Michael J Foley, Christopher A Rajkumar, Fiyyaz Ahmed-Jushuf, Florentina A Simader, Shayna Chotai, Rachel H Pathimagaraj, Muhammad Mohsin, Ahmed Salih, Danqi Wang, Prithvi Dixit, John R Davies, Tom R Keeble, Claudia Cosgrove, James C Spratt, Peter D O'Kane, Ranil De Silva, Jonathan M Hill, Sukhjinder S Nijjer, Sayan Sen, Ricardo Petraco, Ghada W Mikhail, Ramzi Khamis, Tushar Kotecha, Frank E Harrell, Peter Kellman, Darrel P Francis, James P Howard, Graham D Cole, Matthew J Shun-Shin, Rasha K Al-Lamee
BACKGROUND: The coronary sinus reducer (CSR) is proposed to reduce angina in patients with stable coronary artery disease by improving myocardial perfusion. We aimed to measure its efficacy, compared with placebo, on myocardial ischaemia reduction and symptom improvement. METHODS: ORBITA-COSMIC was a double-blind, randomised, placebo-controlled trial conducted at six UK hospitals. Patients aged 18 years or older with angina, stable coronary artery disease, ischaemia, and no further options for treatment were eligible...
April 4, 2024: Lancet