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Piotr Jasielski, Zbigniew Czernicki, Piotr Dąbrowski, Waldemar Koszewski, Rafał Rojkowski
BACKGROUND: Decompressive craniectomy (DC) is a common neurosurgical procedure involving the removal of part of the skull vault combined with subsequent duroplasty. The goal of DC is to produce extra space for the swollen brain and/or to reduce intracranial pressure. In the present study, DC was performed in order to create space for the swollen brain. AIM OF THE STUDY: to compare the volume alteration of selected intracranial fluid spaces before and after DC, to evaluate the volume of post-decompressive brain displacement (PDBD) and the largest dimension of oval craniectomy (LDOC), and to assess the early clinical effects of DC...
February 11, 2019: Neurologia i Neurochirurgia Polska
Yang-Yang Sun, Xiao-Li Zhou, Wei Gao, Yu-Qing Cheng
OBJECTIVE: To investigate the clinicopathological and immunohistochemical features as well as diagnosis, differential diagnosis,treatment and prognosis of patients with primary renal non-hodgkin's lymphoma (PRNHL). METHODS: Clinical data of 2 patients with PRNHL from January 2013 to October 2017 were retrospectively analyzed. RESULTS: One of the two male patients PRNHL aged 51 years old, admitted to hospital for swelling and pain in the right waist, B-ultra sonic examination showed a very solid upper right renal space occupying lesion...
February 2019: Zhongguo Shi Yan Xue Ye Xue za Zhi
Ying-Ying Wang, Yan-Ning Lyu, Hong-Yi Xin, Jun-Ting Cheng, Xiao-Qin Liu, Xian-Wang Wang, Xiao-Chun Peng, Ying Xiang, Victoria W Xin, Cheng-Biao Lu, Bo-Xu Ren, Yan-Fang Liang, Jia-Fu Ji, Zhaowu Ma, Shu-Zhong Cui, Hong-Wu Xin
An oncolytic herpes simplex virus (oHSV) has proven amenable in oncolytic virotherapy and was approved to treat melanoma. The immediate-early (IE) protein ICP27 encoded by gene UL54 is essential for HSV infection. Post-transcriptional modification of UL54 would increase tumor targeting of oHSVs. However, UL54 gene transcription regulatory sequences and factors were not reported yet. Here we isolated a new strain LXMW of type 1 HSV (HSV-1-LXMW) in China and found it's closely related to HSV-1 strains Patton and H129 in the US by the first and next generation DNA sequencing viral DNA phylogenetic analysis...
2019: Journal of Cancer
Ademar Takahama, Heliton Gustavo de Lima, Fabio Augusto Ito, Alfredo Ribeiro-Silva, Jorge Esquiche Leon
Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is characterized by cutaneous and/or mucosal ulcers in patients receiving immunosuppressive medication or with age-related immunosenescence. Its microscopic appearance often leads to a diagnostic challenge, sometimes mimicking an overt lymphoma. A 47-year-old woman, with a previous diagnosis of systemic lupus erythematosus, was referred for evaluation of a gingival ulcer, present for about 2 months and located in the maxillary gingiva around implants, resembling peri-implantitis...
January 5, 2019: Journal of Oral and Maxillofacial Surgery
Tami J Kingsbury, MinJung Kim, Curt I Civin
The PAX-SIX-EYA-DACH network (PSEDN) is a central developmental transcriptional regulatory network from Drosophila to humans. The PSEDN is comprised of four conserved protein families; including paired box (PAX), sine oculis (SIX), eyes absent (EYA), and dachshund (DACH). Aberrant expression of PSEDN members, particularly SIX1, has been observed in multiple human cancers, where SIX1 expression correlates with increased aggressiveness and poor prognosis. In conjunction with its transcriptional activator EYA, the SIX1 transcription factor increases cancer stem cell (CSC) numbers and induces epithelial-mesenchymal transition (EMT)...
