keyword
https://read.qxmd.com/read/38044024/bioavailability-and-daily-requirement-of-vitamin-b-12-in-adult-humans-an-observational-study-of-its-colonic-absorption-and-daily-excretion-as-measured-by-13-c-cyanocobalamin-kinetics
#21
JOURNAL ARTICLE
Anura V Kurpad, Roshni M Pasanna, Shalini G Hegde, Mallikarjun Patil, Arpita Mukhopadhyay, Harshpal S Sachdev, Kishor G Bhat, Ambily Sivadas, Sarita Devi
BACKGROUND: Clinical and biochemical vitamin B12 (B12 ) deficiency is lower than anticipated in vegetarians. Extraileal absorption, such as from the colon, as well as reduced daily excretion, may be adaptive mechanisms to maintain B12 homeostasis with marginal intakes. OBJECTIVE: To measure the absorption of B12 from the small and large intestine, and its daily rate of excretion from the body, using a [13 C]-cyanocobalamin tracer. METHODS: Oral B12 bioavailability was measured over 12 h after administration of [13 C]-cyanocobalamin tracer (2...
December 2023: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38039118/-epi-genetic-and-clinical-characteristics-in-84-patients-with-pseudohypoparathyroidism-type-1b
#22
JOURNAL ARTICLE
Tatsuki Urakawa, Shinichiro Sano, Sayaka Kawashima, Akie Nakamura, Hirohito Shima, Motoki Ohta, Yuki Yamada, Ai Nishida, Hiromune Narusawa, Yoshiaki Ohtsu, Keiko Matsubara, Sumito Dateki, Yoshihiro Maruo, Maki Fukami, Tsutomu Ogata, Masayo Kagami
OBJECTIVE: Pseudohypoparathyroidism type 1B (PHP1B) caused by methylation defects of differentially methylated regions (DMRs) on the GNAS locus can be categorized into groups according to etiologies and methylation defect patterns of the DMRs. The aim of this study was to clarify the clinical characteristics in each group. DESIGN: Comprehensive molecular analyses consisting of methylation, copy number, and microsatellite analyses. METHODS: Eighty-four patients with PHP1B were included in this study...
December 1, 2023: European Journal of Endocrinology
https://read.qxmd.com/read/38017366/a-case-of-pseudohypoparathyroidism-misdiagnosed-as-idiopathic-epilepsy-for-5-years-clinical-analysis-and-follow-up-outcomes
#23
JOURNAL ARTICLE
Li-Zhen Dai, Chenshi Lin, Rui Lei, Yan Zhang, Hong Ma
We report a 15-year-old Chinese girl who presented with intermittent seizure episodes and had been misdiagnosed as having idiopathic epilepsy 5 years previously. Laboratory testing revealed hypocalcemia, hyperphosphatemia, and a high parathyroid hormone (PTH) concentration. She was subsequently shown to have pseudohypoparathyroidism type Ib (PHPIb) based on the results of methylation analysis of the GNAS gene, which showed a loss of methylation of the differentially methylated regions (DMR) of GNAS-AS1 , GNAS-XL , and GNAS-A/B ; and a gain of methylation of the DMR of the GNAS-NESP55 region...
November 2023: Journal of International Medical Research
https://read.qxmd.com/read/38007611/dietary-nitrate-nitrite-and-nitrosamine-in-association-with-diabetes-a-systematic-review-and-meta-analysis
#24
JOURNAL ARTICLE
Nam N Nguyen, Linh T D Tran, Ngan D K Ho, Linh B P Huynh, Hung S Nguyen, Yang-Ching Chen
CONTEXT: Diabetes is a global health concern, and diet is a contributing factor to diabetes. Findings regarding the connection between nitrate, nitrite, and nitrosamine and diabetes risk are inconsistent. OBJECTIVE: The aim was to examine the effects of these dietary compounds on diabetes risk. DATA SOURCES: The data were sourced from PubMed, EMBASE, Scopus, and Web of Science until February 28, 2023. Studies that reported individual-level consumption of these compounds were included...
