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gastric cancer AND pathology

Jin Cheng, Caizhen Feng, Yinli Zhang, Nan Hong, Yingjiang Ye, Yi Wang
OBJECTIVE: This study aimed to investigate the 3-year progression-free survival (PFS) of patients with stage T4a gastric cancer with extramural vessel invasion (EMVI) detected with contrast-enhanced (CE) MDCT. In addition, we investigated the possibility that CT of EMVI could improve clinical nodal (N) staging. MATERIALS AND METHODS: This retrospective study included 143 patients with T4a gastric cancer. Clinical staging was performed with CE-MDCT. All patients underwent radical gastrectomy with extended lymphadenectomy, adjuvant chemotherapy, and conventional follow-up visits...
February 19, 2019: AJR. American Journal of Roentgenology
Masahiro Yura, Takaki Yoshikawa, Sho Otsuki, Yukinori Yamagata, Shinji Morita, Hitoshi Katai, Toshirou Nishida, Takaki Yoshiaki
BACKGROUND: It remains unclear whether total gastrectomy is necessary for patients with proximal T2/T3 gastric cancer. To explore the oncological safety of proximal gastrectomy for proximal T2/T3 gastric cancer, in this study, we evaluated the metastatic rates in and the therapeutic effect of dissection of key distal lymph node stations that are usually excluded in proximal gastrectomy. METHODS: In this study, we examined 202 patients seen between January 2000 and December 2012, who underwent total gastrectomy with lymph node dissection (D1/D1+/D2; 2/17/183) and was pathologically diagnosed as T2/T3 gastric cancer exclusively located in the upper third of the stomach...
February 18, 2019: Gastric Cancer
Daisuke Izumi, Feng Gao, Shusuke Toden, Fuminori Sonohara, Mitsuro Kanda, Takatsugu Ishimoto, Yasuhiro Kodera, Xin Wang, Hideo Baba, Ajay Goel
BACKGROUND: Although identification of lymph node (LN) metastasis is a well-recognized strategy for improving outcomes in patients with gastric cancer (GC), currently there is lack of availability of adequate molecular biomarkers that can identify such metastasis. Herein we have developed a robust gene-expression signature for detecting LN metastasis in early stage GC by using a transcriptome-wide biomarker discovery and subsequent validation in multiple clinical cohorts. METHODS: A total of 532 patients with pathological T1 and T2 GC from 4 different cohorts were analyzed...
February 13, 2019: EBioMedicine
Tong-Peng Xu, Pei Ma, Wen-Yu Wang, You Shuai, Yan-Fen Wang, Tao Yu, Rui Xia, Yong-Qian Shu
It was found in this study that long intergenic non-protein coding RNA 346 (LINC00346) was an lncRNA aberrantly expressed in gastric cancer (GC) based on multiple Gene Expression Omnibus (GEO) databases of GC cohorts. The LINC00346 gene was recurrently amplified and upregulated in GC, and its expression was positively correlated with poor pathologic stage, large tumor size, and poor prognosis. In addition, the oncogenic transcription factors KLF5 and MYC could bind to the LINC00346 promoter and enhance its expression...
February 15, 2019: Cell Death and Differentiation
César Ramírez-Cáceres, Estrella Uzcátegui-Paz, Ricardo Lozano-Hernández
Introduction: Peroperative treatment has required multimodal protocols that stimulate patient evolution and shorten hospital stay. Objective: Identify the type of pathology, intervention performed and evaluate the effectiveness of the Rapid Postoperative Improvement Protocol (RAMPO) in patients undergoing elective gastrointestinal surgery. Method: A total of 122 patients were evaluated, a group of 61 patients received the RAMPO protocol and the other group of equal number of patients were treated with traditional protocols (Controls)...
