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Non linear analysis

N Windarti, S W Hlaing, M Kakinaka
OBJECTIVES: The obesity epidemic has prevailed worldwide and is currently recognized as a global pandemic disease. Given the argument that various socio-economic features contribute to substantial differences in obesity rates across countries, economic development can also be considered a crucial factor of such variation. This study examines the relationship between economic development and each of three weight-related health statuses (rates of overweight, obesity, and morbid obesity)...
February 15, 2019: Public Health
Andrea Brugnolo, Fabrizio De Carli, Marco Pagani, Slivia Morbelli, Cathrine Jonsson, Andrea Chincarini, Giovanni B Frisoni, Samantha Galluzzi, Robert Perneczky, Alexander Drzezga, Bart N M van Berckel, Rik Ossenkoppele, Mira Didic, Eric Guedj, Dario Arnaldi, Federico Massa, Matteo Grazzini, Matteo Pardini, Patrizia Mecocci, Massimo E Dottorini, Matteo Bauckneht, Gianmario Sambuceti, Flavio Nobili
BACKGROUND: Several automatic tools have been implemented for semi-quantitative assessment of brain [18]F-FDG-PET. OBJECTIVE: We aimed to head-to-head compare the diagnostic performance among three statistical parametric mapping (SPM)-based approaches, another voxel-based tool (i.e., PALZ), and a volumetric region of interest (VROI-SVM)-based approach, in distinguishing patients with prodromal Alzheimer's disease (pAD) from controls. METHODS: Sixty-two pAD patients (MMSE score = 27...
February 13, 2019: Journal of Alzheimer's Disease: JAD
Nuno Rodrigues, Ítala M G Marx, Susana Casal, Luís G Dias, Ana C A Veloso, José A Pereira, António M Peres
Olive oil is highly appreciated due to its nutritional and organoleptic characteristics. However, a huge compositional variation is observed between olive oils, requiring the use of diverse analytical techniques for its classification including titration, spectrophotometry and chromatography, as well as sensory analysis. Chemical analysis is usually time-consuming, expensive and require skilled technicians, while the sensorial ones are dependent upon individual subjective evaluations, even if performed by trained panellists...
May 15, 2019: Talanta
Jie Ma, Lei Bian, Lei Zhao, Xiaotong Feng, Lizhi Zhao, Zhaoyan Wang, Qiaosheng Pu
Low-cost and nontoxic fluorescent reagents are important for on-site analysis performed by non-professionals. In this work, a cheap and widely available food additive, caramel was used as an effective fluorescence reagent for the sensitive detection of 2,4,6-trinitrophenol (TNP), 2,4-dinitrophenol (DNP) and 4-nitrophenol (4-NP). Through a simple dialysis, fluorescent components of a commercial caramel were harvested with a yield as high as 60%. The structural characterization demonstrated that the fluorescent components were dehydrated oligomers of carbohydrates...
May 15, 2019: Talanta
D J H A Henssen, R L Witkam, J C M L Dao, D J Comes, A M Van Cappellen van Walsum, T Kozicz, Robert van Dongen, K Vissers, R H M A Bartels, G de Jong, E Kurt
Implantable Motor Cortex Stimulation (iMCS) has been performed for over 25 years to treat various intractable pain syndromes. Its effectiveness shows to be highly variable and although various studies revealed predictive variables, none of these were found repeatedly. This study uses neural network analysis (NNA) to identify predictive factors of iMCS treatment of intractable pain. A systematic review provided a database of patient data on an individual level of patients who underwent iMCS to treat refractory pain between 1991 and 2017...
February 13, 2019: Journal of Pain: Official Journal of the American Pain Society
Kacey Tung, Manuel O Lagravère
The purpose of this study was to determine if there were any common skeletal and dental structural characteristics obtained from CBCTs of patients with different growth patterns (Vertical or Non-Vertical). Sixty-three patients were previously categorized as vertical or not vertical grower using clinical examination and 2D cephalometric created images. Twenty-three landmarks were selected to examine CBCT images and used to calculate linear and angle measurements using geometric and trigonometric equations. Statistical analysis was done using SPSS statistical package and ICC values showed excellent reliability...
February 12, 2019: International Orthodontics
Yuantao Yang, Huailiang Zheng, Yongbo Li, Minqiang Xu, Yushu Chen
Fault diagnosis of rotating machinery is crucial to improve safety, enhance reliability and reduce maintenance cost. The manual feature extraction and selection of traditional fault diagnosis methods depend on signal processing skills and expert experience, which is labor-intensive and time-consuming. As a typical intelligent fault diagnosis method, the convolutional neural network automatically learns features from original data, but it is extremely difficult to design and train a deep network architecture...
