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Keywords Parkinson , multiple sclerosis...

Parkinson , multiple sclerosis, dementia, stroke

https://read.qxmd.com/read/36359383/immunosenescence-in-neurological-diseases-is-there-enough-evidence
#21
REVIEW
Paulus S Rommer, Gabriel Bsteh, Tobias Zrzavy, Romana Hoeftberger, Thomas Berger
The aging of the immune system has recently attracted a lot of attention. Immune senescence describes changes that the immune system undergoes over time. The importance of immune senescence in neurological diseases is increasingly discussed. For this review, we considered studies that investigated cellular changes in the aging immune system and in neurological disease. Twenty-six studies were included in our analysis (for the following diseases: multiple sclerosis, stroke, Parkinson's disease, and dementia)...
November 9, 2022: Biomedicines
https://read.qxmd.com/read/36331984/cough-as-a-neurological-sign-what-a-clinician-should-know
#22
EDITORIAL
Mohammed Al-Biltagi, Adel Salah Bediwy, Nermin Kamal Saeed
Cough is a common respiratory complaint driving patients to seek medical advice. Besides being a fundamental respiratory sign, it is also a crucial neurological sign. There are three main types of coughs: Reflex cough (type I), voluntary cough (type II), and evoked cough (type III). Cough is a reflex predominantly mediated by control centers in the respiratory areas of the brainstem, modulated by the cerebral cortex. Cough reflex sensitivity could be increased in many neurological disorders such as brainstem space-occupying lesions, medullary lesions secondary to Chiari type I malformations, tics disorders such as Tourette's syndrome, somatic cough, cerebellar neurodegenerative diseases, and chronic vagal neuropathy due to allergic and non-allergic conditions...
May 9, 2022: World Journal of Critical Care Medicine
https://read.qxmd.com/read/36265073/burden-of-neurological-diseases-in-asia-from-1990-to-2019-a-systematic-analysis-using-the-global-burden-of-disease-study-data
#23
JOURNAL ARTICLE
Seungji Kang, Seuhyun Eum, Yoonkyung Chang, Ai Koyanagi, Louis Jacob, Lee Smith, Jae Il Shin, Tae-Jin Song
OBJECTIVES: The burden of neurological disorders is increasing worldwide, including Asia. The purpose of this study was to determine the burden of neurological disorders between 1990 and 2019 in Asia using the Global Burden of Disease (GBD) Sociodemographic Index. DESIGN, SETTING, OUTCOME AND PARTICIPANTS: The GBD Study is updated every year and the most recent version provides the burden of diseases according to age, gender and region from 1990 to 2019. The burden of neurological disorders was evaluated as incidence, prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost and years lived with disability...
September 7, 2022: BMJ Open
https://read.qxmd.com/read/36256522/telemedicine-for-neurological-diseases-a-systematic-review-and-meta-analysis
#24
REVIEW
Beatriz León-Salas, Yadira González-Hernández, Diego Infante-Ventura, Aythami de Armas-Castellano, Javier García-García, Miguel García-Hernández, Montserrat Carmona-Rodríguez, Javier Olazarán, José Luis Dobato, Leticia Rodríguez-Rodríguez, María M Trujillo-Martín
BACKGROUND AND PURPOSE: The aim was to systematically review the effectiveness and safety of telemedicine combined with usual care (in-person visits) compared to usual care for the therapeutic management and follow-up assessment of neurological diseases. METHODS: The electronic databases MEDLINE, Embase, Web of Science and Cochrane Central Register of Controlled Trials were searched (June 2021). Randomized controlled trials (RCTs) on patients of any age with neurological diseases were considered...
January 2023: European Journal of Neurology
https://read.qxmd.com/read/36233034/experimental-and-clinical-biomarkers-for-progressive-evaluation-of-neuropathology-and-therapeutic-interventions-for-acute-and-chronic-neurological-disorders
#25
REVIEW
Doodipala Samba Reddy, Hasara Nethma Abeygunaratne
This article describes commonly used experimental and clinical biomarkers of neuronal injury and neurodegeneration for the evaluation of neuropathology and monitoring of therapeutic interventions. Biomarkers are vital for diagnostics of brain disease and therapeutic monitoring. A biomarker can be objectively measured and evaluated as a proxy indicator for the pathophysiological process or response to therapeutic interventions. There are complex hurdles in understanding the molecular pathophysiology of neurological disorders and the ability to diagnose them at initial stages...
October 3, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36116865/documenting-the-need-for-teaching-resourcefulness-skills-to-family-caregivers
#26
JOURNAL ARTICLE
Jaclene A Zauszniewski, John S Sweetko, Hang-Ying She, Nathanial Schreiner
BACKGROUND: Before pursuing randomized controlled trials to determine intervention effectiveness and translating interventions into clinical practice, the need for a specific intervention within a particular population must be established. This need can be determined by using established cut scores on validated measures of relevant constructs. AIM: This study examined differences on caregiver burden and resourcefulness among family caregivers of adults with various health conditions to determine their need for resourcefulness training...
