-photoactivable-nanoplatform-evokes-anti-immune-response-by-inhibiting-brd4-cmyc-pdl1-axis-to-intensify-photo-immunotherapy
#13
JOURNAL ARTICLE
Ayeskanta Mohanty, Mingyu Lee, Adityanarayan Mohapatra, Hwangjae Lee, Arathy Vasukutty, Seonguk Baek, Jae Young Lee, In-Kyu Park
Combinatorial immuno-cancer therapy has been recognized as a promising approach for efficiently treating malignant tumors. Yet, the development of multifunctional nanomedicine capable of precise tumor targeting, remote activation, and immune-regulating drug delivery remains a significant challenge. In this study, we developed nanoparticles loaded with an immune checkpoint inhibitor (JQ-1) using polypyrrole/hyaluronic acid (PPyHA/JQ-1). These nanoparticles offer active tumor targeting, photothermal tumor ablation using near-infrared light, and laser-controlled JQ-1 release for efficient breast cancer treatment...
February 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38401438/glutathione-degradable-manganese-doped-polydopamine-nanoparticles-for-photothermal-therapy-and-cgas-sting-activated-immunotherapy-of-lung-tumor
#14
JOURNAL ARTICLE
Heping Lin, Cong Jiang, Bo Wang, Yubin Wang, Zongxiao Shangguan, Youyi Wu, Xiaoyan Wang, Yiwei Huang, Lihua Wang, Pengcheng Chen, Xianglong Li, Zhengrong Zhong, Songsong Wu
Photothermal therapy (PTT), which utilizes nanomaterials to harvest laser energy and convert it into heat to ablate tumor cells, has been rapidly developed for lung tumor treatment, but most of the PTT-related nanomaterials are not degradable, and the immune response associated with PTT is unclear, which leads to unsatisfactory results of the actual PTT. Herein, we rationally designed and prepared a manganese ion-doped polydopamine nanomaterial (MnPDA) for immune-activated PTT with high efficiency. Firstly, MnPDA exhibited 57...
February 22, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38389925/moving-beyond-traditional-therapies-the-role-of-nanomedicines-in-lung-cancer
#15
REVIEW
Jingjing Zhang, Yanzhi Li, Sa Guo, Weifen Zhang, Bing Fang, Shaohui Wang
Amidst a global rise in lung cancer occurrences, conventional therapies continue to pose substantial side effects and possess notable toxicities while lacking specificity. Counteracting this, the incorporation of nanomedicines can notably enhance drug delivery at tumor sites, extend a drug's half-life and mitigate inadvertent toxic and adverse impacts on healthy tissues, substantially influencing lung cancer's early detection and targeted therapy. Numerous studies signal that while the nano-characteristics of lung cancer nanomedicines play a pivotal role, further interplay with immune, photothermal, and genetic factors exist...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38380506/a-multifunctional-bimetallic-nanoplatform-for-synergic-local-hyperthermia-and-chemotherapy-targeting-her2-positive-breast-cancer
#16
JOURNAL ARTICLE
Li Zhao, Fei Chang, Yao Tong, Jiawei Yin, Jiawen Xu, Hui Li, Lutao Du, Yanyan Jiang
Anti-HER2 (human epidermal growth factor receptor 2) therapies significantly increase the overall survival of patients with HER2-positive breast cancer. Unfortunately, a large fraction of patients may develop primary or acquired resistance. Further, a multidrug combination used to prevent this in the clinic places a significant burden on patients. To address this issue, this work develops a nanotherapeutic platform that incorporates bimetallic gold-silver hollow nanoshells (AuAg HNSs) with exceptional near-infrared (NIR) absorption capability, the small-molecule tyrosine kinase inhibitor pyrotinib (PYR), and Herceptin (HCT)...