January 24, 2019: ISA Transactions
Xiaoning He, Yumei Wang, Hongliang Cong, Chengzhi Lu, Jing Wu
PURPOSE: This study was conducted to examine the use of optimal medical therapy (OMT), consisting of an antiplatelet, a β-blocker, an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB), and a statin combined, after hospital discharge and its relationship with direct medical costs in patients with acute coronary syndromes (ACS) in Tianjin, China. METHODS: Data were obtained from the Tianjin Urban Employee Basic Medical Insurance database (2011-2015)...
February 12, 2019: Clinical Therapeutics
Hanaa Dakour-Aridi, Manasi Arora, Besma Nejim, Satinderjit Locham, Mahmoud B Malas
OBJECTIVE: Drug abuse may affect lower extremity vessels due to ischemia following intra-arterial injections, vasospasm, arterial and venous pseudoaneurysms, arteriovenous fistulae, vasculitis and complicated abscesses. Little is known about the outcomes of Lower Extremity Bypass (LEB) for peripheral arteries disease (PAD) in patients with a history of drug abuse disorder. The aim of this study is to evaluate the outcomes of LEB in this patient population. METHODS: A retrospective study of the Premier Healthcare Database 2009-2015 was performed...
February 12, 2019: Annals of Vascular Surgery
Galit Weinstein, Kendra L Davis-Plourde, Sarah Conner, Jayandra J Himali, Alexa S Beiser, Anne Lee, Andreea M Rawlings, Sanaz Sedaghat, Jie Ding, Erin Moshier, Cornelia M van Duijn, Michal S Beeri, Elizabeth Selvin, M Arfan Ikram, Lenore J Launer, Mary N Haan, Sudha Seshadri
OBJECTIVE: To determine whether classes of diabetes medications are associated with cognitive health and dementia risk, above and beyond their glycemic control properties. RESEARCH DESIGN AND METHODS: Findings were pooled from 5 population-based cohorts: the Framingham Heart Study, the Rotterdam Study, the Atherosclerosis Risk in Communities (ARIC) Study, the Aging Gene-Environment Susceptibility-Reykjavik Study (AGES) and the Sacramento Area Latino Study on Aging (SALSA)...
2019: PloS One
James D Englehardt, Weihsueh A Chiu
Current efforts to assess human health response to chemicals based on high-throughput in vitro assay data on intra-cellular changes have been hindered for some illnesses by lack of information on higher-level extracellular, inter-organ, and organism-level interactions. However, a dose-response function (DRF), informed by various levels of information including apical health response, can represent a template for convergent top-down, bottom-up analysis. In this paper, a general DRF for chronic chemical and other health stressors and mixtures is derived based on a general first-order model previously derived and demonstrated for illness progression...
2019: PloS One
James Palmer, Viraj Pandit, Muhammad Zeeshan, Narong Kulvatunyou, Mohammad Hamidi, Kamil Hanna, Mindy Fain, Janko Nikolich-Zugich, El-Rasheid Zakaria, Bellal Joseph
INTRODUCTION: Frailty is a geriatric syndrome characterized by decreased physiological reserves, increased inflammation, and decreased anabolic-endocrine response. The biomarkers associated with frailty are poorly understood in trauma. The aim of this study was to analyze the association between frailty and immune: IL-1β, IL-6, IL-2Rα, TNF-α and endocrine biomarkers: Insulin-like growth factor-1(IGF-1), and growth hormone(GH) in trauma patients. METHODS: We conducted a one-year(2017-2018) prospective analysis of geriatric(≥ 65y) trauma patients admitted to our level-1 trauma center...
February 13, 2019: Journal of Trauma and Acute Care Surgery
Amit Shalev, John Merranko, Tina Goldstein, David J Miklowitz, David Axelson, Benjamin I Goldstein, David Brent, Kelly Monk, Mary Beth Hickey, Danella M Hafeman, Dara Sakolsky, Rasim Diler, Boris Birmaher
OBJECTIVE: To compare the longitudinal course of family functioning in offspring of parents with bipolar disorder (BD), offspring of parents with non-BD psychopathology, and offspring of healthy control parents (HC). METHOD: Offspring of BD parents (256 parents and 481 offspring), non-BD parents (82 parents and 162 offspring) and HC parents (88 parents and 175 offspring) ages 7-18 at intake, from the Bipolar Offspring Study (BIOS), were followed for an average of 4...