October 2022: Applied Nursing Research: ANR
https://read.qxmd.com/read/36055710/when-to-initiate-palliative-care-in-neurology
#27
REVIEW
Benjamin Dawson, Kayla McConvey, Teneille E Gofton
Life-limiting and life-threatening neurologic conditions often progress slowly. Patients live with a substantial symptom burden over a long period of time, and there is often a high degree of functional and cognitive impairment. Because of this, the most appropriate time to initiate neuropalliative care is often difficult to identify. Further challenges to the incorporation of neuropalliative care include communication barriers, such as profound dysarthria or language impairments, and loss of cognitive function and decision-making capacity that prevent shared decision making and threaten patient autonomy...
2022: Handbook of Clinical Neurology
https://read.qxmd.com/read/35859466/evaluation-of-neurology-consultations-in-a-covid-19-pandemic-hospital-a-retrospective-study
#28
JOURNAL ARTICLE
Z B Gunduz
Background: Affinity of coronavirus disease to the central nervous system is not well known. Aim: We aimed to share the data of COVID-19 patients with neurological complaints in a pandemia hospital. Material and Method: Consultation results requested from the neurology clinic of Konya Meram State Hospital were retrospectively examined. PCR test positive patients, PCR negative patients with positive clinical, laboratory and radiological findings with COVID-19 were evaluated...
July 2022: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/35779628/-r-ketamine-as-prophylactic-and-therapeutic-drug-for-neurological-disorders-beyond-depression
#29
REVIEW
Xingming Wang, Jianjun Yang, Kenji Hashimoto
Neurological disorders are the leading cause of disability and the second leading cause of death worldwide. The increasing social and economic burdens of neurological disorders are driven by global population growth and aging. Depression is a common psychiatric symptom in numerous neurological disorders. It is also a risk factor for Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD), and stroke. The rapid-acting and sustained antidepressant actions of (R,S)-ketamine for severe depression was accidentally discovered...
August 2022: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/35771831/the-many-facets-of-cd26-dipeptidyl-peptidase-4-and-its-inhibitors-in-disorders-of-the-cns-a-critical-overview
#30
REVIEW
Hans-Gert Bernstein, Gerburg Keilhoff, Henrik Dobrowolny, Johann Steiner
Dipeptidyl peptidase 4 is a serine protease that cleaves X-proline or X-alanine in the penultimate position. Natural substrates of the enzyme are glucagon-like peptide-1, glucagon inhibiting peptide, glucagon, neuropeptide Y, secretin, substance P, pituitary adenylate cyclase-activating polypeptide, endorphins, endomorphins, brain natriuretic peptide, beta-melanocyte stimulating hormone and amyloid peptides as well as some cytokines and chemokines. The enzyme is involved in the maintenance of blood glucose homeostasis and regulation of the immune system...
July 1, 2022: Reviews in the Neurosciences
https://read.qxmd.com/read/35538709/the-ean-brain-health-strategy-one-brain-one-life-one-approach
#31
JOURNAL ARTICLE
C L A Bassetti, M Endres, A Sander, M Crean, S Subramaniam, V Carvalho, G Di Liberto, O H Franco, Yolande Pijnenburg, M Leonardi, P Boon
BACKGROUND: Brain health is essential for health, well-being productivity and creativity across the entire life. Its definition goes beyond the absence of disease embracing all cognitive, emotional, behavioural and social functions which are necessary to cope with life situations. METHODS: The EAN Brain Health Strategy responds to the high and increasing burden of neurological disorders. It aims to develop a non-disease, non-age centred holistic and positive approach ('one brain, one life, one approach') to prevent neurological disorders (e...
May 10, 2022: European Journal of Neurology
https://read.qxmd.com/read/35458139/nutrition-education-programs-for-adults-with-neurological-diseases-are-lacking-a-scoping-review
#32
REVIEW
Rebecca D Russell, Lucinda J Black, Andrea Begley
The nutrition recommendation for most common neurological diseases is to follow national dietary guidelines. This is to mitigate malnutrition, reduce the risk of diet-related diseases, and to help manage some common symptoms, including constipation. Nutrition education programs can support people in adhering to guidelines; hence the aim of this scoping review was to explore what programs have been implemented for adults with neurological diseases. We conducted this review according to a published a priori protocol...
April 10, 2022: Nutrients
https://read.qxmd.com/read/35436682/pseudobulbar-affect-in-neurodegenerative-diseases-a-systematic-review-and-meta-analysis
#33
REVIEW
Fardin Nabizadeh, Mahsa Nikfarjam, Mobin Azami, Hossein Sharifkazemi, Fatemeh Sodeifian
BACKGROUND: Pseudobulbar affect (PBA) is characterized by uncontrolled episodes of crying and laughing which is associated with a variety of neurological diseases including traumatic brain injury, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), brain tumors, stroke, Parkinson's disease (PD), Alzheimer's disease (AD) and other dementias. However, there is a lack of exact estimated prevalence of PBA among neurological disorders. AIM: In this systematic review and meta-analysis study we aimed to assess the prevalence of PBA in four neurodegenerative diseases including ALS, MS, AD, and PD...
