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https://read.qxmd.com/read/30870405/notes-from-the-field-hiv-diagnoses-among-persons-who-inject-drugs-northeastern-massachusetts-2015-2018
#1
Kevin Cranston, Charles Alpren, Betsey John, Erica Dawson, Kathleen Roosevelt, Amanda Burrage, Janice Bryant, William M Switzer, Courtney Breen, Philip J Peters, Tracy Stiles, Ashley Murray, H Dawn Fukuda, William Adih, Linda Goldman, Nivedha Panneer, Barry Callis, Ellsworth M Campbell, Liisa Randall, Anne Marie France, R Monina Klevens, Sheryl Lyss, Shauna Onofrey, Christine Agnew-Brune, Michael Goulart, Hongwei Jia, Matthew Tumpney, Paul McClung, Sharoda Dasgupta, Danae Bixler, Kischa Hampton, Jenifer Leaf Jaeger, Kate Buchacz, Alfred DeMaria
No abstract text is available yet for this article.
March 15, 2019: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/30867175/analgesia-for-lumbar-puncture-in-infants-and-children
#2
Ran D Goldman
Question As a family physician who works in the local community emergency department, my skills include performing lumbar puncture in young children and infants. I hear conflicting recommendations in regard to provision of analgesia during lumbar puncture in these patients. Does local analgesia affect the success rate of the procedure? What is the best practice for analgesia in young children and infants? Answer Lumbar puncture is one of the most commonly encountered painful procedures in pediatric medicine; it is imperative for timely diagnosis of central nervous system infections in febrile young infants...
March 2019: Canadian Family Physician Médecin de Famille Canadien
https://read.qxmd.com/read/30867052/lewy-body-dementia-association-s-research-centers-of-excellence-program-inaugural-meeting-proceedings
#3
Bethany Peterson, Melissa Armstrong, Douglas Galasko, James E Galvin, Jennifer Goldman, David Irwin, Henry Paulson, Daniel Kaufer, James Leverenz, Angela Lunde, Ian G McKeith, Andrew Siderowf, Angela Taylor, Katherine Amodeo, Matt Barrett, Kimiko Domoto-Reilly, John Duda, Stephen Gomperts, Neill Graff-Radford, Samantha Holden, Lawrence Honig, Daniel Huddleston, Carol Lippa, Irene Litvan, Carol Manning, Karen Marder, Charbel Moussa, Chiadi Onyike, Fernando Pagan, Alexander Pantelyat, Victoria Pelak, Kathleen Poston, Joseph Quinn, Irene Richard, Liana S Rosenthal, Marwan Sabbagh, Douglas Scharre, Sharon Sha, Holly Shill, Yasar Torres-Yaghi, Tina Christie, Todd Graham, Ian Richards, Mike Koehler, Brad Boeve
The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator's meeting was held on December 14, 2017, in New Orleans. The program was established to increase patient access to clinical experts on Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), and to create a clinical trials-ready network. Four working groups (WG) were created to pursue the LBDA RCOE aims: (1) increase access to high-quality clinical care, (2) increase access to support for people living with LBD and their caregivers, (3) increase knowledge of LBD among medical and allied (or other) professionals, and (4) create infrastructure for a clinical trials-ready network as well as resources to advance the study of new therapeutics...
March 13, 2019: Alzheimer's Research & Therapy
https://read.qxmd.com/read/30858833/ploidy-determination-in-the-pathogenic-fungus-sporothrix-spp
#4
Beatriz H Ferreira, Jorge H Ramírez-Prado, Gabriela W P Neves, Egídio Torrado, Paula Sampaio, Maria Sueli S Felipe, Ana Tereza Vasconcelos, Gustavo H Goldman, Agostinho Carvalho, Cristina Cunha, Leila M Lopes-Bezerra, Fernando Rodrigues
The pathogenic clade of the Sporothrix genus comprises the etiological agents of sporotrichosis, a worldwide emergent disease. Despite the growing understanding of their successful pathogen traits, there is little information on genome sizes and ploidy within the genus. Therefore, in this work, we evaluated the ploidy of four species of the Sporothrix genus, specifically Sporothrix brasiliensis , Sporothrix schenckii , Sporothrix globosa , and Sporothrix pallida . Through cell cycle analysis of the yeast-phase cells, we showed that the DNA content of G0 /G1 cells was similar to the genome size determined by whole genome sequencing...