2019: Advances in Cancer Research
Sita S Withers, Daniel York, Jin W Choi, Kevin D Woolard, Renee Laufer-Amorim, Ellen E Sparger, Jenna H Burton, Stephen J McSorley, Arta M Monjazeb, William J Murphy, Robert J Canter, Robert B Rebhun
Our lack of understanding of the immune microenvironment in canine osteosarcoma (cOSA) has limited the identification of potential immunotherapeutic targets. In particular, our ability to utilize readily available tissue from a dog's primary tumor to predict the type and extent of immune response in their pulmonary metastatic lesions is unknown. We therefore collected 21 matched pairs of primary tumors and pulmonary metastatic lesions from dogs with OSA and performed immunohistochemistry to quantify T lymphocyte (CD3), FOXP3+ cell, B lymphocyte (Pax-5), and CD204+ macrophage infiltration...
January 25, 2019: Veterinary and Comparative Oncology
Xianhuo Wang, Tingting Zhang, Zheng Song, Linyu Li, Xuhan Zhang, Jing Liu, Xianming Liu, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Lixia Feng, Ge Hu, Bin Meng, Qiongli Zhai, Xiubao Ren, Kai Fu, Lanfang Li, Ping Wang, Huilai Zhang
Novel immune checkpoint blockades, including those targeting CD73 and A2aR, are being evaluated in malignancies in clinical trials. Here, we investigated the expression of CD73 and A2aR as well as tumor-infiltrating lymphocytes (TILs), and analyzed their correlations with clinicopathological characteristics and survival in diffuse large B-cell lymphoma (DLBCL). We found that CD73 expression on tumor cells, rather than the total protein and gene levels of CD73, was associated with survival. Patients with CD73+ /Pax-5+ (median survival, 57...
January 21, 2019: International Journal of Cancer. Journal International du Cancer
Xiaofei Zhang, Minghua Yu
No abstract text is available yet for this article.
January 10, 2019: Annals of Diagnostic Pathology
Fangyuan Liu, Ling Wang, Jia-Ling Fu, Yuan Xiao, Xiaodong Gong, Yunfei Liu, Qian Nie, Jia-Wen Xiang, Lan Yang, Zhigang Chen, Yizhi Liu, David Wan-Cheng Li
Pax-6 is a master regulator for eye and brain development. Previous studies including ours have shown that Pax-6 exists in 4 major isoforms. According to their sizes, they are named p48, p46, p43 and p32 with the corresponding molecular weight of 48, 46, 43 and 32 kd, respectively. While p48 and p46 is derived from alternative splicing, p32 Pax-6 is generated through an internal translation initiation site. As for 43 kd Pax-6, two resources have been reported. In bird, it was found that an alternative splicing can generate a p43 Pax-6...
January 11, 2019: Current Molecular Medicine
Leah Stein, Cynthia Bacmeister, Kris Ylaya, Patricia Fetsch, Zengfeng Wang, Stephen M Hewitt, Matti Kiupel
Marginal zone lymphoma (MZL) and mantle cell lymphoma (MCL) belong to a subgroup of indolent B-cell lymphomas most commonly reported in the canine spleen. The goal of this study was to characterize the immunophenotype of splenic MZL and MCL in comparison to their human counterparts. Ten MCLs and 28 MZLs were selected based on morphology. A tissue microarray was generated, and expression of CD3, CD5, CD10, CD45, CD20, CD79a, Pax-5, Bcl-2, Bcl-6, cyclin D1, cyclin D3, MCL-1, MUM-1, and Sox-11 was evaluated. Neoplastic cells in all MCLs and MZLs were positive for CD5, CD20, CD45, CD79a, and BCL2 and negative for CD3, CD10, Bcl-6, cyclin D1, and cyclin D3...
January 13, 2019: Veterinary Pathology
Chao Fang, Sai-Ying Wang, Yu-Ligh Liou, Ming-Hua Chen, Wen Ouyang, Kai-Ming Duan
BACKGROUND: Paired-box gene 1 (PAX1), a member of the PAX family, plays a role in pattern formation during embryogenesis, and might be essential for development of the vertebral column. METHODS: PAX1 is silenced by methylation in several cancers and is considered a tumor suppressor gene. Our previous studies reported PAX1 as hypermethylated in cervical cancer tissues, thereby suggesting it as a potential screening marker. Recently, an increasing number of studies have confirmed PAX1 methylation as a promising biomarker in cervical cancer based on its excellent discriminatory ability between high-grade cervical lesions and normal tissues, resulting in a reduced necessity for referral for colposcopy and biopsy...
