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Hajime Tsuboi, Isao Yokota, Daisuke Miyamori, Yoshihisa Akasaka, Ayumu Yamada, Hiroshi Ikegaya
BACKGROUND: Previous studies have reported relationships between various visual parameters of the skin and changes due to aging. Due to an increase in the discovery of unidentified bodies, the field of forensic medicine anticipates the development of a rapid method for estimating age. The present study measured various visual parameters of the skin in human remains and investigated the correlation between these parameters and age. MATERIALS AND METHODS: Skin images were taken of four body parts (cheek, chin, brachium, and thigh) of 414 forensic cases...
February 15, 2019: Skin Research and Technology
C Sabeta, E C Ngoepe
Rabies is an acute and progressive encephalitis caused by lyssaviruses (family Rhabdoviridae, order Mononegavirales). Approximately 99% of the estimated 59,000 annual human rabies deaths in Africa and Asia are attributed to dog bites and are preventable through parenteral dog vaccination. In addition to dog rabies, the rabies virus also circulates in wildlife carnivores in southern Africa and virus exchange occurs readily across species barriers. In the early 1900s, rabies outbreaks were brought under control by the restriction of animal movements and by killing stray dogs...
August 2018: Revue Scientifique et Technique
Estelle Noyer, Mériem Fournier, Thiéry Constant, Catherine Collet, Jana Dlouhá
PREMISE OF THE STUDY: Thinning is a frequent disturbance in managed forests, especially to increase radial growth. Due to buckling and bending risk associated with height and mass growth, tree verticality is strongly constrained in slender trees growing in dense forests and poor light conditions. Tree verticality is controlled by uprighting movements implemented from local curvatures induced by wood maturation stresses and/or eccentric radial growth. This study presents the first attempt to compare the real uprighting movements in mature trees using a theoretical model of posture control...
February 11, 2019: American Journal of Botany
Issam El Naqa, Jim Irrer, Tim A Ritter, John DeMarco, Hania Al-Hallaq, Jeremy Booth, Grace Kim, Ahmad Alkhatib, Richard Popple, Mario Perez, Karl Farrey, Jean M Moran
PURPOSE: Developing automated methods to identify task-driven quality assurance (QA) procedures is key towards increasing safety, efficacy, and efficiency. We investigate the use of machine learning (ML) methods for possible visualization, automation and targeting of QA, and assess its performance using multi-institutional data. METHODS: To enable automated analysis of QA data given its higher dimensional nature, we used nonlinear kernel mapping with Support Vector Data Description (SVDD) driven approaches...
February 7, 2019: Medical Physics
Peng Liu, Shuaibin Zhang, Bing Zhou, Xi Luo, Xiaofeng Zhou, Bin Cai, Yin Hua Jin, De Niu, Jinxing Lin, Xiaofeng Cao, Jing Bo Jin
Leaf senescence is governed by a complex regulatory network involving dynamic reprogramming of gene expression. Age-dependent induction of senescence-associated genes (SAGs) is associated with increased level of trimethylation of histone H3 at lysine 4 (H3K4me3), but the regulatory mechanism remains elusive. We found that JMJ16, an Arabidopsis JmjC-domain containing protein, is a specific H3K4 demethylase that negatively regulates leaf senescence through its activity. Genome-wide analysis revealed a widespread coordinated up-regulation of gene expression and hyper-methylation of H3K4me3 at JMJ16 binding genes associated with leaf senescence in the loss-of-function jmj16 mutant compared with the wild type...
February 1, 2019: Plant Cell
Jozef Dingemans, Rebecca E Al-Feghali, Gee W Lau, Karin Sauer
The hybrid sensor SagS plays a central role in the formation of P. aeruginosa biofilms, by enabling the switch from the planktonic to the biofilm mode of growth, and by facilitating the transition of biofilm cells to a highly tolerant state. In this study, we examined the importance of the SagS key amino acid residues associated with biofilm formation (L154) and antibiotic tolerance (D105) in P. aeruginosa virulence. Recombinant P. aeruginosa ΔsagS and ΔsagS chromosomally expressing wild-type sagS, or its two variants D105A and L154A, were tested for their potential to form biofilms and cause virulence in plant and mouse models of acute and chronic pneumonia...
