keyword
https://read.qxmd.com/read/38480883/rapid-unleashing-of-macrophage-efferocytic-capacity-via-transcriptional-pause-release
#21
JOURNAL ARTICLE
Turan Tufan, Gamze Comertpay, Ambra Villani, Geoffrey M Nelson, Marina Terekhova, Shannon Kelley, Pavel Zakharov, Rochelle M Ellison, Oleg Shpynov, Michael Raymond, Jerry Sun, Yitan Chen, Enno Bockelmann, Marta Stremska, Lance W Peterson, Laura Boeckaerts, Seth R Goldman, J Iker Etchegaray, Maxim N Artyomov, Francesca Peri, Kodi S Ravichandran
During development, inflammation or tissue injury, macrophages may successively engulf and process multiple apoptotic corpses via efferocytosis to achieve tissue homeostasis1 . How macrophages may rapidly adapt their transcription to achieve continuous corpse uptake is incompletely understood. Transcriptional pause/release is an evolutionarily conserved mechanism, in which RNA polymerase (Pol) II initiates transcription for 20-60 nucleotides, is paused for minutes to hours and is then released to make full-length mRNA2 ...
March 13, 2024: Nature
https://read.qxmd.com/read/38479194/associations-of-history-of-alcohol-use-disorder-with-loneliness-social-support-and-mental-health-during-the-covid-19-pandemic
#22
JOURNAL ARTICLE
Jeremy W Luk, Noa Leiter, Bethany L Stangl, Tommy Gunawan, Melanie L Schwandt, David Goldman, Nancy Diazgranados, Vijay A Ramchandani
This study examined the effects of alcohol use disorder (AUD) and treatment history on changes in loneliness, social support, and mental health symptoms from before to during the pandemic, and tested loneliness and social support as mediators of the AUD-mental health associations. Participants (n = 427) enrolled in the NIAAA COVID-19 Pandemic Impact on Alcohol Study were categorized into three groups: healthy control (62.3%), nontreatment AUD (14.1%), and treatment AUD (23.7%). Multilevel generalized linear models were conducted to examine changes in loneliness, social support, and mental health symptoms by group...
February 27, 2024: Psychiatry Research
https://read.qxmd.com/read/38478079/overactive-bladder-negatively-affects-erectile-function-and-promotes-premature-ejaculation-findings-from-large-representative-population-level-study
#23
JOURNAL ARTICLE
Mikolaj Przydacz, Nadir Osman, Sabrina De Cillis, Cyrille Guillot-Tantay, Francois Herve, Tanja Hüsch, Ester Illiano, Antonio Tienza Fernandez, Manuela Tutolo, Luis Vale, Mehmet Gokhan Culha, Fabiana Cancrini, Steeve Doizi, Paolo Geretto, Nicholas Raison, Howard B Goldman, Piotr Chlosta, Veronique Phe
PURPOSE: The effect of overactive bladder (OAB) on sexual health has been evaluated extensively for women but much less for men. Therefore, the aim of this study was to evaluate the relationship between OAB and men's sexual activity and the effect of OAB on erectile dysfunction (ED) and premature ejaculation (PE) in a large representative cohort of men at the population level. METHODS: This study was based on computer-assisted web interviews that used validated questionnaires...
March 13, 2024: World Journal of Urology
https://read.qxmd.com/read/38463036/balancing-the-benefits-of-vaccination-an-envy-free-strategy
#24
JOURNAL ARTICLE
Pedro Ribeiro de Almeida, Vitor Hirata Sanches, Carla Goldman
The Covid-19 pandemic revealed the difficulties of vaccinating a population under the circumstances marked by urgency and limited availability of doses while balancing benefits associated with distinct guidelines satisfying specific ethical criteria. We offer a vaccination strategy that may be useful in this regard. It relies on the mathematical concept of envy-freeness. We consider finding balance by allocating the resource among individuals that seem heterogeneous concerning the direct and indirect benefits of vaccination, depending on age...
March 2024: PNAS Nexus
https://read.qxmd.com/read/38462589/dysregulation-of-extracellular-potassium-distinguishes-healthy-ageing-from-neurodegeneration
#25
JOURNAL ARTICLE
Fengfei Ding, Qian Sun, Carter Long, Rune Nguyen Rasmussen, Sisi Peng, Qiwu Xu, Ning Kang, Wei Song, Pia Weikop, Steven A Goldman, Maiken Nedergaard
Progressive neuronal loss is a hallmark feature distinguishing neurodegenerative diseases from normal aging. However, the underlying mechanisms remain unknown. Extracellular K+ homeostasis is a potential mediator of neuronal injury since K+ elevations increase excitatory activity. The dysregulation of extracellular K+ and potassium channel expressions during neurodegeneration could contribute to this distinction. We here measured the cortical extracellular K+ concentration ([K+]e) in awake wildtype mice as well as murine models of neurodegeneration using K+-sensitive microelectrodes...
