keyword
https://read.qxmd.com/read/38336152/ala-pdt-promotes-il-1%C3%AE-secretion-from-human-sz95-sebocytes-via-activation-of-the-nlrp3-inflammasome
#1
JOURNAL ARTICLE
Jian Zhang, Yufeng Chang, Suqing Liu, Jiang Tuo, Zhongyi Xu, Jiayi Ying, Yijian Zhu, Zhengzhou Shi, Christos C Zouboulis, Min Jiang, Qianqian Wang, Leihong Xiang
BACKGROUND: 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for pilosebaceous inflammatory diseases, such as acne vulgaris. In this study, we explored ALA-PDT's mechanisms against acne in vitro. METHODS: We treated human SZ95 sebocytes with ALA (0.2 mM) and subjected them to varied PDT doses (0, 5, 10, 20 J/cm²) over 12 hours. We assessed cell viability post-treatment using the Annexin V FITC/PI apoptosis kit. ROS accumulation in the sebocytes was detected with a DCFDA probe...
February 7, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38336151/ipl-pdt-as-an-effective-treatment-for-mild-to-moderate-acne-vulgaris-a-prospective-single-center-self-controlled-study
#2
JOURNAL ARTICLE
Qihang Chang, Xiaojing Liu, Peiru Wang, Yutong Yang, Linglin Zhang, Bo Wang, Xiuli Wang
BACKGROUND: High recurrence rate of mild-to-moderate acne vulgaris following traditional therapy poses a significant challenge. 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) with intense pulsed light (IPL) has emerged as a promising intervention. OBJECTIVES: This study aimed to evaluate the efficacy and safety of IPL-PDT for the treatment of mild-to-moderate acne vulgaris. METHODS: In this prospective, self-controlled study, eligible patients aged from 18-45 years old with Pillsbury grade Ⅰ-III facial acne were included...
February 7, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38316341/a-prospective-split-face-randomized-controlled-trial-of-intense-pulsed-light-photodynamic-therapy-for-seborrhea
#3
JOURNAL ARTICLE
Dixin Wang, Yu Yan, Peiru Wang, Haiyan Zhang, Yajing Cao, Bo Wang, Linglin Zhang, Xiuli Wang
BACKGROUND: Seborrhea poses a common cosmetic concern in adolescents and young adults, often accompanied by enlarged pores, and contributing to various skin conditions, including acne vulgaris and seborrheic dermatitis. At present, there is a lack of effective treatment for this problem, and the potential of photodynamic therapy (PDT) in reducing sebum remains inconclusive. OBJECTIVE: This exploratory, prospective, single-center, double-blinded, randomized split-face controlled trial aimed to compare the efficacy and safety of intense pulsed light-photodynamic therapy (IPL-PDT) versus IPL therapy for seborrhea...
February 3, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/37984524/5-aminolevulinic-acid-photodynamic-therapy-using-with-560-1200-nm-followed-by-420-1200-nm-broadband-light-in-the-treatment-of-moderate-to-severe-acne
#4
JOURNAL ARTICLE
Weinan Zhang, Zhiqiang He, Yingyue Qin, Jie Gong, Wenjun Xie, Li Tong, Shulei Liu, Luoyingzi Xie
BACKGROUND: Moderate-to-severe acne vulgaris, which is a chronic inflammatory skin disease, seriously impacts millions of people. However, traditional therapies may cause severe adverse reactions that are unacceptable to many patients, thus limiting the further application of these therapies. Novel therapeutic approaches to effectively treat moderate-to-severe acne vulgaris with minimal adverse reactions are urgently needed. In this retrospective study, we investigated the efficacy and adverse reactions of photodynamic therapy (PDT) using with 560-1200 nm broadband light (BBL) followed by 420-1200 nm BBL...
November 18, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/37951327/photodynamic-therapy-for-severe-acne
#5
Federica Li Pomi, Mario Vaccaro, Lucia Peterle, Francesco Borgia
Acne is an inflammatory cutaneous disease affecting the pilosebaceous unit and hair follicles on the face, neck, back, and chest, with a typical onset in adolescence and, in some cases, persisting into adulthood. Systemic treatments with antibiotics or isotretinoin present many limitations, like antimicrobial resistance phenomena and teratogenicity, which appear more relevant in the pediatric population, both for the treatment-related risks and for the reticence of the parents. Photodynamic therapy (PDT) has already shown encouraging results in the treatment of acne in adult patients, with good aesthetic results compared to other therapies and few side effects...
