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Chao-Hua Fang, Cheng-Kung Cheng, Tie-Bing Qu, Jun-Hui Zhang, Bo Zhang, Qun Hua, Shi-Gui Yan
Rotational malalignment between the femoral and tibial components in total knee arthroplasty (TKA) can affect clinical outcomes, but there is no consensus on how to best determine tibia tray orientation. The posterolateral corner-locked (PLCL) technique may be a new method. This study aims to assess the applicability of this technique in a Chinese population. Forty normal Chinese volunteers were recruited and underwent computed tomography (CT) of the lower limbs. Knee model reconstructions and simulated standard tibial osteotomy were conducted digitally...
February 14, 2019: Journal of Knee Surgery
Enio Campos Amico, Izadora K de Souza, Juliana R Grigório Trigueiro, Fernanda Cunha Miranda, Rogério Lacerda Sousa, Adriano de Araújo Lima Liguori
BACKGROUND: Focal nodular hyperplasia (FNH) is a frequent benign liver lesion. Its course is considered benign, and there is no recommendation for its treatment. Nevertheless, the literature presents a high incidence of surgery. AIM: To evaluate the results of conservative treatment in a series of patients with presumed FNH. METHODS: The study included patients diagnosed with FNH from May 2007 to July 2017 based on conventional imaging or magnetic resonance imaging with liver-specific contrast (MRI-LSC) or lesion biopsy (histology/immunohistochemical analysis)...
February 14, 2019: Digestive Diseases
Adnan I Qureshi, Mushtaq H Qureshi, Li-Ming Lien, Jiunn-Tay Lee, Jiann-Shing Jeng, Chaur-Jong Hu, Ta-Chang Lai, Chung-Hsiang Liu, Chih-Hung Chen, Po-Lin Chen, Tsang-Shan Chen, Jie-Yuan Li, Cheng-Li Lin, Chung Y Hsu
BACKGROUND: The natural history of vertebrobasilar artery (VBA) stenosis or occlusion remains understudied. METHODS: Patients with diagnosis of ischemic stroke or transient ischemic attack (TIA) who were noted to have VBA stenosis based on computed tomography or magnetic resonance imaging or catheter-based angiogram were selected from Taiwan Stroke Registry. Cox proportional hazards model was used to determine the hazards ratio (HR) of recurrent stroke and death within 1 year of index event in various groups based on severity of VBA stenosis (none to mild: 0-49%; moderate to severe: 50-99%: occlusion: 100%) after adjusting for differences in demographic and clinical characteristics between groups at baseline evaluation...
February 14, 2019: Cerebrovascular Diseases
Mindy X Wang, Garrett Smith, Mehmet Albayram
Spinal cord watershed ischemia is a rare phenomenon often associated with cardiac arrest, prolonged hypotension, and atherosclerotic disease. It can manifest as central necrosis with peripheral sparing in the transverse axis, and central lesion with rostral and caudal sparing in the longitudinal axis. Few reports provide detailed imaging findings of spinal cord watershed ischemia lesions. We present a patient who experienced watershed infarcts of the brain and spinal cord following prolonged hypotension due to blood loss after an aortic aneurysm repair...
January 31, 2019: Clinical Imaging
Yosuke Namba, Akihiko Oshita, Takashi Nishisaka, Maiko Namba, Tamito Sasaki, Yasuhiro Matsugu, Toshiyuki Itamoto
INTRODUCTION: A lymphoepithelial cyst (LEC) of the pancreas is a benign and rare lesion that is difficult to diagnose preoperatively based on imaging studies. PRESENTATION OF CASE: We report a case of a 49-year-old man who presented with weight loss and diarrhea. The serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels were slightly elevated to 6.7 ng/mL (reference value <5.0 ng/mL) and 45 U/mL (reference value <37 U/mL), respectively...
January 30, 2019: International Journal of Surgery Case Reports
Amit Ghosh, Shouvik Das, Tuhin Ghosh, Sugata Hazra
Anthropogenic climate change is considered as one of the greatest environmental, social and economic threats to the future world. Low lying deltas all over the world are increasingly subjected to multidimensional risk of sea level rise, cyclone, surges and salinisation. The life and livelihood of the communities of such deltas are endangered due to climate change acting as risk multiplier. The Mahanadi delta in the state of Odisha, India is one of the such populous deltas with estimated 8 million population in 2011 with a density of 613 persons/km2 ...
