keyword
Keywords high mobility group box-1 prot...

high mobility group box-1 protein 1

https://read.qxmd.com/read/38456997/neutrophil-extracellular-traps-mediate-cardiomyocyte-ferroptosis-via-the-hippo-yap-pathway-to-exacerbate-doxorubicin-induced-cardiotoxicity
#21
JOURNAL ARTICLE
Peng Zhao, You Li, Xiangli Xu, Haobo Yang, Xintong Li, Shuai Fu, Zihong Guo, Jianing Zhang, Hairu Li, Jiawei Tian
Doxorubicin-induced cardiotoxicity (DIC), which is a cardiovascular complication, has become the foremost determinant of decreased quality of life and mortality among survivors of malignant tumors, in addition to recurrence and metastasis. The limited ability to accurately predict the occurrence and severity of doxorubicin-induced injury has greatly hindered the prevention of DIC, but reducing the dose to mitigate side effects may compromise the effective treatment of primary malignancies. This has posed a longstanding clinical challenge for oncologists and cardiologists...
March 8, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38449454/non-invasive-radiofrequency-hyperthermia-attenuates-hmgb1-tlr4-nf-%C3%AE%C2%BAb-inflammatory-axis-in-a-chronic-prostatitis-chronic-pelvic-pain-syndrome-rat-model
#22
JOURNAL ARTICLE
Soomin Kim, Jun Jie Piao, Seokhwan Bang, Hyong Woo Moon, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Hae Hoon Kim, Ha Nul Kim, Kyung-Hwa Jeon, Mahadevan Raj Rajasekaran, Sae Woong Kim, Woong Jin Bae
PURPOSE: The primary goal of this study is to evaluate the effect of the non-invasive radiofrequency hyperthermia (RFHT) device on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) rat model and investigate the underlying mechanism. MATERIALS AND METHODS: In this study, Sprague-Dawley rats were randomly distributed into three groups: (1) normal control group, (2) CP/CPPS group, and (3) RFHT group. CP/CPPS rat models were induced by 17β-estradiol and dihydrotestosterone for 4 weeks and RFHT was administered for 5 weeks after model establishment...
February 19, 2024: World Journal of Men's Health
https://read.qxmd.com/read/38448779/lupus-autoantibodies-initiate-neuroinflammation-sustained-by-continuous-hmgb1-rage-signaling-and-reversed-by-increased-lair-1-expression
#23
JOURNAL ARTICLE
Kaitlin R Carroll, Mark Mizrachi, Sean Simmons, Bahtiyar Toz, Czeslawa Kowal, Jeffrey Wingard, Nazila Tehrani, Aida Zarfeshani, Nina Kello, Lara El Khoury, Rachel Weissman-Tsukamoto, Joshua Z Levin, Bruce T Volpe, Betty Diamond
Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus erythematosus, present in up to 80% of patients and leading to a diminished quality of life. In the present study, we used a model of lupus-like cognitive impairment that is initiated when antibodies that crossreact with excitatory neuronal receptors penetrate the hippocampus, causing immediate, self-limited, excitotoxic death of hippocampal neurons, which is then followed by a significant loss of dendritic complexity in surviving neurons...
March 6, 2024: Nature Immunology
https://read.qxmd.com/read/38439048/microfluidics-enabled-fluorinated-assembly-of-egcg-ligands-sitox-nanoparticles-for-synergetic-tumor-cells-and-exhausted-t-cells-regulation-in-cancer-immunotherapy
#24
JOURNAL ARTICLE
Xiaowei Han, Guozheng Zhang, Xiaozhen Wu, Shufeng Xu, Jiahuan Liu, Kaikai Wang, Tianqing Liu, Pengkai Wu
Immune checkpoint inhibitor (ICI)-derived evolution offers a versatile means of developing novel immunotherapies that targets programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) axis. However, one major challenge is T cell exhaustion, which contributes to low response rates in "cold" tumors. Herein, we introduce a fluorinated assembly system of LFNPs/siTOX complexes consisting of fluorinated EGCG (FEGCG), fluorinated aminolauric acid (LA), and fluorinated polyethylene glycol (PEG) to efficiently deliver small interfering RNA anti-TOX (thymus high mobility group box protein, TOX) for synergistic tumor cells and exhausted T cells regulation...
