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JOURNAL ARTICLE
Alister Scott, Matthew Kirby
This paper assesses how strategic planning for nature can be improved for England's built and natural environment using mainstreaming and landscape-scale concepts. Whilst both concepts feature in academic literature, there has been limited attention on their role as catalytic agents for strategic planning. Addressing this gap, evidence is used from two stakeholder workshops involving 62 senior policy experts managing a range of operational and hypothetical strategic spatial planning challenges. The results reveal a significantly weakened strategic planning arena characterised by policy disintegration, short termism and uncertainty...
March 15, 2024: Ambio
#22
JOURNAL ARTICLE
Syed Salman Shahid, Mario Dzemidzic, Elizabeth R Butch, Erin E Jarvis, Scott E Snyder, Yu-Chien Wu
In vivo noninvasive imaging of neurometabolites is crucial to improve our understanding of the underlying pathophysiological mechanism in neurodegenerative diseases. Abnormal changes in synaptic organization leading to synaptic degradation and neuronal loss is considered as one of the primary factors driving Alzheimer's disease pathology. Magnetic resonance based molecular imaging techniques such as chemical exchange saturation transfer (CEST) and magnetic resonance spectroscopy (MRS) can provide neurometabolite specific information which may relate to underlying pathological and compensatory mechanisms...
2024: PloS One
#23
JOURNAL ARTICLE
Stuart Robertson, Andrew McClintock, Kenny Jolley, Han Zhou, Sam Davis, Houzheng Wu, Changqing Liu, Scott Doak, Zhaoxia Zhou
A new method is proposed to measure the linear coefficient of thermal expansion (CTE) of solid metals and ceramics of micron-sized dimensions. This approach uses a focused ion beam (FIB) to extract and transfer a slab of the sample, typically (15-20) ×10 × (3-5) µm onto a Micro-Electro-Mechanical Systems (MEMS) in situ heating holder inside a scanning electron microscope (SEM). CTE is thereafter calculated by image correlating the change of length (ΔL) between the fiducial marks on the slab as a function of temperature, taking advantage of the temperature calibration of the MEMS heating holder and nanometre resolution of the scanning electron microscope...
March 14, 2024: Journal of Microscopy
#24
JOURNAL ARTICLE
Anahita Jalilvand, Megan Ireland, Courtney Collins, Whitney Kellett, Scott Strassel, Robert Tamer, Wendy Wahl, Jon Wisler
INTRODUCTION: While obesity is a risk factor for post-operative complications, its impact following sepsis is unclear. The primary objective of this study was to evaluate the association between obesity and mortality following admission to the surgical ICU (SICU) with sepsis. METHODS: We conducted a single center retrospective review of SICU patients grouped into obese (n = 766, BMI ≥30 kg/m2) and non-obese (n = 574, BMI 18-29.9 kg/m2) cohorts. Applying 1:1 propensity matching for age, sex, comorbidities, SOFA, and transfer status, demographic data, comorbidities, and sepsis presentation were compared between groups...
March 14, 2024: Journal of Trauma and Acute Care Surgery
#25
JOURNAL ARTICLE
Aditi Pradhan, Hayley Mounford, Jessica Peixinho, Edward Rea, Emmanouela Epeslidou, Julia S Scott, Joanna Cull, Susan Maxwell, Richard Webster, David Beeson, Yin Yao Dong, Stefan Prekovic, Isabel Bermudez, Dianne F Newbury
Recent work putatively linked a rare genetic variant of the chaperone Resistant to Inhibitors of acetylcholinesterase (RIC3) (NM_024557.4:c.262G > A, NP_078833.3:p.G88R) to a unique ability to speak backwards, a language skill that is associated with exceptional working memory capacity. RIC3 is important for the folding, maturation, and functional expression of α7 nicotinic acetylcholine receptors (nAChR). We compared and contrasted the effects of RIC3G88R on assembly, cell surface expression, and function of human α7 receptors using fluorescent protein tagged α7 nAChR and Förster resonance energy transfer (FRET) microscopy imaging in combination with functional assays and 125 I-α-bungarotoxin binding...
