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intraarterial cisplatin

Ryuji Kawaguchi, Haruki Nakamura, Sachiko Morioka, Huminori Ito, Yasuhito Tanase, Shoji Haruta, Seiji Kanayama, Shozo Yosida, Naoto Furukawa, Hidekazu Oi, Hiroshi Kobayashi
Background: The purpose of this study was to compare the long-term survival of patients with stage IIIB squamous cell carcinoma of the cervix treated with neoadjuvant intraarterial chemotherapy (IA-NAC) versus those treated with concurrent chemoradiotherapy (CCRT). Methods: We retrospectively reviewed the clinical records of 38 patients with stage IIIB squamous cell carcinoma of the cervix admitted between January 1994 and December 1999 who received IA-NAC followed by abdominal radical hysterectomy (ARH) or radiotherapy (RT)...
December 2013: World Journal of Oncology
Bernhard Robl, Sander Martijn Botter, Giovanni Pellegrini, Olga Neklyudova, Bruno Fuchs
BACKGROUND: Osteosarcoma is the most common primary malignancy of bone. Its treatment relies on the administration of neoadjuvant and adjuvant chemotherapy combined with surgery. Alternative to common intravenous (i.v.) administration of chemotherapeutic drugs, clinical studies also evaluated the benefit of intraarterial (i.a.) administrations. However, conflicting results were obtained when both routes of administration of cisplatin (CDDP), a gold standard drug in osteosarcoma treatment, were compared...
July 16, 2016: Journal of Experimental & Clinical Cancer Research: CR
De-Hua Wu, Min-Ju Li, Da-Xing Tang, Shan Xu, Yong Huang, Jin-Hu Wang, Qiang Shu
Six patients (aged 3-36 mo) with vaginal tumors (rhabdomyosarcoma and endodermal sinus tumor [EST]; n = 3 each) received intraarterial chemotherapy (IAC) and intravenous chemotherapy. Patients underwent internal iliac artery infusion with cisplatin, pirarubicin, and vindesine. Intravenous chemotherapy with vindesine, ifosfamide, and etoposide was administered after 3 weeks. Vaginal tumors disappeared in all patients after 2 or 3 cycles of alternating therapy. Two patients underwent resection of pelvic metastases...
July 2016: Journal of Vascular and Interventional Radiology: JVIR
Kenji Wakayama, Toshiya Kamiyama, Hideki Yokoo, Tatsuhiko Kakisaka, Tatsuya Orimo, Yosuke Tsuruga, Hirofumi Kamachi, Takeshi Soyama, Yusuke Sakuhara, Daisuke Abo, Akinobu Taketomi
Continuous hepatic artery infusion chemotherapy for hepatocellular carcinoma (HCC) refractory to trans-arterial chemoembolization ( TACE) sometimes adversely affects the quality of life (QOL) of patients. Herein, we report a one-shot intraarterial infusion of cisplatin powder (IA-call®) combined with oral anticancer drugs for recurrent HCC refractory to TACE after liver resection.From July 2013, 4 patients who were diagnosed with recurrent HCC refractory to TACE after liver resection were treated with IA-call® infusions at 1-2 month intervals...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Daisuke Yunaiyama, Kazuhiro Saito, Tomokazu Funatsu, Hidetsugu Nakayama, Akira Shimizu, Hiroyuki Ito, Mamoru Suzuki, Soichi Akata, Koichi Tokuuye
OBJECTIVE: The purpose of this study was to evaluate the effectiveness of CT assist for intraarterial chemotherapy in relation to the therapeutic outcomes of intraarterial chemoradiation for advanced head and neck cancer with extension across the anatomical midline (EAM). METHODS: This retrospective study evaluated 64 consecutive patients. In total, 26 and 38 patients had cancer with or without EAM, respectively. These patients underwent an intraarterial cisplatin infusion (200 mg/m(2), days 1 and 35) and intravenous 5-FU infusion (800 mg/m(2), days 1-5 and 36-39) concomitantly with radiotherapy...
December 2014: Japanese Journal of Radiology
Yusuke Mada, Keiichi Koshitsuka, Fumie Ihara, Yuji Ueki, Akiyoshi Konno
We report herein on 32 cases of head and neck carcinoma with cervical lymph node metastases treated by radiotherapy and concomitant intraarterial cisplatin (RADPLAT) from April 2009 to May 2013. N3 cases revealed residual disease of the cervical lymph nodes in 7/9 cases. Among the 22 patients excluding N1 and N3 cases, the pathological CR rate was 63.6%. Among the 13 patients in whom the anticancer drug was directly infused into the cervical lymph nodes, the pathological CR rate was 76.9%, whereas in the 9 patients without direct infusion of the cervical lymph nodes, the pathological CR rate was 44...
