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Preterm AND NICU

Cathrine Fowler, Janet Green, Doug Elliott, Julia Petty, Lisa Whiting
AIMS: To explore the experiences of mothers of extremely premature babies during their Neonatal Intensive Care Unit stay and transition home. BACKGROUND: Mothers of extremely preterm infants (28-weeks-or-less gestation) experience a continuum of regular and repeated stressful and traumatic events; during the perinatal period, while the Neonatal Intensive Care Unit, and during transition home. METHOD: An interpretive description method guided this study...
February 20, 2019: Journal of Clinical Nursing
Karen Luyt, Sally Jary, Charlotte Lea, Grace J Young, David Odd, Helen Miller, Grazyna Kmita, Cathy Williams, Peter S Blair, Aída Moure Fernández, William Hollingworth, Michelle Morgan, Adam Smith-Collins, N Jade Thai, Steven Walker-Cox, Kristian Aquilina, Ian Pople, Andrew Whitelaw
BACKGROUND: The drainage, irrigation and fibrinolytic therapy (DRIFT) trial, conducted in 2003-6, showed a reduced rate of death or severe disability at 2 years in the DRIFT compared with the standard treatment group, among preterm infants with intraventricular haemorrhage (IVH) and post-haemorrhagic ventricular dilatation. OBJECTIVES: To compare cognitive function, visual and sensorimotor ability, emotional well-being, use of specialist health/rehabilitative and educational services, neuroimaging, and economic costs and benefits at school age...
February 2019: Health Technology Assessment: HTA
Andrea Sucasas Alonso, Alejandro Avila-Alvarez, Marina Combarro Eiriz, Cristina Martínez Roca, Pedro Yáñez Gómez, Alejandra Codias López, Jose Luis Fernández Trisac, Sonia Pértega Díaz
OBJECTIVE: To evaluate the prevalence of non-approved prescriptions (off-label and unlicensed) in a Neonatal Intensive Care Unit (NICU), and to describe factors of the neonate associated with its use. MATERIALS AND METHODS: Observational prospective study in a level III NICU during a 6-month period. Every prescription was analysed using the summary of product characteristics as a reference. A sequential algorithm was used to create a classification of prescriptions based on current status: approved, unlicensed, off-label (by age, route of administration, dosage, or indication)...
February 13, 2019: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Katja Schneider, Boris Metze, Christoph Bührer, Marina Cuttini, Lars Garten
OBJECTIVE: To assess changes in attitudes of neonatologists regarding the care of extremely preterm infants and parental involvement over the last 20 years. STUDY DESIGN: Internet-based survey (2016) involving 170 tertiary neonatal intensive care units in Austria, Switzerland, and Germany using the European Project on Parents' Information and Ethical Decision Making in Neonatal Intensive Care Units questionnaire (German edition) with minor modifications to the original survey from 1996 to 1997...
February 13, 2019: Journal of Pediatrics
Elizabeth Enlow, Megan M Gray, Sara Wallace-Keeshen, Jo Ann D'Agostino, Soraya Abbasi, Scott A Lorch
OBJECTIVE: To determine the prevalence of limited health literacy in parents of infants born ≤32 and 0/7 weeks and if health literacy changes during hospitalization. STUDY DESIGN: Multi-site, prospective cohort study measuring health literacy using the Parent Health Literacy Activities Test, which estimates caregivers' ability to complete tasks such as reading prescription labels and preparing bottles. Data were analyzed using parametric and nonparametric comparison tests and multivariable regression to control for confounders...
February 15, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
Matthew R Olm, Patrick T West, Brandon Brooks, Brian A Firek, Robyn Baker, Michael J Morowitz, Jillian F Banfield
BACKGROUND: Fungal infections are a significant cause of mortality and morbidity in hospitalized preterm infants, yet little is known about eukaryotic colonization of infants and of the neonatal intensive care unit as a possible source of colonizing strains. This is partly because microbiome studies often utilize bacterial 16S rRNA marker gene sequencing, a technique that is blind to eukaryotic organisms. Knowledge gaps exist regarding the phylogeny and microdiversity of eukaryotes that colonize hospitalized infants, as well as potential reservoirs of eukaryotes in the hospital room built environment...
February 15, 2019: Microbiome
Emily D Gerstein, Wanjiku F M Njoroge, Rachel A Paul, Christopher D Smyser, Cynthia E Rogers
OBJECTIVE: Previous studies suggest that maternal postpartum mental health issues may impact parenting and child development in preterm infants, but have often not measured symptomatology in the Neonatal Intensive Care Unit (NICU) nor followed families through early childhood. This study examines how maternal depressive symptoms and stress in the NICU are related to parenting behaviors at age 5 years, in mothers of children born very preterm (≤30 weeks gestation). METHOD: This longitudinal study followed a diverse sample of 74 very preterm children and their mothers...
