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Tromso study

Knut Hagen, Laila A Hopstock, Anne Elise Eggen, Ellisiv B Mathiesen, Kristian Bernhard Nilsen
BACKGROUND: The relationship between high sensitivity C-reactive protein and migraine is unclear. The aim of this cross-sectional population-based study was to investigate the association between high sensitivity C-reactive protein and types of headache, and to evaluate the impact of insomnia on this association. METHODS: A total of 20,486 (63%) out of 32,591 invited, aged ≥40 years or older, participated in the seventh wave of the Tromsø study conducted in 2015-2016 and had valid information on headache, insomnia and high sensitivity C-reactive protein...
March 12, 2019: Cephalalgia: An International Journal of Headache
Chanakya Sharma, Warren Raymond, Gro Eilertsen, Johannes Nossent
OBJECTIVES: To assess the impact of achieving Lupus Low Disease Activity State (LLDAS-50) on damage accrual and mortality in an inception cohort of patients with Systemic Lupus Erythematosus (SLE). METHODS: We used data from the Tromsø Lupus Cohort, a longitudinal population-based study of all SLE patients in the 2 northern-most counties in Norway. LLDAS was defined as a) SLEDAI-2K ≤4, with no activity in major organ systems b) no new features of lupus disease activity c) current prednisolone (or equivalent) dose ≤7...
March 1, 2019: Arthritis Care & Research
H Kileng, T Gutteberg, R Goll, E J Paulssen
BACKGROUND: Chronic hepatitis C virus (HCV) infection can progress to cirrhosis and end-stage liver disease in a substantial proportion of patients. The infection is frequently asymptomatic, leaving many infected individuals unaware of the diagnosis until complications occur. This advocates the screening of healthy individuals. The aim of this study was to estimate the prevalence of HCV infection in the general adult population of the municipality of Tromsø, Norway, and to evaluate the efficiency of such an approach in a presumed low-prevalence area...
February 26, 2019: BMC Infectious Diseases
Ludvig B Rinde, Vania M Morelli, Birgit Småbrekke, Ellisiv B Mathiesen, Maja-Lisa Løchen, Inger Njølstad, Tom Wilsgaard, Erin Smith, Frits R Rosendaal, Kelly A Frazer, Sigrid K Braekkan, John-Bjarne Hansen
BACKGROUND: Patients with ischemic stroke have a transient increased risk of subsequent venous thromboembolism (VTE). Prothrombotic genotypes may augment VTE risk under conditions of high thrombosis risk related to stroke. AIMS: To investigate the effect of prothrombotic genotypes in patients with ischemic stroke on the risk of VTE in a population-based case-cohort study. METHODS: Cases with incident VTE (n=664) and a randomly selected age-weighted sub-cohort (n=1817) were sampled from three surveys of the Tromsø Study (1994-2008)...
February 18, 2019: Journal of Thrombosis and Haemostasis: JTH
Amalie Nilsen, Tove A Hanssen, Knut T Lappegård, Anne E Eggen, Maja-Lisa Løchen, Inger Njølstad, Tom Wilsgaard, Laila Hopstock
BACKGROUND: Primary prevention guidelines promote the use of risk assessment tools to estimate total cardiovascular risk. We aimed to study trends in cardiovascular risk and contribution of single risk factors, using the newly developed NORRISK 2 risk score, which estimates 10-year risk of fatal and non-fatal cardiovascular events. DESIGN: Prospective population-based study. METHODS: We included women and men aged 45-74 years attending the sixth and seventh survey of the Tromsø Study (Tromsø 6, 2007-2008, n = 7284 and Tromsø 7, 2015-2016, n = 14,858) to study secular trends in NORRISK 2 score...
February 12, 2019: European Journal of Preventive Cardiology
Inger P Landsem, Bjørn H Handegård, Per I Kaaresen, Jorunn Tunby, Stein E Ulvund, John A Rønning
The Tromsø Intervention Study on Preterms (TISP) randomized 146 preterm-born children either to the Mother-Infant Transaction Program (MITP) or to a preterm control group. Previously, significant reductions of child behavior problems and maternal stress have been reported in the intervention group. This follow-up study examines whether the MITP may have affected the longitudinal adaptation between mothers and their children from two until nine years, expressed as associations between different behavioral problems and parenting stress reported by mothers...
