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REVIEW
Weizhe Li, W Scott Burgin, Kanita Beba Abadal, Maxim Mokin, Zeguang Ren
Background: Rapid and effective revascularization is the cornerstone of acute ischemic stroke treatment. Endovascular thrombectomy reperfusion has dramatically changed patients' outcomes with large vessel occlusions. Results of randomized controlled trials have shown that the benefit of this treatment is highly time-sensitive. The purpose of this review is to introduce a new approach to acute stroke treatment - direct angiographic intervention for selected patients. Methods & Results: We examined the issues related to the current guideline-based practice, emphasizing whether the benefit of using advanced multimodal imaging is worth the potential resultant disability generated by delayed reperfusion times...
November 2021: Neurological Research
#22
JOURNAL ARTICLE
Raul G Nogueira, Muhammad M Qureshi, Mohamad Abdalkader, Sheila Ouriques Martins, Hiroshi Yamagami, Zhongming Qiu, Ossama Yassin Mansour, Anvitha Sathya, Anna Czlonkowska, Georgios Tsivgoulis, Diana Aguiar de Sousa, Jelle Demeestere, Robert Mikulik, Peter Vanacker, James E Siegler, Janika Kõrv, Jose Biller, Conrad W Liang, Navdeep S Sangha, Alicia M Zha, Alexandra L Czap, Christine Anne Holmstedt, Tanya N Turan, George Ntaios, Konark Malhotra, Ashis Tayal, Aaron Loochtan, Annamarei Ranta, Eva A Mistry, Anne W Alexandrov, David Y Huang, Shadi Yaghi, Eytan Raz, Sunil A Sheth, Mahmoud H Mohammaden, Michael Frankel, Eric Guemekane Bila Lamou, Hany M Aref, Ahmed Elbassiouny, Farouk Hassan, Tarek Menecie, Wessam Mustafa, Hossam M Shokri, Tamer Roushdy, Fred S Sarfo, Tolulope Oyetunde Alabi, Babawale Arabambi, Ernest O Nwazor, Taofiki Ajao Sunmonu, Kolawole Wahab, Joseph Yaria, Haytham Hussein Mohammed, Philip B Adebayo, Anis D Riahi, Samia Ben Sassi, Lenon Gwaunza, Gift Wilson Ngwende, David Sahakyan, Aminur Rahman, Zhibing Ai, Fanghui Bai, Zhenhui Duan, Yonggang Hao, Wenguo Huang, Guangwen Li, Wei Li, Ganzhe Liu, Jun Luo, Xianjin Shang, Yi Sui, Ling Tian, Hongbin Wen, Bo Wu, Yuying Yan, Zhengzhou Yuan, Hao Zhang, Jun Zhang, Wenlong Zhao, Wenjie Zi, Thomas W Leung, Chandril Chugh, Vikram Huded, Bindu Menon, Jeyaraj Durai Pandian, P N Sylaja, Fritz Sumantri Usman, Mehdi Farhoudi, Elyar Sadeghi Hokmabadi, Anat Horev, Anna Reznik, Rotem Sivan Hoffmann, Nobuyuki Ohara, Nobuyuki Sakai, Daisuke Watanabe, Ryoo Yamamoto, Ryosuke Doijiri, Naoki Tokuda, Takehiro Yamada, Tadashi Terasaki, Yukako Yazawa, Takeshi Uwatoko, Tomohisa Dembo, Hisao Shimizu, Yuri Sugiura, Fumio Miyashita, Hiroki Fukuda, Kosuke Miyake, Junsuke Shimbo, Yusuke Sugimura, Yoshiki Yagita, Yohei Takenobu, Yuji Matsumaru, Satoshi Yamada, Ryuhei Kono, Takuya Kanamaru, Hidekazu Yamazaki, Manabu Sakaguchi, Kenichi Todo, Nobuaki Yamamoto, Kazutaka Sonoda, Tomoko Yoshida, Hiroyuki Hashimoto, Ichiro Nakahara, Aida Kondybayeva, Kamila Faizullina, Saltanat Kamenova, Murat Zhanuzakov, Jang-Hyun Baek, Yangha Hwang, Jin Soo Lee, Si Baek Lee, Jusun Moon, Hyungjong Park, Jung Hwa Seo, Kwon-Duk Seo, Sung Il Sohn, Chang Jun Young, Rechdi Ahdab, Wan Asyraf Wan Zaidi, Zariah Abdul Aziz, Hamidon Bin Basri, Law Wan Chung, Aznita Binti Ibrahim, Khairul Azmi Ibrahim, Irene Looi, Wee Yong Tan, Nafisah Wan Yahya, Stanislav Groppa, Pavel Leahu, Amal M Al Hashmi, Yahia Zakaria Imam, Naveed Akhtar, Maria Carissa Pineda-Franks, Christian Oliver Co, Dmitriy Kandyba, Adel Alhazzani, Hosam Al-Jehani, Carol Huilian Tham, Marlie Jane Mamauag, Narayanaswamy Venketasubramanian, Chih-Hao Chen, Sung-Chun Tang, Anchalee Churojana, Esref Akil, Özlem Aykaç, Atilla Ozcan Ozdemir, Semih Giray, Syed Irteza Hussain, Seby John, Huynh Le Vu, Anh Duc Tran, Huy Hoang Nguyen, Thong Nhu Pham, Thang Huy Nguyen, Trung Quoc Nguyen, Thomas Gattringer, Christian Enzinger, Monika Killer-Oberpfalzer, Flavio Bellante, Sofie De