November 9, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/37943263/the-interventions-to-minimize-pain-during-photodynamic-therapy-with-5-aminolevulinic-acid-for-the-treatment-of-cutaneous-diseases
#6
JOURNAL ARTICLE
Neal Bhatia
Photosensitization with 5-aminolevulinic acid (ALA) combined with photodynamic therapy (PDT) is approved in the United States for the treatment of actinic keratosis (AK) and is used off-label for other indications including acne treatment and photo rejuvenation. However, pain, particularly during the initial illumination period, limits the utility of this highly efficacious therapy. Although modifications to conventional ALA-PDT protocols that improve tolerability without diminishing efficacy have been identified, few have been evaluated in randomized, controlled trials, and the number of variables involved in ALA incubation (eg, duration, occlusion, ALA formulation, and strength) and PDT illumination (eg, light source, fluence rate, irradiance, and duration) confounds standardization...
November 1, 2023: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/37920822/5-aminolevulinic-acid-photodynamic-therapy-combined-with-intralesional-triamcinolone-and-5-fluorouracil-to-treat-acne-hypertrophic-scar
#7
Jingjing Wei, Lingyun Du, Zhiqiang Cao, Mingming Li, Chunhong Zhang, Chunmin Zhang, Liya Meng
BACKGROUND: Acne is a chronic inflammatory disease of the pilosebaceous unit. Improper treatment of acne can lead to skin lesions in some people. Acne hypertrophic scar is relatively rare, but it significantly affects the appearance and beauty, and usually has a great psychological and social impact on patients. OBJECTIVE: To evaluate the clinical efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with 5-fluorouracil (5-FU) injection and triamcinolone acetonide (TAC) solution in the treatment of acne hypertrophic scars...
2023: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/37881149/analysis-of-the-effectiveness-of-pdt-with-5-aminolevulinic-acid-in-comparison-to-blue-red-light-combined-with-intralesional-triamcinolone-injection-in-treatment-of-severe-inflammatory-acne-a-retrospective-study
#8
JOURNAL ARTICLE
Yi Hu, Yang Cheng, Wang Jie
OBJECTIVE: In this study, the therapeutic effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in comparison to blue/red light combined with intralesional triamcinolone injection for severe inflammatory acne was evaluated and analyzed. METHODS: One hundred and four cases of severe inflammatory acne were analyzed in this study. They were divided into two groups as control and observation groups, 52 cases in each group. The control group (group A) received red and blue light combined with triamcinolone injection and lidocaine injection (1:4), while the observation group (Group B) was treated with ALA-PDT...
October 25, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/37858910/preliminary-study-of-low-dose-photodynamic-therapy-on-the-oxidative-stress-response-of-cutibacterium-acnes
#9
JOURNAL ARTICLE
Shi-Xin He, Wei Liu, Jun-Ru Ye, Xiang-Ning Huang, Tong-Dan Zou, Qian Wang, Yi Wang, Shi Cheng, Gang Liu
Purpose The objective of this study was to investigate the influence of photodynamic therapy (PDT) employing different, lower 5-aminolevulinic acid (ALA) dosages (0.05 mmol/L; 0.1 mmol/L; 0.5 mmol/L; 1.0 mmol/L; 2.5 mmol/L) on the proliferative activity of Cutibacterium acnes (C. acnes). Methods In this in vitro bacterial experiment, we examined the effects of PDT using different doses of ALA (0.05 mmol/L; 0.1 mmol/L; 0.5 mmol/L; 1.0 mmol/L; 2.5 mmol/L). To elucidate the underlying mechanisms, we assessed colony-forming units (CFU), bacterial staining for live/dead, antioxidant enzyme activity, and gene expression of oxidative stress markers following treatment with different doses of ALA-PDT...
October 17, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/37843672/the-quantitative-analysis-of-low-concentration-2-ala-pdt-assisted-with-q-switch-1064-nm-nd-yag-laser-for-acne-vulgaris-treatment
#10
JOURNAL ARTICLE
Yu-Tsung Chen, Yun-Jhen Lin, Chang-Cheng Chang, Po-Heng Liu, Yung-Hsueh Huang, Jia-Wei Shen, Meng-En Lu, Hsiu-Mei Chiang, Bor-Shyh Lin
Conventional 5-aminolevulinic acid-photodynamic (ALA-PDT) therapy (10-20%) has been widely applied for moderate-to-severe acne. The aim of this study is to investigate the effects of non-ablative Q-switched 1064-nm Nd:YAG laser-assisted ALA-PDT with low concentration (2%) on the treatment of acne vulgaris. Enrolled patients were randomly assigned to 2 groups. One group received combined therapy of 2% ALA-PDT and non-ablative Q-switched 1064-nm Nd:YAG laser, and the other received only 2% ALA-PDT. Patients in each group had received 3-session treatments with 4-week intervals (week 0, 4, and 8)...