November 25, 2023: Nutrition Reviews
https://read.qxmd.com/read/37992972/association-between-public-health-policies-on-alcohol-and-worldwide-cancer-liver-disease-and-cardiovascular-disease-outcomes
#25
JOURNAL ARTICLE
Luis Antonio Díaz, Eduardo Fuentes-López, Francisco Idalsoaga, Gustavo Ayares, Oscar Corsi, Jorge Arnold, Macarena Cannistra, Danae Vio, Andrea Márquez-Lomas, Carolina Ramirez-Cadiz, María Paz Medel, María Hernandez-Tejero, Catterina Ferreccio, Mariana Lazo, Juan Pablo Roblero, Thomas G Cotter, Anand V Kulkarni, Won Kim, Mayur Brahmania, Alexandre Louvet, Elliot B Tapper, Winston Dunn, Douglas Simonetto, Vijay H Shah, Patrick S Kamath, Jeffrey V Lazarus, Ashwani K Singal, Ramon Bataller, Marco Arrese, Juan Pablo Arab
BACKGROUND & AIMS: The long-term impact of alcohol-related public health policies (PHPs) on disease burden is unclear. We aimed to assess the association between alcohol-related PHPs and alcohol-related health consequences. METHODS: We conducted an ecological multi-national study including 169 countries. We collected data on alcohol-related PHPs from the WHO Global Information System of Alcohol and Health 2010. Data on alcohol-related health consequences between 2010-2019 were obtained from the Global Burden of Disease database...
November 21, 2023: Journal of Hepatology
https://read.qxmd.com/read/37964932/impact-of-food-based-fortification-on-nutritional-outcomes-and-acceptability-in-older-adults-systematic-literature-review
#26
Alexia Geny, Maité Petitjean, Virginie Van Wymelbeke-Delannoy, Claire Sulmont-Rossé
BACKGROUND: "Do it yourself" (DIY) food-based fortification involves adding fortificants into everyday foods. It is a flexible solution that allows older people with reduced appetite to meet their nutritional needs. OBJECTIVES: The aims of the systematic review are (a) to describe DIY fortified recipes, (b) to evaluate their acceptability, and (c) to evaluate whether they are effective levers to improve nutritional outcomes in older people. METHODS: A systematic search of 3 databases (Web of Science, PubMed, Scopus, last searched on January 2022) was undertaken...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37948605/gate-tuning-hybrid-polaritons-in-twisted-%C3%AE-moo-3-graphene-heterostructures
#27
JOURNAL ARTICLE
Zhou Zhou, Renkang Song, Junbo Xu, Xiang Ni, Zijia Dang, Zhichen Zhao, Jiamin Quan, Siyu Dong, Weida Hu, Di Huang, Ke Chen, Zhanshan Wang, Xinbin Cheng, Markus B Raschke, Andrea Alù, Tao Jiang
Modulating anisotropic phonon polaritons (PhPs) can open new avenues in infrared nanophotonics. Promising PhP dispersion engineering through polariton hybridization has been demonstrated by coupling gated graphene to single-layer α-MoO3 . However, the mechanism underlying the gate-dependent modulation of hybridization has remained elusive. Here, using IR nanospectroscopic imaging, we demonstrate active modulation of the optical response function, quantified in measurements of gate dependence of wavelength, amplitude, and dissipation rate of the hybrid plasmon-phonon polaritons (HPPPs) in both single-layer and twisted bilayer α-MoO3 /graphene heterostructures...
November 10, 2023: Nano Letters
https://read.qxmd.com/read/37931159/effect-of-pseudostellaria-heterophylla-polysaccharide-on-the-growth-and-liver-metabolism-of-chicks
#28
JOURNAL ARTICLE
Yange Yu, Zhaoyan Zhu, Mengxia Ding, Bingxin Wang, Yadong Tian, Ruirui Jiang, Guirong Sun, Ruili Han, Xiangtao Kang, Fengbin Yan, Yujie Guo
In this study, the effects of Pseudostellaria heterophylla polysaccharide (PHP) on the growth, development and liver metabolism of chicks were investigated by feeding chicks diets. Four hundred 7-day-old Gushi roosters were selected and randomly divided into four groups, labeled A, B, C and D. Group A was fed the basal diet, and Groups B, C and D were fed 100 mg, 200 mg and 400 mg PHP per kilogram of basal diet, respectively. At 14, 21, 28 and 35 days of age, five chicks were randomly selected from each group to collect samples for index detection...