June 2014: Nihon Jibiinkoka Gakkai Kaiho
P-H Chiang, C-H Chen, Y-C Shen
BACKGROUND: Limited literature on the role of intraarterial chemotherapy as first-line therapy for penile squamous cell carcinoma is available. METHODS: From 2005 to 2013, a total of 12 patients with various stages of penile squamous cell carcinoma received intraarterial chemotherapy. The chemotherapeutic agents used were methotrexate, mitomycin C, bleomycin, cisplatin, and 5-fluorouracil. Surgery was followed by the tumour responses. RESULTS: An objective tumour response was noted in 10 of 12 patients (83%, 4 complete responders and 6 partial responders)...
September 9, 2014: British Journal of Cancer
Lijuan Jiang, Zhiling Zhang, Pei Dong, Yonghong Li, Kai Yao, Zhuowei Liu, Hui Han, Zike Qin, Min Yao, Fangjian Zhou
BACKGROUND: Bladder cancer is the ninth most common cancer in the world; fewer than 15% of transitional-cell carcinoma patients survive 2 years if left untreated. Although radical cystectomy is the standard treatment of choice, much of them relapse and the necessity of adjuvant chemotherapy is still under debate. The aim of the study was to evaluate the efficacy of adjuvant intraarterial chemotherapy (IAC) with gemcitabine and cisplatin (GC) on locally advanced bladder cancer. METHODS: This is a retrospective study on 60 patients with locally advanced bladder carcinoma who underwent radical cystectomy between May 2000 and June 2011...
2014: Chinese Medical Journal
Manri Kawakami, Masahiko Koda, Mari Mandai, Keiko Hosho, Yoshikazu Murawaki, Wakako Oda, Kazuhiko Hayashi
The aim of this study was to clarify the clinical features of patients with isolated HCC metastases to the heart. A 66-year-old female hospitalized with a hepatocellular carcinoma (HCC) ranging from the right to the left lobe and with a tumor thrombus in the main portal vein, was treated with intraarterial cisplatin, 5-fluouracil, adriamycin and mitomycin. Computed tomography (CT) one month later revealed that the HCC had progressed with multiple lung metastases and moderate ascites. The patient had no symptoms...
May 2013: Oncology Letters
Jian-Ye Liu, Yong-Hong Li, Zhuo-Wei Liu, Zhi-Ling Zhang, Yun-Lin Ye, Kai Yao, Hui Han, Zi-Ke Qin, Fang-Jian Zhou
The prognosis of locally advanced or recurrent squamous cell carcinoma (SCC) of the penis after conventional treatment is dismal. This study aimed to evaluate the therapeutic effects of intraarterial chemotherapy with gemcitabine and cisplatin on locally advanced or recurrent SCC of the penis. Between April 1999 and May 2011, we treated 5 patients with locally advanced penile SCC and 7 patients with recurrent disease with intraarterial chemotherapy. The response rate and toxicity data were analyzed, and survival rates were calculated...
November 2013: Chinese Journal of Cancer
M Sinn, A Nicolaou, B Gebauer, P Podrabsky, D Seehofer, J Ricke, B Dörken, H Riess, B Hildebrandt
BACKGROUND: Effective and tolerable chemotherapy with gemcitabine and cisplatin for advanced biliary tract cancer (BTC) has been established recently. However, overall prognosis is still poor, and additional therapeutic approaches are needed for patients with locally advanced, irresectable and/or pretreated tumors. Hepatic arterial infusion (HAI) of chemotherapy represents a safe and well-established treatment modality, but data on its use in patients with BTC are still sparse. METHODS: Patients with irresectable BTC predominant to the liver were included in a prospective, open phase II study investigating HAI provided through interventionally implanted port catheters...
August 2013: Digestive Diseases and Sciences
Kersten Berndt, Johannes Vogel, Christopher Buehler, Peter Vogt, Walter Born, Bruno Fuchs
Intraarterial chemotherapy (IAC) is considered effective for the treatment of solid tumors with high local doses of systemically toxic chemotherapeutics. Osteosarcoma, which is often located in the extremities, is a potential target for IAC. However, the efficacy of this treatment modality has varied, and standardized protocols are difficult to establish due to tumor heterogeneity and the limited numbers of patients available for clinical trials. Reproducible experimental models are needed to further investigate IAC in osteosarcoma...
November 2012: Journal of the American Association for Laboratory Animal Science: JAALAS
A F Kovács, N Döbert, K Engels
AIM OF STUDY: To assess the effect of strictly local treatment [intraarterial chemotherapy (iaCHT) with high-dose cisplatin and parallel neutralization] in the primary oral and oropharyngeal cancer (OOSCC) on the dependent cervical lymph nodes. PATIENTS AND METHODS: Seventeen consecutive patients with OOSCC and clinically positive necks underwent a prospective blinded comparison of two pre-surgical fluor18-deoxyglucose (FDG)-positron emission tomography (PET) examinations: baseline examination 1 week before and follow-up examination 3 weeks after iaCHT...