2019: Cirugia y Cirujanos
Toshiki Noma, Tsuyoshi Takahashi, Yasuhiro Miyazaki, Yukinori Kurokawa, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Makoto Yamasaki, Masaki Mori, Yuichiro Doki
A 46-year-old male patient with anorexia consulted our hospital. A scirrhous gastric cancer was found, and he was introduced to us. Laparoscopic examination was performed, and advanced peritoneal disseminated nodules were confirmed(CY1, P1). S-1 plus docetaxel therapy was introduced as first-line chemotherapy. Although the best effect judgment was PR, the primary lesion re-increased in size. We changed to the secondary weekly paclitaxel therapy. After 7 courses of the therapy, a second laparoscopic examination was performed, which confirmed the microscopic residual cancer cells(P1)in the reduced peritoneal nodules...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Hiroki Kudo, Yasuji Seyama, Hiroyuki Kanomata, Masamichi Takahashi, Tachen Chang, Yujiro Matsuoka, Tomoyo Machida, Yohei Furumoto, Masahiro Warabi, Tooru Tanizawa, Ikuo Wada, Tsuyoshi Maeshiro, Sachio Miyamoto, Nobutaka Umekita
A 72-year-old man with general fatigue was referred, and CT and MRI revealed a pancreatic mass with necrosis that was suspected of invading the stomach, splenic artery, celiac artery, liver, and portal vein. Upper gastrointestinal endoscopy showed an extrinsic mass with ulcer formation in the posterior wall of the upper gastric corpus and irregular mucosa in the lower esophagus incidentally. Biopsy showed squamous cell carcinoma from both lesions, leading to the diagnosis of pancreatic adenosquamous carcinoma and early esophageal cancer...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Makoto Nakai, Yutaro Hara, Shinnosuke Yonaiyama, Hiroyuki Jin, Tomohisa Tokura, Kazunori Aoki, Hiroaki Kawashima, Yoshikazu Toyoki, Masaaki Endo
A 65-year-old man was hospitalized for gastric cancer. Abdominal computed tomography detected lower gastric cancer and invasion of the liver. Initial laboratory data showed high levels of serum AFP(2,688.6 ng/mL). He underwent distal gastrectomy with left lobectomy of the liver and cholecystectomy. Histology confirmed that the tumor consisted of 2 components: primary gastric choriocarcinoma and AFP-producing carcinoma. The pathological staging was pT4b(liver), N3aM0, Stage ⅢC. After surgery, AFP levels decreased to within the normal limits...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Megumi Watanabe, Takayoshi Miyake, Yu Mikane, Ryohei Syoji, Yoshinori Kajiwara, Katsuyuki Aoyama, Tomohiro Nogami, Hitoshi Nishikawa, Susumu Shinoura, Kaori Shigemitsu, Yasuyuki Nonaka, Dofu Hayashi
The patient was a 59-year-old man with type 2 advanced gastric cancer in the antrum. Abdominal computed tomography revealed the primary tumor with regional lymph node metastasis. Distal gastrectomy and D2 lymph node dissection were performed. Histopathological findings indicated gastric small cell carcinoma. Lymph node metastasis was observed microscopically in the #6 lymph nodes. Peritoneal lavage cytology was positive. The pathologic stage of the disease was pT2(MP), med, INF b, ly2, v2, pPM0, pDM0, pN2(6/33: #5, #6), M1, P0, CY1, H0, stage Ⅳ, R1(cy+)...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Takashi Takenoya, Nobushige Yabe, Shiho Morishige, Eri Tamura, Yuri Sakimoto, Yuki Tajima, Ippei Oto, Takahisa Yoshikawa, Koji Osumi, Shinji Murai
A man in the 60s visited our hospital with the complaints of epigastralgia and weight loss. Following an investigation, he was diagnosed with human epidermal growth factor receptor 2(HER2)-positive gastric cancer with invasion to the pancreas (T4b[pancreas], N2, M0, Stage ⅣA[Union for International Cancer Control 8th edition]). Preoperatively, he was administered a chemotherapeutic regimen of S-1 and cisplatin plus trastuzumab. After 2 courses of chemotherapy, computed tomography revealed invasion to the abdominal wall and pyloric stenosis; however, invasion to the pancreas was obscured, and the lymph node metastases had shrunk...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yutaka Hattori, Masaya Nakauchi, Yasuhiro Tsuru, Sayaka Amano, Ai Goto, Makoto Tomatsu, Kenichi Nakamura, Kenji Kikuchi, Shinichi Kadoya, Kazuki Inaba, Yutaro Kato, Tsunekazu Hanai, Atsushi Sugioka, Ichiro Uyama
This case involved a 69-year-old female patient with peritoneal dissemination of an advanced gastric cancer. She underwent chemotherapy comprisingintravenous and intraperitoneal paclitaxel combined with S-1. After 20 courses, a staging laparoscopy was performed, and pathological analysis of the peritoneal dissemination and cytologic analysis of ascites fluid yielded negative results. A radical robot-assisted total gastrectomy was successfully performed. The pathological stage was determined to be ypT4aN2M0, ypStage ⅢB...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Koki Tamai, Chikara Ebisui, Noriyuki Yamamura, Takayuki Minoji, Hiroyuki Takabatake, Tomohiro Kitahara, Noriyuki Watanabe, Shu Okamura, Nariaki Fukuchi, Hideoki Yokouchi, Masakatsu Kinuta, Kazuhito Ohishi