October 16, 2023: Lasers in Medical Science
https://read.qxmd.com/read/37643988/a-preliminary-study-on-the-evaluation-of-photodynamic-diagnosis-for-acne-inflammatory-skin-lesions
#11
JOURNAL ARTICLE
ChunLan Xu, Dan Yuan, Shi Cheng, XiaoLing Lan, Qian Wang, XinYu Lin, Wei Liu
OBJECTIVE: This study aimed to observe the fluorescence characteristics of acne inflammatory skin lesions in 5-aminolevulinic acid-based photodynamic diagnosis (ALA-PDD), and discuss the viability of using ALA-PDD to evaluate acne inflammatory skin lesions and explore the advantages of predicting subclinical skin lesions. METHODS: The OBSERV facial skin detector collected photographs of 20 patients before and after optical intra-tissue fiber irradiation photodynamic therapy(OFI-ALA-PDT) in both ALA-PDD and white light patterns...
August 29, 2023: Journal of Biophotonics
https://read.qxmd.com/read/37595671/corrigendum-to-ala-pdt-augments-intense-inflammation-in-the-treatment-of-acne-vulgaris-by-cox2-trem1-mediated-m1-macrophage-polarization-biochemical-pharmacology-208-2023-115403
#12
JOURNAL ARTICLE
Pei Liu, Xiaojing Liu, Linglin Zhang, Guorong Yan, Haiyan Zhang, Detian Xu, Yun Wu, Guolong Zhang, Peiru Wang, Qingyu Zeng, Xiuli Wang
No abstract text is available yet for this article.
August 16, 2023: Biochemical Pharmacology
https://read.qxmd.com/read/37250640/case-report-acne-vulgaris-treatment-with-5-aminolaevulinic-acid-photodynamic-therapy-and-adalimumab-a-novel-approach
#13
Yang Ping, Zhong Jian Bo, Zhao Xing Yun, Kamran Ali, Chen Jun, Inmaculada Xu Lou, Li Ming Wu
Acne vulgaris is a common skin condition that affects a large proportion of teenagers and young adults. Despite the availability of various treatment options, many patients experience inadequate relief or intolerable side effects. Photodynamic therapy (PDT) is a growing interest in the treatment of acne vulgaris, with 5-Aminolaevulinic acid (ALA) being one of the most commonly used photosensitizers. Adalimumab is a biologic medication used to treat inflammatory skin conditions such as Psoriasis and Hidradenitis suppurativa (HS), which targets TNF-α...
2023: Frontiers in Medicine
https://read.qxmd.com/read/36842473/effect-of-thirteen-types-of-photodynamic-therapy-on-inflammatory-and-non-inflammatory-lesions-in-patients-with-acne-a-network-meta-analysis-of-randomized-controlled-trials
#14
JOURNAL ARTICLE
Xin-Xin Long, Ai-Di Xie, Peng Yang, Jie Xie, Xiao-Li Chen, Yun-Di Huang, Li-Ping Zhang, Xue-Biao Peng
BACKGROUND: Recent studies have demonstrated that photodynamic therapy (PDT) is safe and effective in treating acne vulgaris. The present study aimed to evaluate 13 PDTs on inflammatory and non-inflammatory lesions in patients with acne by a network meta-analysis (NMA) of randomized controlled trials (RCTs). METHODS: The researchers of this paper searched PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases from inception to March 2022 to identify suitable RCTs...
February 24, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/36592708/ala-pdt-augments-intense-inflammation-in-the-treatment-of-acne-vulgaris-by-cox2-trem1-mediated-m1-macrophage-polarization
#15
JOURNAL ARTICLE
Pei Liu, Xiaojing Liu, Linglin Zhang, Guorong Yan, Haiyan Zhang, Detian Xu, Yun Wu, Guolong Zhang, Peiru Wang, Qingyu Zeng, Xiuli Wang
Severe acne vulgaris is a common chronic inflammatory skin disease worldwide. 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is effective and safe for severe acne. However, the mechanism is not fully understood. Intense acute inflammatory response at 24 h after ALA-PDT is reported positively correlated to the effectiveness. Inflammation regulation influence the progression or outcome of diseases. ALA-PDT may exert its therapeutic effect by augmenting intense inflammation and break the chronic inflammation...