April 2012: Indian Journal of Cancer
Shoji Kaku, Kentaro Takahashi, Yoshitaka Murakami, Shirou Wakinoue, Tetsuya Nakagawa, Yoshihiko Shimizu, Nobuyuki Kita, Yoichi Noda, Takashi Murakami
Chemoradiotherapy is currently the main treatment for locally advanced cervical cancer, but neoadjuvant intraarterial chemotherapy (IA-NAC) has been reported to achieve favorable results. This study investigated the efficacy of several different IA-NAC regimens. The subjects were 55 patients with stage IIB-IIIB cervical cancer who received IA-NAC between January 1991 and April 2006. IA-NAC was administered for a total of 1-3 courses at 3-week intervals, with three different regimens being employed in chronological order...
July 2010: Experimental and Therapeutic Medicine
Ron C Gaba, Brian Jin, Dingxin Wang, Robert J Lewandowski, Ann B Ragin, Andrew C Larson, Riad Salem, Reed A Omary
OBJECTIVE: To our knowledge there is currently no quantitative preprocedural method for predicting the distribution and selectivity of delivery of chemoembolic material during trans-arterial chemoembolization. Transcatheter intraarterial perfusion MRI has been developed as a method of quantifying hepatic arterial perfusion. The purpose of this study was to investigate whether findings at transcatheter intraarterial perfusion MRI before chemoembolization can be used to predict uptake of the chemoembolic material delivered during chemoembolization...
May 2012: AJR. American Journal of Roentgenology
Sandeep Samant, Michiel W van den Brekel, Merrill S Kies, Jim Wan, K Thomas Robbins, David I Rosenthal, Coen Rasch, Randal S Weber
BACKGROUND: We performed a retrospective review of patients with nonresected head and neck adenoid cystic carcinoma (ACC) treated with concurrent chemoradiation. METHODS: Sixteen patients (nasopharynx 7, oropharynx 4, trachea 3, oral and nasal cavity 1 each) were treated at 3 tertiary care centers. Six patients received intraarterial cisplatin and 10 received intravenous cisplatin or carboplatin concurrently with radiation. RESULTS: Thirteen patients are alive, 7 without signs of disease with a median follow-up of 61 months...
September 2012: Head & Neck
Ryota Nishio, Kazuhiro Saito, Hiroyuki Ito, Tomoyuki Yoshida, Koichi Kitamura, Akira Shimizu, Naoto Kanesaka, Ryuji Mikami, Daisuke Hasegawa, Mamoru Suzuki, Koichi Tokuuye
PURPOSE: Cisplatin has shown a high tumor response rate among head and neck carcinomas, and the tumor response is related to the cisplatin dosage. The purpose of this study was to evaluate the efficacy and toxicity of selective intraarterial chemoradiation therapy for oropharyngeal carcinomas with high-dose cisplatin. MATERIALS AND METHODS: This retrospective study consisted of 21 patients with oropharyngeal carcinoma, stages II-IVB, in whom intraarterial chemoradiation therapy was performed between 2000 and 2008...
October 2011: Japanese Journal of Radiology
Dingfeng Li, Qiu Cui, Yaosheng Liu, Xiaohong Wang, Cheng Liu, Shubin Liu, Yanjun Zeng
To summarize the experience in intraarterial neoadjuvant chemotherapy for extremity osteosarcoma. Between January 2002 and December 2007,111 patients with stage IIB extremity osteosarcoma received preoperative intraarterial therapy with subcutaneous implantation of chemotherapy pump as well as en bloc resection, and postoperative adjuvant chemotherapy. There were 63 males and 48 females with an average age of 18 (range, 14 ~ 39 years). The time from symptom onset to hospitalization varied from several days to 6 months...
December 2011: Pathology Oncology Research: POR
Soojung Hong, Sang Joon Shin, Minkyu Jung, Jaeheon Jeong, Young Joo Lee, Kyoo-Ho Shin, Jae Kyung Roh, Sun Young Rha
OBJECTIVE: This study compared outcomes between doublet (AP) and triplet (IAP) neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremity. METHODS: A total of 124 patients were enrolled. In the AP group, a doublet regimen of intraarterial cisplatin and intravenous doxorubicin was given to 77 patients from 1991 to 1999. In the IAP group, a triplet regimen of additional intravenous ifosfamide was given to 47 patients from 2000 to 2007. After completion of 3 cycles of chemotherapy, patients underwent surgery...
2011: Oncology
H Tsuchiya, K Tomita, H Yasutake, Y Takagi, S Katsuo, Y Tokuumi, M Sugihara
We report on the effects of intraarterial cisplatin and caffeine with/without doxorubicin on high-grade spindle cell sarcomas of bone and soft tissue based on the fact that caffeine enhances cytocidal effects of DNA-damaging agents. Intraarterial cisplatin and caffeine with/without doxorubicin was preoperatively given three times to ail patients and two courses of high-dose methotrexate with the citrovorum factor and vincristine were administered to the patients with skeletal spindle cell sarcoma. Tumor response was assessed radiographically and histologically...
January 1994: Oncology Reports
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