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Bisoprolol OR Nebivolol

Michal Shani, Alex Lustman, Shlomo Vinker
Good medication adherence is a key factor in chronic disease management. Poor adherence is associated with adverse outcomes and high costs. We aimed to explore adherence rates among oral antihypertensive medications. The study included members of the Central District of Clalit Health Services in Israel aged between 40 and 75 years, who were diagnosed with hypertension before 2012 and who filled at least one prescription per year during 2012-2014, for the following medications: hydrochlorothiazide, nifedipine, amlodipine, lercanidipine hydrochloride, atenolol, bisoprolol, angiotensin-converting enzyme inhibitors (ACEI), angiotensin II receptor antagonists (ARBs), and statins...
February 7, 2019: Journal of Clinical Hypertension
Mabel Aoun, Randa Tabbah
Beta-blockers have numerous indications in the general population and are strongly recommended in heart failure, post-myocardial infarction and arrhythmias. In hemodialysis patients, their use is based on weak evidence because of the lack of a sufficient number of randomized clinical trials. The strongest evidence is based on two trials. The first showed better survival with carvedilol in hemodialysis patients with four sessions per week and systolic heart failure. The second found reduced cardiovascular morbidity with atenolol compared to lisinopril in mostly black hypertensive hemodialysis patients...
February 1, 2019: Néphrologie & Thérapeutique
Edmund Cheung So, Ning-Ping Foo, Shun Yao Ko, Sheng-Nan Wu
Bisoprolol (BIS) is a selective antagonist of β₁ adrenergic receptors. We examined the effects of BIS on M-type K⁺ currents (IK(M) ) or erg -mediated K⁺ currents (IK(erg) ) in pituitary GH3, R1220 cells, and hippocampal mHippoE-14 cells. As GH₃ cells were exposed to BIS, amplitude of IK(M) was suppressed with an IC50 value of 1.21 μM. The BIS-induced suppression of IK(M) amplitude was not affected by addition of isoproterenol or ractopamine, but attenuated by flupirtine or ivabradine. In cell-attached current, BIS decreased the open probability of M-type K⁺ (KM ) channels, along with decreased mean opening time of the channel...
February 2, 2019: International Journal of Molecular Sciences
O D Ostroumova, A I Kochetkov
The review presents a modern view on stress as a risk factor for the development of arterial hypertension (AH). A variety pathogenic mechanisms responsible for increase of blood pressure during stress exposure are described in detail. The importance of the sympathetic activation as a key link in the development of stress-induced AH and initiation of a cascade of pathophysiological reactions that realize their adverse effects at the level of the whole organism is underlined. Particular attention is paid to worksite AH as a variant of stress-induced hypertension due to its wide prevalence and association with an increased risk of cardiovascular complications, primarily myocardial infarction and stroke...
September 20, 2018: Terapevticheskiĭ Arkhiv
Josef Finsterer, Claudia Stollberger
INTRODUCTION: Simultaneous occurrence of transient global amnesia and Takotsubo syndrome has been only rarely reported. Here we report another patient with a transient global amnesia and concomitant Takotsubo syndrome. CASE PRESENTATION: Our patient is a 64-year-old white man with a previous history of myocarditis from borreliosis who developed sudden-onset confusional state with perseverations and repetition of the same questions during a funeral for his brother-in-law...
January 25, 2019: Journal of Medical Case Reports
Roberto Ramos Barbosa, Taissa Borges Bourguignon, Luíza Dias Torres, Lorenza Silveira Arruda, Tiago de Melo Jacques, Renato Giestas Serpa, Osmar de Araujo Calil, Luiz Fernando Machado Barbosa
OBJECTIVES: This study aimed at assessing the role of beta-blockers on preventing anthracycline-induced cardiotoxicity in adults. METHODS: A systematic review was performed on electronic databases, including relevant studies that analysed beta-blockers as cardioprotective agents before the use of anthracyclines by adult oncologic patients. RESULTS: After application of eligibility and selection criteria, eight articles were considered as high quality, complying with the proposed theme; all eight clinical trials, four of them placebo-controlled, with a total number of 655 patients included...
August 2018: Revista da Associação Médica Brasileira
Hannah Chaouki Sinclair, Paul Russhard, Chris Howell Critoph, Christopher D Steadman
A 70-year-old female with exertional dyspnoea was found to have basal septal hypertrophy, or a 'basal septal bulge', with evidence of mild left ventricular outflow tract obstruction (LVOT) at rest on her initial echocardiogram. She was usually fit and well and had no significant past medical history. She had no history of hypertension. There was no family history of hypertrophic cardiomyopathy (HCM). A cardiac MRI did not demonstrate any typical features of HCM. ECG showed sinus tachycardia but was otherwise unremarkable, Appendix 1...
