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https://read.qxmd.com/read/30876613/peritoneal-dialysis-access-associated-infections
#1
REVIEW
Scott Bieber, Rajnish Mehrotra
Infection is a significant driver of morbidity and mortality in patients with end-stage renal disease undergoing maintenance dialysis. In the United States, septicemia and other infections account for 8% deaths in patients undergoing dialysis. In patients undergoing peritoneal dialysis (PD), PD-related peritonitis remains the most frequent treatment-related infection and is the greatest contributor to infection-related morbidity, including risk for hospitalization, and temporary or permanent transfer to hemodialysis...
January 2019: Advances in Chronic Kidney Disease
https://read.qxmd.com/read/30870097/maintenance-of-near-normal-bone-mass-and-architecture-in-lethally-irradiated-female-mice-following-adoptive-transfer-with-as-few-as-750-purified-hematopoietic-stem-cells
#2
Richard T Deyhle, Carmen P Wong, Stephen A Martin, Melissa Q McDougall, Dawn A Olson, Adam J Branscum, Scott A Menn, Urszula T Iwaniec, David M Hamby, Russell T Turner
Total-body irradiation (TBI) followed by transfer of bone marrow cells from donors is routinely performed in immunology research and can be used to manipulate differentiation and/or function of bone cells. However, exposure to high-dose radiation can result in irreversible osteopenia, and transfer of heterogeneous cell populations can complicate interpretation of results. The goal of this research was to establish an approach for reconstituting bone marrow using small numbers of purified donor-derived hematopoietic stem cells (HSCs) without negatively affecting bone metabolism...
March 14, 2019: Radiation Research
https://read.qxmd.com/read/30869178/dipolar-dc-induced-collisional-activation-of-non-dissociated-electron-transfer-products
#3
Sarju Adhikari, Eric T Dziekonski, Frank A Londry, Scott A McLuckey
The application of electron transfer and dipolar direct current induced collisional activation (ET-DDC) for enhanced sequence coverage of peptide/protein cations is described. A DDC potential is applied across one pair of opposing rods in the high-pressure collision cell of a hybrid quadrupole/time-of-flight tandem mass spectrometer (QqTOF) to induce collisional activation, in conjunction with electron transfer reactions. As a broadband technique, DDC can be employed for the simultaneous collisional activation of all the first-generation charge reduced precursor ions (e...
March 14, 2019: Journal of Mass Spectrometry: JMS
https://read.qxmd.com/read/30863216/free-flap-reconstruction-of-skull-base-and-orbital-defects
#4
REVIEW
Weitao Wang, Aurora Vincent, Mofiyinfolu Sokoya, Scott Kohlert, Sameep Kadakia, Yadranko Ducic
Orbital and anterior skull base defects present a significant challenge for reconstruction due to the complexity of the anatomy and the need for separation of intracranial and extracranial contents in this area. While endoscopic techniques have revolutionized the treatment of many anterior skull base defects, microvascular free tissue transfer is a viable option for large volume defects not suitable for traditional open approaches or for cases where endoscopic techniques have failed. The various free tissue transfer techniques for anterior skull base and orbit, as well as the advantages and disadvantages, are reviewed...
February 2019: Seminars in Plastic Surgery
https://read.qxmd.com/read/30863207/postoperative-free-flap-monitoring-techniques
#5
REVIEW
Scott Kohlert, Alexandra E Quimby, Masoud Saman, Yadranko Ducic
Free tissue transfer is commonly employed in the reconstruction of large or complicated defects. Postoperative flap failure from microvascular compromise is an uncommon but major potential complication of this procedure. As such, many postoperative monitoring techniques devices have been developed. This paper provides an overview of the wide variety of options available for surgeons today.
February 2019: Seminars in Plastic Surgery
https://read.qxmd.com/read/30860852/structure-and-reactivity-of-highly-twisted-n-acylimidazoles
#6
Elizabeth A Stone, Brandon Q Mercado, Scott J Miller
A modular and efficient synthesis of highly twisted N-acylimidazoles is reported. These twist amides were characterized via X-ray crystallography, NMR spectroscopy, IR spectroscopy, and DFT calculations. Modification of the substituent proximal to the amide revealed a maximum torsional angle of 88.6° in the solid state, which may be the most twisted amide reported for a nonbicyclic system to date. Reactivity and stability studies indicate that these twisted N-acylimidazoles may be valuable, namely as acyl transfer reagents...