March 4, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38414294/hmgb1-regulates-th17-cell-differentiation-and-function-in-patients-with-psoriasis
#25
JOURNAL ARTICLE
Xiaofeng Zhu, Yue Dou, Yawen Lin, Gaoping Chu, Jing Wang, Lei Ma
BACKGROUND: Psoriasis is an immune-mediated chronic inflammatory skin disease, in which T helper 17 (Th17) cells and its effective cytokine interleukin (IL)-17A play a pivotal pathogenic role. High mobility group box 1 (HMGB1) is an important proinflammatory cytokine, which has been confirmed to be highly expressed in the peripheral circulation and epidermis tissues of psoriasis patients. The regulatory effect of HMGB1 on IL-17A expression and function has been reported in some inflammatory and autoimmune diseases by the HMGB1-Toll-like receptor 4 (TLR4)-interleukin (IL)-23-IL-17A pathway...
February 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38407083/investigation-of-correlation-between-resistance-to-diazepam-and-expression-of-inflammatory-markers-in-the-peripheral-blood-of-patients-with-status-epilepticus
#26
JOURNAL ARTICLE
Corry Novita Mahama, Melva Louisa, Fitri Octaviana, Dwi Anita Suryandari, Astri Budikayanti, Heri Wibowo
OBJECTIVE: This study investigated several inflammatory markers' gene and protein expression in status epilepticus (SE) and their correlation with diazepam resistance. MATERIALS AND METHODS: Peripheral blood samples were collected from 18 adult patients with SE in Cipto Mangunkusumo Central Hospital, consisting of 12 diazepam-responsive and six diazepam-resistant samples, within 72 hours of the onset of the seizure. We collected baseline demographic and clinical data from each subject...
December 2023: Acta Medica Academica
https://read.qxmd.com/read/38403005/guhan-yangsheng-jing-mitigates-hippocampal-neuronal-pyroptotic-injury-and-magnifies-learning-and-memory-capabilities-in-sleep-deprived-mice-via-the-nlrp3-caspase1-gsdmd-signaling-pathway
#27
JOURNAL ARTICLE
Xinying Fu, Siyang Yan, Zongren Hu, Wen Sheng, Wanyu Li, Shida Kuang, Xue Feng, Lumei Liu, Wei Zhang, Qinghu He
ETHNOPHARMACOLOGICAL RELEVANCE: Guhan Yangsheng Jing (GHYSJ) is a traditional Chinese patent medicine, that has the function of nourishing the kidney and replenishing the essence, invigorating the brain and calming the mind. It is often used to treat dizziness, memory loss, sleep disorders, fatigue, and weakness, etc. However, its mechanism for improving sleep has not yet been determined. AIM OF THE STUDY: This study aims to explore the effects of GHYSJ on Sleep Deprivation (SD)-induced hippocampal neuronal pyroptotic injury, learning and cognitive abilities, and sleep quality in mice...
February 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38402931/demotion-of-canonical-non-canonical-inflammasome-and-pyroptosis-alleviates-ischemia-reperfusion-induced-acute-kidney-injury-novel-role-of-the-d2-d3-receptor-agonist-ropinirole
#28
JOURNAL ARTICLE
Nada T Henedak, Hanan S El-Abhar, Dalaal M Abdallah, Kawkab A Ahmed, Ayman A Soubh
Ropinirole used to treat Parkinson's disease highly targets the dopaminergic receptor D3 over the D2 receptor but although both are expressed in the kidneys the ropinirole potential to treat kidney injury provoked by ischemia/reperfusion (I/R) is undraped. We investigated whether ropinirole can alleviate renal I/R by studying its anti-inflammatory, antioxidant, and anti-pyroptotic effects targeting its aptitude to inhibit the High-mobility group box 1/Toll-like receptor 4/Nuclear factor-kappa B (HMGB1/TLR4/NF-κB) cue and the canonical/non-canonical NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome trajectories...