January 31, 2019: Children
Michael Stylidis, Ekaterina Sharashova, Tom Wilsgaard, David A Leon, Geir Heggelund, Assami Rösner, Inger Njølstad, Maja-Lisa Løchen, Henrik Schirmer
AIMS: To examine the associations between diastolic dysfunction indices and long-term risk of all-cause mortality in adults over 23-year follow-up. METHODS AND RESULTS: Participants (n = 2734) of the population-based Tromsø Study of Norway had echocardiography in 1994-1995. Of these 67% were repeated in 2001 and/or 2007-2008. Mortality between 1994 and 2016 was determined by linkage to the national death registry. Cox regression was used to model the hazard of all-cause mortality in relation to left atrial parameters (treated as time-dependent using repeated measurements) adjusted for traditional risk factors and cardiovascular disease...
January 28, 2019: Echocardiography
Guri Skeie, Vårin Sandvær, Guri Grimnes
High intake of sugar-sweetened beverages (SSB) has been associated with weight gain and chronic disease. The objective of this paper was to study the intake of SSB and characteristics associated with SSB intake in adolescents from Troms, Norway. We present results from a cross-sectional analysis from the Tromsø Study: Fit Futures , with 426 female and 444 male students aged 15⁻17 years (93% participation rate). Descriptive statistics and logistic regression analyses were performed. Among females, 31.8% drank at least one glass of SSB per day on average, compared to 61...
January 22, 2019: Nutrients
Trond Isaksen, Line H Evensen, Stein Harald Johnsen, Bjarne K Jacobsen, Kristian Hindberg, Sigrid K Brækkan, John-Bjarne Hansen
Background: Studies on the association between long-chained n-3 polyunsaturated fatty acids (n-3 PUFAs) and risk of venous thromboembolism (VTE) are conflicting, potentially due to challenges related to assessment of n-3 PUFA intake and changes in diet during follow-up. Objectives: To investigate whether dietary intake of marine n-3 PUFAs was associated with risk of incident VTE in a population-based cohort with repeated assessments of n-3 PUFA intake. Methods: We recruited 21 970 participants (after excluding 7570 with incomplete data) from the fourth (1994-1995) and sixth (2007-2008) surveys of the Tromsø Study, and recorded incident VTEs up to 2016...
January 2019: Research and Practice in Thrombosis and Haemostasis
Oddgeir Friborg, Nina Emaus, Jan H Rosenvinge, Unni Bilden, Jan Abel Olsen, Gunn Pettersen
[This corrects the article DOI: 10.1371/journal.pone.0136588.].
2019: PloS One
Elin Evensen, Nina Emaus, Anne-Sofie Furberg, Ane Kokkvoll, Jonathan Wells, Tom Wilsgaard, Anne Winther, Guri Skeie
BACKGROUND: Fat and fat-free masses and fat distribution are related to cardiometabolic risk. OBJECTIVES: to explore how birth weight, childhood body mass index (BMI) and BMI gain were related to adolescent body composition and central obesity. METHODS: In a population-based longitudinal study, body composition was measured by dual-energy X-ray absorptiometry in 907 Norwegian adolescents (48% girls). Associations between birth weight, BMI categories, and BMI gain were evaluated by fitting linear mixed models and conditional growth models with fat mass index (FMI, kg/m2 ), fat-free mass index (FFMI, kg/m2 ) standard deviation scores (SDS), and central obesity at 15 to 20 years, as well as change in FMI SDS and FFMI SDS between ages 15 to 17 and 18 to 20 as outcomes...
December 27, 2018: Pediatric Obesity
Rolf Jorde, Guri Grimnes
BACKGROUND: Low serum 25-hydroxyvitamin D (25(OH)D) levels have consistently been associated with hypertension. During the last decades there has been an unexplained reduction in blood pressure (BP) in Western countries. We therefore examined the relation between serum 25(OH)D and BP in the 7th survey of the Tromsø study 2015/2016. METHODS: Blood pressure and serum 25(OH)D were measured and life-style factors registered in 15,951 subjects not using BP medication...
December 26, 2018: Blood Pressure
Terry Solomon, John D Lapek, Søren Beck Jensen, William W Greenwald, Kristian Hindberg, Hiroko Matsui, Nadezhda Latysheva, Sigrid K Braekken, David J Gonzalez, Kelly A Frazer, Erin N Smith, John-Bjarne Hansen
BACKGROUND: Identifying genetic variation associated with plasma protein levels, and the mechanisms by which they act, could provide insight into alterable processes involved in regulation of protein levels. Although protein levels can be affected by genetic variants, their estimation can also be biased by missense variants in coding exons causing technical artifacts. Integrating genome sequence genotype data with mass spectrometry-based protein level estimation could reduce bias, thereby improving detection of variation that affects RNA or protein metabolism...