Blauwe, Geert Vanhooren, Sylvie De Raedt, Anne Dusart, Robin Lemmens, Noemie Ligot, Matthieu Pierre Rutgers, Laetitia Yperzeele, Filip Alexiev, Teodora Sakelarova, Marina Roje Bedeković, Hrvoje Budincevic, Igor Cindric, Zlatko Hucika, David Ozretic, Majda Seferovic Saric, František Pfeifer, Igor Karpowic, David Cernik, Martin Sramek, Miroslav Skoda, Helena Hlavacova, Lukas Klecka, Martin Koutny, Daniel Vaclavik, Ondrej Skoda, Jan Fiksa, Katerina Hanelova, Miroslava Nevsimalova, Robert Rezek, Petr Prochazka, Gabriela Krejstova, Jiri Neumann, Marta Vachova, Henryk Brzezanski, David Hlinovsky, Dusan Tenora, Rene Jura, Lubomír Jurák, Jan Novak, Ales Novak, Zdenek Topinka, Petr Fibrich, Helena Sobolova, Ondrej Volny, Hanne Krarup Christensen, Nicolas Drenck, Helle Klingenberg Iversen, Claus Z Simonsen, Thomas Clement Truelsen, Troels Wienecke, Riina Vibo, Katrin Gross-Paju, Toomas Toomsoo, Katrin Antsov, Francois Caparros, Charlotte Cordonnier, Maria Dan, Jean-Marc Faucheux, Laura Mechtouff, Omer Eker, Emilie Lesaine, Basile Ondze, Roxane Peres, Fernando Pico, Michel Piotin, Raoul Pop, Francois Rouanet, Tatuli Gubeladze, Mirza Khinikadze, Nino Lobjanidze, Alexander Tsiskaridze, Simon Nagel, Peter Arthur Ringleb, Michael Rosenkranz, Holger Schmidt, Annahita Sedghi, Timo Siepmann, Kristina Szabo, Götz Thomalla, Lina Palaiodimou, Dimitrios Sagris, Odysseas Kargiotis, Peter Klivenyi, Laszlo Szapary, Gabor Tarkanyi, Alessandro Adami, Fabio Bandini, Paolo Calabresi, Giovanni Frisullo, Leonardo Renieri, Davide Sangalli, Anne Pirson, Maarten Uyttenboogaart, Ido van den Wijngaard, Espen Saxhaug Kristoffersen, Waldemar Brola, Małgorzata Fudala, Ewa Horoch-Lyszczarek, Michal Karlinski, Radoslaw Kazmierski, Pawel Kram, Marcin Rogoziewicz, Rafal Kaczorowski, Piotr Luchowski, Halina Sienkiewicz-Jarosz, Piotr Sobolewski, Waldemar Fryze, Anna Wisniewska, Malgorzata Wiszniewska, Patricia Ferreira, Paulo Ferreira, Luisa Fonseca, João Pedro Marto, Teresa Pinho E Melo, Ana Paiva Nunes, Miguel Rodrigues, Vítor Tedim Cruz, Cristian Falup-Pecurariu, Georgi Krastev, Miroslav Mako, María Alonso de Leciñana, Juan F Arenillas, Oscar Ayo-Martin, Antonio Cruz Culebras, Exuperio Diez Tejedor, Joan Montaner, Soledad Pérez-Sánchez, Miguel Angel Tola Arribas, Alejandro Rodriguez Vasquez, Michael Mayza, Gianmarco Bernava, Alex Brehm, Paolo Machi, Urs Fischer, Jan Gralla, Patrik L Michel, Marios-Nikos Psychogios, Davide Strambo, Soma Banerjee, Kailash Krishnan, Joseph Kwan, Asif Butt, Luciana Catanese, Andrew M Demchuk, Thalia Field, Jennifer Haynes, Michael D Hill, Houman Khosravani, Ariane Mackey, Aleksandra Pikula, Gustavo Saposnik, Courtney Anne Scott, Ashkan Shoamanesh, Ashfaq Shuaib, Samuel Yip, Miguel A Barboza, Jose Domingo Barrientos, Ligia Ibeth Portillo Rivera, Fernando Gongora-Rivera, Nelson Novarro-Escudero, Anmylene Blanco, Michael Abraham, Diana Alsbrook, Dorothea Altschul, Anthony J Alvarado-Ortiz, Ivo Bach, Aamir Badruddin, Nobl Barazangi, Charmaine Brereton, Alicia Castonguay, Seemant Chaturvedi, Saqib A Chaudry, Hana Choe, Jae H Choi, Sushrut Dharmadhikari, Kinjal Desai, Thomas G Devlin, Vinodh T Doss, Randall Edgell, Mark Etherton, Mudassir Farooqui, Don Frei, Dheeraj Gandhi, Mikayel Grigoryan, Rishi Gupta, Ameer E Hassan, Johanna Helenius, Artem Kaliaev, Ritesh Kaushal, Priyank Khandelwal, Ayaz M Khawaja, Naim N Khoury, Benny S Kim, Dawn O Kleindorfer, Feliks Koyfman, Vivien H Lee, Lester Y Leung, Guillermo Linares, Italo Linfante, Helmi L Lutsep, Lisa Macdougall, Shailesh Male, Amer M Malik, Hesham Masoud, Molly McDermott, Brijesh P Mehta, Jiangyong Min, Manoj Mittal, Jane G Morris, Sumeet S Multani, Fadi Nahab, Krishna Nalleballe, Claude B Nguyen, Roberta Novakovic-White, Santiago Ortega-Gutierrez, Rahul H Rahangdale, Pankajavalli Ramakrishnan, Jose Rafael Romero, Natalia Rost, Aaron Rothstein, Sean Ruland, Ruchir Shah, Malveeka