January 1, 2019: Echo Research and Practice
Xiaodong Sun, Kang Liu, Yingxiang Du, Jie Liu, Xiaofei Ma
Recently, chiral ionic liquids (CILs) have received increasing interest in chiral separation by capillary electrophoresis. Nevertheless, the lack of deep perception of the specific mechanism about CILs in CE for enantioseparation still perplexes a legion of researchers, despite the strenuous efforts. In this paper, a lactobionic acid based ionic liquid, tetramethylammonium-lactobionate (TMA-LA) was applied for the first time in CE to establish dual selector system with clindamycin phosphate (CP) for enantiomeric separation...
January 21, 2019: Electrophoresis
Gaëlle Guillet, Julia L A Knapp, Sylvain Merel, Olaf A Cirpka, Peter Grathwohl, Christian Zwiener, Marc Schwientek
Interpreting the fate of wastewater contaminants in streams is difficult because their inputs vary in time and several processes synchronously affect reactive transport. We present a method to disentangle the various influences by performing a conservative-tracer test while sampling a stream section at various locations for chemical analysis of micropollutants. By comparing the outflow concentrations of contaminants with the tracer signal convoluted by the inflow time series, we estimated reaction rate coefficients and calculated the contaminant removal along a river section...
March 15, 2019: Science of the Total Environment
O D Ostroumova, A I Kochetkov
In the review, the clinical significance of increased myocardial stiffness and strain impairment in the settings of arterial hypertension is considered. The mechanisms of increasing myocardial stiffness as a part of hypertensive heart disease are presented. Particular attention is paid to the role of the sympathetic nervous system activation as one of the triggers that induce the connective tissue alteration of cardiac interstitium. The possibilities of echocardiography in the early noninvasive detection of myocardial strain abnormalities are discussed...
November 24, 2018: Kardiologiia
S R Gilyarevsky, M V Golshmid, I M Kuzmina
In this article we deal with the problem of low adherence of patients with ischemic heart disease (IHD) to drug therapy congruent to current recommendations including patients who underwent invasive interventions aimed at myocardial revascularization. Based on analysis of literature, we undertake an attempt to answer the question: which of components of this therapy patients with IHD are the least likely to continue taking? We also discuss approaches to the search for optimal composition of a combination preparation with fixed doses of an adreno-blocker and angiotensin converting enzyme inhibitor...
November 24, 2018: Kardiologiia
Charalampos Loutradis, Athanasios Bikos, Vassilios Raptis, Zoe Afkou, Georgios Tzanis, Nikolaos Pyrgidis, Stylianos Panagoutsos, Ploumis Pasadakis, Elias Balaskas, Pantelis Zebekakis, Vassilios Liakopoulos, Aikaterini Papagianni, Gianfranco Parati, Pantelis Sarafidis
Increased blood pressure (BP) variability (BPV) is associated with high cardiovascular risk in hemodialysis. Studies on the effects of antihypertensive drugs on BPV in hemodialysis are scarce. This study examines the effects of nebivolol and irbesartan on short-term BPV in patients with intradialytic hypertension. This randomized-cross-over study included 38 patients (age: 60.4 ± 11.1 years, male: 65.8%) with intradialytic hypertension (intradialytic-SBP increase ≥ 10 mmHg at ≥4 over 6 consecutive sessions)...
January 8, 2019: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Isil Ozakca
The antihypertrophic effect of nebivolol over cardioselective beta-blockers (β-blockers) is attributed to the activation of cardiac nitric oxide signaling. However, the precise role of nebivolol on hypertrophied cardiomyocytes remains unclear. In the current study, in vitro cardiomyocyte hypertrophy model was induced with isoprenaline (10μM), angiotensin II (1μM) and phenylephrine (20μM) in neonatal cardiomyocytes isolated from 0-2 days old Sprague-Dawley rats. In addition to hypertrophic agents, cardiomyocytes were treated with nebivolol (1μM), metoprolol (10μM), N(ω)-nitro-L-arginine methyl ester(L-NAME) (100μM), KT5823 (1μM), DETA-NONOate (1-10μM) and BAY412272 (10μM)...
December 27, 2018: Journal of Cardiovascular Pharmacology
Hien Ha, Annika Gonzalez
Migraines impose significant health and financial burdens. Approximately 38% of patients with episodic migraines would benefit from preventive therapy, but less than 13% take prophylactic medications. Preventive medication therapy reduces migraine frequency, severity, and headache-related distress. Preventive therapy may also improve quality of life and prevent the progression to chronic migraines. Some indications for preventive therapy include four or more headaches a month, eight or more headache days a month, debilitating headaches, and medication-overuse headaches...