December 2018: Circulation. Genomic and Precision Medicine
Xīn Gào, Tom Wilsgaard, Eugène Hjm Jansen, Bernd Holleczek, Yan Zhang, Yang Xuan, Ankita Anusruti, Hermann Brenner, Ben Schöttker
Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured d-ROM in a cohort sample of n = 4,345 participants of the German ESTHER study and in a case-cohort sample of the Norwegian Tromsø study (cancer cases: n = 941; sub-cohort: n = 1,000). Moreover, d-ROM was repeatedly measured at follow-ups of both studies...
December 18, 2018: International Journal of Cancer. Journal International du Cancer
Lena Henriksen, Anette Borgen, Jeanette Risløkken, Mirjam Lukasse
BACKGROUND: There is increasing evidence that fear of birth can have long-term effects on the childbearing woman and the method of birth. AIM: To examine differences between five hospitals in Norway in the occurrence of fear of birth, counselling received and method of birth. METHOD: Source data was from the Norwegian cohort of the Bidens study and retrieved through a questionnaire and electronic patient records from five different hospitals in Oslo, Drammen, Tromsø, Ålesund and Trondheim, which included 2145 women...
December 3, 2018: Women and Birth: Journal of the Australian College of Midwives
I D Jacobsen, C-G Crossner, H M Eriksen, I Espelid, C Ullbro
AIM: To assess the prevalence of proximal enamel lesions, the need for non-operative caries treatment and the quality of dental restorations in 869 students aged 16 years from Northern Norway. METHODS: All first year upper secondary school students in Tromsø and Balsfjord municipalities were invited to participate in an oral- and general health project (Fit Futures). The attendance rate was 90%, and all subjects born in 1994 (449 males and 420 females) were included in the present study...
December 4, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Anne K Gulsvik, Marius Myrstad, Ida Wilson Landgraff, Nina Emaus, Anette Hylen Ranhoff
Background: Physical activity (PA) is generally beneficial for bone health, but the effect of high levels of PA over many years, in older women, is unknown. Methods: T-score from Dual-energy X-ray absorptiometry (DXA), and self-reported baseline characteristics were recorded for 24 female, cross-country-skiing-competitors, aged 68-76 years, from the Birkebeiner Ageing Study. Data from 647 women in the same age range from the Tromso-6 population study, with recorded DXA findings, were used for comparison...
2018: European Review of Aging and Physical Activity
Nils Abel Aars, Bjarne K Jacobsen, Anne-Sofie Furberg, Sameline Grimsgaard
AIM: We studied the cross-sectional association between self-reported physical activity and body composition in adolescents. METHODS: The Norwegian Fit Futures Cohort Study was conducted in the Tromsø and Balsfjord municipalities during 2010-2011. All 1,117 students in their first year of upper secondary high school were invited to attend an examination at the Clinical Research Unit at the University Hospital of Northern Norway and 93% agreed. After exclusions, we analysed 945 participants (51% boys) with a mean age of 16...
November 25, 2018: Acta Paediatrica
Maria Averina, Jan Brox, Sandra Huber, Anne-Sofie Furberg, Martin Sørensen
BACKGROUND: Exposure to environmental pollutants may contribute to the development of asthma and other allergies. The aim of this study was to investigate possible associations between asthma and other allergies with exposure to perfluoroalkyl substances (PFASs) in adolescents from the Arctic region of Norway. METHODS: The Tromsø study Fit Futures 1 (TFF1) and 3-year follow-up Fit Futures 2 study (TFF2) included 675 adolescents that completed a questionnaire about health conditions and underwent a clinical examination with blood tests and fractional nitric oxide (FeNO) measurement...
November 5, 2018: Environmental Research
Albert K Imsland, Thor Arne Hangstad, Thor Magne Jonassen, Sigurd O Stefansson, Tom Ole Nilsen, Peter Hovgaard, Tor Anders Elvegård, Ken Ståle Lindberg, Bjørn Mikalsen, Tonje Cecilie Urskog, Birgitta Norberg, Eva Andersson, Frank Spetland, Patrick Reynolds
In order to provide year round spawning broodstock, lumpfish (initial size 746 g and 24.9 cm) were reared under four different photoperiod regimes from January 2017 to July 2018. One group was reared under simulated natural photoperiod (LDN, control group) for Tromsø (70°N). The second group was transferred to continuous light (LD240) on 30 January 2017 and reared at LD24:0 throughout the trial period. Two compressed and phase advanced photoperiods were also established. Both groups were moved from LDN to LD24:0 on 30 January 2017, and after that reared at compressed natural photoperiods where the annual photoperiod was compressed down to six months (L6) or nine months (L9) for the duration of the study...
November 12, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
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