February 5, 2019: Science of the Total Environment
Flávio H D Araújo, Romuere R V Silva, Daniela M Ushizima, Mariana T Rezende, Cláudia M Carneiro, Andrea G Campos Bianchi, Fátima N S Medeiros
Ninety years after its invention, the Pap test continues to be the most used method for the early identification of cervical precancerous lesions. In this test, the cytopathologists look for microscopic abnormalities in and around the cells, which is a time-consuming and prone to human error task. This paper introduces computational tools for cytological analysis that incorporate cell segmentation deep learning techniques. These techniques are capable of processing both free-lying and clumps of abnormal cells with a high overlapping rate from digitized images of conventional Pap smears...
January 30, 2019: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
Yahui Zhao, Shaochen Yu, Jiaxi Li, Junlin Lu, Qian Zhang, Dong Zhang, Rong Wang, Yuanli Zhao
OBJECTIVES: Anterior cerebral artery (ACA) territory, a crucial area of intellectual development in children, is frequently involved in the progress of moyamoya disease (MMD). However, revascularization surgeries for this area are not as established as surgeries for middle cerebral artery (MCA) territory. This study aimed to describe our experience and study the effect of revascularizing ACA territory with periocranium and dural leaflets, which is referred to as 'encephalo-duro-periosteal-synangiosis (EDPS)'...
February 4, 2019: Clinical Neurology and Neurosurgery
F Girinon, S Ketoff, Q Hennocq, N Kogane, N Ullman, N Kadlub, E Galliani, C Neiva-Vaz, M P Vazquez, A Picard, R H Khonsari
AIM AND SCOPE: Result assessment in cleft surgery is a technical challenge and requires the development of dedicated morphometric tools. Two cohorts of patients managed according to two different protocols were assessed at similar ages and their palatal shape was compared using geometric morphometrics. Material and Methods Ten patients (protocol №1) benefited from early lip closure (1-3 months) and secondary combined soft and hard palate closure (6-9 months); 11 patients (protocol №2) benefited from later combined lip and soft palate closure (6 months) followed by hard palate closure (18 months)...
February 11, 2019: Journal of Stomatology, Oral and Maxillofacial Surgery
Cheng Shi, Jiaxing Chen, Bin Xiao, Xinyue Kang, Xingzhen Lao, Heng Zheng
OBJECTIVES: Human health is seriously threatened by metallo-beta-lactamase(MBL)-mediated bacterial resistance. Among them, the New Delhi metallo-beta-lactamase-1(NDM-1) has received great attention due to its extensive substrate specificity and high lateral gene transfer. Currently there is no inhibitor of NDM-1 available in clinical therapy, thus making an argent need for the research and development of novel NDM-1 inhibitors. METHODS: A natural compound library was screened to determine potential inhibitors of NDM-1 based on the crystal structure of NDM-1...
February 11, 2019: Journal of Global Antimicrobial Resistance
Barbara Carl, Miriam Bopp, Benjamin Voellger, Benjamin Saß, Christopher Nimsky
OBJECTIVE: To investigate how augmented reality (AR) can be applied to support transsphenoidal surgery. METHODS: AR was established using the head-up displays integrated into operating microscopes. Navigation registration was performed either fiducial-based or by automatic registration applying intraoperative computed tomography (iCT). Correct microscope calibration was ensured by checking the geometric overlap between the AR representation of the reference array and 3-D reality while focusing on the reference array...
February 11, 2019: World Neurosurgery
Perica Mutavdzic, Marko Dragas, Biljana Kukic, Ksenija Stevanovic, Igor Končar, Nikola Ilić, Ivan Tomic, Milos Sladojevic, Lazar Davidovic
We present a case of successfully treated abdominal aortic aneurysm in a 24-year old patient with Marfan's syndrome. Following initial physical and ultrasound examination, the multislice computed tomography scan revealed infrarenal aortic aneurysm of 6 cm in diameter, 10 cm long, along with slightly dilated iliac arteries. However, dimensions of aortic root, aortic arch and descending suprarenal aorta were within normal limits. Further on, since the patient presented with signs of impending rupture, an urgent surgical intervention was performed...
February 11, 2019: Annals of Vascular Surgery
Yasunori Iida, Koji Osumi, Hiroshi Koganei
An 87-year-old man with severe intermittent claudication and lower limb pain at rest was referred to our hospital for examination. Computed tomography (CT) angiography imaging showed a severe stenosis in the infrarenal abdominal aorta. The ankle brachial indices (ABIs) were 0.62 (right) and 0.60 (left). Endovascular aortic repair was performed with distal protection. The postoperative course was uneventful, and postoperative CT showed no stenosis or distal embolization. The ABI improved to the normal values of 1...