November 1, 2023: Journal of Animal Science
https://read.qxmd.com/read/37856187/effects-of-using-websites-on-physical-activity-and-diet-quality-for-adults-living-with-chronic-health-conditions-systematic-review-and-meta-analysis
#29
REVIEW
Dina Pogrebnoy, Amy M Dennett, Dawn B Simpson, Lesley MacDonald-Wicks, Amanda J Patterson, Coralie English
BACKGROUND: Adults with chronic health conditions need support to manage modifiable risk factors such as physical inactivity and poor diet. Disease-specific websites with health information on physical activity and diet quality may be effective in supporting adults in managing their chronic illnesses. OBJECTIVE: The primary aim of this review was to determine whether using websites with health information can lead to improvements in physical activity levels or diet quality in adults with chronic health conditions...
October 19, 2023: Journal of Medical Internet Research
https://read.qxmd.com/read/37835962/influence-of-particle-size-on-the-mechanical-performance-and-sintering-quality-of-peanut-husk-powder-pes-composites-fabricated-through-selective-laser-sintering
#30
JOURNAL ARTICLE
Aboubaker I B Idriss, Chun-Mei Yang, Jian Li, Yanling Guo, Jiuqing Liu, Alaaeldin A A Abdelmagid, Gafer A Ahmed, Hao Zhang
This study intends to enhance the mechanical strength of wood-plastic composite selective laser sintering (SLS) parts by using a sustainable composite, peanut husk powder (PHP)/poly ether sulfone (PES) (PHPC). The study aims to address agricultural waste pollution by encouraging the eco-friendly utilization of such waste in SLS technology. To ensure the sintering quality and mechanical properties and prevent deformation and warping during sintering, the thermo-physical properties of PHP and PES powders were analyzed to determine a suitable preheating temperature for PHPC...
September 28, 2023: Polymers
https://read.qxmd.com/read/37789375/development-of-a-foot-and-ankle-strengthening-program-for-the-treatment-of-plantar-heel-pain-a-delphi-consensus-study
#31
JOURNAL ARTICLE
John W A Osborne, Hylton B Menz, Glen A Whittaker, Karl B Landorf
BACKGROUND: People with plantar heel pain (PHP) have reduced foot and ankle muscle function, strength and size, which is frequently treated by muscle strengthening exercises. However, there has been little investigation of what exercises are used and there is no sound evidence base to guide practice. This study aimed to develop a consensus-driven progressive muscle strengthening program for PHP. METHODS: Thirty-eight experts were invited to participate in the study over three rounds...
October 3, 2023: Journal of Foot and Ankle Research
https://read.qxmd.com/read/37749609/effects-of-an-educational-planetary-plate-graphic-on-meat-consumption-in-a%C3%A2-stanford-university-dining-hall-a-randomized-controlled-trial
#32
JOURNAL ARTICLE
Alessandra L Marcone, Gary L Darmstadt, Ghislaine Amsler Challamel, Maya B Mathur, Christopher D Gardner
BACKGROUND: Assess the impact of an educational Planetary Health Plate (PHP) graphic on meat-related dietary choices of Stanford University dining hall patrons using a randomized controlled trial crossover design. All patrons entering the dining hall during study periods were enrolled as participants. Control, n = 631; PHP, n = 547. METHODS: Compare dietary behavior without signage to behavior while exposed to PHP during four equivalent dinner meals...