March 12, 2024: Cellular and Molecular Life Sciences: CMLS
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JOURNAL ARTICLE
Zhicheng Luo, Li Li, Vy T Nguyen, Uddhav Kanbur, Yuting Li, Jie Zhang, Renfeng Nie, Abhranil Biswas, Sergey L Bud'ko, Jinsu Oh, Lin Zhou, Wenyu Huang, Aaron D Sadow, Bin Wang, Susannah L Scott, Long Qi
Atomically dispersed first-row transition metals embedded in nitrogen-doped carbon materials (M-N-C) show promising performance in catalytic hydrogenation but are less well-studied for reactions with more complex mechanisms, such as hydrogenolysis. Their ability to catalyze selective C-O bond cleavage of oxygenated hydrocarbons such as aryl alcohols and ethers is enhanced with the participation of ligands directly bound to the metal ion as well as longer-range contributions from the support. In this article, we describe how Fe-N-C catalysts with well-defined local structures for the Fe sites catalyze C-O bond hydrogenolysis...
March 12, 2024: Journal of the American Chemical Society
#27
JOURNAL ARTICLE
Emily F Kaplan, Courtney N Link, Scott Schmalzried, Amanda Rosenblatt, Ann Kellams, Eliza Holland
Background: The use of cannabis and its perceived safety among pregnant and breastfeeding women has increased in the context of expanding legalization. Current guidelines recommend abstaining from the use of cannabis while pregnant or breastfeeding due to the potential for harm, although there is still much that is unknown in this field. Case Presentation: A 5-week-old infant presented with recurrent apneic episodes and a positive urine delta-9-tetrahydrocannabinol (THC) screening test. The infant's mother reported regular cannabis use for treatment of depression and anxiety while pregnant and breastfeeding...
March 12, 2024: Breastfeeding Medicine
#28
JOURNAL ARTICLE
Samantha M Ree, Howard Greenwood, Jennifer D Young, Rachel F C Roberts, Francis R Livens, Scott L Heath, Jane K Sosabowski
Targeted alpha therapy (TAT) is a promising form of oncology treatment utilising alpha-emitting radionuclides that can specifically accumulate at disease sites. The high energy and high linear energy transfer associated with alpha emissions causes localised damage at target sites whilst minimising that to surrounding healthy tissue. The lack of appropriate radionuclides has inhibited research in TAT. The identification of appropriate radionuclides should be primarily a function of the radionuclide's nuclear decay properties, and not their biochemistry or economic factors since these last two factors can change; however, the nuclear decay properties are fixed to that nuclide...
March 11, 2024: Nuclear Medicine Communications
#29
JOURNAL ARTICLE
Eric J Cotter, Lisa M Cotter, Colleen N Riley, Jonah Dixon, Nicholas VanDerwerker, Aniekanabasi Ime Ufot, Jared Godfrey, David Gold, Scott J Hetzel, Nasia Safdar, Brian F Grogan
BACKGROUND: Blue light therapy (BLT) is a Food and Drug Administration cleared modality used in dermatology as an effective treatment of acne. The primary purpose of this study is to determine if there are dose-dependent antimicrobial effects of BLT against Cutibacterium acnes (C. acnes) . METHODS: A known strain of C. acnes was grown on chocolate agar in a controlled laboratory environment under anaerobic conditions for 1 week. After 1 week, 2-3 colonies of C...
March 2024: JSES international
#30
F Aaron Cruz-Navarrete, Wezley C Griffin, Yuk-Cheung Chan, Maxwell I Martin, Jose L Alejo, S Kundhavai Natchiar, Isaac J Knudson, Roger B Altman, Alanna Schepartz, Scott J Miller, Scott C Blanchard
Templated synthesis of proteins containing non-natural amino acids (nnAAs) promises to vastly expand the chemical space available to biological therapeutics and materials. Existing technologies limit the identity and number of nnAAs than can be incorporated into a given protein. Addressing these bottlenecks requires deeper understanding of the mechanism of messenger RNA (mRNA) templated protein synthesis and how this mechanism is perturbed by nnAAs. Here we examine the impact of both monomer backbone and side chain on formation and ribosome-utilization of the central protein synthesis substate: the ternary complex of native, aminoacylated transfer RNA (aa-tRNA), thermally unstable elongation factor (EF-Tu), and GTP...
February 27, 2024: bioRxiv
#31
JOURNAL ARTICLE
Michael St Paul, Samuel D Saibil, Meghan Kates, SeongJun Han, Scott C Lien, Rob C Laister, Kebria Hezaveh, Andreas Kloetgen, Susanne Penny, Tingxi Guo, Carlos Garcia-Batres, Logan K Smith, Douglas C Chung, Alisha R Elford, Azin Sayad, Devanand Pinto, Tak W Mak, Naoto Hirano, Tracy McGaha, Pamela S Ohashi
The manipulation of T cell metabolism to enhance anti-tumor activity is an area of active investigation. Here, we report that activating the amino acid starvation response in effector CD8+ T cells ex vivo using the general control non-depressible 2 (GCN2) agonist halofuginone (halo) enhances oxidative metabolism and effector function. Mechanistically, we identified autophagy coupled with the CD98-mTOR axis as key downstream mediators of the phenotype induced by halo treatment. The adoptive transfer of halo-treated CD8+ T cells into tumor-bearing mice led to robust tumor control and curative responses...