February 2, 2019: Molecular Microbiology
E G Okuneva, A A Kozina, N V Baryshnikova, A Yu Krasnenko, K Yu Tsukanov, O I Klimchuk, E I Surkova, V V Ilinsky
BACKGROUND: Cutis laxa (CL) is a rare connective tissue disorder characterized by loose, redundant, inelastic and wrinkled skin. Patients develop a prematurely aged appearance. Inheritance can be autosomal dominant or autosomal recessive. The X-linked form is now classified in the group of copper transport diseases. Autosomal dominant CL is characterized by wrinkled, redundant and sagging, inelastic skin and in some cases is associated with internal organ involvement. CASE PRESENTATION: We report a familial case of autosomal dominant CL, which includes a 33-year-old woman and her 11-year-old son with dry, thin and wrinkled skin that appeared prematurely aged...
January 31, 2019: BMC Dermatology
Julian Mustroph, Charlotte M Lücht, Olivia Wagemann, Thomas Sowa, Karin P Hammer, Can M Sag, Daniel Tarnowski, Andreas Holzamer, Steffen Pabel, Bo Eric Beuthner, Samuel Sossalla, Lars S Maier, Stefan Wagner
No abstract text is available yet for this article.
January 29, 2019: Diabetologia
Shinichiro Mori, Yukinobu Sakata, Ryusuke Hirai, Wataru Furuichi, Kazuki Shimabukuro, Ryosuke Kohno, Woong Sub Koom, Shigeru Kasai, Keiko Okaya, Yasushi Iseki
PURPOSE: To perform the final quality assurance of our fluoroscopic-based markerless tumor tracking for gated carbon-ion pencil beam scanning (C-PBS) radiotherapy using a rotating gantry system, we evaluated the geometrical accuracy and tumor tracking accuracy using a moving chest phantom with simulated respiration. METHODS: The positions of the dynamic flat panel detector (DFPD) and X-ray tube are subject to changes due to gantry sag. To compensate for this, we generated a geometrical calibration table (gantry flex map) in 15° gantry angle steps by the bundle adjustment method...
January 28, 2019: Medical Physics
Lisa Ramaut, Patrick Tonnard, Alexis Verpaele, Koenraad Verstraete, Phillip Blondeel
BACKGROUND: In scientific literature, numerous theories on the mechanism of facial aging can be found. The debate about facial sagging versus deflation is still ongoing. In this study, the metric changes in perioral soft tissue were demonstrated. These data can contribute to a better understanding of physical changes in the aging perioral area. METHODS: Upper lip measurements were performed on cranial magnetic resonance images of 200 Caucasian subjects (100 men and 100 women)...
February 2019: Plastic and Reconstructive Surgery
Gabriele F. Muti
Background: Calcium hydroxylapatite (CaHA, Radiesse®) with integral 0.3% lidocaine (CaHA(+)) has recently been approved for use in aesthetic medicine. This study assessed the performance of CaHA(+) in subjects undergoing treatment for facial volume loss and evaluated subject and physician satisfaction. Methods: In a prospective, open-label, post-marketing study, 25 women seeking treatment for age-related facial volume loss received CaHA(+) injections in 1–3 facial areas including the cheeks, marionette lines, prejowl sulcus, and jawline...
January 1, 2019: Journal of Drugs in Dermatology: JDD
Vennila Krishnan, Chitra Loganathan, Palvannan Thayumanavan
s-allyl glutathione (SAG) an analogue of glutathione is explored for its antioxidative and liver protection property in recent years. Selenium nanoparticles (Sh-SeNPs) were synthesized using medicinal plant Spermacoce hispida and conjugated with SAG (SAG-Sh-SeNPs). SAG-Sh-SeNPs and Sh-SeNPs were characterized using by Fourier transform infrared spectroscopy, Transmission electron microscopy, Energy dispersive X-ray analysis, X-ray diffraction analysis and zeta potential analysis. SAG-Sh-SeNPs and Sh-SeNPs were evaluated against acetaminophen (APAP)-induced liver and kidney injury in rat...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Ruri D Pamela
Background: Chronic exposure to solar ultraviolet irradiation can result in facial fine lines and wrinkles, poor texture, and sagging skin. Growth factors are polypeptides or proteins that play a key role in the regulation of a number of physiological processes. Topical application of growth factors also reduces signs of photoaging, promotes fibroblast and keratinocyte proliferation, and induces extracellular matrix formation. Objective: This study evaluated the efficacy of topical growth factor after microneedling treatment for the reduction of visual signs of facial photoaging in Fitzpatrick skin types III to IV...
December 2018: Journal of Clinical and Aesthetic Dermatology
Martina Kerscher, Arti Tania Nurrisyanti, Christine Eiben-Nielson, Susanne Hartmann, Judith Lambert-Baumann
Purpose: The efficacy of microfocused ultrasound with visualization (MFU-V; Ultherapy® ) has been demonstrated in clinical studies and daily practice. However, data addressing skin physiology after MFU-V treatment are lacking. This observational evaluation was aimed to assess skin physiology before and after MFU-V treatment using noninvasive biophysical measurements. Patients and methods: Twenty-two female patients with moderate-to-severe skin sagging at the jawline and submental region on the Merz Aesthetics Scale obtained a single MFU-V treatment according to protocol...
