keyword
https://read.qxmd.com/read/38536234/target-product-profile-for-a-machine-learning-automated-retinal-imaging-analysis-software-for-use-in-english-diabetic-eye-screening-protocol-for-a-mixed-methods-study
#1
JOURNAL ARTICLE
Trystan Macdonald, Jacqueline Dinnes, Gregory Maniatopoulos, Sian Taylor-Phillips, Bethany Shinkins, Jeffry Hogg, John Kevin Dunbar, Ameenat Lola Solebo, Hannah Sutton, John Attwood, Michael Pogose, Rosalind Given-Wilson, Felix Greaves, Carl Macrae, Russell Pearson, Daniel Bamford, Adnan Tufail, Xiaoxuan Liu, Alastair K Denniston
BACKGROUND: Diabetic eye screening (DES) represents a significant opportunity for the application of machine learning (ML) technologies, which may improve clinical and service outcomes. However, successful integration of ML into DES requires careful product development, evaluation, and implementation. Target product profiles (TPPs) summarize the requirements necessary for successful implementation so these can guide product development and evaluation. OBJECTIVE: This study aims to produce a TPP for an ML-automated retinal imaging analysis software (ML-ARIAS) system for use in DES in England...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38535054/pan-immune-inflammation-value-could-be-a-new-marker-to-predict-amyloidosis-and-disease-severity-in-familial-mediterranean-fever
#2
JOURNAL ARTICLE
Tuğba Ocak, Ahmet Görünen, Belkıs Nihan Coşkun, Burcu Yağız, Sebnem Ozemri Sağ, Gökhan Ocakoğlu, Ediz Dalkılıç, Yavuz Pehlivan
Familial Mediterranean fever (FMF) is characterized by recurrent episodes of fever and serositis. Blood-based biomarkers determined in FMF patients during attack-free periods could be used to predict the risk of amyloidosis and the severity of the disease. The recently defined pan-immune-inflammation value (PIV) comprises four distinct subsets of blood cells and serves as an easily accessible and cost-effective marker. The objective of this study was to assess the role of PIV in predicting amyloidosis and moderate-to-severe disease...
March 16, 2024: Diagnostics
https://read.qxmd.com/read/38533721/new-developments-in-cosmetic-applications-of-electromagnetic-fields-client-and-occupational-hazard-assessment
#3
REVIEW
Rianne Stam
Energy-based devices are used to improve features of appearance for aesthetic reasons while avoiding more invasive methods. Examples of treatment targets are the reduction of wrinkles, sagging, unwanted skin lesions, body hair and excess fatty tissue, and the enhancement of muscle tissue. One treatment modality is the use of electromagnetic fields (EMF, 0‒300 GHz). The present work aims to give an up-to-date survey of cosmetic applications of EMF for professional use with an assessment of client and worker exposure and possible adverse effects...
March 27, 2024: Bioelectromagnetics
https://read.qxmd.com/read/38533502/5-6-dimethylxanthenone-4-acetic-acid-dmxaa-a-partial-sting-agonist-competes-for-human-sting-activation
#4
JOURNAL ARTICLE
Burcu Temizoz, Takayuki Shibahara, Kou Hioki, Tomoya Hayashi, Kouji Kobiyama, Michelle Sue Jann Lee, Naz Surucu, Erdal Sag, Atsushi Kumanogoh, Masahiro Yamamoto, Mayda Gursel, Seza Ozen, Etsushi Kuroda, Cevayir Coban, Ken J Ishii
5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity. Although DMXAA cannot fully activate human STING, DMXAA reached phase III in lung cancer clinical trials. How DMXAA is effective against human lung cancer is completely unknown. Here, we show that DMXAA is a partial STING agonist interfering with agonistic STING activation, which may explain its partial anti-tumor effect observed in humans, as STING was reported to be pro-tumorigenic for lung cancer cells with low antigenicity...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529651/prediction-of-lymphovascular-space-invision-in-endometrial-cancer-based-on-multi-parameter-mri-radiomics-model
#5
JOURNAL ARTICLE
Jin Jun Wang, Xiao Hong Zhang, Xing Hua Guo, Yang Ying, Xiang Wang, Zhong Hua Luan, Wei Qin Lv, Peng Fei Wang
UNLABELLED: <p>Objective: To explore the application value of a combined model based on multi-parameter MRI radiomics and clinical features in preoperative prediction of lymphatic vascular space invasion (LVSI) in endometrial carcinoma (EC). METHODS: This retrospective study collected the clinicopathological and imaging data of 218 patients with EC in Yuncheng Central Hospital from March 2018 to May 2022. The patients were randomly divided into training group (n=152) and validation group (n= 66) according to the ratio of 7: 3...