March 12, 2019: Organic Letters
https://read.qxmd.com/read/30851084/reduction-of-active-fel-d1-from-cats-using-an-antifel-d1-egg-igy-antibody
#7
Ebenezer Satyaraj, Cari Gardner, Ivan Filipi, Kerry Cramer, Scott Sherrill
BACKGROUND: Fel d1 is the most important allergen from cats. Fel d1 is produced primarily in saliva and spread to the haircoat during grooming and then transferred to the environment via hair and dander. OBJECTIVES: A novel approach to reducing allergenic Fel d1 exposure was evaluated, involving binding the Fel d1 with an anti-Fel d1 polyclonal egg IgY antibody. The hypothesis was that hair from cats who had been fed foods containing anti-Fel d1 IgY would show a significant reduction in active Fel d1 (aFel d1)...
March 9, 2019: Immunity, Inflammation and Disease
https://read.qxmd.com/read/30850057/dual-color-pulse-chase-ubiquitination-assays-to-simultaneously-monitor-substrate-priming-and-extension
#8
Daniel C Scott, Brenda A Schulman
Many fundamental discoveries in ubiquitin-proteasome research have relied on reconstitution of activities from purified or recombinantly expressed components. These include landmark discoveries of E1-E2-E3 mechanisms, in which ubiquitin (UB) is initially activated and then covalently shuttled between enzyme active sites and ultimately ligated to substrate or substrate-linked UBs during polyubiquitination. However, recent studies have unearthed enormous variations on the E1-E2-E3 theme; for example, one E3 may employ two distinct E2s, or two different E3s may act in a single assembly or in series, to prime substrates directly with UB and subsequently decorate them with myriad types of polyubiquitin chains...
2019: Methods in Enzymology
https://read.qxmd.com/read/30844419/conjugative-and-replicative-biology-of-the-staphylococcus-aureus-antimicrobial-resistance-plasmid-pc02
#9
Patrick T LaBreck, Zhaozhang Li, Kevin P Gibbons, D Scott Merrell
Genetic transfer among bacteria propels rapid resistance to antibiotics and decreased susceptibility to antiseptics. Staphylococcus aureus is a common culprit of hospital and community acquired infections, and S. aureus plasmids have been shown to carry a multitude of antimicrobial resistance genes. We previously identified a novel conjugative, multidrug resistance plasmid, pC02, from the clinical S. aureus isolate C02. This plasmid contained the chlorhexidine resistance gene qacA, and we were able to demonstrate that conjugative transfer of pC02 imparted decreased chlorhexidine susceptibility to recipient strains...
March 4, 2019: Plasmid
https://read.qxmd.com/read/30842865/the-role-of-halogens-in-the-catalyst-transfer-polycondensation-for-%C3%AF-conjugated-polymers
#10
Shuyang Ye, Scott M Foster, Adam A Pollit, Susan Cheng, Dwight S Seferos
Catalyst transfer polycondensation is the only method to prepare π-conjugated polymers in a chain-growth manner, yet several aspects that underlie this polymerization are not fully understood. Here, we investigate the nickel-catalyzed polymerization mechanisms of a series of thiophene monomers bearing different halogen functionalities (Cl, Br, I). We have discovered the significant role that halogens and magnesium salts play in this polymerization. More specifically, the catalyst resting state changes depending on the type of halogenated monomer...
February 21, 2019: Chemical Science
https://read.qxmd.com/read/30839476/intermediate-to-long-term-results-of-femoral-neck-lengthening-morscher-osteotomy
#11
Mark Eidelman, Doron Keshet, Scott Nelson, Noam Bor
BACKGROUND: Femoral neck lengthening and transfer of the greater trochanter were introduced by Morscher as treatment for patients with coxa breva and overgrowth of the greater trochanter. In this study we evaluated intermediate and long-term results of this operation. METHODS: We reviewed clinical and radiographic results of 18 patients (20 hips) who were treated by Morscher osteotomy. Ten patients had Perthes disease, 4 had developmental dysplasia of the hip, and 4 had avascular necrosis of the hip...