2019: Clinical, Cosmetic and Investigational Dermatology
Sergey Gorelick, Alex de Marco
The high refractive index of lithium niobate crystal (n = 2.2) and the highly transparent range (300-5000 nm), makes it a perfect material for refractive lenses and other types of micro-optical elements. This material already finds extensive use in waveguides and photonic crystals, however, little work has been done on producing refractive optical components in lithium niobate, presumably due to the challenges associated with its fragility and difficulties in three-dimensional micromachining. In this study, we fabricated high-quality refractive micro-lenses and micro-axicons with low surface roughness (< λvis / 20), with 220 µm diameters and sag heights up to 22 µm in single-crystal LN using focused Xe beam milling...
November 26, 2018: Optics Express
Ibrahim Tekedereli, Emine Demiral, Ismail K Gokce, Zeynep Esener, Emine Camtosun, Aysehan Akinci
FBLN5-related cutis laxa (CL) is a rare syndrome that can be inherited in an autosomal dominant or recessive manner. Autosomal recessive cutis laxa (ARCL), type IA, has been reported to be more severe. The disease is characterized by microcephaly, sagging cheeks, loose, wrinkled and redundant skin, emphysema, aorta or pulmonary artery abnormalities, inguinal hernia, and anomalies of internal organs. Homozygous mutations in the FBLN5 gene are responsible for the clinical manifestations. We report a family study of a child with ARCL...
January 11, 2019: Clinical Dysmorphology
Haipeng Jiang, Xian Wang, Xiaoliang Cui
SAG (Smo agonist) is high specific agonist of Smo receptor, it is widely used as chemical probe to explore the therapeutic value of activating the Hh-signaling pathway. In the present work, the coexistence of two distinct conformers (A and B) of SAG are revealed by solution NMR, the 3D structural difference of the two conformers are elucidated by ROESY spectroscopy and MMFF94 program. It is discovered that both conformers are agonists of Smo receptor, and the minor conformer (conformer B) in D2 O solution has higher affinity to Smo receptor by molecular docking...
December 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
Shaocheng Zhang, Xia Huo, Yu Zhang, Yu Huang, Xiangbin Zheng, Xijin Xu
Ambient fine particulate matter (PM2.5 ) is a risk factor for respiratory diseases. Previous studies suggest that PM2.5 exposure may down-regulate airway antimicrobial proteins and peptides (AMPs), thereby accelerating airway pathogen infection. However, epidemiological research is scarce. Hence, we estimated the associations between individual PM2.5 chronic daily intake (CDI) and the levels of the airway AMP salivary agglutinin (SAG), as well as peripheral leukocyte counts and pro-inflammatory cytokines, of preschool children in Guiyu (an e-waste area) and Haojiang (a reference area located 31...
January 3, 2019: Environment International
James Ronald, Rajiv Rao, Steven S Choi, Matthew Kappus, Jonathan G Martin, Alan A Sag, Waleska M Pabon-Ramos, Paul V Suhocki, Tony P Smith, Charles Y Kim
PURPOSE: To compare survival after transjugular intrahepatic portosystemic shunt (TIPS) creation versus serial large volume paracenteses (LVP) in patients with refractory ascites and higher Model for End-Stage Liver Disease (MELD) scores. MATERIALS AND METHODS: In this retrospective study, from 1/1/2013 to 10/1/2018, 478 patients (294 male; mean age 58, range 23-89) underwent serial LVP (n = 386) or TIPS (n = 92) for ascites. Propensity-matched cohorts were constructed based on age, MELD, Charlson comorbidity index, varices, and hepatic encephalopathy...
January 2, 2019: Cardiovascular and Interventional Radiology
Tara A Janes, Stephanie Fournier, Simon Chamberland, Gregory D Funk, Richard Kinkead
Amphibian respiratory development involves a dramatic metamorphic transition from gill- to lung-breathing, and coordination of distinct motor outputs. To determine whether the emergence of adult respiratory motor patterns was associated with similarly dramatic changes in motoneuron (MN) properties, we characterized the intrinsic electrical properties of American bullfrog trigeminal MNs innervating respiratory muscles comprising the buccal pump. In pre-metamorphic tadpoles (TK stages IX-XVIII) and adult frogs, morphometric analyses and whole-cell recordings were performed in trigeminal MNs identified using fluorescent retrograde labeling...
January 2, 2019: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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