June 2022: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/35400321/exploring-the-recent-trends-in-management-of-dementia-and-frailty-focus-on-diagnosis-and-treatment
#34
JOURNAL ARTICLE
Md Mominur Rahman, Sadia Afsana Mim, Md Rezaul Islam, Anwar Parvez, Fahadul Islam, Mohammad Borhan Uddin, Md Saidur Rahaman, Pollob Ahmed Shuvo, Muniruddin Ahmed, Nigel H Greig, Mohammad Amjad Kamal
Dementia and frailty increase health adversities in older adults, which are topics of growing research interest. Frailty is considered to correspond to a biological syndrome associated with age. Frail patients may ultimately develop multiple dysfunctions across several systems, including stroke, transient ischemic attack, vascular dementia, Parkinson's disease, Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, cortico-basal degeneration, multiple system atrophy, amyotrophic lateral sclerosis, and Creutzfeldt-Jakob disease...
2022: Current Medicinal Chemistry
https://read.qxmd.com/read/35323084/predictors-and-correlates-of-emotionalism-across-acquired-and-progressive-neurological-conditions-a-systematic-review
#35
JOURNAL ARTICLE
Sophie Fitzgerald, Fergus Gracey, Emma Trigg, Niall Broomfield
Emotionalism can develop following a range of neurological disorders; however the aetiology of emotionalism is still unclear. To identify anatomical, neuropsychological and psychological predictors and correlates of emotionalism across neurological disorders: stroke, Parkinson's disease, multiple sclerosis, traumatic brain injury, Alzheimer's disease, vascular dementia and amyotrophic lateral sclerosis. To explore if these predictors and correlates of emotionalism differ across neurological disorders. A comprehensive systematic search was completed of four databases: MEDLINE, CINAHL Complete, PsycINFO and EMBASE...
March 24, 2022: Neuropsychological Rehabilitation
https://read.qxmd.com/read/35109386/aim2-inflammasome-mediates-hallmark-neuropathological-alterations-and-cognitive-impairment-in-a-mouse-model-of-vascular-dementia
#36
JOURNAL ARTICLE
Luting Poh, David Fann, Peiyan Wong, Vismitha Rajeev, Sharmelee Selvaraji, Christopher Chen, Mitchell Kim Peng Lai, Hsiu Kim Lina Lim, Thiruma Valavan Arumugam
BACKGROUND: Chronic cerebral hypoperfusion is associated with vascular dementia (VaD). Cerebral hypoperfusion may initiate complex molecular and cellular inflammatory pathways that contribute to long term cognitive impairment and memory loss. Inflammasome is an intracellular multi-protein complex that initiates an innate immune response, and is involved in multiple acute and chronic neurological diseases such as ischemic stroke, Alzheimer's disease (AD), Parkinson's Disease (PD), and amyotrophic lateral sclerosis (ALS)...
December 2021: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/34959661/aptamer-applications-in-neuroscience
#37
REVIEW
Meric Ozturk, Marit Nilsen-Hamilton, Muslum Ilgu
Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epilepsy, stroke, migraine, meningitis, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, prion disease, or brain tumors. The diagnosis and treatment options are limited for many of these diseases. Aptamers, being small and non-immunogenic nucleic acid molecules that are easy to chemically modify, offer potential diagnostic and theragnostic applications to meet these needs...
December 3, 2021: Pharmaceuticals
https://read.qxmd.com/read/34955663/recommendations-for-traveling-to-altitude-with-neurological-disorders
#38
REVIEW
Marika Falla, Guido Giardini, Corrado Angelini
Background: Several neurological conditions might worsen with the exposure to high altitude (HA). The aim of this review was to summarize the available knowledge on the neurological HA illnesses and the risk for people with neurological disorders to attend HA locations. Methods: A search of literature was conducted for several neurological disorders in PubMed and other databases since 1970. The neurological conditions searched were migraine, different cerebrovascular disease, intracranial space occupying mass, multiple sclerosis, peripheral neuropathies, neuromuscular disorders, epileptic seizures, delirium, dementia, and Parkinson's disease (PD)...
2021: Journal of Central Nervous System Disease
https://read.qxmd.com/read/34858320/editorial-update-on-vascular-contributions-to-age-related-neurodegenerative-diseases-and-cognitive-impairment-research-of-isnvd-2020-meeting
#39
EDITORIAL
Yulin Ge, Robert Zivadinov, Meiyun Wang, Andreas Charidimou, E Mark Haacke
No abstract text is available yet for this article.
2021: Frontiers in Neurology
https://read.qxmd.com/read/34622720/caregivers-use-of-personal-and-social-resourcefulness-differences-by-care-recipient-condition
#40
JOURNAL ARTICLE
Jaclene A Zauszniewski, Christopher J Burant, Richard J Martin, John S Sweetko, Evelina DiFranco
Although family caregivers who use both the personal and social resourcefulness skills have the best health outcomes, it is unknown whether their tendency toward personal or social resourcefulness varies by their care recipient's condition. This cross-sectional study of existing data from 234 caregivers of persons with various conditions examined five item pairs from the Resourcefulness Scale© with responses capturing personal and social resourcefulness in relation to anxiety, anger, sadness, indecision, and financial distress...
March 2022: Western Journal of Nursing Research
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