2019: Frontiers in Microbiology
https://read.qxmd.com/read/30858534/ting-kai-li-m-d
#5
David Goldman
No abstract text is available yet for this article.
March 11, 2019: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://read.qxmd.com/read/30858177/substitutions-that-lock-and-unlock-the-proton-coupled-folate-transporter-pcft-slc46a1-in-an-inward-open-conformation
#6
Srinivas Aluri, Rongbao Zhao, Kai Lin, Daniel Sanghoon Shin, Andras Fiser, I David Goldman
The proton-coupled folate transporter (PCFT) mediates intestinal absorption of folates and their transport from blood to cerebrospinal fluid across the choroid plexus. Substitutions at Asp109 in the first intracellular loop between the first and second transmembrane domains (TMDs) abolish PCFT function, but protein expression and trafficking to the cell membrane are retained. Here, we used site-directed mutagenesis, the substituted-cysteine accessibility method, functional analyses and homology modeling, to determine whether the D109A substitution locks PCFT in one of its conformational states...
March 11, 2019: Journal of Biological Chemistry
https://read.qxmd.com/read/30850373/de-novo-missense-variant-in-the-gtpase-effector-domain-ged-of-dnm1l-leads-to-static-encephalopathy-and-seizures
#7
Nurit Assia Batzir, Pranjali Bhagwat, Tanya Eble, Pengfei Liu, Christine Eng, Sarah H Elsea, Laurie A Robak, Fernando Scaglia, Alica Goldman, Shweta U Dhar, Michael F Wangler
DNM1L encodes a GTPase of the dynamin superfamily which plays a crucial role in mitochondrial and peroxisomal fission. Pathogenic variants affecting the middle domain and the GTPase domain of DNM1L have been implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 (EMPF1, MIM #614388). Patients show variable phenotypes ranging from severe hypotonia leading to death in the neonatal period to developmental delay/regression, with or without seizures. Familial pathogenic variants in the GTPase domain have also been associated with isolated optic atrophy...
March 8, 2019: Cold Spring Harbor Molecular Case Studies
https://read.qxmd.com/read/30842251/potent-antineoplastic-effects-of-combined-pi3k%C3%AE-mnk-inhibition-in-medulloblastoma
#8
Frank Eckerdt, Jonathan B Bell, Elspeth M Beauchamp, Jessica Clymer, Gavin T Blyth, Ewa M Kosciuczuk, Quanhong Ma, David Z Chen, Craig Horbinski, Stewart Goldman, Hidayatullah G Munshi, Rintaro Hashizume, Leonidas C Platanias
Medulloblastoma is a highly malignant pediatric brain tumor associated with poor outcome. Developing treatments that target the cancer stem cell (CSC) population in medulloblastoma are important to prevent tumor relapse and induce long-lasting clinical responses. We utilized medulloblastoma neurospheres that display CSC characteristics and found activation of the PI3K/AKT pathway in sphere-forming cells. Of all class IA PI3Ks, only the PI3Kα isoform was required for sphere formation by medulloblastoma cells...
March 6, 2019: Molecular Cancer Research: MCR
https://read.qxmd.com/read/30839344/differential-expression-of-plag1-in-apocrine-and-eccrine-cutaneous-mixed-tumors-evidence-for-distinct-molecular-pathogenesis
#9
Eleanor Russell-Goldman, Adrian Dubuc, John Hanna
Cutaneous mixed tumors, also known as chondroid syringomas, are benign adnexal neoplasms that share histomorphologic features with pleomorphic adenomas of the salivary gland. Recent work suggests that the similarity between these 2 tumor types extends to the molecular level because both harbor identical chromosomal rearrangements involving the PLAG1 gene. The resulting nuclear PLAG1 overexpression can be detected by immunohistochemistry and has become a useful diagnostic adjunct for both tumor types. In the skin, however, there are 2 morphologically distinct types of mixed tumor, which have been referred to as apocrine-type cutaneous mixed tumor (AMT) and eccrine-type cutaneous mixed tumor (EMT)...