March 11, 2024: Brain
https://read.qxmd.com/read/38458871/a-community-engaged-approach-to-translate-a-vaccine-hesitancy-scale-into-haitian-creole
#26
JOURNAL ARTICLE
Greta Sirek, Sciaska Ulysse, Marie Jacques Toussaint, Chisa Nosamiefan, Ludwige Desrosiers, Mia Chandler, Rosalind Ramsey-Goldman, Dieufort J Fleurissaint, Candace H Feldman
OBJECTIVE: Accurately translated health materials are needed to achieve equity in vaccine uptake among U.S. individuals with non-English language preferences. Verbatim translations may not capture the cultural and linguistic vernacular required to understand vaccine hesitancy. We leveraged a community-engaged approach to translate the Vaccine Hesitancy Scale (VHS) into Haitian Creole. METHODS: Following the "WHO Guidelines on Translation and Adaptation of Instruments" and a community-engaged framework, a validated 10-question Vaccine Hesitancy Scale (VHS) underwent forward translation, expert panel review, back translation, and focus group pilot testing...
March 7, 2024: Vaccine
https://read.qxmd.com/read/38458325/major-complications-and-adverse-events-related-to-use-of-spaceoar-hydrogel-for-prostate-cancer-radiotherapy
#27
JOURNAL ARTICLE
Jack Millot, Camilo Arenas-Gallo, Esther Silver, Mollie Goldman, Shany Picciotto, Angela Y Jia, Nicholas G Zaorsky, Daniel E Spratt, Elisha T Fredman, Jonathan E Shoag
OBJECTIVE: To determine the prevalence and severity of SpaceOARTM -related adverse events using the Manufacturer and User Facility Device Experience (MAUDE) database. METHODS: We analyzed SpaceOAR-related adverse event reports in the Manufacturer and User Facility Device Experience (MAUDE) database from January 2015 to May 2023. For each report, the event type, associated device and patient problems, event description, event timing, and event severity stratified by the Common Terminology Criteria for Adverse Events version 5...
March 6, 2024: Urology
https://read.qxmd.com/read/38457731/probing-hydrodynamic-fluctuation-induced-forces-with-an-oscillating-robot
#28
JOURNAL ARTICLE
Steven W Tarr, Joseph S Brunner, Daniel Soto, Daniel I Goldman
We study the dynamics of an oscillating, free-floating robot that generates radially expanding gravity-capillary waves at a fluid surface. In open water, the device does not self-propel; near a rigid boundary, it can be attracted or repelled. Visualization of the wave field dynamics reveals that when near a boundary, a complex interference of generated and reflected waves induces a wave amplitude fluctuation asymmetry. Attraction increases as wave frequency increases or robot-boundary separation decreases. Theory on confined gravity-capillary wave radiation dynamics developed by Hocking in the 1980s captures the observed parameter dependence due to these "Hocking fields...
February 23, 2024: Physical Review Letters
https://read.qxmd.com/read/38456576/data-stewardship-in-ftld-research-investigator-and-research-participant-views
#29
JOURNAL ARTICLE
Jalayne J Arias, Ana M Tyler, Laura M Beskow, Maria C Carillo, Susan Dickinson, Jill Goldman, Mary A Majumder, Michelle M Mello, Heather M Snyder, Jennifer S Yokoyama
INTRODUCTION: Federal policies and guidelines have expanded the return of individual results to participants and expectations for data sharing between investigators and through repositories. Here, we report investigators' and study participants' views and experiences with data stewardship practices within frontotemporal lobal degeneration (FTLD) research, which reveal unique ethical challenges. METHODS: Semi-structured interviews with (1) investigators conducting FTLD research that includes genetic data collection and/or analysis and (2) participants enrolled in a single site longitudinal FTLD study...
March 8, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38455748/further-validation-of-poor-prognosis-for-pediatric-kmt2a-rearranged-leukemia-and-the-need-for-rapid-integration-of-targeted-therapies-for-these-patients
#30
EDITORIAL
Joshua W Goldman, Rajen J Mody
No abstract text is available yet for this article.