January 12, 2019: Molecular Genetics & Genomic Medicine
Yaling Feng, Jianxia Wang, Yue He, Heng Zhang, Minhui Jiang, Dandan Cao, Aiping Wang
This study aimed to unravel the molecular basis underlying PAX3 down-regulation, known to be involved in preeclampsia (PE) occurrence and development. Data obtained from databases suggested that Pax 3 methylation levels in the promoter region are high in the placentas of PE patients. However, the expression of methylation-adjusting enzymes, including DNMT1, LSD1, and EZH2, did not change. Since lncRNAs enhance the function of methylation-related enzymes independently of expression, we selected three lncRNAs, RP11-269F21...
January 9, 2019: Bioscience Reports
Ursula Moore, Marni Jacobs, Meredith K James, Anna G Mayhew, Roberto Fernandez-Torron, Jia Feng, Avital Cnaan, Michelle Eagle, Karen Bettinson, Laura E Rufibach, Robert Muni Lofra, Andrew M Blamire, Pierre G Carlier, Plavi Mittal, Linda Pax Lowes, Lindsay Alfano, Kristy Rose, Tina Duong, Katherine M Berry, Elena Montiel-Morillo, Irene Pedrosa-Hernández, Scott Holsten, Mohammed Sanjak, Ai Ashida, Chikako Sakamoto, Takayuki Tateishi, Hiroyuki Yajima, Aurélie Canal, Gwenn Ollivier, Valerie Decostre, Juan Bosco Mendez, Nieves Sánchez-Aguilera Praxedes, Simone Thiele, Catherine Siener, Jeanine Shierbecker, Julaine M Florence, Bruno Vandevelde, Brittney DeWolf, Meghan Hutchence, Richard Gee, Juliana Prügel, Elke Maron, Heather Hilsden, Hanns Lochmüller, Ulrike Grieben, Simone Spuler, Carolina Tesi Rocha, John W Day, Kristi J Jones, Diana X Bharucha-Goebel, Emmanuelle Salort-Campana, Matthew Harms, Alan Pestronk, Sabine Krause, Olivia Schreiber-Katz, Maggie C Walter, Carmen Paradas, Jean-Yves Hogrel, Tanya Stojkovic, Shin'ichi Takeda, Madoka Mori-Yoshimura, Elena Bravver, Susan Sparks, Jordi Díaz-Manera, Luca Bello, Claudio Semplicini, Elena Pegoraro, Jerry R Mendell, Kate Bushby, Volker Straub
OBJECTIVE: To assess the ability of functional measures to detect disease progression in dysferlinopathy over 6 months and 1 year. METHODS: One hundred ninety-three patients with dysferlinopathy were recruited to the Jain Foundation's International Clinical Outcome Study for Dysferlinopathy. Baseline, 6-month, and 1-year assessments included adapted North Star Ambulatory Assessment (a-NSAA), Motor Function Measure (MFM-20), timed function tests, 6-minute walk test (6MWT), Brooke scale, Jebsen test, manual muscle testing, and hand-held dynamometry...
January 9, 2019: Neurology
Michelle Petri, Wei Fu, Ann Ranger, Norm Allaire, Patrick Cullen, Laurence S Magder, Yuji Zhang
BACKGROUND: We assessed the stability of BAFF, interferon, plasma cell and LDG neutrophil gene expression signatures over time, and whether changes in expression coincided with changes in SLE disease activity. METHODS: Two hundred forty-three patients with SLE were evaluated for disease activity, serological parameters and peripheral blood gene signatures in clinic visits (2 or more per patient) that occurred between 2009 and 2012. Levels of the BAFF gene transcript, plasma cell signature, Interferon (IFN) signature and the low density granulocytes (LDG)-associated neutrophil gene signature were assessed in PAX-gene-preserved peripheral blood by global microarray...