February 28, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30837981/mapping-the-fungal-battlefield-using-in-situ-chemistry-and-deletion-mutants-to-monitor-interspecific-chemical-interactions-between-fungi
#10
Sonja L Knowles, Huzefa A Raja, Allison J Wright, Ann Marie L Lee, Lindsay K Caesar, Nadja B Cech, Matthew E Mead, Jacob L Steenwyk, Laure N A Ries, Gustavo H Goldman, Antonis Rokas, Nicholas H Oberlies
Fungi grow in competitive environments, and to cope, they have evolved strategies, such as the ability to produce a wide range of secondary metabolites. This begs two related questions. First, how do secondary metabolites influence fungal ecology and interspecific interactions? Second, can these interspecific interactions provide a way to "see" how fungi respond, chemically, within a competitive environment? To evaluate these, and to gain insight into the secondary metabolic arsenal fungi possess, we co-cultured Aspergillus fischeri , a genetically tractable fungus that produces a suite of mycotoxins, with Xylaria cubensis , a fungus that produces the fungistatic compound and FDA-approved drug, griseofulvin...
2019: Frontiers in Microbiology
https://read.qxmd.com/read/30837793/predictors-of-abnormalities-on-magnetic-resonance-cholangiopancreatography-is-there-a-role-when-the-biliary-tree-is-normal-on-previous-imaging
#11
Bhamini Vadhwana, John Graby, Martin Lewis, Anouchka Goldman, Antoni Sergot, Catherine Ramsey, Kevin J Monahan
Background: There is limited evidence supporting the use of magnetic resonance cholangiopancreatography (MRCP) if the biliary tree is within normal limits on ultrasound scan (US) or computed tomography (CT). The aim of this study was to assess the role of MRCP in the absence of a dilated biliary system on index imaging. Methods: A retrospective observational study of consecutive MRCP investigations (n=427) was performed between October 2010 and June 2013 at a single district general hospital...
March 2019: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://read.qxmd.com/read/30825656/white-matter-connectomes-at-birth-accurately-predict-cognitive-abilities-at-age-2
#12
Jessica B Girault, Brent C Munsell, Danaële Puechmaille, Barbara D Goldman, Juan C Prieto, Martin Styner, John H Gilmore
Cognitive ability is an important predictor of mental health outcomes that is influenced by neurodevelopment. Evidence suggests that the foundational wiring of the human brain is in place by birth, and that the white matter (WM) connectome supports developing brain function. It is unknown, however, how the WM connectome at birth supports emergent cognition. In this study, a deep learning model was trained using cross-validation to classify full-term infants (n = 75) as scoring above or below the median at age 2 using WM connectomes generated from diffusion weighted magnetic resonance images at birth...
February 27, 2019: NeuroImage
https://read.qxmd.com/read/30821968/correct-symmetry-treatment-for-x-x-reactions-prevents-large-errors-in-predicted-isotope-enrichment
#13
Mark Jacob Goldman, Shuhei Ono, William H Green
Confusion over how to account for symmetry numbers when reactants are identical can cause significant errors in isotopic studies. An extraneous factor of two in the reaction symmetry number, as proposed in literature, violates reaction equilibrium and causes huge enrichment errors in isotopic analysis. In actuality, no extra symmetry factor is needed with identical reactants.
March 1, 2019: Journal of Physical Chemistry. A
https://read.qxmd.com/read/30821255/aperiodic-order-coming-of-age-from-inorganic-materials-to-dynamic-protein-superstructures
#14
Gloria Borgstahl, Alan I Goldman, Patricia A Thiel
No abstract text is available yet for this article.