April 2019: Journal of Pediatric Orthopedics
https://read.qxmd.com/read/30822067/constraining-the-p-mode-g-mode-tidal-instability-with-gw170817
#12
B P Abbott, R Abbott, T D Abbott, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, B Agarwal, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, B Allen, G Allen, A Allocca, M A Aloy, P A Altin, A Amato, A Ananyeva, S B Anderson, W G Anderson, S V Angelova, S Antier, S Appert, K Arai, M C Araya, J S Areeda, M Arène, N Arnaud, K G Arun, S Ascenzi, G Ashton, M Ast, S M Aston, P Astone, D V Atallah, F Aubin, P Aufmuth, C Aulbert, K AultONeal, C Austin, A Avila-Alvarez, S Babak, P Bacon, F Badaracco, M K M Bader, S Bae, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, S Banagiri, J C Barayoga, S E Barclay, B C Barish, D Barker, K Barkett, S Barnum, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, I Bartos, R Bassiri, A Basti, J C Batch, M Bawaj, J C Bayley, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, A S Bell, D Beniwal, M Bensch, B K Berger, G Bergmann, S Bernuzzi, J J Bero, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, R Bhandare, I A Bilenko, S A Bilgili, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, S Biscoveanu, A Bisht, M Bitossi, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, N Bode, M Boer, Y Boetzel, G Bogaert, A Bohe, F Bondu, E Bonilla, R Bonnand, P Booker, B A Boom, C D Booth, R Bork, V Boschi, S Bose, K Bossie, V Bossilkov, J Bosveld, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, A Bramley, M Branchesi, J E Brau, T Briant, F Brighenti, A Brillet, M Brinkmann, V Brisson, P Brockill, A F Brooks, D D Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, M Canepa, P Canizares, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, M F Carney, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, P Cerdá-Durán, G Cerretani, E Cesarini, O Chaibi, S J Chamberlin, M Chan, S Chao, P Charlton, E Chase, E Chassande-Mottin, D Chatterjee, Katerina Chatziioannou, B D Cheeseboro, H Y Chen, X Chen, Y Chen, H-P Cheng, H Y Chia, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, K W Chung, S Chung, G Ciani, A A Ciobanu, R Ciolfi, F Cipriano, C E Cirelli, A Cirone, F Clara, J A Clark, P Clearwater, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, D Cohen, A Colla, C G Collette, C Collins, L R Cominsky, M Constancio, L Conti, S J Cooper, P Corban, T R Corbitt, I Cordero-Carrión, K R Corley, N Cornish, A Corsi, S Cortese, C A Costa, R Cotesta, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, G Dálya, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, D Davis, E J Daw, B Day, D DeBra, M Deenadayalan, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, N Demos, T Denker, T Dent, R De Pietri, J Derby, V Dergachev, R De Rosa, C De Rossi, R DeSalvo, O de Varona, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, B Ding, S Di Pace, I Di Palma, F Di Renzo, A Dmitriev, Z Doctor, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, M Dovale Álvarez, T P Downes, M Drago, C Dreissigacker, J C Driggers, Z Du, P Dupej, S E Dwyer, P J Easter, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, M Eisenmann, R A Eisenstein, R C Essick, H Estelles, D Estevez, Z B Etienne, T Etzel, M Evans, T M Evans, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, C Fee, H Fehrmann, J Feicht, M M Fejer, F Feng, A Fernandez-Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, I Fiori, D Fiorucci, M Fishbach, R P Fisher, J M Fishner, M Fitz-Axen, R Flaminio, M Fletcher, H Fong, J A Font, P W F Forsyth, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, P Fritschel, V V Frolov, P Fulda, M Fyffe, H A Gabbard, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, M R Ganija, S G Gaonkar, A Garcia, C García-Quirós, F Garufi, B Gateley, S Gaudio, G Gaur, V Gayathri, G Gemme, E Genin, A Gennai, D George, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, B Giacomazzo, J A Giaime, K D Giardina, A Giazotto, K Gill, G Giordano, L Glover, E Goetz, R Goetz, B Goncharov, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, R