February 23, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38387685/functional-identification-of-two-hmgb1-paralogues-provides-insights-into-autophagic-machinery-in-teleost
#29
JOURNAL ARTICLE
Dan Wang, Xiaoyu Ma, Hengyi Hu, Jingqi Ren, Jiaxi Liu, Hong Zhou
High mobility group box 1 (HMGB1) is a multifunctional regulator that plays different roles in various physiological and pathological processes including cell development, autophagy, inflammation, tumor metastasis, and cell death based on its cellular localization. Unlike mammalian HMGB1, two HMGB1 paralogues (HMGB1a and HMGB1b) have been found in fathead minnow and other fish species and its function as an inflammatory cytokine has been well investigated. However, the role of fish HMGB1 in autophagy regulation has not been well clarified...
February 20, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38384464/spinal-hmgb1-participates-in-the-early-stages-of-paclitaxel-induced-neuropathic-pain-via-microglial-tlr4-and-rage-activation
#30
JOURNAL ARTICLE
Thamyris Reis Moraes, Flavio Protasio Veras, Angel Roberto Barchuk, Ester Siqueira Caixeta Nogueira, Alexandre Kanashiro, Giovane Galdino
INTRODUCTION: Chemotherapy-induced neuropathic pain (CINP) is one of the main adverse effects of chemotherapy treatment. At the spinal level, CINP modulation involves glial cells that upregulate Toll-like receptor 4 (TLR4) and signaling pathways, which can be activated by pro-inflammatory mediators as the high mobility group box-1 (HMGB1). OBJECTIVE: To evaluate the spinal role of HMGB1 in the paclitaxel-induced neuropathic pain via receptor for advanced glycation end products (RAGE) and TLR4 activation expressed in glial cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38371266/n-acetylserotonin-alleviates-retinal-ischemia-reperfusion-injury-via-hmgb1-rage-nf-%C3%AE%C2%BAb-pathway-in-rats
#31
JOURNAL ARTICLE
Yu-Ze Zhao, Xue-Ning Zhang, Yi Yin, Pei-Lun Xiao, Meng Gao, Lu-Ming Zhang, Shuan-Hu Zhou, Shu-Na Yu, Xiao-Li Wang, Yan-Song Zhao
AIM: To observe the effects of N-acetylserotonin (NAS) administration on retinal ischemia-reperfusion (RIR) injury in rats and explore the underlying mechanisms involving the high mobility group box 1 (HMGB1)/receptor for advanced glycation end-products (RAGE)/nuclear factor-kappa B (NF-κB) signaling pathway. METHODS: A rat model of RIR was developed by increasing the pressure of the anterior chamber of the eye. Eighty male Sprague Dawley were randomly divided into five groups: sham group ( n =8), RIR group ( n =28), RIR+NAS group ( n =28), RIR+FPS-ZM1 group ( n =8) and RIR+NAS+ FPS-ZM1 group ( n =8)...
2024: International Journal of Ophthalmology
https://read.qxmd.com/read/38369216/imp7-sirna-nanoparticles-protect-against-mechanical-ventilation-associated-liver-injury-by-inhibiting-hmgb1-production-and-nets-formation
#32
JOURNAL ARTICLE
Ning Ding, Hui Xiao, Lixiao Zhen, Huiqing Li, Zengzhen Zhang, Junke Ge
Mechanical ventilation (MV) has the potential to induce extra-pulmonary organ damage by adversely affecting the lungs and promoting the secretion of inflammatory cytokines. High-mobility group box 1 protein (HMGB1) is a pro-inflammatory mediator in ventilator-induced lung injury (VILI), but its effect on MV-associated liver injury and the mechanisms are poorly understood. In the present study, mice were subjected to high-volume MV (20 ml/kg) to induce VILI. MV-induced HMGB1 prompted neutrophil extracellular traps (NETs) formation and PANoptosis within the liver...
