Valentina Angerilli, Alessandro Vanoli, Giulia Celin, Carlotta Ceccon, Jessica Gasparello, Marianna Sabbadin, Giuseppe De Lisi, Michele Paudice, Marco Vincenzo Lenti, Laura Rovedatti, Antonio Di Sabatino, Francesca Bazzocchi, Sara Lonardi, Edoardo Savarino, Claudio Luchini, Paola Parente, Federica Grillo, Luca Mastracci, Matteo Fassan
Patients with autoimmune gastritis (AIG) have a 13-fold risk of developing type-1 neuroendocrine tumors, whereas the risk for gastric adenocarcinoma is still uncertain. Here we describe the clinicopathological and molecular features of a series of gastric carcinomas (GC) arising in the context of AIG. A total of 26 AIG-associated GC specimens were collected from four Italian Institutions. Immunohistochemistry for MUC1, MUC2, MUC5AC, MUC6, CDX2, HER2, PD-L1, CLDN18, Mismatch Repair (MMR) proteins, and p53 and EBER in situ hybridization were performed...
April 6, 2024: Modern Pathology