February 29, 2024: Translational Pediatrics
https://read.qxmd.com/read/38452896/incidental-dvt-diagnosed-on-lower-extremity-ct-is-a-rare-but-clinically-impactful-finding
#31
JOURNAL ARTICLE
Peter A L Barros, Daniel J Castro, Roger E Goldman, Mimmie Kwong
BACKGROUND: In the setting of a known thrombotic event, computed tomography (CT) studies provide reasonable sensitivity for the diagnosis of deep venous thrombosis (DVT). However, the incidence and accuracy of a DVT diagnosis on CT studies not targeted for the detection of DVT is not well described. Additionally, the clinical impact of DVTs incidentally identified on CT is unknown. METHODS: In this single institution retrospective study, we queried all contrasted CT studies of the lower extremities performed over a 10-year period...
February 22, 2024: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://read.qxmd.com/read/38451856/interactions-between-circuit-architecture-and-plasticity-in-a-closed-loop-cerebellar-system
#32
JOURNAL ARTICLE
Hannah L Payne, Jennifer L Raymond, Mark S Goldman
Determining the sites and directions of plasticity underlying changes in neural activity and behavior is critical for understanding mechanisms of learning. Identifying such plasticity from neural recording data can be challenging due to feedback pathways that impede reasoning about cause and effect. We studied interactions between feedback, neural activity, and plasticity in the context of a closed-loop motor learning task for which there is disagreement about the loci and directions of plasticity: vestibulo-ocular reflex learning...
March 7, 2024: ELife
https://read.qxmd.com/read/38451077/histone-acetyltransferase-sas3-contributes-to-fungal-development-cell-wall-integrity-and-virulence-in-aspergillus-fumigatus
#33
JOURNAL ARTICLE
Yamei Wang, Jialu Fan, Zhengyu Zhou, Gustavo H Goldman, Ling Lu, Yuanwei Zhang
UNLABELLED: Histone acetyltransferase (HAT)-mediated epigenetic modification is essential for diverse cellular processes in eukaryotes. However, the functions of HATs in the human pathogen Aspergillus fumigatus remain poorly understood. In this study, we characterized the functions of <u>M</u>OZ, <u>Y</u>bf2/<u>S</u>as3, Sas2, and <u>T</u>ip60 (MYST)-family histone acetyltransferase something about silencing (Sas3) in A. fumigatus . Phenotypic analysis revealed that loss of Sas3 results in significant impairments in colony growth, conidiation, and virulence in the Galleria mellonella model...
March 7, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38450731/a-reactive-molecular-dynamics-model-for-uranium-hydrogen-containing-systems
#34
JOURNAL ARTICLE
Artem Soshnikov, Rebecca Lindsey, Ambarish Kulkarni, Nir Goldman
Uranium-based materials are valuable assets in the energy, medical, and military industries. However, understanding their sensitivity to hydrogen embrittlement is particularly challenging due to the toxicity of uranium and the computationally expensive nature of quantum-based methods generally required to study such processes. In this regard, we have developed a Chebyshev Interaction Model for Efficient Simulation (ChIMES) that can be employed to compute energies and forces of U and UH3 bulk structures with vacancies and hydrogen interstitials with accuracy similar to that of Density Functional Theory (DFT) while yielding linear scaling and orders of magnitude improvement in computational efficiency...
March 7, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38448582/a-concerted-neuron-astrocyte-program-declines-in-ageing-and-schizophrenia
#35
JOURNAL ARTICLE
Emi Ling, James Nemesh, Melissa Goldman, Nolan Kamitaki, Nora Reed, Robert E Handsaker, Giulio Genovese, Jonathan S Vogelgsang, Sherif Gerges, Seva Kashin, Sulagna Ghosh, John M Esposito, Kiely Morris, Daniel Meyer, Alyssa Lutservitz, Christopher D Mullally, Alec Wysoker, Liv Spina, Anna Neumann, Marina Hogan, Kiku Ichihara, Sabina Berretta, Steven A McCarroll
Human brains vary across people and over time; such variation is not yet understood in cellular terms. Here we describe a relationship between people's cortical neurons and cortical astrocytes. We used single-nucleus RNA sequencing to analyse the prefrontal cortex of 191 human donors aged 22-97 years, including healthy individuals and people with schizophrenia. Latent-factor analysis of these data revealed that, in people whose cortical neurons more strongly expressed genes encoding synaptic components, cortical astrocytes more strongly expressed distinct genes with synaptic functions and genes for synthesizing cholesterol, an astrocyte-supplied component of synaptic membranes...