March 1, 2024: Cell reports medicine
#32
JOURNAL ARTICLE
Scott John, Guillaume Calmettes, Shili Xu, Bernard Ribalet
During hypoxia accumulation of lactate may be a key factor in acidosis-induced tissue damage. Binding of hexokinase (HK) to the outer membrane of mitochondria may have a protective effect under these conditions. We have investigated the regulation of lactate metabolism by hexokinases (HKs), using HEK293 cells in which the endogenous hexokinases have been knocked down to enable overexpression of wild type and mutant HKs. To assess the real-time changes in intracellular lactate levels the cells were also transfected with a lactate specific FRET probe...
2024: PloS One
#33
JOURNAL ARTICLE
Nicole M Brundridge, Jordan M Fritz, Jonathan Dickerhoff, Danzhou Yang, Scott A McLuckey
G-quadruplex (G4) DNA can form highly stable secondary structures in the presence of metal cations, and research has shown its potential as a transcriptional regulator for oncogenes in the human genome. In order to explore the interactions of DNA with metal cations using mass spectrometry, employing complementary fragmentation methods can enhance structural information. This study explores the use of ion-ion reactions for sequential negative electron transfer collision-induced dissociation (nET-CID) as a complement to traditional ion-trap CID (IT-CID)...
March 8, 2024: Journal of the American Society for Mass Spectrometry
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JOURNAL ARTICLE
Jia Nong, Patrick M Glassman, Vladimir V Shuvaev, Sahily Reyes-Esteves, Helene C Descamps, Raisa Y Kiseleva, Tyler E Papp, Mohamad-Gabriel Alameh, Ying K Tam, Barbara L Mui, Serena Omo-Lamai, Marco E Zamora, Tea Shuvaeva, Evguenia Arguiri, Xijing Gong, Taylor V Brysgel, Ai Wen Tan, Ashley G Woolfork, Aalim Weljie, Christoph A Thaiss, Jacob W Myerson, Drew Weissman, Scott E Kasner, Hamideh Parhiz, Vladimir R Muzykantov, Jacob S Brenner, Oscar A Marcos-Contreras
Effective delivery of mRNA or small molecule drugs to the brain is a significant challenge in developing treatment for acute ischemic stroke. To address the problem, we have developed targeted nanomedicine to increase drug concentrations in endothelial cells of the blood-brain barrier (BBB) of the injured brain. Inflammation during ischemic stroke causes continuous neuronal death and increase of the infarct volume. To enable targeted delivery to the inflamed BBB, we conjugated lipid nanocarriers with antibodies that bind cell adhesion molecules expressed at the BBB...
March 6, 2024: Molecular Therapy
#35
JOURNAL ARTICLE
Cassandra M J Wannan, Barnaby Nelson, Jean Addington, Kelly Allott, Alan Anticevic, Celso Arango, Justin T Baker, Carrie E Bearden, Tashrif Billah, Sylvain Bouix, Matthew R Broome, Kate Buccilli, Kristin S Cadenhead, Monica E Calkins, Tyrone D Cannon, Guillermo Cecci, Eric Yu Hai Chen, Kang Ik K Cho, Jimmy Choi, Scott R Clark, Michael J Coleman, Philippe Conus, Cheryl M Corcoran, Barbara A Cornblatt, Covadonga M Diaz-Caneja, Dominic Dwyer, Bjørn H Ebdrup, Lauren M Ellman, Paolo Fusar-Poli, Liliana Galindo, Pablo A Gaspar, Carla Gerber, Louise Birkedal Glenthøj, Robert Glynn, Michael P Harms, Leslie E Horton, René S Kahn, Joseph Kambeitz, Lana Kambeitz-Ilankovic, John M Kane, Tina Kapur, Matcheri S Keshavan, Sung-Wan Kim, Nikolaos Koutsouleris, Marek Kubicki, Jun