January 3, 2019: Journal of the American Academy of Child and Adolescent Psychiatry
Nuran Ustun, Nilnur Eyerci, Nilgun Karadag, Ahmet Yesilyurt, Aysegul Zenciroglu, Nurullah Okumus
BACKGROUND: Vitamin D and its receptor (VDR) have important roles in perinatal lung development. The objective of this study was to investigate the possible association between VDR FokI and TaqI polymorphism and development of respiratory distress syndrome (RDS) in preterm infants. METHOD: A total of 173 premature infants < 34 weeks: 82 with RDS and 91 without RDS were enrolled. Genotyping of VDR polymorphisms were assayed by real-time PCR. Serum 25-hydroxyvitamin D (25-OHD) levels were measured by ELISA in blood samples that were obtained at the time of admission to the neonatal intensive care unit...
February 13, 2019: Journal of Maternal-fetal & Neonatal Medicine
Aurélie Maiguy-Foinard, Bertrand Décaudin, Pierre Tourneux, Bernard Guillois, Thierry Blanc, Sophie Galène-Gromez, Morgane Masse, Pascal Odou, Fannette Denies, Benoît Dervaux, Alain Duhamel, Laurent Storme
BACKGROUND: Catheter-related bacteremia (CRB) is the most frequent nosocomial infection in neonatal intensive care unit (NICU) patients, especially in very low-birth-weight infants. Administration of injectable drugs in premature newborn infants has many particularities and several types of infusion incidents have been reported. The Edelvaiss® Multiline NEO device is a novel multi-lumen access infusion device adapted to the specificities of infusion in neonatology. This multicenter, randomized, controlled study was therefore designed to determine whether or not Edelvaiss® Multiline NEO reduces the risk of CRB in preterm newborn infants in an NICU...
February 11, 2019: Trials
Carlo Pietrasanta, Lorenza Pugni, Daniela Merlo, Barbara Acaia, Dario Consonni, Andrea Ronchi, Manuela Wally Ossola, Beatrice Ghirardi, Ilaria Bottino, Fulvia Milena Cribiù, Silvano Bosari, Fabio Mosca
OBJECTIVE: To investigate the impact of different stages of intrauterine inflammation (IUI) on neonatal outcomes, before and after adjusting for gestational age (GA) and other perinatal confounders. METHODS: This was an observational, prospective, single-center cohort study including all eligible neonates with GA < 35 weeks and/or birth weight ≤ 1500 g born at a 3rd level Neonatal Intensive Care Unit between 2011 and 2014. Pathological patterns of placenta, membranes and cord were classified according to Redline's criteria...
2019: PloS One
Catrin Månsson, Bengt Sivberg, Bo Selander, Pia Lundqvist
AIM: To evaluate the impact on parental stress of an individualised neonatal parent support programme. METHOD: A quasi-experimental design. Parents of preterm infants, at a level II NICU, were consecutively assigned to a control group (n = 130) and to an intervention group (n = 101). The programme focused on person-centred communication and consisted of four individual nurse-parent dialogues during the infants' hospitalisation. The Swedish version of the Parental Stressor Scale: Neonatal Intensive Care Unit was used to assess parental stress...
February 8, 2019: Scandinavian Journal of Caring Sciences
Balaji Govindaswami, Matthew Nudelman, Sudha Rani Narasimhan, Angela Huang, Sonya Misra, Gilbert Urquidez, Alganesh Kifle, Monica Stemmle, Cathy Angell, Rupalee Patel, Christina Anderson, Dongli Song, Glenn DeSandre, James Byrne, Priya Jegatheesan
Introduction: Avoiding intubation and promoting noninvasive modes of ventilator support including continuous positive airway pressure (CPAP) in preterm infants minimizes lung injury and optimizes neonatal outcomes. Discharge home on oxygen is an expensive morbidity in very preterm infants (VPI) with lung disease. In 2007 a standardized bundle was introduced for VPI admitted to the neonatal care unit (NICU) which included delayed cord clamping (DCC) at birth and noninvasive ventilation as first-line cardiorespiratory support in the delivery room (DR), followed by bubble CPAP upon NICU admission...
2019: BioMed Research International
Phyllis A Dennery, Juliann M Di Fiore, Namasivayam Ambalavanan, Eduardo Bancalari, John L Carroll, Nelson Claure, Aaron Hamvas, Anna Maria Hibbs, Premananda Indic, James Kemp, Katy N Krahn, Douglas Lake, Aaron Laposky, Richard J Martin, Aruna Natarajan, Casey Rand, Molly Schau, Debra E Weese-Mayer, Amanda M Zimmet, J Randall Moorman
BACKGROUND: The increasing incidence of bronchopulmonary dysplasia in premature babies may be due in part to immature ventilatory control, contributing to hypoxemia. The latter responds to ventilation and/or oxygen therapy, treatments associated with adverse sequelae. This is an overview of the Prematurity-Related Ventilatory Control Study which aims to analyze the under-utilized cardiorespiratory continuous waveform monitoring data to delineate mechanisms of immature ventilatory control in preterm infants and identify predictive markers...