February 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38368252/image-guided-photothermal-and-immune-therapy-of-tumors-via-melanin-producing-genetically-engineered-bacteria
#17
JOURNAL ARTICLE
Weijian Song, Yaling He, Yanan Feng, Yuanyuan Wang, Xiaoying Li, Yingnan Wu, Shanxin Zhang, Lin Zhong, Fei Yan, Litao Sun
Photothermal therapy (PTT) is a new treatment modality for tumors. However, the efficient delivery of photothermal agents into tumors remains difficult, especially in hypoxic tumor regions. In this study, an approach to deliver melanin, a natural photothermal agent, into tumors using genetically engineered bacteria for image-guided photothermal and immune therapy is developed. An Escherichia coli MG1655 is transformed with a recombinant plasmid harboring a tyrosinase gene to produce melanin nanoparticles. Melanin-producing genetically engineered bacteria (MG1655-M) are systemically administered to 4T1 tumor-bearing mice...
February 17, 2024: Small
https://read.qxmd.com/read/38348177/precision-uspio-peg-sle-x-nanotheranostic-agent-targeted-photothermal-therapy-for-enhanced-anti-pd-l1-immunotherapy-to-treat-immunotherapy-resistance
#18
JOURNAL ARTICLE
Ting Li, Lianshan Guo, Jiaxu Li, Xingyu Mu, Lijuan Liu, Shulin Song, Ningbin Luo, Qi Zhang, Bin Zheng, Guanqiao Jin
BACKGROUND: The anti-Programmed Death-Ligand 1 (termed aPD-L1) immune checkpoint blockade therapy has emerged as a promising treatment approach for various advanced solid tumors. However, the effect of aPD-L1 inhibitors limited by the tumor microenvironment makes most patients exhibit immunotherapy resistance. METHODS: We conjugated the Sialyl Lewis X with a polyethylene glycol-coated ultrasmall superparamagnetic iron oxide (USPIO-PEG) to form UPS nanoparticles (USPIO-PEG-SLex , termed UPS)...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38301594/acyltransferase-zinc-finger-dhhc-type-containing-2-aggravates-gastric-carcinoma-growth-by-targeting-nrf2-signaling-a-mechanism-based-multicombination-bionic-nano-drug-therapy
#19
JOURNAL ARTICLE
Luguang Liu, Longgang Wang, Liqing Liu, Xianlin Qu, Weizhu Zhao, Jishuang Ding, Siwei Zhao, Botao Xu, Hang Yu, Bing Liu, Jie Chai
The significant regulatory role of palmitoylation modification in cancer-related targets has been demonstrated previously. However, the biological functions of Nrf2 in stomach cancer and whether the presence of Nrf2 palmitoylation affects gastric cancer (GC) progression and its treatment have not been reported. Several public datasets were used to look into the possible link between the amount of palmitoylated Nrf2 and the progression and its outcome of GC in patients. The palmitoylated Nrf2 levels in tumoral and peritumoral tissues from GC patients were also evaluated...
January 23, 2024: Redox Biology
https://read.qxmd.com/read/38286337/supramolecular-prodrug-like-nanotheranostics-with-dynamic-and-activatable-nature-for-synergistic-photothermal-immunotherapy-of-metastatic-cancer
#20
JOURNAL ARTICLE
Yajie Li, Xueluer Mu, Wenbi Feng, Min Gao, Zigeng Wang, Xue Bai, Xiangru Ren, Yingxi Lu, Xianfeng Zhou
Synergistic photothermal immunotherapy has attracted widespread attention due to the mutually reinforcing therapeutic effects on primary and metastatic tumors. However, the lack of clinical approval nanomedicines for spatial, temporal, and dosage control of drug co-administration underscores the challenges facing this field. Here, a photothermal agent (Cy7-TCF) and an immune checkpoint blocker (NLG919) are conjugated via disulfide bond to construct a tumor-specific small molecule prodrug (Cy7-TCF-SS-NLG), which self-assembles into prodrug-like nano-assemblies (PNAs) that are self-delivering and self-formulating...
January 27, 2024: Journal of Controlled Release
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