Green, E M Gretarsson, P Groot, H Grote, S Grunewald, P Gruning, G M Guidi, H K Gulati, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, O Halim, B R Hall, E D Hall, E Z Hamilton, H F Hamilton, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, O A Hannuksela, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, C-J Haster, K Haughian, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, A W Heptonstall, F J Hernandez, M Heurs, S Hild, T Hinderer, D Hoak, S Hochheim, D Hofman, N A Holland, K Holt, D E Holz, P Hopkins, C Horst, J Hough, E A Houston, E J Howell, A Hreibi, E A Huerta, D Huet, B Hughey, M Hulko, S Husa, S H Huttner, T Huynh-Dinh, A Iess, N Indik, C Ingram, R Inta, G Intini, H N Isa, J-M Isac, M Isi, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, D S Johnson, W W Johnson, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, C V Kalaghatgi, V Kalogera, B Kamai, S Kandhasamy, G Kang, J B Kanner, S J Kapadia, S Karki, K S Karvinen, M Kasprzack, M Katolik, S Katsanevas, E Katsavounidis, W Katzman, S Kaufer, K Kawabe, N V Keerthana, F Kéfélian, D Keitel, A J Kemball, R Kennedy, J S Key, F Y Khalili, B Khamesra, H Khan, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, Chunglee Kim, J C Kim, K Kim, W Kim, W S Kim, Y-M Kim, E J King, P J King, M Kinley-Hanlon, R Kirchhoff, J S Kissel, L Kleybolte, S Klimenko, T D Knowles, P Koch, S M Koehlenbeck, S Koley, V Kondrashov, A Kontos, M Korobko, W Z Korth, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, R Kumar, S Kumar, L Kuo, A Kutynia, S Kwang, B D Lackey, K H Lai, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, M Leonardi, N Leroy, N Letendre, Y Levin, J Li, T G F Li, X Li, S D Linker, T B Littenberg, J Liu, X Liu, R K L Lo, N A Lockerbie, L T London, A Longo, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, G Lovelace, H Lück, D Lumaca, A P Lundgren, R Lynch, Y Ma, R Macas, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, I Magaña Hernandez, F Magaña-Sandoval, L Magaña Zertuche, R M Magee, E Majorana, I Maksimovic, N Man, V Mandic, V Mangano, G L Mansell, M Manske, M Mantovani, F Marchesoni, F Marion, S Márka, Z Márka, C Markakis, A S Markosyan, A Markowitz, E Maros, A Marquina, F Martelli, L Martellini, I W Martin, R M Martin, D V Martynov, K Mason, E Massera, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, A Matas, F Matichard, L Matone, N Mavalvala, N Mazumder, J J McCann, R McCarthy, D E McClelland, S McCormick, L McCuller, S C McGuire, J McIver, D J McManus, T McRae, S T McWilliams, D Meacher, G D Meadors, M Mehmet, J Meidam, E Mejuto-Villa, A Melatos, G Mendell, D Mendoza-Gandara, R A Mercer, L Mereni, E L Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdorff, P M Meyers, H Miao, C Michel, H Middleton, E E Mikhailov, L Milano, A L Miller, A Miller, B B Miller, J Miller, M Millhouse, J Mills, M C Milovich-Goff, O Minazzoli, Y Minenkov, J Ming, C Mishra, S Mitra, V P Mitrofanov, G Mitselmakher, R Mittleman, D Moffa, K Mogushi, M Mohan, S R P Mohapatra, M Montani, C J Moore, D Moraru, G Moreno, S Morisaki, B Mours, C M Mow-Lowry, G Mueller, A W Muir, Arunava Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, E A Muñiz, M Muratore, P G Murray, A Nagar, K Napier, I Nardecchia, L Naticchioni, R K Nayak, J Neilson, G Nelemans, T J N Nelson, M Nery, A Neunzert, L Nevin, J M Newport, K Y Ng, S Ng, P Nguyen, T T Nguyen, D Nichols, A B Nielsen, S Nissanke, A Nitz, F Nocera, D Nolting, C North, L K Nuttall, M Obergaulinger, J Oberling, B D O'Brien, G D O'Dea, G H Ogin, J J Oh, S H Oh, F Ohme, H Ohta, M A Okada, M Oliver, P Oppermann, Richard J Oram, B O'Reilly, R Ormiston, L F Ortega, R O'Shaughnessy, S Ossokine, D J Ottaway, H Overmier, B J Owen, A E Pace, G Pagano, J Page, M A Page, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, Howard Pan, Huang-Wei Pan, B Pang, P T H Pang, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, A Parida, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, M Patil, B Patricelli, B L Pearlstone, C Pedersen, M