February 1, 2019: Pediatric Research
Suchitra Rao, Musheng Alishahi, Lauren De Crescenzo, Amanda F Dempsey
INTRODUCTION: Influenza causes significant morbidity among young children, and vaccination remains the best strategy to prevent disease. Understanding factors influencing early influenza vaccination uptake are important to identify strategies to increase vaccination rates. OBJECTIVE: To assess maternal and neonatal factors associated with influenza vaccination among first-born children within the first two years of life. METHODS: We conducted a retrospective population-based cohort study linking Colorado Birth Registry data and state immunization data of all live births between 2008 and 2016...
February 2, 2019: Vaccine
Brenda S Lessen Knoll, Tipawan Daramas, Victoria Drake
OBJECTIVE: To evaluate the effect of the Premature Infant Oral Motor Intervention (PIOMI) on preterm newborns' feeding efficiency and rates of improvement across Days 1, 3, and 5 of oral feeding in a Thai NICU. DESIGN: Randomized controlled trial. SETTING: A 20-bed special neonatal ward and 8-bed NICU in urban Thailand. PARTICIPANTS: Stable newborns (N = 30) born between 26 and 34 weeks postmenstrual age (PMA) without comorbidities...
February 2, 2019: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Sae Lin Oh, Tae Yeon Jeon, So-Young Yoo, Se In Sung, Hye Won Kim, Yun Sil Chang, Won Soon Park, Ji Hye Kim
OBJECTIVES: To investigate the incidence of, clinical outcome of, and risk factors for perirenal subcapsular fluid collections in extremely preterm infants with acute kidney injury (AKI). METHODS: Extremely preterm infants with AKI who underwent renal ultrasonography (US) during neonatal intensive care unit stay were classified into two groups according to the presence of a perirenal subcapsular fluid collection at US. Clinical outcome was compared, and relevant data were analysed, including demographics and comorbidities of the infants, as well as maternal demographics...
February 4, 2019: European Radiology
M T K Zia, S Golombek, L Lemon, S Nitkowski Keever, U Paudel
BACKGROUND: Breastfeeding (BF) neonates generally lose weight after birth. Neonatal factors like gestational age, birth weight and mode of delivery can affect the neonatal weight loss after birth. Similarly, maternal age, parity and illness may contribute to newborn weight loss. However, influence of the time of birth and season on changes in weight is not well elucidated. OBJECTIVE: The aim of this study is to determine the effect of birth time and the seasonal variations on weight loss in BF newborns...
January 28, 2019: Journal of Neonatal-perinatal Medicine
Ann Simonin, Azif Safarulla, Zachary Farmer, Joshua Coleman, Danielle Sutton, Kelli Wheeler, Jennifer Waller, Jatinder Bhatia
OBJECTIVE: To determine if umbilical cord milking performed on a cut umbilical cord segment increased the hemoglobin/hematocrit, with a reduction in the incidence of intraventricular hemorrhage, need for blood transfusions, and pressor requirement in infants with <35-weeks gestation. STUDY DESIGN: This was a single center, observational study in the NICU. One-hundred-six neonates received cut umbilical cord milking and two hundred ninety seven served as historical controls...
February 3, 2019: Journal of Maternal-fetal & Neonatal Medicine
M Panda, J McIntosh, T Chaudhari, A L Kent
Objective: To determine the prevalence of Vitamin D (VitD) deficiency/insufficiency in mothers of preterm neonates less than or equal to 32 weeks of gestation and determine if the current level of VitD supplementation used for preterm neonates is appropriate. Design: Prospective study from 10th May 2015 to 1st November 2016. Setting: Neonatal Intensive Care Unit at the Canberra Hospital. Patients: Mothers and their preterm neonates born less than or equal to 32 weeks gestation...
2019: International Journal of Pediatrics
Trisha M Prentice, Annie Janvier, Lynn Gillam, Susan Donath, Peter G Davis
AIM: To develop a neonatal intervention score to describe the clinical trajectory of a neonate throughout their neonatal intensive care unit (NICU) admission. METHODS: The Neonatal Intervention Score (NIS) was developed by modifying the Neonatal Therapeutic Intervention Scoring System (NTISS) to reflect illness severity, dependency on life-sustaining interventions and overall life trajectory on a longitudinal basis, rather than illness burden. Validity for longitudinal use within the NICU was tested by calculating the score for 99 preterm babies born less than 28 weeks at predetermined time points throughout their admission to tertiary level care at two institutions...
February 1, 2019: Acta Paediatrica
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