September 25, 2023: BMC Nutrition
https://read.qxmd.com/read/37744388/disparity-of-smell-tests-in-alzheimer-s-disease-and-other-neurodegenerative-disorders-a-systematic-review-and-meta-analysis
#33
Silin Liu, Zhihui Jiang, Jing Zhao, Zhensheng Li, Ruixin Li, Yunyi Qiu, Hua Peng
BACKGROUND: There are discrepancies of olfactory impairment between Alzheimer's disease (AD) and other neurodegenerative disorders. Olfactory deficits may be a potential marker for early and differential diagnosis of AD. We aimed to assess olfactory functions in patients with AD and other neurodegenerative disorders, to further evaluate the smell tests using subgroup analysis, and to explore moderating factors affecting olfactory performance. METHODS: Cross-sectional studies relating to olfactory assessment for both AD and other neurodegenerative disorders published before 27 July 2022 in English, were searched on PubMed, Embase and Cochrane...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37732548/alleviation-of-ultraviolet-b-radiation-induced-photoaging-using-saussurea-medusa-maxim-polysaccharide
#34
JOURNAL ARTICLE
Yan Guo, Yue Kong, Juan Sun, Yang Jiao, Yan Hong, Yan Wang
Saussurea medusa polysaccharide, the polysaccharide extract of Saussurea medusa Maxim, a traditional Chinese herbal medicine, is used to combat intense ultraviolet radiation, cold, and hypoxia in patients, as well as during drought. This polysaccharide has rich medicinal and ecological values. We aimed to determine whether saussurea medusa polysaccharides can reduce ultraviolet B (UVB)-induced skin photoaging. Seventy-five male Kunming mice were divided into five groups: control, UVB-only, UVB plus vitamin E (VE group), UVB plus saussurea medusa (2 g/kg), and UVB plus saussurea medusa (6 g/kg)...
September 21, 2023: Photochemistry and Photobiology
https://read.qxmd.com/read/37692781/does-invasive-acupuncture-improve-postoperative-ileus-after-colorectal-cancer-surgery-a-systematic-review-and-meta-analysis
#35
REVIEW
Xiaohu Zhao, Shangkun Si, Xin Liu, Jingxuan Liu, Dongbin Zhang, Yuejun Mu, Aihua Hou
BACKGROUND: Postoperative ileus (POI) is one of the main complications after colorectal cancer (CRC) surgery, and there is still a lack of effective treatment. At present, the evidence for improvement of POI by invasive acupuncture (manual acupuncture and electroacupuncture, IA) is limited. This meta-analysis of randomized controlled trials (RCTs) aims to systematically review and evaluate the effect of IA in improving POI after CRC surgery. METHODS: This meta-analysis was reported according to PRISMA statement and AMSTAR guidelines...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37689140/the-effectiveness-of-medical-nutrition-therapy-provided-by-a-dietitian-in-adults-with-prediabetes-a-systematic-review-and-meta-analysis
#36
JOURNAL ARTICLE
Josephine M Dudzik, Katelyn E Senkus, Alison B Evert, Hollie A Raynor, Mary R Rozga, Deepa Handu, Lisa M Moloney
BACKGROUND: A total of 374 million adults worldwide are living with prediabetes, 70% of whom will develop type 2 diabetes mellitus (T2DM) in their lifetime. Medical nutrition therapy (MNT) provided by a dietitian, such as that found in lifestyle interventions, has the potential to improve glycemic control and prevent progression to T2DM. OBJECTIVES: The objective of this systematic review was to examine the effectiveness of MNT provided by a dietitian, compared with standard care, on glycemic, cardiometabolic, and anthropometric outcomes in adults with prediabetes...