Pedraza, R Pedurand, L Pekowsky, A Pele, S Penn, C J Perez, A Perreca, L M Perri, H P Pfeiffer, M Phelps, K S Phukon, O J Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pirello, M Pitkin, R Poggiani, P Popolizio, E K Porter, L Possenti, A Post, J Powell, J Prasad, J W W Pratt, G Pratten, V Predoi, T Prestegard, M Principe, S Privitera, G A Prodi, L G Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, V Quetschke, E A Quintero, R Quitzow-James, D S Rabeling, H Radkins, P Raffai, S Raja, C Rajan, B Rajbhandari, M Rakhmanov, K E Ramirez, A Ramos-Buades, Javed Rana, P Rapagnani, V Raymond, M Razzano, J Read, T Regimbau, L Rei, S Reid, D H Reitze, W Ren, F Ricci, P M Ricker, K Riles, M Rizzo, N A Robertson, R Robie, F Robinet, T Robson, A Rocchi, L Rolland, J G Rollins, V J Roma, R Romano, C L Romel, J H Romie, D Rosińska, M P Ross, S Rowan, A Rüdiger, P Ruggi, G Rutins, K Ryan, S Sachdev, T Sadecki, M Sakellariadou, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, L M Sampson, E J Sanchez, L E Sanchez, N Sanchis-Gual, V Sandberg, J R Sanders, N Sarin, B Sassolas, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, M Scheel, J Scheuer, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B W Schulte, B F Schutz, S G Schwalbe, J Scott, S M Scott, E Seidel, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, Y Setyawati, D A Shaddock, T J Shaffer, A A Shah, M S Shahriar, M B Shaner, L Shao, B Shapiro, P Shawhan, H Shen, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, M Sieniawska, D Sigg, A D Silva, L P Singer, A Singh, A Singhal, A M Sintes, B J J Slagmolen, T J Slaven-Blair, B Smith, J R Smith, R J E Smith, S Somala, E J Son, B Sorazu, F Sorrentino, T Souradeep, A P Spencer, A K Srivastava, K Staats, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, B Steltner, S P Stevenson, D Stocks, R Stone, D J Stops, K A Strain, G Stratta, S E Strigin, A Strunk, R Sturani, A L Stuver, T Z Summerscales, L Sun, S Sunil, J Suresh, P J Sutton, B L Swinkels, M J Szczepańczyk, M Tacca, S C Tait, C Talbot, D Talukder, D B Tanner, M Tápai, A Taracchini, J D Tasson, J A Taylor, R Taylor, S V Tewari, T Theeg, F Thies, E G Thomas, M Thomas, P Thomas, K A Thorne, E Thrane, S Tiwari, V Tiwari, K V Tokmakov, K Toland, M Tonelli, Z Tornasi, A Torres-Forné, C I Torrie, D Töyrä, F Travasso, G Traylor, J Trinastic, M C Tringali, L Trozzo, K W Tsang, M Tse, R Tso, D Tsuna, L Tsukada, D Tuyenbayev, K Ueno, D Ugolini, A L Urban, S A Usman, H Vahlbruch, G Vajente, G Valdes, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, J V van Heijningen, A A van Veggel, M Vardaro, V Varma, S Vass, M Vasúth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, G Venugopalan, D Verkindt, F Vetrano, A Viceré, A D Viets, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, S P Vyatchanin, A R Wade, L E Wade, M Wade, R Walet, M Walker, L Wallace, S Walsh, G Wang, H Wang, J Z Wang, W H Wang, Y F Wang, R L Ward, J Warner, M Was, J Watchi, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, F Wellmann, L Wen, E K Wessel, P Weßels, J Westerweck, K Wette, J T Whelan, B F Whiting, C Whittle, D Wilken, D Williams, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Woehler, J K Wofford, W K Wong, J Worden, J L Wright, D S Wu, D M Wysocki, S Xiao, W Yam, H Yamamoto, C C Yancey, L Yang, M J Yap, M Yazback, Hang Yu, Haocun Yu, M Yvert, A Zadrożny, M Zanolin, T Zelenova, J-P Zendri, M Zevin, J Zhang, L Zhang, M Zhang, T Zhang, Y-H Zhang, C Zhao, M Zhou, Z Zhou, S J Zhu, X J Zhu, A B Zimmerman, M E Zucker, J Zweizig, N N Weinberg
We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers energy from the orbit of the binary to internal modes of the stars, accelerating the gravitational-wave driven inspiral. We model the impact of this instability on the phasing of the gravitational wave signal using three parameters per star: an overall amplitude, a saturation frequency, and a spectral index. Incorporating these additional parameters, we compute the Bayes factor (lnB_{!pg}^{pg}) comparing our p-g model to a standard one...
