Pavandeep Gill, Kristen Richards, Woo Cheal Cho, Priyadharsini Nagarajan, Phyu P Aung, Doina Ivan, Jonathan L Curry, Victor G Prieto, Carlos A Torres-Cabala
Localized cutaneous argyria is a rare cutaneous disorder that has been associated with occupational exposure, dental procedures, topical agents, acupuncture, earrings, and nasal piercings. In this paper, we review the current literature on localized cutaneous argyria, highlight its clinical and histologic diagnostic features, and then discuss the clinical and histological differential diagnoses for blue-gray skin and black dermal pigment, respectively. We also discuss the utility of ancillary techniques, such as deeper histologic levels, special stains, darkfield microscopy, and advanced micro-analytical techniques in helping diagnose localized cutaneous argyria...
October 2021: Annals of Diagnostic Pathology