Sharma, Brian Silver, Marc Simmons, Abhishek Singh, Amy K Starosciak, Sheryl L Strasser, Viktor Szeder, Mohamed Teleb, Jenny P Tsai, Barbara Voetsch, Oscar Balaguera, Virginia A Pujol Lereis, Adriana Luraschi, Marcele Schettini Almeida, Fabricio Buchdid Cardoso, Adriana Conforto, Leonardo De Deus Silva, Luidia Varrone Giacomini, Fabricio Oliveira Lima, Alexandre L Longo, Pedro S C Magalhães, Rodrigo Targa Martins, Francisco Mont'alverne, Daissy Liliana Mora Cuervo, Leticia Costa Rebello, Lenise Valler, Viviane Flumignan Zetola, Pablo M Lavados, Victor Navia, Verónica V Olavarría, Juan Manuel Almeida Toro, Pablo Felipe Ricardo Amaya, Hernan Bayona, Angel Corredor, Carlos Eduardo Rivera Ordonez, Diana Katherine Mantilla Barbosa, Osvaldo Lara, Mauricio R Patiño, Luis Fernando Diaz Escobar, Donoband Edson Dejesus Melgarejo Fariña, Analia Cardozo Villamayor, Adolfo Javier Zelaya Zarza, Danny Moises Barrientos Iman, Liliana Rodriguez Kadota, Bruce Campbell, Graeme J Hankey, Casey Hair, Timothy Kleinig, Alice Ma, Rodrigo Tomazini Martins, Ramesh Sahathevan, Vincent Thijs, Daniel Salazar, Teddy Yuan-Hao Wu, Diogo C Haussen, David Liebeskind, Dileep R Yavagal, Tudor G Jovin, Osama O Zaidat, Thanh N Nguyen
OBJECTIVE: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. METHODS: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases...
June 8, 2021: Neurology
#23
JOURNAL ARTICLE
Juma Magogo, Albert Lazaro, Mechris Mango, Scott L Zuckerman, Andreas Leidinger, Salim Msuya, Nicephorus Rutabasibwa, Hamisi K Shabani, Roger Härtl
STUDY DESIGN: Retrospective case series. OBJECTIVE: Little is known about operative management of traumatic spinal injuries (TSI) in low- and middle-income countries (LMIC). In patients undergoing surgery for TSI in Tanzania, we sought to (1) determine factors involved in the operative decision-making process, specifically implant availability and surgical judgment; (2) report neurologic outcomes; and (3) evaluate time to surgery. METHODS: All patients from October 2016 to June 2019 who presented with TSI and underwent surgical stabilization...
January 2021: Global Spine Journal
#24
JOURNAL ARTICLE
Ameet N Dravid, Raviraj Gawali, Tarun P Betha, Avadesh K Sharma, Mahenderkumar Medisetty, Kartik Natrajan, Milind M Kulkarni, Chinmay K Saraf, Uma S Mahajan, Sachin D Kore, Niranjan M Rathod, Umakant S Mahajan, Scott L Letendre, Rustom S Wadia, Andrea Calcagno
Symptomatic cerebrospinal fluid (CSF) viral escape (sCVE) is reported in people with HIV, who are on ritonavir-boosted protease inhibitor (PI/r) containing antiretroviral therapy (ART). Management of sCVE includes performing genotypic HIV-1 resistance testing (GRT) on CSF and plasma HIV and changing ART accordingly. Neither GRT nor newer drugs (Dolutegravir and Darunavir/ritonavir) are routinely available in India. As a result, management of sCVE includes 2 modalities: a) ART intensification by adding drugs that reach therapeutic concentrations in CSF, like Zidovudine, to existing ART or b) Changing to a regimen containing newer boosted PI/r and integrase strand transfer inhibitor (INSTI) as per GRT or expert opinion...
June 12, 2020: Medicine (Baltimore)
#25
JOURNAL ARTICLE
Christopher L Pulliam, Scott R Stanslaski, Timothy J Denison
Neuromodulation therapies offer a unique opportunity for translating brain-computer interface (BCI) technologies into a clinical setting. Several diseases such as Parkinson's disease are effectively treated by invasive device stimulation therapies, and the addition of sensing and algorithm technology is an obvious evolutionary expansion of capabilities. In addition, this infrastructure might enable a roadmap of novel BCI technologies. While the initial applications are focused on epilepsy and movement disorders, the technology is potentially transferable to a broader base of disorders, including stroke and rehabilitation...