February 15, 2019: Physical Review Letters
https://read.qxmd.com/read/30814732/nr4a-transcription-factors-limit-car-t-cell-function-in-solid-tumours
#13
Joyce Chen, Isaac F López-Moyado, Hyungseok Seo, Chan-Wang J Lio, Laura J Hempleman, Takashi Sekiya, Akihiko Yoshimura, James P Scott-Browne, Anjana Rao
T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies1,2 . CAR T cells have been less effective against solid tumours3-5 , in part because they enter a hyporesponsive ('exhausted' or 'dysfunctional') state6-9 triggered by chronic antigen stimulation and characterized by upregulation of inhibitory receptors and loss of effector function. To investigate the function of CAR T cells in solid tumours, we transferred hCD19-reactive CAR T cells into hCD19+ tumour-bearing mice...
February 27, 2019: Nature
https://read.qxmd.com/read/30814006/not-just-fundamental-research-education-equal-opportunities-knowledge-and-technology-transfer-and-communication-at-the-nccr-bio-inspired-materials
#14
Scott Capper, Eliav Haskal, Andreas Kilbinger, Lucas Montero de Espinosa, Barbara Rothen-Rutishauser, Curzio Rüegg, Christoph Weder
<i/> Besides conducting excellent fundamental research in domains of strategic importance, the National Centers of Competence in Research (NCCRs) also aim to become centers of reference for education, equal opportunities, and knowledge and technology transfer. These activities are supported by a communication strategy focused on specific target groups. This article describes some of the main strategic goals and achievements of the NCCR Bio-Inspired Materials, presents the main activities launched by the Center throughout its first funding phase, and provides a glimpse of new plans and directions for the second phase...
February 27, 2019: Chimia
https://read.qxmd.com/read/30810306/structural-and-functional-characterization-of-sulfonium-carbon-oxygen-hydrogen-bonding-in-the-deoxyamino-sugar-methyltransferase-tylm1
#15
Robert James Fick, Scott Horowitz, Brandon George McDole, Mary C Clay, Ryan A Mehl, Hashim M Al-Hashimi, Steve Scheiner, Raymond C Trievel
The N-methyltransferase TylM1 from Streptomyces fradiae catalyzes the final step in the biosynthesis of the deoxyamino sugar mycaminose, a substituent of the antibiotic tylosin. The high-resolution crystal structure of TylM1 bound to the methyl donor S-adenosylmethionine (AdoMet) illustrates a network of carbon-oxygen (CH•••O) hydrogen bonds between the substrate's sulfonium cation and residues within the active site. These interactions include hydrogen bonds between the methyl and methylene groups of the AdoMet sulfonium cation and the hydroxyl groups of Tyr14 and Ser120 in the enzyme...
February 27, 2019: Biochemistry
https://read.qxmd.com/read/30809855/regulation-of-articular-chondrocyte-catabolic-genes-by-growth-factor-interaction
#16
Shuiliang Shi, Scott Mercer, George J Eckert, Stephen B Trippel
Osteoarthritis is characterized by a loss of articular cartilage homeostasis in which degradation exceeds formation. Several growth factors have been shown to promote cartilage formation by augmenting articular chondrocyte anabolic activity. This study tests the hypothesis that such growth factors also play an anticatabolic role. We transferred individual or combinations of the genes encoding insulin-like growth factor-I, bone morphogenetic protein-2, bone morphogenetic protein-7, transforming growth factor-β1, and fibroblast growth factor-2, into adult bovine articular chondrocytes and measured the expression of catabolic marker genes encoding A disintegrin and metalloproteinase with thrombospondin motifs-4 and -5, matrix metalloproteinases-3 and -13, and interleukin-6...