March 19, 2024: Current medical imaging
https://read.qxmd.com/read/38525840/age-related-nonparalytic-hypertropia-clinical-features
#6
JOURNAL ARTICLE
Akihiko Oohira
PURPOSE: Age-related nonparalytic hypertropia (ARNH) is reported to be involved in sagging eye syndrome, where excyclotorsion is large and the lower eye is more extorted. The primary aim of this study was to describe the clinical profiles of patients with ARNH. The secondary aim was to compare cyclotorsion in patients with ARNH with that in normal individuals. METHODS: Inclusion criteria for ARNH were insidious onset of diplopia at distance after 50 years of age, nonparalytic hyperdeviation and follow-up >6 months...
March 25, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38524495/evaluating-the-effect-of-claytone-em-on-the-performance-of-oil-based-drilling-fluids
#7
JOURNAL ARTICLE
Ali Mahmoud, Rahul Gajbhiye, Salaheldin Elkatatny
This study provides a detailed characterization and evaluation of Claytone-EM as a rheological additive to enhance the performance of oil-based drilling fluids (OBDFs) under high-pressure, high-temperature (HPHT) conditions. It also offers a comparative evaluation of the effectiveness of Claytone-EM with an existing organoclay, analyzing their mineral and chemical compositions, morphologies, and particle sizes. A series of experiments are performed to evaluate Claytone-EM's influence on crucial drilling mud properties, such as mud density, electrical stability, sagging tendency, rheology, viscoelastic properties, and filtration properties, to formulate a stable and high-performing OBDF...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38522068/homozygous-missense-variants-in-ykt6-result-in-loss-of-function-and-are-associated-with-developmental-delay-with-or-without-severe-infantile-liver-disease-and-risk-for-hepatocellular-carcinoma
#8
JOURNAL ARTICLE
Mengqi Ma, Mythily Ganapathi, Yiming Zheng, Kai-Li Tan, Oguz Kanca, Kevin E Bove, Norma Quintanilla, Sebnem O Sag, Sehime G Temel, Charles A LeDuc, Amanda J McPartland, Elaine M Pereira, Yufeng Shen, Jacob Hagen, Christie P Thomas, Nhu Thao Nguyen Galván, Xueyang Pan, Shenzhao Lu, Jill A Rosenfeld, Daniel G Calame, Michael F Wangler, James R Lupski, Davut Pehlivan, Paula M Hertel, Wendy K Chung, Hugo J Bellen
PURPOSE: YKT6 plays important roles in multiple intracellular vesicle trafficking events but has not been associated with Mendelian diseases. METHODS: We report three unrelated individuals with rare homozygous missense variants in YKT6 who exhibited neurological disease with or without a progressive infantile liver disease. We modeled the variants in Drosophila. We generated wild-type and variant genomic rescue constructs (GRs) of the fly ortholog dYkt6 and compared their ability in rescuing the loss-of-function phenotypes in mutant flies...
March 21, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://read.qxmd.com/read/38521011/modular-preparation-of-biphenyl-triazoles-via-click-chemistry-as-non-competitive-hyaluronidase-inhibitors
#9
JOURNAL ARTICLE
Yiman Qin, Guanyi Li, Ling Wang, Guangyuan Yin, Xiang Zhang, Hongxiang Wang, Pengfei Zheng, Wentao Hua, Yan Cheng, Yaxue Zhao, Jiong Zhang
Hyaluronidase is a promising target in drug discovery, given its overexpression in a range of physiological and pathological processes, including tumor migration, skin aging, sagging, and wrinkling, as well as inflammation and bacterial infections. In this study, to identify novel hyaluronidase inhibitors, we applied click chemistry for the modular synthesis of 370 triazoles in 96-well plates, starting with biphenyl azide. Utilizing an optimized turbidimetric screening assay in microplates, we identified Fmoc-containing triazoles 5 and 6, as well as quinoline-containing triazoles 15 and 16, as highly effective hyaluronidase inhibitors...