2020: Handbook of Clinical Neurology
#26
JOURNAL ARTICLE
Vincent Rossi, Anthony Asher, David Peters, Scott L Zuckerman, Mark Smith, Martin Henegar, Hunter Dyer, Domagoj Coric, Deborah Pfortmiller, Tim Adamson, Matthew McGirt
OBJECTIVE: Several studies have demonstrated that anterior cervical discectomy and fusion (ACDF) surgery in the outpatient versus hospital setting provides improved efficiency, cost-effectiveness, and patient satisfaction without a compromise in safety or outcome. Recent anecdotal reports, however, have questioned whether outpatient ACDF surgery is safe in the > 65-year-old Medicare population. To date, no clinical study has assessed the safety of outpatient ACDF in an ambulatory surgery center (ASC), specifically in a Medicare population...
November 15, 2019: Journal of Neurosurgery. Spine
#27
REVIEW
Beau M Ances, Scott L Letendre
Investigators reported many new neuroHIV research findings at the 2019 Conference on Retroviruses and Opportunistic Infections (CROI). These findings included confirmation that HIV-associated neurocognitive disorder (HAND) remains common with an increasingly recognized role for comorbidities (eg, obesity) and neurodegenerative conditions (eg, Alzheimer's disease), especially as persons living with HIV (PLWH) advance into their seventh decade of life and beyond. HAND is increasingly recognized as a heterogeneous disorder that differs between individuals (eg, by sex) in the trajectory of specific neurocognitive abilities (eg, executive functioning)...
April 2019: Topics in Antiviral Medicine
#28
JOURNAL ARTICLE
Early Progressive Mobilization of Patients with External Ventricular Drains: Safety and Feasibility.
Rebekah A Yataco, Scott M Arnold, Suzanne M Brown, W David Freeman, C Carmen Cononie, Michael G Heckman, Luke W Partridge, Craig M Stucky, Laurie N Mellon, Jennifer L Birst, Kristien L Daron, Martha H Zapata-Cooper, Danton M Schudlich
BACKGROUND/OBJECTIVE: Early mobilization of critically ill patients has been shown to improve functional outcomes. Neurosurgery patients with an external ventricular drain (EVD) due to increased intracranial pressure often remain on bed rest while EVD remains in place. The prevalence of mobilizing patients with EVD has not been described, and the literature regarding the safety and feasibility of mobilizing patients with EVDs is limited. The aim of our study was to describe the outcomes and adverse events of the first mobilization attempt in neurosurgery patients with EVD who participated in early functional mobilization with physical therapy or occupational therapy...
April 2019: Neurocritical Care
#29
JOURNAL ARTICLE
Liberty François-Moutal, Shahriyar Jahanbakhsh, Andrew D L Nelson, Debashish Ray, David D Scott, Matthew R Hennefarth, Aubin Moutal, Samantha Perez-Miller, Andrew J Ambrose, Ahmed Al-Shamari, Philippe Coursodon, Bessie Meechoovet, Rebecca Reiman, Eric Lyons, Mark Beilstein, Eli Chapman, Quaid D Morris, Kendall Van Keuren-Jensen, Timothy R Hughes, Rajesh Khanna, Carla Koehler, Joanna Jen, Vijay Gokhale, May Khanna
Mutations of EXOSC3 have been linked to the rare neurological disorder known as Pontocerebellar Hypoplasia type 1B (PCH1B). EXOSC3 is one of three putative RNA-binding structural cap proteins that guide RNA into the RNA exosome, the cellular machinery that degrades RNA. Using RNAcompete, we identified a G-rich RNA motif binding to EXOSC3. Surface plasmon resonance (SPR) and microscale thermophoresis (MST) indicated an affinity in the low micromolar range of EXOSC3 for long and short G-rich RNA sequences. Although several PCH1B-causing mutations in EXOSC3 did not engage a specific RNA motif as shown by RNAcompete, they exhibited lower binding affinity to G-rich RNA as demonstrated by MST...