February 27, 2019: Journal of Cellular Biochemistry
https://read.qxmd.com/read/30809636/evaluating-movement-of-patients-with-carbapenem-resistant-enterobacteriaceae-infections-in-the-greater-atlanta-metropolitan-area-using-social-network-analysis
#17
Chris W Bower, Daniel W Fridkin, Hannah M Wolford, Rachel B Slayton, Julianne N Kubes, Jesse T Jacob, Susan M Ray, Scott K Fridkin
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent threat with potential for rapid spread. We evaluated the role of Medicare patient movement between facilities to model the spread of CRE within a region. METHODS: Through population-based CRE surveillance in the 8-county Atlanta Metropolitan area (population 4.1 million), all Escherichiacoli, Enterobacter spp, or Klebsiella spp. resistant to ≥1 carbapenem collected from urine or a normally sterile site were reported from residents...
February 27, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://read.qxmd.com/read/30796216/stat1-signaling-shields-t-cells-from-nk-cell-mediated-cytotoxicity
#18
Yu Hui Kang, Amlan Biswas, Michael Field, Scott B Snapper
The JAK-STAT pathway critically regulates T-cell differentiation, and STAT1 is postulated to regulate several immune-mediated diseases by inducing proinflammatory subsets. Here we show that STAT1 enables CD4+ T-cell-mediated intestinal inflammation by protecting them from natural killer (NK) cell-mediated elimination. Stat1-/- T cells fail to expand and establish colitis in lymphopenic mice. This defect is not fully recapitulated by the combinatorial loss of type I and II IFN signaling. Mechanistically, Stat1-/- T cells have reduced expression of Nlrc5 and multiple MHC class I molecules that serve to protect cells from NK cell-mediated killing...
February 22, 2019: Nature Communications
https://read.qxmd.com/read/30786884/transition-to-active-learning-in-rural-nepal-an-adaptable-and-scalable-curriculum-development-model
#19
Stephen Mehanni, Lena Wong, Bibhav Acharya, Pawan Agrawal, Anu Aryal, Madhur Basnet, David Citrin, Binod Dangal, Grace Deukmedjian, Santosh Kumar Dhungana, Bikash Gauchan, Tula Krishna Gupta, Scott Halliday, S P Kalaunee, Uday Kshatriya, Anirudh Kumar, Duncan Maru, Sheela Maru, Viet Nguyen, Jhalak Sharma Paudel, Pragya Rimal, Marwa Saleh, Ryan Schwarz, Sikhar Bahadur Swar, Aradhana Thapa, Aparna Tiwari, Rebecca White, Wan-Ju Wu, Dan Schwarz
BACKGROUND: Traditional medical education in much of the world has historically relied on passive learning. Although active learning has been in the medical education literature for decades, its incorporation into practice has been inconsistent. We describe and analyze the implementation of a multidisciplinary continuing medical education curriculum in a rural Nepali district hospital, for which a core objective was an organizational shift towards active learning. METHODS: The intervention occurred in a district hospital in remote Nepal, staffed primarily by mid-level providers...
February 20, 2019: BMC Medical Education
https://read.qxmd.com/read/30763770/microrna-375-suppresses-the-growth-and-invasion-of-fibrolamellar-carcinoma
#20
Timothy A Dinh, Mark L Jewell, Matt Kanke, Adam Francisco, Ramja Sritharan, Rigney E Turnham, Seona Lee, Edward R Kastenhuber, Eliane Wauthier, Cynthia D Guy, Raymond S Yeung, Scott W Lowe, Lola M Reid, John D Scott, Anna M Diehl, Praveen Sethupathy
BACKGROUND & AIMS: Fibrolamellar carcinoma (FLC) is a rare liver cancer that primarily affects adolescents and young adults. It is characterized by a heterozygous approximately 400-kb deletion on chromosome 19 that results in a unique DNAJB1-PRKACA fusion. The role of microRNAs (miRNAs) in FLC remains unclear. We identified dysregulated miRNAs in FLC and investigated whether dysregulation of 1 key miRNA contributes to FLC pathogenesis. METHODS: We analyzed small RNA sequencing (smRNA-seq) data from The Cancer Genome Atlas to identify dysregulated miRNAs in primary FLC tumors and validated the findings in 3 independent FLC cohorts...
February 11, 2019: Cellular and Molecular Gastroenterology and Hepatology
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