December 18, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
Sebastian Fischer, Claudia Braun, Armin Kibele
The aim of this study was to examine the importance of the change-over time in swimming relay races. Top-class international 4 x 100 m freestyle races were analysed across a 10-year period including three Olympic Games and five European and World Championships. A total of 220 swimmers (116 female, 104 male) were included in this study with an average participation of 1.7 ± 1.2 races. To consider such repeated measurements and other factors (e.g., ranking in the relay race, position in the relay team) linear mixed models for longitudinal data were used for the statistical evaluation...
February 15, 2019: Journal of Sports Sciences
Brigitte Wirth, Fabienne Riner, Cynthia Peterson, Barry Kim Humphreys, Mazda Farshad, Susanne Becker, Petra Schweinhardt
Background: A close collaboration between surgeons and non-surgical spine experts is crucial for optimal care of low back pain (LBP) patients. The affiliation of a chiropractic teaching clinic to a university hospital with a large spine division in Zurich, Switzerland, enables such collaboration. The aim of this study was to describe the trajectories and outcomes of patients with chronic LBP referred from the spine surgery division to the chiropractic teaching clinic. Methods: The patients filled in an 11-point numeric rating scale (NRS) for pain intensity and the Bournemouth Questionnaire (BQ) (bio-psycho-social measure) at baseline and after 1 week, 1, 3, 6 and 12 months...
2019: Chiropractic & Manual Therapies
Gyanranjan Rout, Saurabh Kedia, Baibaswata Nayak, Rajni Yadav, Prasenjit Das, Subrat K Acharya, Deepak Gunjan, Vishwajeet Singh, Mousumi Mahanta, Swatantra Gupta, Sandeep Aggarwal, Shalimar
Background/Aims: The gold standard method for measurement of hepatic steatosis is liver histology. Controlled Attenuation Parameter (CAP) can measure hepatic steatosis non-invasively. We aimed to assess the accuracy of CAP for detection of hepatic steatosis. Methods: A total of 462 patients (May 2012-January 2017)-89 non-alcoholic fatty liver disease, 182 chronic hepatitis B, 88 chronic hepatitis C and 103 patients with other etiologies who underwent simultaneous liver biopsy and CAP estimation using Transient Elastography (TE) were included...
January 2019: Journal of Clinical and Experimental Hepatology
Francesca Parisi, Melek Rousian, Anton H J Koning, Sten P Willemsen, Eric A P Steegers, Régine P M Steegers-Theunissen
RESEARCH QUESTION: Is embryonic morphological development according to the Carnegie stages associated with pregnancy outcome? DESIGN: In a tertiary hospital-based cohort, 182 singleton non-malformed pregnancies were selected. Serial transvaginal three-dimensional ultrasound (3D-US) scans were carried out between 6+0 and 10+2 gestational weeks. Embryonic development was annotated according to the morphological criteria of the Carnegie classification using a virtual reality system...
December 21, 2018: Reproductive Biomedicine Online
Clara Rodriguez-Sabate, Ingrid Morales, Jesus N Lorenzo, Manuel Rodriguez
The motor symptoms in Parkinson's disease (PD) have been linked to changes in the excitatory/inhibitory interactions of centers involved in the cortical-subcortical closed-loop circuits which connect basal ganglia (BG) and the brain cortex. This approach may explain some motor symptoms of PD but not others, which has driven the study of BG from new perspectives. Besides their cortical-subcortical linear circuits, BG have a number of subcortical circuits which directly or indirectly connect each BG with all the others...
February 3, 2019: NeuroImage: Clinical
Ross C Puffer, John K Yue, Matthew Mesley, Julia B Billigen, Jane Sharpless, Anita L Fetzick, Ava M Puccio, Ramon Diaz-Arrastia, David O Okonkwo
INTRODUCTION: Prospects for recovery after traumatic brain injury (TBI) are often underestimated, potentially leading to withdrawal of care in the comatose TBI patient who may ultimately have a favorable outcome with aggressive care. Outcomes and trajectories of recovery in a large series of TBI patients were evaluated at 30, 90 and 180 days post-injury. METHODS: A secondary analysis of the Phase 3 COBRIT was performed analyzing recovery trajectories and long-term outcomes at 30, 90 and 180 days post-injury...
February 11, 2019: World Neurosurgery
Dan Weaving, Ben Jones, Matt Ireton, Sarah Whitehead, Kevin Till, Clive B Beggs
OBJECTIVES: Professional sporting organisations invest considerable resources collecting and analysing data in order to better understand the factors that influence performance. Recent advances in non-invasive technologies, such as global positioning systems (GPS), mean that large volumes of data are now readily available to coaches and sport scientists. However analysing such data can be challenging, particularly when sample sizes are small and data sets contain multiple highly correlated variables, as is often the case in a sporting context...
2019: PloS One
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