September 6, 2018: ACS Chemical Biology
#30
JOURNAL ARTICLE
Verneri Anttila, Brendan Bulik-Sullivan, Hilary K Finucane, Raymond K Walters, Jose Bras, Laramie Duncan, Valentina Escott-Price, Guido J Falcone, Padhraig Gormley, Rainer Malik, Nikolaos A Patsopoulos, Stephan Ripke, Zhi Wei, Dongmei Yu, Phil H Lee, Patrick Turley, Benjamin Grenier-Boley, Vincent Chouraki, Yoichiro Kamatani, Claudine Berr, Luc Letenneur, Didier Hannequin, Philippe Amouyel, Anne Boland, Jean-François Deleuze, Emmanuelle Duron, Badri N Vardarajan, Christiane Reitz, Alison M Goate, Matthew J Huentelman, M Ilyas Kamboh, Eric B Larson, Ekaterina Rogaeva, Peter St George-Hyslop, Hakon Hakonarson, Walter A Kukull, Lindsay A Farrer, Lisa L Barnes, Thomas G Beach, F Yesim Demirci, Elizabeth Head, Christine M Hulette, Gregory A Jicha, John S K Kauwe, Jeffrey A Kaye, James B Leverenz, Allan I Levey, Andrew P Lieberman, Vernon S Pankratz, Wayne W Poon, Joseph F Quinn, Andrew J Saykin, Lon S Schneider, Amanda G Smith, Joshua A Sonnen, Robert A Stern, Vivianna M Van Deerlin, Linda J Van Eldik, Denise Harold, Giancarlo Russo, David C Rubinsztein, Anthony Bayer, Magda Tsolaki, Petra Proitsi, Nick C Fox, Harald Hampel, Michael J Owen, Simon Mead, Peter Passmore, Kevin Morgan, Markus M Nöthen, Martin Rossor, Michelle K Lupton, Per Hoffmann, Johannes Kornhuber, Brian Lawlor, Andrew McQuillin, Ammar Al-Chalabi, Joshua C Bis, Agustin Ruiz, Mercè Boada, Sudha Seshadri, Alexa Beiser, Kenneth Rice, Sven J van der Lee, Philip L De Jager, Daniel H Geschwind, Matthias Riemenschneider, Steffi Riedel-Heller, Jerome I Rotter, Gerhard Ransmayr, Bradley T Hyman, Carlos Cruchaga, Montserrat Alegret, Bendik Winsvold, Priit Palta, Kai-How Farh, Ester Cuenca-Leon, Nicholas Furlotte, Tobias Kurth, Lannie Ligthart, Gisela M Terwindt, Tobias Freilinger, Caroline Ran, Scott D Gordon, Guntram Borck, Hieab H H Adams, Terho Lehtimäki, Juho Wedenoja, Julie E Buring, Markus Schürks, Maria Hrafnsdottir, Jouke-Jan Hottenga, Brenda Penninx, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Eija Hämäläinen, Hailiang Huang, Jie Huang, Cynthia Sandor, Caleb Webber, Bertram Muller-Myhsok, Stefan Schreiber, Veikko Salomaa, Elizabeth Loehrer, Hartmut Göbel, Alfons Macaya, Patricia Pozo-Rosich, Thomas Hansen, Thomas Werge, Jaakko Kaprio, Andres Metspalu, Christian Kubisch, Michel D Ferrari, Andrea C Belin, Arn M J M van den Maagdenberg, John-Anker Zwart, Dorret Boomsma, Nicholas Eriksson, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Andreja Avbersek, Larry Baum, Samuel Berkovic, Jonathan Bradfield, Russell J Buono, Claudia B Catarino, Patrick Cossette, Peter De Jonghe, Chantal Depondt, Dennis Dlugos, Thomas N Ferraro, Jacqueline French, Helle Hjalgrim, Jennifer Jamnadas-Khoda, Reetta Kälviäinen, Wolfram S Kunz, Holger Lerche, Costin Leu, Dick Lindhout, Warren Lo, Daniel Lowenstein, Mark McCormack, Rikke S Møller, Anne Molloy, Ping-Wing Ng, Karen Oliver, Michael Privitera, Rodney Radtke, Ann-Kathrin Ruppert, Thomas Sander, Steven Schachter, Christoph Schankin, Ingrid Scheffer, Susanne Schoch, Sanjay M Sisodiya, Philip Smith, Michael Sperling, Pasquale Striano, Rainer Surges, G Neil Thomas, Frank Visscher, Christopher D Whelan, Federico Zara, Erin L Heinzen, Anthony Marson, Felicitas Becker, Hans Stroink, Fritz Zimprich, Thomas Gasser, Raphael Gibbs, Peter Heutink, Maria Martinez, Huw R Morris, Manu Sharma, Mina Ryten, Kin Y Mok, Sara Pulit, Steve Bevan, Elizabeth Holliday, John Attia, Thomas Battey, Giorgio Boncoraglio, Vincent Thijs, Wei-Min Chen, Braxton Mitchell, Peter Rothwell, Pankaj Sharma, Cathie Sudlow, Astrid Vicente, Hugh Markus, Christina Kourkoulis, Joana Pera, Miriam Raffeld, Scott Silliman, Vesna Boraska Perica, Laura M Thornton, Laura M Huckins, N William Rayner, Cathryn M Lewis, Monica Gratacos, Filip Rybakowski, Anna Keski-Rahkonen, Anu Raevuori, James I Hudson, Ted Reichborn-Kjennerud, Palmiero Monteleone, Andreas Karwautz, Katrin Mannik, Jessica H Baker, Julie K O'Toole, Sara E Trace, Oliver S P Davis, Sietske G Helder, Stefan Ehrlich, Beate Herpertz-Dahlmann, Unna N Danner, Annemarie A