February 16, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38367818/high-mobility-group-box-1-a-therapeutic-target-for-analgesia-and-associated-symptoms-in-chronic-pain
#33
REVIEW
Norimitsu Morioka, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakata
The number of patients with chronic pain continues to increase against the background of an ageing society and a high incidence of various epidemics and disasters. One factor contributing to this situation is the absence of truly effective analgesics. Chronic pain is a persistent stress for the organism and can trigger a variety of neuropsychiatric symptoms. Hence, the search for useful analgesic targets is currently being intensified worldwide, and it is anticipated that the key to success may be molecules involved in emotional as well as sensory systems...
February 15, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38361784/hmga2-promotes-cancer-metastasis-by-regulating-epithelial-mesenchymal-transition
#34
REVIEW
Qing Ma, Sisi Ye, Hong Liu, Yu Zhao, Yan Mao, Wei Zhang
Epithelial-mesenchymal transition (EMT) is a complex physiological process that transforms polarized epithelial cells into moving mesenchymal cells. Dysfunction of EMT promotes the invasion and metastasis of cancer. The architectural transcription factor high mobility group AT-hook 2 (HMGA2) is highly overexpressed in various types of cancer (e.g., colorectal cancer, liver cancer, breast cancer, uterine leiomyomas) and significantly correlated with poor survival rates. Evidence indicated that HMGA2 overexpression markedly decreased the expression of epithelial marker E-cadherin (CDH1) and increased that of vimentin (VIM), Snail, N-cadherin (CDH2), and zinc finger E-box binding homeobox 1 (ZEB1) by targeting the transforming growth factor beta/SMAD (TGFβ/SMAD), mitogen-activated protein kinase (MAPK), and WNT/beta-catenin (WNT/β-catenin) signaling pathways...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38350817/role-of-diesel-exhaust-particle-induced-cellular-senescence-in-the-development-of-asthma-in-young-and-old-mice
#35
JOURNAL ARTICLE
Hyun Seung Lee, Heung-Woo Park
BACKGROUND: Although it has been reported that cellular senescence is important in the pathogenesis of asthma, the differential effects of diesel exhaust particle (DEP)-induced cellular senescence on the development of asthma according to age have not been thoroughly studied. METHODS: We first confirmed that DEP induced cellular senescence in mouse lungs, and then that DEP-induced cellular senescence followed by intranasal instillation of a low-dose house dust mite (HDM) allergen resulted in murine asthma...
February 12, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/38348572/preclinical-efficacy-of-carfilzomib-in-braf-mutant-colorectal-cancer-models
#36
JOURNAL ARTICLE
Federica Maione, Daniele Oddo, Federica Galvagno, Chiara Falcomatà, Marta Pandini, Marco Macagno, Valeria Pessei, Ludovic Barault, Chiara Gigliotti, Alessia Mira, Giorgio Corti, Simona Lamba, Chiara Riganti, Barbara Castella, Massimo Massaia, Roland Rad, Dieter Saur, Alberto Bardelli, Federica Di Nicolantonio
Serine/threonine-protein kinase B-raf (BRAF) mutations are found in 8-15% of colorectal cancer patients and identify a subset of tumors with poor outcome in the metastatic setting. We have previously reported that BRAF-mutant human cells display a high rate of protein production, causing proteotoxic stress, and are selectively sensitive to the proteasome inhibitors bortezomib and carfilzomib. In this work, we tested whether carfilzomib could restrain the growth of BRAF-mutant colorectal tumors not only by targeting cancer cells directly, but also by promoting an immune-mediated antitumor response...