March 1, 2019: Acta Crystallographica. Section A, Foundations and Advances
https://read.qxmd.com/read/30820907/human-glial-chimeric-mice-to-define-the-role-of-glial-pathology-in-human-disease
#15
John N Mariani, Lisa Zou, Steven A Goldman
Human glial progenitor cells (hGPCs) can engraft, expand, and differentiate into functional oligodendrocytes and astrocytes when transplanted neonatally into murine hosts, in which they outcompete the host glial pool to ultimately colonize and dominate the recipient brains. When congenitally hypomyelinated mutants are used as hosts, the donor hGPCs generate myelinogenic oligodendrocytes as well as astrocytes, so that the recipient mice develop a largely humanized white matter, with entirely human-derived myelin...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30820754/concussion-pathophysiology-and-injury-biomechanics
#16
REVIEW
Rafael Romeu-Mejia, Christopher C Giza, Joshua T Goldman
PURPOSE OF REVIEW: The concussion public health burden has increased alongside our knowledge of the pathophysiology of mild traumatic brain injury (mTBI). The purpose of this review is to summarize our current understanding of mTBI pathophysiology and biomechanics and how these underlying principles correlate with clinical manifestations of mTBI. RECENT FINDINGS: Changes in post-mTBI glutamate and GABA concentrations seem to be region-specific and time-dependent...
February 28, 2019: Current Reviews in Musculoskeletal Medicine
https://read.qxmd.com/read/30819475/balloon-occluded-transarterial-chemoembolization-for-the-treatment-of-hepatocellular-carcinoma-a-single-center-us-preliminary-experience
#17
Daryl T Goldman, Manu Singh, Rahul S Patel, F Scott Nowakowski, Vivian Bishay, Mona Ranade, Robert A Lookstein, Aaron M Fischman
This report describes a single-center experience with balloon-occluded transarterial chemoembolization for liver-directed therapy. A total of 26 patients (11 male, 4 female; mean age, 65 y ± 7) with 28 tumors (mean diameter, 2.7 cm; range, 1.1-5.9 cm) were treated. Technical success rate was 100% (28 of 28 cases), with 1 minor complication of left portal vein thrombosis and small liver infarct. Of the 15 tumors analyzed for response, 60% (9 of 15) exhibited complete response, 33.3% (5 of 15) exhibited partial response, and 6...
March 2019: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/30819153/short-term-budget-affordability-of-hepatitis-c-treatments-for-state-medicaid-programs
#18
Jacquelyn W Chou, Alison R Silverstein, Dana P Goldman
BACKGROUND: With some Medicaid state programs still restricting patient access to hepatitis C (HCV) treatment, it is important to demonstrate how states could expand treatment access to a broader Medicaid population and balance short-term budget concerns. METHODS: We used the HCV Transmission and Progression (TaP) Markov model to quantify the impact of removing restrictions to HCV treatment access on the infected populations, expenditures, and net social value for the North Carolina (NC), Oregon (OR), and Wisconsin (WI) Medicaid programs...
February 28, 2019: BMC Health Services Research
https://read.qxmd.com/read/30816938/use-safety-and-efficacy-of-single-patient-use-of-the-us-food-and-drug-administration-expanded-access-program
#19
Noah Z Feit, Debra A Goldman, Evan Smith, Jenny Deighan, Alexia Iasonos, Oliver Zivanovic, David M Hyman
No abstract text is available yet for this article.
February 28, 2019: JAMA Oncology
https://read.qxmd.com/read/30816680/proteasome-%C3%AE-5-subunit-overexpression-improves-proteostasis-during-aging-and-extends-lifespan-in-drosophila-melanogaster
#20
Nga N Nguyen, Anil Rana, Camille Goldman, Rhiannon Moore, Justin Tai, Yongchan Hong, Jingyi Shen, David W Walker, Jae H Hur
The β5 subunit of the proteasome has been shown in worms and in human cell lines to be regulatory. In these models, β5 overexpression results in upregulation of the entire proteasome complex which is sufficient to increase proteotoxic stress resistance, improve metabolic parameters, and increase longevity. However, fundamental questions remain unanswered, including the temporal requirements for β5 overexpression and whether β5 overexpression can extend lifespan in other species. To determine if adult-only overexpression of the β5 subunit can increase proteasome activity in a different model, we characterized phenotypes associated with β5 overexpression in Drosophila melanogaster adults...
February 28, 2019: Scientific Reports
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