January 9, 2019: BMC Medical Genomics
Pei Zhang, Mick Rose, Lukas Van Zwieten
Background: Although glyphosate is widely used in agriculture, information on its residue level in soils remains scarce partly because of the difficulty in its analysis. Objective: Develop and validate a method to directly analyze glyphosate and its metabolite aminomethylphosphonic acid (AMPA) in soil. Method: Soils were extracted with 0.6 M KOH solution, and coextracted interferences were removed using a mixed-mode Bond Elut Plexa PAX® . The extracts were analyzed by LC-tandem MS fitted with a Hypercarb column and isotope-labeled (13 C,15 N) glyphosate and AMPA were used as internal standards...
January 7, 2019: Journal of AOAC International
Lauren J Maskell, Anupam V Mahadeo, Vishwanie S Budhram-Mahadeo
The development of drug resistance following treatment with chemotherapeutic agents such as cisplatin (cis) and paclitaxel (pax) contributes to high morbidity and mortality in ovarian cancers. However, the molecular mechanisms underlying such changes are not well understood. In this study, we demonstrate that the Brn-3b transcription factor was increased in different ovarian cancer cells including SKOV3 and A2780 following treatment with cis and pax. Furthermore, sustained increases in Brn-3b were associated with survival in drug resistant cells and correlated with elevated HSP27 expression...
December 4, 2018: Oncotarget
Jason Harquail, Nicolas LeBlanc, Rodney J Ouellette, Gilles A Robichaud
Recent studies have enabled the identification of important factors regulating cancer progression, such as Pax-5. This transcription factor has consistently been associated to B cell cancer lesions and more recently solid tumors including breast carcinoma. Although Pax-5 downstream activity is relatively well characterized, aberrant Pax-5 expression in a cancer specific context is poorly understood. To investigate the regulation of Pax-5 expression, we turned to micro-RNAs (miRNAs), small non-coding RNA molecules that regulate key biological processes...
January 3, 2019: Carcinogenesis
Danieli Moura Brasil, Ruben Pauwels, Wim Coucke, Francisco Haiter-Neto, Reinhilde Jacobs
METHODS: Clinical (CL) and quantitative (QUANT) evaluations of image quality were performed using an anthropomorphic phantom. Technical (TECH) evaluation was performed with a polymethyl methacrylate phantom. Images were obtained using a PaX-i3D Green CBCT (Vatech, Hwaseong, Korea) device, with a large 21 × 19  and a medium 12 × 9  cm field of view (FOV), and high-dose (HD-ranging from 85 to 110 kV) and low-dose (LD-ranging from 75 to 95 kV) protocols, totalling four groups (21 × 19  cm HD, 21 × 19  cm LD, 12 × 9  cm HD, 12 × 9  cm LD)...
January 3, 2019: Dento Maxillo Facial Radiology
Man-Li Tang, Xiang-Jun Bai, Yong Li, Xiao-Jing Dai, Fan Yang
Osteosarcoma is the most common primary malignant bone tumor in childhood, and it maintains a high level of recurrence. Matrix metalloproteinase-1 (MMP-1) was found to contribute to cancer progression. The present study was to investigate the in vitro effects of MMP-1 over-expression on the proliferation, invasion, metastasis and stem-like properties of osteosarcoma MG-63 cells. The MG-63 cells were cultured and had a full length MMP-1 cDNA inserted by the lentiviral vector (MG-63MMP-1+ ). MG-63 negative control and MG-63 blank control groups were established as well...
October 2018: Current medical science
Muhammad Rahil Khan, Arsalan Ahmad, Naila Kayani, Khurram Minhas
Background: B-cell malignancies including Precursor B-cell lymphoblastic lymphoma/leukemia and Hodgkin Lymphoma show a wide spectrum of B-cell differentiation from early stage B-cell precursors to mature B-cells ending in terminal differentiation to plasma cells. Pan-B-cell antigens routinely used for the diagnosis of B-cell lymphoma, include CD19, CD20, CD22 and CD79a.PAX-5 protein, also known as B-cell-specific activation protein is a B-cell-specific transcription factor; essential for commitment and functional maintenance used in the diagnosis of B cell Hodgkin and non-Hodgkin lymphoma...
December 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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