van Elburg, Maurizio Clementi, Monica Forzan, Elisa Docampo, Jolanta Lissowska, Joanna Hauser, Alfonso Tortorella, Mario Maj, Fragiskos Gonidakis, Konstantinos Tziouvas, Hana Papezova, Zeynep Yilmaz, Gudrun Wagner, Sarah Cohen-Woods, Stefan Herms, Antonio Julià, Raquel Rabionet, Danielle M Dick, Samuli Ripatti, Ole A Andreassen, Thomas Espeseth, Astri J Lundervold, Vidar M Steen, Dalila Pinto, Stephen W Scherer, Harald Aschauer, Alexandra Schosser, Lars Alfredsson, Leonid Padyukov, Katherine A Halmi, James Mitchell, Michael Strober, Andrew W Bergen, Walter Kaye, Jin Peng Szatkiewicz, Bru Cormand, Josep Antoni Ramos-Quiroga, Cristina Sánchez-Mora, Marta Ribasés, Miguel Casas, Amaia Hervas, Maria Jesús Arranz, Jan Haavik, Tetyana Zayats, Stefan Johansson, Nigel Williams, Astrid Dempfle, Aribert Rothenberger, Jonna Kuntsi, Robert D Oades, Tobias Banaschewski, Barbara Franke, Jan K Buitelaar, Alejandro Arias Vasquez, Alysa E Doyle, Andreas Reif, Klaus-Peter Lesch, Christine Freitag, Olga Rivero, Haukur Palmason, Marcel Romanos, Kate Langley, Marcella Rietschel, Stephanie H Witt, Soeren Dalsgaard, Anders D Børglum, Irwin Waldman, Beth Wilmot, Nikolas Molly, Claiton H D Bau, Jennifer Crosbie, Russell Schachar, Sandra K Loo, James J McGough, Eugenio H Grevet, Sarah E Medland, Elise Robinson, Lauren A Weiss, Elena Bacchelli, Anthony Bailey, Vanessa Bal, Agatino Battaglia, Catalina Betancur, Patrick Bolton, Rita Cantor, Patrícia Celestino-Soper, Geraldine Dawson, Silvia De Rubeis, Frederico Duque, Andrew Green, Sabine M Klauck, Marion Leboyer, Pat Levitt, Elena Maestrini, Shrikant Mane, Daniel Moreno- De-Luca, Jeremy Parr, Regina Regan, Abraham Reichenberg, Sven Sandin, Jacob Vorstman, Thomas Wassink, Ellen Wijsman, Edwin Cook, Susan Santangelo, Richard Delorme, Bernadette Rogé, Tiago Magalhaes, Dan Arking, Thomas G Schulze, Robert C Thompson, Jana Strohmaier, Keith Matthews, Ingrid Melle, Derek Morris, Douglas Blackwood, Andrew McIntosh, Sarah E Bergen, Martin Schalling, Stéphane Jamain, Anna Maaser, Sascha B Fischer, Céline S Reinbold, Janice M Fullerton, José Guzman-Parra, Fermin Mayoral, Peter R Schofield, Sven Cichon, Thomas W Mühleisen, Franziska Degenhardt, Johannes Schumacher, Michael Bauer, Philip B Mitchell, Elliot S Gershon, John Rice, James B Potash, Peter P Zandi, Nick Craddock, I Nicol Ferrier, Martin Alda, Guy A Rouleau, Gustavo Turecki, Roel Ophoff, Carlos Pato, Adebayo Anjorin, Eli Stahl, Markus Leber, Piotr M Czerski, Cristiana Cruceanu, Ian R Jones, Danielle Posthuma, Till F M Andlauer, Andreas J Forstner, Fabian Streit, Bernhard T Baune, Tracy Air, Grant Sinnamon, Naomi R Wray, Donald J MacIntyre, David Porteous, Georg Homuth, Margarita Rivera, Jakob Grove, Christel M Middeldorp, Ian Hickie, Michele Pergadia, Divya Mehta, Johannes H Smit, Rick Jansen, Eco de Geus, Erin Dunn, Qingqin S Li, Matthias Nauck, Robert A Schoevers, Aartjan Tf Beekman, James A Knowles, Alexander Viktorin, Paul Arnold, Cathy L Barr, Gabriel Bedoya-Berrio, O Joseph Bienvenu, Helena Brentani, Christie Burton, Beatriz Camarena, Carolina Cappi, Danielle Cath, Maria Cavallini, Daniele Cusi, Sabrina Darrow, Damiaan Denys, Eske M Derks, Andrea Dietrich, Thomas Fernandez, Martijn Figee, Nelson Freimer, Gloria Gerber, Marco Grados, Erica Greenberg, Gregory L Hanna, Andreas Hartmann, Matthew E Hirschtritt, Pieter J Hoekstra, Alden Huang, Chaim Huyser, Cornelia Illmann, Michael Jenike, Samuel Kuperman, Bennett Leventhal, Christine Lochner, Gholson J Lyon, Fabio Macciardi, Marcos Madruga-Garrido, Irene A Malaty, Athanasios Maras, Lauren McGrath, Eurípedes C Miguel, Pablo Mir, Gerald Nestadt, Humberto Nicolini, Michael S Okun, Andrew Pakstis, Peristera Paschou, John Piacentini, Christopher Pittenger, Kerstin Plessen, Vasily Ramensky, Eliana M Ramos, Victor Reus, Margaret A Richter, Mark A Riddle, Mary M Robertson, Veit Roessner, Maria Rosário, Jack F Samuels, Paul Sandor, Dan J Stein, Fotis Tsetsos, Filip Van Nieuwerburgh, Sarah Weatherall, Jens R Wendland, Tomasz Wolanczyk, Yulia Worbe, Gwyneth Zai, Fernando S Goes, Nicole McLaughlin, Paul S Nestadt, Hans-Jorgen