Soo Kwon, Kerstin Langbein, Kathryn E Lewandowski, Gregory A Light, Daniel Mamah, Patricia J Marcy, Daniel H Mathalon, Patrick D McGorry, Vijay A Mittal, Merete Nordentoft, Angela Nunez, Ofer Pasternak, Godfrey D Pearlson, Jesus Perez, Diana O Perkins, Albert R Powers, David R Roalf, Fred W Sabb, Jason Schiffman, Jai L Shah, Stefan Smesny, Jessica Spark, William S Stone, Gregory P Strauss, Zailyn Tamayo, John Torous, Rachel Upthegrove, Mark Vangel, Swapna Verma, Jijun Wang, Inge Winter-van Rossum, Daniel H Wolf, Phillip Wolff, Stephen J Wood, Alison R Yung, Carla Agurto, Mario Alvarez-Jimenez, Paul Amminger, Marco Armando, Ameneh Asgari-Targhi, John Cahill, Ricardo E Carrión, Eduardo Castro, Suheyla Cetin-Karayumak, M Mallar Chakravarty, Youngsun T Cho, David Cotter, Simon D'Alfonso, Michaela Ennis, Shreyas Fadnavis, Clara Fonteneau, Caroline Gao, Tina Gupta, Raquel E Gur, Ruben C Gur, Holly K Hamilton, Gil D Hoftman, Grace R Jacobs, Johanna Jarcho, Jie Lisa Ji, Christian G Kohler, Paris Alexandros Lalousis, Suzie Lavoie, Martin Lepage, Einat Liebenthal, Josh Mervis, Vishnu Murty, Spero C Nicholas, Lipeng Ning, Nora Penzel, Russell Poldrack, Pablo Polosecki, Danielle N Pratt, Rachel Rabin, Habiballah Rahimi Eichi, Yogesh Rathi, Avraham Reichenberg, Jenna Reinen, Jack Rogers, Bernalyn Ruiz-Yu, Isabelle Scott, Johanna Seitz-Holland, Vinod H Srihari, Agrima Srivastava, Andrew Thompson, Bruce I Turetsky, Barbara C Walsh, Thomas Whitford, Johanna T W Wigman, Beier Yao, Hok Pan Yuen, Uzair Ahmed, Andrew Jin Soo Byun, Yoonho Chung, Kim Do, Larry Hendricks, Kevin Huynh, Clark Jeffries, Erlend Lane, Carsten Langholm, Eric Lin, Valentina Mantua, Gennarina Santorelli, Kosha Ruparel, Eirini Zoupou, Tatiana Adasme, Lauren Addamo, Laura Adery, Munaza Ali, Andrea Auther, Samantha Aversa, Seon-Hwa Baek, Kelly Bates, Alyssa Bathery, Johanna M M Bayer, Rebecca Beedham, Zarina Bilgrami, Sonia Birch, Ilaria Bonoldi, Owen Borders, Renato Borgatti, Lisa Brown, Alejandro Bruna, Holly Carrington, Rolando I Castillo-Passi, Justine Chen, Nicholas Cheng, Ann Ee Ching, Chloe Clifford, Beau-Luke Colton, Pamela Contreras, Sebastián Corral, Stefano Damiani, Monica Done, Andrés Estradé, Brandon Asika Etuka, Melanie Formica, Rachel Furlan, Mia Geljic, Carmela Germano, Ruth Getachew, Mathias Goncalves, Anastasia Haidar, Jessica Hartmann, Anna Jo, Omar John, Sarah Kerins, Melissa Kerr, Irena Kesselring, Honey Kim, Nicholas Kim, Kyle Kinney, Marija Krcmar, Elana Kotler, Melanie Lafanechere, Clarice Lee, Joshua Llerena, Christopher Markiewicz, Priya Matnejl, Alejandro Maturana, Aissata Mavambu, Rocío Mayol-Troncoso, Amelia McDonnell, Alessia McGowan, Danielle McLaughlin, Rebecca McIlhenny, Brittany McQueen, Yohannes Mebrahtu, Martina Mensi, Christy Lai Ming Hui, Yi Nam Suen, Stephanie Ming Yin Wong, Neal Morrell, Mariam Omar, Alice Partridge, Christina Phassouliotis, Anna Pichiecchio, Pierluigi Politi, Christian Porter, Umberto Provenzani, Nicholas Prunier, Jasmine Raj, Susan Ray, Victoria Rayner, Manuel Reyes, Kate Reynolds, Sage Rush, Cesar Salinas, Jashmina Shetty, Callum Snowball, Sophie Tod, Gabriel Turra-Fariña, Daniela Valle, Simone Veale, Sarah Whitson, Alana Wickham, Sarah Youn, Francisco Zamorano, Elissa Zavaglia, Jamie Zinberg, Scott W Woods, Martha E Shenton
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community...