February 13, 2024: Molecular Oncology
https://read.qxmd.com/read/38346523/free-total-rhubarb-anthraquinones-protect-intestinal-mucosal-barrier-of-sap-rats-via-inhibiting-the-nlrp3-caspase-1-gsdmd-pyroptotic-pathway
#37
JOURNAL ARTICLE
Yue Zeng, Xingyu Liu, Qing Yi, Gan Qiao, Lulu Wang, Li Chen, Ling Fan, Yao Li, Lingjing Duan, Liqiang Huang, Qian Zhuang, Yejiang Zhou, Yuxia Xiong
ETHNOPHARMACOLOGICAL RELEVANCE: Rhubarb is the peeled and dried roots of Rheum palmatum L. and Rheum tanguticum Maxim. ex Balf. or Rheum officinale Baill. Free total rhubarb anthraquinones (FTRAs) were isolated and extracted from rhubarb. Previous studies have revealed that the early administration of FTRAs protects the intestinal mucosal barrier in rats with severe acute pancreatitis (SAP), the mechanism of which is not yet clear. However, we observed an enhanced expression of intestinal pyroptotic factors in rats treated with SAP, which may be related to the mechanism of intestinal barrier protection by FTRAs...
February 10, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38336101/sterile-inflammation-induces-vasculopathy-and-chronic-lung-injury-in-murine-sickle-cell-disease
#38
JOURNAL ARTICLE
Kevin R Rarick, Keguo Li, Ru-Jeng Teng, Xigang Jing, Dustin P Martin, Hao Xu, Deron W Jones, Neil Hogg, Cheryl A Hillery, Guilherme Garcia, Billy W Day, Stephen Naylor, Kirkwood A Pritchard
Murine sickle cell disease (SCD) results in damage to multiple organs, likely mediated first by vasculopathy. While the mechanisms inducing vascular damage remain to be determined, nitric oxide bioavailability and sterile inflammation are both considered to play major roles in vasculopathy. Here, we investigate the effects of high mobility group box-1 (HMGB1), a pro-inflammatory damage-associated molecular pattern (DAMP) molecule on endothelial-dependent vasodilation and lung morphometrics, a structural index of damage in sickle (SS) mice...
February 7, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38318031/ho-1-attenuates-testicular-ischaemia-reperfusion-injury-by-activating-the-phosphorylated-c-jun-mir-221-222-tox-pathway
#39
JOURNAL ARTICLE
Bo Xie, Bing Cheng, Lugeng He, Yunfu Liu, Ning He
AIMS: Heme oxygenase (HO-1) affords protection against ischaemia/reperfusion (I/R) injury; however, its effects on testicular I/R injury remain poorly explored. Herein, we aimed to examine the effects of HO-1 on testicular I/R injury and elucidate the underlying mechanism. METHODS: Using the TALEN technique, we knocked out the HO-1 gene from rats. In vivo : Thirty hmox+/+ and 30 hmox-/- rats were randomly assigned to six groups: sham-operated (sham), I/R (the left testicle torsion/detorsion) 0 d,I/R 1d, I/R 3d, I/R 7d and I/R 28d...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38308863/therapeutic-effects-of-anti-diabetic-drugs-on-traumatic-brain-injury
#40
REVIEW
Seyed Mehrad Razavi, Zahra Najafi Arab, Amirhossein Niknejad, Yasamin Hosseini, Abtin Fouladi, Saba Darban Khales, Mostafa Shahali, Saeideh Momtaz, Alexandra E Butler, Vasily N Sukhorukov, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, Amirhossein Sahebkar
AIMS: In this narrative review, we have analyzed and synthesized current studies relating to the effects of anti-diabetic drugs on traumatic brain injury (TBI) complications. METHODS: Eligible studies were collected from Scopus, Google Scholar, PubMed, and Cochrane Library for clinical, in-vivo, and in-vitro studies published on the impact of anti-diabetic drugs on TBI. RESULTS: Traumatic brain injury (TBI) is a serious brain disease that is caused by any type of trauma...
January 26, 2024: Diabetes & Metabolic Syndrome
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