Grabe, Christel Depienne, Anuar Konkashbaev, Nuria Lanzagorta, Ana Valencia-Duarte, Elvira Bramon, Nancy Buccola, Wiepke Cahn, Murray Cairns, Siow A Chong, David Cohen, Benedicto Crespo-Facorro, James Crowley, Michael Davidson, Lynn DeLisi, Timothy Dinan, Gary Donohoe, Elodie Drapeau, Jubao Duan, Lieuwe Haan, David Hougaard, Sena Karachanak-Yankova, Andrey Khrunin, Janis Klovins, Vaidutis Kučinskas, Jimmy Lee Chee Keong, Svetlana Limborska, Carmel Loughland, Jouko Lönnqvist, Brion Maher, Manuel Mattheisen, Colm McDonald, Kieran C Murphy, Igor Nenadic, Jim van Os, Christos Pantelis, Michele Pato, Tracey Petryshen, Digby Quested, Panos Roussos, Alan R Sanders, Ulrich Schall, Sibylle G Schwab, Kang Sim, Hon-Cheong So, Elisabeth Stögmann, Mythily Subramaniam, Draga Toncheva, John Waddington, James Walters, Mark Weiser, Wei Cheng, Robert Cloninger, David Curtis, Pablo V Gejman, Frans Henskens, Morten Mattingsdal, Sang-Yun Oh, Rodney Scott, Bradley Webb, Gerome Breen, Claire Churchhouse, Cynthia M Bulik, Mark Daly, Martin Dichgans, Stephen V Faraone, Rita Guerreiro, Peter Holmans, Kenneth S Kendler, Bobby Koeleman, Carol A Mathews, Alkes Price, Jeremiah Scharf, Pamela Sklar, Julie Williams, Nicholas W Wood, Chris Cotsapas, Aarno Palotie, Jordan W Smoller, Patrick Sullivan, Jonathan Rosand, Aiden Corvin, Benjamin M Neale, Jonathan M Schott, Richard Anney, Josephine Elia, Maria Grigoroiu-Serbanescu, Howard J Edenberg, Robin Murray
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders...
June 22, 2018: Science
#31
JOURNAL ARTICLE
Christopher A Pennell, Jessie L Barnum, Cameron S McDonald-Hyman, Angela Panoskaltsis-Mortari, Megan J Riddle, Zhengming Xiong, Michael Loschi, Govindarajan Thangavelu, Heather M Campbell, Meghan D Storlie, Yosef Refaeli, Scott N Furlan, Michael C Jensen, Leslie S Kean, Jeffrey S Miller, Jakub Tolar, Mark J Osborn, Bruce R Blazar
The clinical success of chimeric antigen receptor (CAR) T cell therapy for CD19+ B cell malignancies can be limited by acute toxicities and immunoglobulin replacement needs due to B cell aplasia from persistent CAR T cells. Life-threatening complications include cytokine release syndrome and neurologic adverse events, the exact etiologies of which are unclear. To elucidate the underlying toxicity mechanisms and test potentially safer CAR T cells, we developed a mouse model in which human CD19 (hCD19)-specific mouse CAR T cells were adoptively transferred into mice whose normal B cells express a hCD19 transgene at hemizygous levels...
June 6, 2018: Molecular Therapy
#32
JOURNAL ARTICLE
Joel R Garbow, Christina I Tsien, Scott C Beeman
Radiation therapy (RT) plays a central role in the treatment of primary brain tumors. However, despite recent advances in RT treatment, local recurrences following therapy remain common. Radiation necrosis (RN) is a severe, late complication of radiation therapy in the brain. RN is a serious clinical problem often associated with devastating neurologic complications. Therapeutic strategies, including neuroprotectants, have been described, but have not been widely translated in routine clinical use. We have developed a mouse model that recapitulates all of the major pathologic features of late-onset RN for the purposes of characterizing the basic pathogenesis of RN, identifying non-invasive (imaging) biomarkers of RN that might allow for the radiologic discernment of tumor and RN, systematic testing of tumor and RN therapeutics, and exploring the complex interplay between RN pathogenesis and tumor recurrence...
July 2018: Journal of Magnetic Resonance
#33
JOURNAL ARTICLE
David M Robinson, Moussa S Bazzi, Scott R Millis, Ali A Bitar
OBJECTIVES: To investigate the frequency of and reasons for readmissions to acute care (RTAC) during inpatient rehabilitation (IPR) after non-traumatic spinal cord injury (NT-SCI). To develop a predictive model for RTAC using identified risk factors. DESIGN: Retrospective case-control. SETTING: Academic IPR hospital. PARTICIPANTS: Individuals with NT-SCI admitted to an academic SCI rehabilitation unit from January 2014-December 2015...