March 7, 2024: Schizophrenia Bulletin
#36
JOURNAL ARTICLE
Philip Knight, Victoria Norman, Rochelle Gully, Dora Wood, Dusan Raffaj, Laura Riddick, Stephen Hancock, Sanjay Revanna, Mohammed Uvaise, Sasha Herring, Mark Worrall, Ashley Daye, Mark Terris, Cormac O'Brien, Ananth Kumar, Sophie Scott, Lisa Pritchard, Srinivasan Palaniappan, Charlotte Hughes, Michael J Griksaitis, Shelley Riphagen, Padmanabhan Ramnarayan
OBJECTIVE: This study describes the baseline clinical characteristics, predictors of successful extubation at referring hospitals and short-term outcomes of children intubated for status epilepticus and referred to United Kingdom (UK) paediatric critical care transport teams (PCCTs). DESIGN: Multicentre audit with case-control analysis, conducted between 1 September 2018 and 1 September 2020. SETTING: This study involved 10 UK PCCTs. PATIENTS: Children over 1 month of age intubated during emergency management for status epilepticus (SE), referred to UK PCCTs...
March 6, 2024: Archives of Disease in Childhood
#37
JOURNAL ARTICLE
Zhongyou Li, Roxanna Barnaby, Amanda B Nymon, Carolyn Roche, Katja Koeppen, Alix Ashare, Deborah A Hogan, Scott A Gerber, Douglas J Taatjes, Thomas H Hampton, Bruce A Stanton
Although tobramycin increases lung function in people with cystic fibrosis (pwCF), the density of Pseudomonas aeruginosa (P. aeruginosa) in the lungs is only modestly reduced by tobramycin; hence, the mechanism whereby tobramycin improves lung function is not completely understood. Here, we demonstrate that tobramycin increases 5' tRNA-fMet halves in outer membrane vesicles (OMVs) secreted by laboratory and CF clinical isolates of P. aeruginosa . The 5' tRNA-fMet halves are transferred from OMVs into primary CF human bronchial epithelial cells (CF-HBEC), decreasing OMV-induced IL-8 and IP-10 secretion...
March 5, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
#38
JOURNAL ARTICLE
Paul G Young, Jesper Levring, Karol Fiedorczuk, Scott C Blanchard, Jue Chen
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that regulates electrolyte and fluid balance in epithelial tissues. While activation of CFTR is vital to treating cystic fibrosis, selective inhibition of CFTR is a potential therapeutic strategy for secretory diarrhea and autosomal dominant polycystic kidney disease. Although several CFTR inhibitors have been developed by high-throughput screening, their modes of action remain elusive. In this study, we determined the structure of CFTR in complex with the inhibitor CFTRinh -172 to an overall resolution of 2...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America
#39
JOURNAL ARTICLE
Connor P Delaney, Andrew F Zahrt, Vincent M Kassel, Scott E Denmark
The structure of the diol from which an arylboronic ester is derived dramatically influences the rate of transmetalation in the Suzuki-Miyaura cross-coupling reaction. Some esters undergo transmetalation more than 20 times faster than the parent arylboronic acid. Herein, investigations into the influence of arylboronic ester ring size and steric properties on the mechanism of transmetalation in the Suzuki-Miyaura reaction are described. Both factors impact the propensity of an arylboronic ester to bind to a dimeric palladium hydroxide complex...
February 29, 2024: Journal of Organic Chemistry
#40
JOURNAL ARTICLE
Mayra A Carrillo, Anjie Zhen, Wenli Mu, Valerie Rezek, Heather Martin, Christopher W Peterson, Hans-Peter Kiem, Scott G Kitchen
Adoptive cell therapy (ACT) using T cells expressing chimeric antigen receptors (CARs) is an area of intense investigation in the treatment of malignancies and chronic viral infections. One of the limitations of ACT-based CAR therapy is the lack of in vivo persistence and maintenance of optimal cell function. Therefore, alternative strategies that increase the function and maintenance of CAR-expressing T cells are needed. In our studies using the humanized bone marrow/liver/thymus (BLT) mouse model and nonhuman primate model (NHP) of HIV infection, we evaluated two CAR-based gene therapy approaches...
February 26, 2024: Molecular Therapy
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