March 16, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38516888/stimulation-of-skeletal-stem-cells-in-the-growth-plate-promotes-linear-bone-growth
#10
JOURNAL ARTICLE
Dana Trompet, Anastasiia D Kurenkova, Baoyi Zhou, Lei Li, Ostap Dregval, Anna P Usanova, Tsz Long Chu, Alexandra Are, Andrei A Nedorubov, Maria Kasper, Andrei S Chagin
Recently, skeletal stem cells were shown to be present in the epiphyseal growth plate (epiphyseal skeletal stem cells, epSSCs), but their function in connection with linear bone growth remains unknown. Here, we explore the possibility that modulating the number of epSSCs can correct differences in leg length. First, we examined regulation of the number and activity of epSSCs by Hedgehog (Hh) signaling. Both systemic activation of Hh pathway with Smoothened agonist (SAG) and genetic activation of Hh pathway by Patched1 (Ptch1) ablation in Pthrp-creER Ptch1fl/fl tdTomato mice promoted proliferation of epSSCs and clonal enlargement...
February 13, 2024: JCI Insight
https://read.qxmd.com/read/38510259/targeting-staphylococcal-enterotoxin-b-binding-to-cd28-as-a-new-strategy-for-dampening-superantigen-mediated-intestinal-epithelial-barrier-dysfunctions
#11
JOURNAL ARTICLE
Carola Amormino, Emanuela Russo, Valentina Tedeschi, Maria Teresa Fiorillo, Alessandro Paiardini, Francesco Spallotta, Laura Rosanò, Loretta Tuosto, Martina Kunkl
Staphylococcus aureus is a gram-positive bacterium that may cause intestinal inflammation by secreting enterotoxins, which commonly cause food-poisoning and gastrointestinal injuries. Staphylococcal enterotoxin B (SEB) acts as a superantigen (SAg) by binding in a bivalent manner the T-cell receptor (TCR) and the costimulatory receptor CD28, thus stimulating T cells to produce large amounts of inflammatory cytokines, which may affect intestinal epithelial barrier integrity and functions. However, the role of T cell-mediated SEB inflammatory activity remains unknown...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38506380/a-rare-cause-of-intestinal-obstruction-right-paraduodenal-hernia
#12
Tuba Atak
Internal herniation is an extremely rare cause of intestinal obstruction. Paraduodenal hernias result from abnormal rotation of the bowel. Symptoms that may range from recurrent abdominal pain to acute obstruction may occur. If it is not diagnosed and treated in time, the disease may result in intestinal ischemia. This article aimed to present the diagnosis and treatment process of a 47-year-old male presenting with acute abdomen symptoms by evaluating retrospectively with the accompaniment of literature. During the abdominal exploration of the patient, nearly all of the intestines were observed to be herniated from the right paraduodenal region to the posterior area...
March 2024: Turkish Journal of Trauma & Emergency Surgery: TJTES
https://read.qxmd.com/read/38503783/examining-preharvest-genetic-and-morphological-factors-contributing-to-lettuce-lactuca-sativa-l-shelf-life
#13
JOURNAL ARTICLE
Kathryn Chase, Catherine Belisle, Yogesh Ahlawat, Fahong Yu, Steven Sargent, Germán Sandoya, Kevin Begcy, Tie Liu
Lettuce is a highly perishable horticultural crop with a relatively short shelf-life that limits its commercial value and contributes to food waste. Postharvest senescence varies with influences of both environmental and genetic factors. From a larger pool of romaine lettuce genotypes, we identified three genotypes with variable shelf lives and evaluated their leaf morphology characteristics and transcriptomic profiles at preharvest to predict postharvest quality. Breeding line 60184 had the shortest shelf-life (SSL), cultivar 'Manatee' had an intermediate shelf-life (ISL), and 'Okeechobee' had the longest shelf-life (LSL)...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38494986/botulinum-toxin-injection-technique-for-reducing-the-masseter-size-and-enhancing-the-jawline
#14
JOURNAL ARTICLE
Jun Zhuang, Liya Jiang, Yuejie Zhou, Cheng Wang, Yi Chen, Xueshang Su, Qingqian Wei, Ziming Zhang, Jintian Hu
BACKGROUND: The injection of botulinum toxin into the masseter muscle is an important method used to improve hypertrophy. However, some patients may experience adverse reactions, such as sagging of the lower jaw. Therefore, we proposed a method of injecting botulinum toxin into the masseter and platysma muscles that would reduce masseter size and enhance the jawline. OBJECTIVES: Reducing the masseter size while enhancing the jawline. METHODS: Twenty patients received botulinum toxin injections into the masseter and platysma muscles...