March 6, 2024: Nature
https://read.qxmd.com/read/38445873/phylogenomics-reveals-extensive-misidentification-of-fungal-strains-from-the-genus-aspergillus
#36
JOURNAL ARTICLE
Jacob L Steenwyk, Charu Balamurugan, Huzefa A Raja, Carla Gonçalves, Ningxiao Li, Frank Martin, Judith Berman, Nicholas H Oberlies, John G Gibbons, Gustavo H Goldman, David M Geiser, Jos Houbraken, David S Hibbett, Antonis Rokas
Modern taxonomic classification is often based on phylogenetic analyses of a few molecular markers, although single-gene studies are still common. Here, we leverage genome-scale molecular phylogenetics (phylogenomics) of species and populations to reconstruct evolutionary relationships in a dense data set of 710 fungal genomes from the biomedically and technologically important genus Aspergillus . To do so, we generated a novel set of 1,362 high-quality molecular markers specific for Aspergillus and provided profile Hidden Markov Models for each, facilitating their use by others...
March 6, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38436657/sleep-disturbance-as-a-mediator-of-lung-cancer-stigma-on-psychological-distress-and-physical-symptom-burden
#37
JOURNAL ARTICLE
Timothy J Williamson, Edward B Garon, Michael R Irwin, Alyssa K Choi, Jonathan W Goldman, Annette L Stanton
OBJECTIVE: This study tested sleep disturbance as a mediator through which stigma and discrimination predict psychological distress and physical symptom burden in adults with lung cancer. METHODS: Lung cancer patients on active oncological treatment (N = 108; 74.1% Stage IV) completed questionnaires on lung cancer stigma, sleep, distress, and physical symptoms at study entry and at 6- and 12-week follow-up. Mediation analyses were conducted to investigate whether stigma and discrimination predicted distress and physical symptoms at study entry and across 12 weeks through disrupted sleep...
February 27, 2024: Psychosomatic Medicine
https://read.qxmd.com/read/38436520/ten-year-follow-up-of-cavoportal-hemitransposition-in-pediatric-liver-transplantation-for-complete-portomesenteric-venous-thrombosis-a-case-report-and-literature-review
#38
REVIEW
John O Barron, Kadakkal Radhakrishnan, Christopher Coppa, Deborah Goldman, Vera Hupertz, Mike Leonis, Bijan Eghtesad, Koji Hashimoto
BACKGROUND: Portal vein thrombosis is a potentially devastating complication following pediatric liver transplantation. In rare instances of complete portomesenteric thrombosis, cavoportal hemitransposition may provide graft inflow. Here we describe long-term results following a case of pediatric cavoportal hemitransposition during liver transplantation and review the current pediatric literature. METHODS: A 9-month-old female with a history of biliary atresia and failed Kasai portoenterostomy underwent living donor liver transplantation, which was complicated by portomesenteric venous thrombosis...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433189/natural-language-processing-to-identify-lupus-nephritis-phenotype-in-electronic-health-records
#39
JOURNAL ARTICLE
Yu Deng, Jennifer A Pacheco, Anika Ghosh, Anh Chung, Chengsheng Mao, Joshua C Smith, Juan Zhao, Wei-Qi Wei, April Barnado, Chad Dorn, Chunhua Weng, Cong Liu, Adam Cordon, Jingzhi Yu, Yacob Tedla, Abel Kho, Rosalind Ramsey-Goldman, Theresa Walunas, Yuan Luo
BACKGROUND: Systemic lupus erythematosus (SLE) is a rare autoimmune disorder characterized by an unpredictable course of flares and remission with diverse manifestations. Lupus nephritis, one of the major disease manifestations of SLE for organ damage and mortality, is a key component of lupus classification criteria. Accurately identifying lupus nephritis in electronic health records (EHRs) would therefore benefit large cohort observational studies and clinical trials where characterization of the patient population is critical for recruitment, study design, and analysis...
March 3, 2024: BMC Medical Informatics and Decision Making
https://read.qxmd.com/read/38431870/hematological-inflammatory-biomarkers-in-patients-with-alcohol-and-cocaine-use-disorders
#40
JOURNAL ARTICLE
Andressa Goldman Ruwel, Juliana Nichterwitz Scherer, Daiane Silvello, Felix Henrique Paim Kessler, Lisia von Diemen, Jaqueline Bohrer Schuch
BACKGROUND: Neutrophil-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelets-lymphocyte ratio (PLR) are biomarkers easy-to-obtain and could be used in clinical practice to verify an inflammatory status and are associated with alcohol use disorder (AUD) and cocaine use disorder (CUD). Our aim was to compare NLR, MLR and PLR among men with AUD and CUD and to assess the relationship between these biomarkers and addiction-related outcomes. METHODS: This is a cross-sectional study comprising 979 inpatient men diagnosed with substance use disorder (391 with AUD and 588 with CUD) under hospital treatment for drug addiction...
March 3, 2024: Trends in Psychiatry and Psychotherapy
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