A 78-year-oldwoman was referredfor exertional dyspnea. Severe anemia(Hb 4.2 g/dL)was detected, and upper endoscopy revealeda giant ulcer at the posterior wall of the gastric body. Computedtomography showeda mass protruding from the gastric wall, suggestive of a submucosal tumor. Although biopsy did not confirm a diagnosis, we performed distal gastrectomy to control the bleeding. The pathological findings and systemic examination confirmed a diagnosis of extramedullary plasmacytoma of the stomach. Plasmacytoma is a tumor of the bone marrow derived from plasma cells that mature from B cells...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Chikara Ebisui, Noriyuki Yamamura, Takayuki Minoji, Hiroyuki Takabatake, Koki Tamai, Tomohiro Kitahara, Noriyuki Watanabe, Shu Okamura, Nariaki Fukuchi, Hideoki Yokouchi, Masakatsu Kinuta, Kazuhito Ohishi
An 82-year-oldwoman was admittedto our hospital because of appetite loss andwas diagnosedwith a Type 3 tumor in the lower gastric body. Pathological examination suggested moderately differentiated adenocarcinoma with negative staining for HER2 by immunohistochemistry. An abdominal CT revealedthickening of the gastric wall andparaaortic lymph node metastases. The clinical findings suggested Stage Ⅳ disease(T4aN3M1). Chemotherapy was administered with a combination of S-1 plus oxaliplatin(SOX). After 2 courses of the SOX regimen, an abdominal CT showed a reduction of the paraaor- tic lymph node metastases, and the CEA level hadd ecreasedto 6...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Kojiro Ono, Takuo Takehana, Kazuhiro Yamamoto, Shunsuke Kawai, Michitaka Nagase
A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Contrast computed tomography(CT)showed upper gastric wall thickening, and #1, #3, #7, #8a, and #11p enlarged lymph nodes but no distant metastasis. We diagnosed gastric cancer, UM, Less, Type 3, gastric neuroendocrine carcinoma, cT4aN3M0P0CY0, Stage ⅢC...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Katsuya Gunjigake, Koichi Okamoto, Ryosuke Gabata, Takahisa Yamaguchi, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
Docetaxel, cisplatin, and 5-FU(DCF)chemotherapy for esophageal cancer has been reported to be highly effective, but often causes serious adverse events, including severe bone marrow suppression. We report the successful treatment of a 67- year-old man with highly advanced esophageal cancer with invasion of the left bronchus and broad lymph node metastases. He received induction chemotherapy with DCF therapy, and prophylactic administration of pegfilgrastim. He safely completed 5 courses of DCF therapy without serious adverse events, such as neutropenia and febrile neutropenia...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
S Peri, A Biagioni, F Cianchi, I Skalamera, F Staderini, N Schiavone, L Papucci, L Magnelli
No abstract text is available yet for this article.
July 2018: Journal of Biological Regulators and Homeostatic Agents
Matthew Mah, Lloyd A Mack, Scott Hurton, Antoine Bouchard-Fortier
BACKGROUND: Cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) are commonly used in the treatment of peritoneal carcinomatosis (PC) originating from colorectal, appendiceal and ovarian cancers. It is unclear what benefit CRS/HIPEC might have for PC from uncommon etiologies, therefore we sought to describe local practice patterns and evaluate overall survival (OS). METHODS: All patients who had CRS/HIPEC between 2000 and 2016 were identified using our institutional cancer database...
January 25, 2019: American Journal of Surgery
Makoto Takahashi, Hideyuki Yoshitomi, Atsushi Kato, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Kensuke Sugiura, Keishi Kawasaki, Masaru Miyazaki, Masayuki Ohtsuka
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) readily metastasizes to the lymph nodes, liver, lung, and peritoneum; however, gastric and gallbladder metastases are rare. We report a case of metachronous gastric and gallbladder metastases from PDAC. CASE PRESENTATION: The patient is a 71-year-old man who underwent distal pancreatectomy for PDAC. Seventeen months after the surgery, a 30-mm nodule was detected at the lesser curvature of the stomach, which was diagnosed as recurrence of PDAC in the lymph nodes...
February 13, 2019: Surgical Case Reports
Hiroki Tanabe, Katsuyoshi Ando, Daisuke Sutoh, Katsuhisa Ohta, Hironori Ohdaira, Yutaka Suzuki, Mikihiro Fujiya, Toshikatsu Okumura
Endoscopic ultrasound-guided sampling is indicated to achieve an accurate diagnosis of subepithelial lesions of the stomach when a standard biopsy fails. Gastric carcinoma with lymphoid stroma (GCLS) is located under the epithelial layer with dense lymphocytic infiltration, making a pathological diagnosis by a biopsy difficult. We herein report a case of the pathological diagnosis of GCLS using an endoscopic ultrasound-guided fine-needle biopsy. The patient underwent distal gastrectomy and was diagnosed with Epstein-Barr virus-negative cancer...
February 12, 2019: Journal of Clinical Ultrasound: JCU
Xiangbo Chen, Yisen Huang, Yubin Wang, Qiuli Wu, Shunzhong Hong, Zicheng Huang
Gastric cancer (GC), a common and lethal cancer in the world, has a high risk of metastasis. Our study was to explore the effects of THBS4 on GC progress and metastasis and the underlying mechanisms. The proliferations of MGC-803 and BGC-823 cells were analyzed via cell count, MTT, and soft agar colony formation assay. The migration and invasion of transfected GC cells was investigated via transwell migration and invasion assay. The mRNA abundance of THBS4 and KLF9 was detected by quantitative real-time PCR (qPCR)...
February 12, 2019: Journal of Physiology and Biochemistry
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