July 2018: Journal of Spinal Cord Medicine
#34
JOURNAL ARTICLE
Vamsi Kantamaneni, Vikas Sunder, Mohammad Bilal, Scott Vargo
Lyme disease (LD) is a tick-borne illness caused by Borrelia burgdorferi sensu stricto . An 80-year-old female from Pennsylvania, USA, presented to an outside hospital with fever, confusion, lower extremity weakness, and stool incontinence. CT head and MRI spine were unremarkable. An infectious work-up including lumbar puncture was negative. She was transferred to our tertiary care hospital. Patient was noted to have mild unilateral right-sided facial droop and a diffuse macular rash throughout the body. She denied any outdoor activities, tick bites, or previous rash...
2017: Case Reports in Infectious Diseases
#35
JOURNAL ARTICLE
Kanut Laoharawee, Kelly M Podetz-Pedersen, Tam T Nguyen, Laura B Evenstar, Kelley F Kitto, Zhenhong Nan, Carolyn A Fairbanks, Walter C Low, Karen F Kozarsky, R Scott McIvor
Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a rare X-linked recessive lysosomal disorder caused by defective iduronate-2-sulfatase (IDS), resulting in accumulation of heparan sulfate and dermatan sulfate glycosaminoglycans (GAGs). Enzyme replacement is the only Food and Drug Administration-approved therapy available for MPS II, but it is expensive and does not improve neurologic outcomes in MPS II patients. This study evaluated the effectiveness of adeno-associated virus (AAV) vector encoding human IDS delivered intracerebroventricularly in a murine model of MPS II...
August 2017: Human Gene Therapy
#36
JOURNAL ARTICLE
Karina A Top, Marie-Noelle Billard, Marie-Claude Gariepy, Isabelle Rouleau, Jeffrey M Pernica, Anne Pham-Huy, Caroline Quach, Dat Tran, Wendy Vaudry, Simon Dobson, François D Boucher, Alex Carignan, Taj Jadavji, Athena McConnell, Shelly A McNeil, Scott A Halperin, Gaston De Serres
BACKGROUND: For patients who have experienced adverse events following immunization (AEFI) or who have specific medical conditions, there is limited evidence regarding the best approach to immunization. The Special Immunization Clinics (SICs) Network was established to standardize patient management and assess outcomes after reimmunization. The study objective was to describe the first 2 years of the network's implementation. METHODS: Twelve SICs were established across Canada by infectious diseases specialists and allergists...
December 2016: Pediatric Infectious Disease Journal
#37
JOURNAL ARTICLE
James J Yue, Paul C Ivancic, David L Scott
BACKGROUND: We report a case of a young male athlete who sustained a three column displaced teardrop fracture of the C5 vertebra due to a head-first impact in hockey, suffered neurapraxia, yet made full neurological recovery. This full recovery was in sharp contrast to multiple case series which reported permanent quadriplegia in the vast majority of teardrop fracture patients. We investigate the etiology and biomechanical mechanisms of injury. METHODS: Admission imaging revealed the teardrop fracture which consisted of: a frontal plane fracture which separated an anterior quadrilateral-shaped fragment from the posterior vertebral body; a vertical fracture of the posterior vertebral body in the sagittal plane; and incomplete fractures of the neural arch that initiated superiorly at the anterior aspect of the spinous process and left lamina adjacent to the superior facet...
2016: International Journal of Spine Surgery
#38
JOURNAL ARTICLE
Julia C Nantes, Jidan Zhong, Scott A Holmes, Sridar Narayanan, Yves Lapierre, Lisa Koski
BACKGROUND: Multimodal research combining biomarkers of intracortical activity and cortical damage could shed light on pathophysiological and adaptive neural processes related to the clinical severity of neurological conditions such as multiple sclerosis (MS). OBJECTIVE: Among people with relapsing-remitting and progressive forms of MS, we assessed the extent to which transcranial magnetic stimulation (TMS)-based biomarkers of excitatory and inhibitory cortical activity are related to cortical damage and clinical impairment...
July 2016: Brain Stimulation
#39
JOURNAL ARTICLE
Kate Kloot, Scott Salzman, Sue Kilpatrick, Tim Baker, Susan A Brumby
OBJECTIVE: The objective of this present study was to describe the initial destination hospital of paediatric patients transported by Ambulance Victoria paramedics within the South Western area of Victoria to determine the proportion of patients that bypassed their closest hospital. METHODS: All Ambulance Victoria primary ambulance transports for paediatric patients aged 1 month to 14 years in the Barwon South West region between 1 April 2008 and 28 February 2011 were reviewed...
April 2016: Emergency Medicine Australasia: EMA
#40
JOURNAL ARTICLE
Jennifer Hong, Sebastian Rubino, Stuart Scott Lollis
BACKGROUND: Helicopter transport may shorten transport time to neurosurgical intervention; however, there are few data regarding its utility for nontraumatic emergencies. METHODS: Prehospital and hospital records of all patients transferred via helicopter to Dartmouth-Hitchcock Medical Center for spontaneous subarachnoid hemorrhage between January 2007 and December 2011 were reviewed. Primary outcome measure was emergent tertiary-level care intervention, defined as ventriculostomy, conventional angiography, endovascular treatment, or craniotomy within 3 hours of arrival...
March 2016: World Neurosurgery
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