September 9, 2023: American Journal of Clinical Nutrition
https://read.qxmd.com/read/37675134/the-impact-of-phosphodiesterase-inhibition-on-neurobehavioral-outcomes-in-preclinical-models-of-traumatic-and-non-traumatic-spinal-cord-injury-a-systematic-review
#37
Max B Butler, Sundar K Vellaiyappan, Faheem Bhatti, Fazal-E-Momin Syed, Amir Rafati Fard, Jye Quan Teh, Ben Grodzinski, Melika Akhbari, Sylva Adeeko, Rory Dilworth, Aniqah Bhatti, Unaiza Waheed, Sophie Robinson, Temidayo Osunronbi, Benn Walker, Luke Ottewell, Gayathri Suresh, Isla Kuhn, Benjamin M Davies, Mark R N Kotter, Oliver D Mowforth
STUDY DESIGN: Systematic review. OBJECTIVE: The objective of this study was to evaluate the impact of phosphodiesterase (PDE) inhibitors on neurobehavioral outcomes in preclinical models of traumatic and non-traumatic spinal cord injury (SCI). METHODS: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and was registered with PROSPERO (CRD42019150639). Searches were performed in MEDLINE and Embase...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37628705/finding-an-appropriate-mouse-model-to-study-the-impact-of-a-treatment-for-friedreich-ataxia-on-the-behavioral-phenotype
#38
JOURNAL ARTICLE
Camille Bouchard, Catherine Gérard, Solange Gni-Fiene Yanyabé, Nathalie Majeau, Malek Aloui, Gabrielle Buisson, Pouiré Yameogo, Vanessa Couture, Jacques P Tremblay
Friedreich ataxia (FRDA) is a progressive neurodegenerative disease caused by a GAA repeat in the intron 1 of the frataxin gene (FXN) leading to a lower expression of the frataxin protein. The YG8sR mice are Knock-Out (KO) for their murine frataxin gene but contain a human frataxin transgene derived from an FRDA patient with 300 GAA repeats. These mice are used as a FRDA model but even with a low frataxin concentration, their phenotype is mild. We aimed to find an optimized mouse model with a phenotype comparable to the human patients to study the impact of therapy on the phenotype...
August 19, 2023: Genes
https://read.qxmd.com/read/37624734/positron-emission-tomography-quantitative-assessment-of-off-target-whole-body-biodistribution-of-i-124-labeled-adeno-associated-virus-capsids-administered-to-cerebral-spinal-fluid
#39
JOURNAL ARTICLE
Jonathan B Rosenberg, Edward K Fung, Jonathan Dyke, Bishnu P De, Howard Lou, James Kelly, Layla Reejhsinghani, Rodolfo J Ricart Arbona, Dolan Sondhi, Stephen M Kaminsky, Nathalie Cartier, Christian J Hinderer, Juliette Hordeaux, James M Wilson, Douglas Ballon, Ronald G Crystal
Based on studies in experimental animals demonstrating that administration of adeno-associated virus (AAV) vectors to the cerebrospinal fluid (CSF) is an effective route to transfer genes to the nervous system, there are increasing number of clinical trials using the CSF route to treat nervous system disorders. With the knowledge that the CSF turns over 4 to 5 times daily, and evidence in experimental animals that at least some of CSF administered AAV vectors are distributed to systemic organs, we asked: with AAV administration to the CSF, what fraction of the total dose remains in the nervous system and what fraction goes off target and is delivered systemically? To quantify the biodistribution of AAV capsids immediately after administration, we covalently labeled AAV capsids with iodine 124 (I-124), a cyclotron generated positron emitter, enabling quantitative positron tomography (PET) scanning of capsid distribution for up to 96 hours after AAV vector administration...
August 25, 2023: Human Gene Therapy
https://read.qxmd.com/read/37502183/endovascular-repair-of-acute-vs-subacute-uncomplicated-type-b-aortic-dissection-a-systematic-review-and-meta-analysis
#40
REVIEW
WenXin Zhao, Yang Yang, ZhiYuan Wu, ZuoGuan Chen, YongPeng Diao, Yong Lan, YongJun Li
OBJECTIVE: This study aimed to conduct a meta-analysis evaluating the optimal timing for endovascular repair of acute versus subacute uncomplicated Type B Aortic Dissection. METHOD: PubMed, EMBASE, web of science and Cochrane Library was interrogated to identify Electronic bibliographic studies updated to January 2023 to collect studies compared the clinical outcomes of endovascular repair for Acute Versus Subacute Uncomplicated Type B Aortic Dissection. Data were aggregated as pooled odds ratios (OR) using the fixed or random effects models according to the significance of heterogeneity, Pooled odds ratios (OR) were calculated by RevMan 5...
2023: Frontiers in Cardiovascular Medicine
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