March 18, 2024: Aesthetic Surgery Journal
https://read.qxmd.com/read/38489771/single-cell-genomics-of-a-bloom-forming-phytoplankton-species-reveals-population-genetic-structure-across-continents
#15
JOURNAL ARTICLE
Raphael Gollnisch, Dag Ahrén, Karin Rengefors
The study of microbial diversity over time and space is fundamental to the understanding of their ecology and evolution. The underlying processes driving these patterns are not fully resolved but can be studied using population genetic approaches. Here we investigated the population genetic structure of Gonyostomum semen, a bloom-forming phytoplankton species, across two continents. The species appears to be expanding in Europe, whereas similar trends are not observed in the United States. Our aim was to investigate if populations of G...
March 15, 2024: ISME Journal
https://read.qxmd.com/read/38486115/risk-factors-of-failure-results-after-double-bundle-reconstruction-with-autogenous-hamstring-grafts-for-isolated-posterior-cruciate-ligament-rupture-cases
#16
JOURNAL ARTICLE
Yudai Morita, Takuya Tajima, Nami Yamaguchi, Takuji Yokoe, Makoto Nagasawa, Tomomi Ota, Kouki Ouchi, Etsuo Chosa
Posterior tibial translation (PTT) after double-bundle posterior cruciate ligament (PCL) reconstruction has sometimes occurred. Purpose of this study is to identify the risk factors for postoperative PTT after double-bundle PCL reconstruction with a hamstring autograft. Comparing the results of bilateral gravity sag view (GSV) at 12 months after surgery, over 5-mm PTT was defined as 'failure' in this study. Of 26 isolated PCL reconstruction cases, over 5-mm PTT was seen in 7 cases (group F: 9.57 ± 1...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38479571/sonic-hedgehog-restrains-the-ubiquitin-dependent-degradation-of-sp1-to-inhibit-neuronal-glial-senescence-associated-phenotypes-in-chemotherapy-induced-peripheral-neuropathy-via-the-trim25-cxcl13-axis
#17
JOURNAL ARTICLE
Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo
INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication that affects an increasing number of cancer survivors. However, the current treatment options for CIPN are limited. Paclitaxel (PTX) is a widely used chemotherapeutic drug that induces senescence in cancer cells. While previous studies have demonstrated that Sonic hedgehog (Shh) can counteract cellular dysfunction during aging, its role in CIPN remains unknown. OBJECTIVES: Herein, the aim of this study was to investigate whether Shh activation could inhibits neuronal/glial senescence and alleviates CIPN...
March 11, 2024: Journal of Advanced Research
https://read.qxmd.com/read/38470987/suture-net-technique-for-mid-face-superficial-fat-compartments-restoration
#18
JOURNAL ARTICLE
Lu Chen, Zhimo Liu, Yuyu Zhang, Weiwei Bian, Liying Cheng
BACKGROUND: Facial fold and groove formation is influenced by the ptosis of the superficial fat compartments in the mid-face region. OBJECTIVE: This study aimed to design a facial rejuvenation technique that targets sagging of the mid-face fat compartments and achieves a youthful facial configuration. MATERIALS AND METHODS: A total of 102 patients underwent suture net restoration. Each specific ptosis fat compartment was carefully lifted and held at the regional facial ligaments to effectively restore volume distribution...
March 12, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/38465526/ventricular-aneurysm-mimicking-the-image-of-a-muscular-bridge-in-the-right-coronary-artery
#19
JOURNAL ARTICLE
Ömer Ferudun Akkuş, Melik Demir, Fethi Emre Ustabaşıoğlu, Servet Altay
No abstract text is available yet for this article.
March 2024: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://read.qxmd.com/read/38464205/the-ubiquitin-ligase-rbx2-sag-regulates-mitochondrial-ubiquitination-and-mitophagy
#20
Wenjuan Wang, Ermin Li, Jianqiu Zou, Qu Chen, Juan Ayala, Yuan Wen, Md Sadikul Islam, Neal L Weintraub, David J Fulton, Qiangrong Liang, Jiliang Zhou, Jinbao Liu, Jie Li, Yi Sun, Huabo Su
UNLABELLED: Clearance of damaged mitochondria via mitophagy is crucial for cellular homeostasis. While the role of ubiquitin (Ub) ligase PARKIN in mitophagy has been extensively studied, increasing evidence suggests the existence of PARKIN-independent mitophagy in highly metabolically active organs such as the heart. Here, we identify a crucial role for Cullin-RING Ub ligase 5 (CRL5) in basal mitochondrial turnover in cardiomyocytes. CRL5 is a multi-subunit Ub ligase comprised by the catalytic RING box protein RBX2 (also known as SAG), scaffold protein Cullin 5 (CUL5), and a substrate-recognizing receptor...
February 28, 2024: bioRxiv
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