January 1, 2019: American Family Physician
Takeshi Yamashita, Takanori Ikeda, Yasuhiko Akita
BACKGROUND: TY-0201 (TY) is a transdermal patch containing bisoprolol. The objectives of this study were to evaluate the noninferiority of TY to bisoprolol oral formulation (BO) in patients with persistent or permanent atrial fibrillation (AF). METHODS: In this multicenter, double-blind, comparative study, Japanese patients with persistent or permanent AF were randomized to TY 4-mg (n=55), TY 8-mg (n=55), BO 2.5-mg (n=55), or BO 5-mg (n=55) groups. All patients were administered TY 4mg or BO 2...
December 24, 2018: Journal of Cardiology
Enisa Hodžić, Adnan Durek, Edin Begić, Nirvana Šabanović Bajramović
Aim To investigate etiological link between acute myocardial infarction (AMI) and the accompanying impotence/erectile dysfunction (ED). Methods Study included 99 male patients (48 who had AMI - patient group, and 51 healthy examinees without previous cardiovascular disease - control group). All patients completed a standardized questionnaire, the International Index of Erectile Function (IIEF-5). Results Older patients had significantly lower IIEF-5 score (negative correlation) (p<0.05), but higher ED degree (significant positive correlation) (rho=0...
February 1, 2019: Medicinski Glasnik
Enisa Hodžić, Adnan Durek, Edin Begić, Nirvana Šabanović Bajramović
Aim To investigate etiological link between acute myocardial infarction (AMI) and the accompanying impotence/erectile dysfunction (ED). Methods Study included 99 male patients (48 who had AMI - patient group, and 51 healthy examinees without previous cardiovascular disease - control group). All patients completed a standardized questionnaire, the International Index of Erectile Function (IIEF-5). Results Older patients had significantly lower IIEF-5 score (negative correlation) (p<0.05), but higher ED degree (significant positive correlation) (rho=0...
February 1, 2019: Medicinski Glasnik
A Sas, M Protasiewicz, J Kurcz, M Podgórski, A Mysiak, K Nowanska, M Klinger, M Banasik
INTRODUCTION: Hypertension is prevalent in most patients after renal transplantation, and it is the main factor contributing to cardiovascular diseases that cause death of a significant number of these patients. Up to 95% of patients after transplantation have hypertension, and among them are patients with refractory hypertension. Elevated blood pressure is one of the causes of deterioration of transplant function and may accelerate transplant loss. CASE REPORT: We present the first case in the world of a patient (who was 61 years old) in whom denervation of native renal arteries was performed after renal transplantation (2004)...
December 2018: Transplantation Proceedings
John P Bourke, Gillian Watson, Francesco Muntoni, Stefan Spinty, Helen Roper, Michela Guglieri, Chris Speed, Elaine McColl, Ashish Chikermane, Sandeep Jayawant, Satish Adwani, Tracey Willis, Jennifer Wilkinson, Andrew Bryant, Thomas Chadwick, Ruth Wood, Kate Bushby
INTRODUCTION: Although cardiologists were 'late-comers' to the multidisciplinary team-contributing to the complex care of patients with Duchenne muscular dystrophy (DMD), they now recognise the importance of systematic cardiac surveillance and timely therapy to prolonged survival in patients with DMD. Empirical deployment of cardioactive medications has already improved outcomes, but the evidence base for clinical decision making is weak. Fundamental questions remain as to whether prophylactic therapy is justified and convincingly superior to prompt deployment of the same therapies once left ventricular (LV) dysfunction is detected...
December 19, 2018: BMJ Open
Stefan Momčilović, Jasmina R Milovanović, Slobodan M Janković, Andriana Jovanović, Suzana Tasić-Otašević, Dragana Stanojević, Miroslav Krstić, Sonja Šalinger-Martinović, Danijela Djordjević Radojković, Miodrag Damjanović, Milan Živković, Bojan Maričić, Goran Ranković, Aleksandar Mihajlović, Valentina N Nikolić
To date, many questions about the extent and cause of pharmacokinetic variability of even the most widely studied and prescribed β1-adrenergic receptor blockers, such as metoprolol and bisoprolol, remain unanswered. Given that there are still no published population pharmacokinetic (PopPK) analyses of bisoprolol in routinely treated patients with acute coronary syndrome (ACS), the aim of this study was to determine its PK variability in 71 Serbian patients with ACS. PopPK analysis was carried out using a non-linear mixed effects model (NONMEM), version 7...
December 10, 2018: Journal of Cardiovascular Pharmacology
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