December 30, 2022: Biochemical Pharmacology
https://read.qxmd.com/read/36587863/clinical-practice-guidelines-for-5-aminolevulinic-acid-photodynamic-therapy-for-acne-vulgaris-in-china
#16
REVIEW
Peiru Wang, Bo Wang, Linglin Zhang, Xiaojing Liu, Lei Shi, Xiaojing Kang, Xia Lei, Kun Chen, Zhou Chen, Chengxin Li, Chunlei Zhan, Ping Tu, Meng Pan, Qiang Ju, Xiaoyong Man, Yan Lu, Nan Yu, Yuzhen Li, Huilan Zhu, Ruzhi Zhang, Juan Su, Shiqin Tao, Jianjun Qiao, Qiri Mu, Weihui Zeng, Zhiming Li, Ying Gao, Heng Gu, Xiuli Wang
A variety of evidence suggest that 5-Aminolevulinic acid-based photodynamic therapy (ALA-PDT) is clinically effective in management of acne vulgaris. Several clinical guidelines for acne recommend PDT as an alternative treatment modality for severe acne. However, there is a lack of detailed clinical guideline for PDT in acne treatment. To propose up-to-date, evidence-based and practical recommendations on application of ALA-PDT for acne vulgaris, dermatologists and PDT experts from the Photodynamic Therapy Research Center of the CMA and Photodynamic Therapy Rehabilitation Training Center of CARD achieved consensus and guidelines based on careful evaluation of published literature, expert opinions and experience...
December 29, 2022: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/36384211/a-systematic-review-and-meta-analysis-of-randomized-clinical-trials-of-fire-needle-combined-with-ala-pdt-for-the-treatment-of-moderate-to-severe-acne
#17
REVIEW
Lei Tang, Qiang Fu, Zi-Wenyan Zhou, Lin Liu, Mengya Huang, Qi Zheng, Fujun Huang, Miao Zhang, Xun Zhou
BACKGROUND: Moderate-to-severe acne affects people's health and quality of life. As first-line therapeutic medications, isotretinoin and antibiotics was used to treat moderate-to-severe acne.However,some patient does not tolerate pills. Thus, It is important to improve therapeutic tools for those people. Now, there are more and more clinical studies on the treatment of moderate-to-severe acne treated by the combination of fire needle and ALA-PDT, which provides us with a new idea for the treatment of moderate-to-severe acne...
November 13, 2022: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/36376760/topical-methylene-blue-nanoformulation-for-the-photodynamic-therapy-of-acne-vulgaris
#18
JOURNAL ARTICLE
Yong-Deok Lee, Jin-Kyoung Yang, Sunmi Han, Bo Ri Kim, Jung-Won Shin, Joona Bang, Sehoon Kim
Acne vulgaris is a common skin disease caused by multifactorial reasons involving excessive sebum secretion and inflammation by Cutibacterium acnes (C. acnes). Various conventional therapies are available for the treatment of acne vulgaris; however, topical photodynamic therapy (PDT) has attracted much attention because of its great potential for sebum-reducing, anti-inflammatory, and antimicrobial activities. Although 5-aminolevulinic acid (ALA) has been broadly used as a photosensitizer for topical PDT, it has several limitations such as long incubation time, pain, and post-inflammatory hyperpigmentation...
November 14, 2022: Archives of Dermatological Research
https://read.qxmd.com/read/35792252/5-aminolevulinic-acid-mediated-photodynamic-therapy-ala-pdt-for-acneform-rash-induced-by-erlotinib-a-case-report
#19
Yanlan Yu, Junzhao Li, Yongzhen Zou, Rui Yin
Erlotinib is an anticancer drug approved for the treatment of non-small cell lung cancer. It inhibits growth and proliferation of tumor cells by targeting epidermal growth factor receptor (EGFR). Dermatological toxicities are common side effects associated with EGFR inhibition. Here we describe a patient with acneform rash following oral medication of erlotinib, presented as facial erythema, papules and pustules. Two sessions of 5-aminolevulinic acid induced photodynamic therapy (ALA-PDT) with a 2-week interval were performed...
September 2022: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/35760351/a-case-of-5-aminolevulinic-acid-photodynamic-therapy-ala-pdt-combined-with-surgery-for-the-treatment-of-acne-conglobata
#20
Qing-Yun Wu, Qian Zhang, Wen-Bo Bu, Fang Fang
We report the case of a 20-year-old man with acne conglobata (AC) who was treated with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) sequentially to deroofing, and finally used fractional carbon dioxide laser for esthetic requirements, achieving satisfying results. AC is a severe form of acne vulgaris that can lead to significant scarring and has serious negative effects on a patient's psychological well-being and quality of life. Some cases are likely resistant to currently available treatments. This report describes a promising, and effective method for the treatment of AC...
September 2022: Photodiagnosis and Photodynamic Therapy
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