February 11, 2019: Annals of Vascular Surgery
Nitika Paudel, Derek Schulze, Ryan D Gentzler, Andrew M Evens, Irene Helenowski, Gary Dillehay, Olga Frankfurt, Jayesh Mehta, Eric D Donnelly, Leo I Gordon, Jane N Winter, Bharat B Mittal
PURPOSE: The patterns of failure and long-term outcomes of patients with relapsed or refractory classical Hodgkin lymphoma (cHL) treated with total lymphoid irradiation (TLI) and high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (aSCT) is reported. METHODS AND MATERIALS: Patients with biopsy-proven primary refractory/relapsed cHL who received salvage chemotherapy and accelerated hyperfractionated TLI prior to HDCT and aSCT were included...
February 11, 2019: International Journal of Radiation Oncology, Biology, Physics
Xiaojing Ma, Laichun Song, Hongping Yang, Juan Xia, Chunxia Wu, Yafeng He
Impending paradoxical embolism (IPDE) is the presence of a thrombus in the patent foramen ovale (PFO). Usually, IPDE is diagnosed by echocardiography or an Multislice computer tomography (MSCT) scan and is performed during the evaluation of a patient presenting with suspected pulmonary embolism (PE). We report two patients who presented with IPDE and were successfully treated with cardiac surgery and thrombolytic therapy. Thus, we focus our discussion on the diagnosis and treatment modalities of this rare entity...
February 11, 2019: Annals of Thoracic Surgery
Aaron B Gertz, James B Davies, Samantha L Black
Coastal cities around the world have experienced large costs from major flooding events in recent years. Climate change is predicted to bring an increased likelihood of flooding due to sea level rise and more frequent severe storms. In order to plan future development and adaptation, cities must know the magnitude of losses associated with these events, and how they can be reduced. Often losses are calculated from insurance claims or surveying flood victims. However, this largely neglects the loss due to the disruption of economic activity...
February 14, 2019: Risk Analysis: An Official Publication of the Society for Risk Analysis
Joung Kyue Han, Keun Churl Chun, Seong In Lee, Saintpee Kim, Churl Hong Chun
The purpose of this study was to compare the clinical, 3-dimensional computed tomography, magnetic resonance imaging, and second-look arthroscopic findings of the modified transtibial technique with those of the anteromedial portal technique in single-bundle anterior cruciate ligament reconstruction (SB-ACLR). Among patients who underwent SB-ACLR from February 2012 to May 2014, 95 patients with a minimum of 36 months of follow-up were included in this retrospective study. Forty-five patients underwent a reconstruction using the modified transtibial technique...
February 14, 2019: Orthopedics
Zully Santiago, John Loustau, David Meretzky, Devarshi Rawal, Derrick Brazill
We present a technical platform that allows us to monitor and measure cortex and membrane dynamics during bleb-based chemotaxis. Using D. discoideum cells expressing LifeAct-GFP and crawling under agarose containing RITC-dextran, we were able to simultaneously visualize the actin cortex and the cell membrane throughout bleb formation. Using these images, we then applied edge detect to generate points on the cell boundary with coordinates in a coordinate plane. Then we fitted these points to a curve with known x and y coordinate functions...
2019: PloS One
J E Johnson, C Beltran, H Wan Chan Tseung, D W Mundy, J J Kruse, T J Whitaker, M G Herman, K M Furutani
The purpose of this work was to develop an end-to-end patient-specific quality assurance (QA) technique for spot-scanned proton therapy that is more sensitive and efficient than traditional approaches. The patient-specific methodology relies on independently verifying the accuracy of the delivered proton fluence and the dose calculation in the heterogeneous patient volume. A Monte Carlo dose calculation engine, which was developed in-house, recalculates a planned dose distribution on the patient CT data set to verify the dose distribution represented by the treatment planning system...
2019: PloS One
Julia Herzen, Dimitrios C Karampinos, Peter Foehr, Lorenz Birnbacher, Manuel Viermetz, Rainer Burgkart, Thomas Baum, Fabian Lohoefer, Moritz Wildgruber, Franz Schilling, Marian Willner, Mathias Marschner, Peter B Noël, Ernst J Rummeny, Franz Pfeiffer, Pia M Jungmann
OBJECTIVE: Aim of this study was, to demonstrate the feasibility of high-resolution grating-based X-ray phase-contrast computed tomography (PCCT) for quantitative assessment of cartilage. MATERIALS AND METHODS: In an experimental setup, 12 osteochondral samples were harvested from n = 6 bovine knees (n = 2 each). From each knee, one cartilage sample was degraded using 2.5% Trypsin. In addition to PCCT and biomechanical cartilage stiffness measurements, 3T and 7T MRI was performed including MSME SE T2 and ME GE T2* mapping sequences for relaxationtime measurements...
2019: PloS One
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