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laboratory haematology

Kathryn M Forwood, Edwin Lee, Philip J Crispin
INTRODUCTION: Bone marrow biopsies are a key diagnostic and monitoring intervention in haematology with manual bone marrow techniques the established method of choice. Powered biopsy devices are now available, but are not widely used in haematology. This study compared the quality of bone marrow trephines obtained with the Jamshidi needle and OnControl powered drill system. METHODS: Retrospective analysis was undertaken on trephine samples prior to and after implementation of the OnControl drill system...
February 19, 2019: International Journal of Laboratory Hematology
Elin N Opheim, Torunn O Apelseth, Simon J Stanworth, Geir E Eide, Tor Hervig
BACKGROUND: In thrombocytopenic patients better assessment of bleeding risk than that provided by platelet count alone is required. Multiplate® aggregometry and thromboelastography (TEG) could be used, but information on their role in such patients is limited. The primary aim of this study was to investigate the feasibility of Multiplate® analyses in patients with haematological malignancies. A secondary aim was to explore whether a multiple logistic regression model combining Multiplate® , TEG, clinical and laboratory variables was associated with risk of bleeding...
December 13, 2018: Blood Transfusion, Trasfusione del Sangue
Tiffany Yang, Heather L Haas, Samir Patel, Ronald Smolowitz, Michael C James, Amanda S Williard
We documented blood biochemistry and haematology of healthy loggerhead turtles ( Caretta caretta ) in the Northwest (NW) Atlantic in order to establish clinical reference intervals (RIs) for this threatened population. Blood samples were analysed from migratory loggerheads captured off the Mid-Atlantic coast of the USA in 2011, 2012, 2013 and 2016 as part of a long-term research program. Blood variables were determined using a point-of-care analyser, and a veterinary diagnostic laboratory service. We calculated 95% RIs with associated 90% confidence intervals (CIs) for each blood variable...
2019: Conservation Physiology
Noelle Frey, Jun Ho Jang, Jeff Szer, Árpád Illés, Hee-Je Kim, Ron Ram, Beng H Chong, Jacob M Rowe, Elena Borisenkova, Jane Liesveld, Eric S Winer, Azzeddine Cherfi, Vassilios Aslanis, Farhat Ghaznawi, Stephen Strickland
BACKGROUND: Patients with acute myeloid leukaemia frequently have thrombocytopenia during induction chemotherapy. Eltrombopag, an oral thrombopoietin receptor agonist, stimulates platelet production by a similar mechanism to endogenous thrombopoietin. This study investigated safety and efficacy of eltrombopag versus placebo during anthracycline-based induction treatment of patients with acute myeloid leukaemia. METHODS: In this randomised, double-blind, phase 2 study, treatment-naive patients were recruited from clinical centres across 10 countries (Australia, Belgium, Canada, Greece, Hungary, Israel, South Korea, Poland, Russia, and the USA)...
January 28, 2019: Lancet Haematology
Linus Knips, Nils Bergenthal, Fiona Streckmann, Ina Monsef, Thomas Elter, Nicole Skoetz
BACKGROUND: Although people with haematological malignancies have to endure long phases of therapy and immobility, which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocytopenia from which many patients suffer. The inability to perform activities of daily living restricts them, diminishes their quality of life and can influence medical therapy...
January 31, 2019: Cochrane Database of Systematic Reviews
K A Rack, E van den Berg, C Haferlach, H B Beverloo, D Costa, B Espinet, N Foot, S Jeffries, K Martin, S O'Connor, J Schoumans, P Talley, N Telford, S Stioui, Z Zemanova, R J Hastings
Cytogenomic investigations of haematological neoplasms, including chromosome banding analysis, fluorescence in situ hybridisation (FISH) and microarray analyses have become increasingly important in the clinical management of patients with haematological neoplasms. The widespread implementation of these techniques in genetic diagnostics has highlighted the need for guidance on the essential criteria to follow when providing cytogenomic testing, regardless of choice of methodology. These recommendations provide an updated, practical and easily available document that will assist laboratories in the choice of testing and methodology enabling them to operate within acceptable standards and maintain a quality service...
January 29, 2019: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
A A Bukar, M M Sulaiman, A I Ladu, A M Abba, M K Ahmed, G T Marama, U M Abjah
Background: Involvement of the kidneys in patients with sickle cell anaemia is a well recognised chronic complication. This study seeks to determine the prevalence of chronic kidney disease in patients with homozygous sickle cell disease (HbSS) and to identify risk factors associated with its development. Methodology: The subjects consisted of adolescents and adults with HbSS recruited sequentially from the adult haematology outpatient clinic and Daycare ward of the unit...
2019: Mediterranean Journal of Hematology and Infectious Diseases
Hyun Park, Sabah Bhatti, Subarna Chakravorty
BACKGROUND: Despite the well-established efficacy of hydroxycarbamide in the management of sickle cell disease (SCD), the paucity of real-world clinical data limits the establishment of a practical dosing strategy. The aim of this study was to analyse the dose-response metrics of hydroxycarbamide associated with the minimum effective dose protocol - specifically, between dose groups and differing degrees of myelosuppression. DESIGN/METHODS: A retrospective cohort study was conducted on 93 patients who were initiated on hydroxycarbamide between 2005 and 2017 at a tertiary haemoglobinopathy centre in London, UK...
January 21, 2019: Pediatric Blood & Cancer
Xiao Li, Ming-Zhe Wen, Li-Xin Su, Xi-Tao Yang, Yi-Feng Han, Xin-Dong Fan
Kaposiform haemangioendotheliomas (KHEs) complicated by the Kasabach-Merritt phenomenon (KMP) are rare and severe neoplastic lesions often associated with locally aggressive disease, consumption coagulopathy and high mortality rates. Current regimens have yet to achieve a satisfactory therapeutic effect. Thus, an effective and minimally invasive approach for treating complex KHE/KMP cases is necessary for clinical management. The present case series describes patients with KHE/KMP who underwent local suture ligation-assisted percutaneous sclerotherapy to minimise surgical trauma and ensure effective treatment...
January 2019: Oncology Letters
L Wuyts, M Wojciechowski, P Maes, L Matthieu, J Lambert, O Aerts
BACKGROUND: Ecthyma gangrenosum (EG) is characterized by the occurrence of erythematous, violaceous or hemorrhagic macules and/or vesicles, often evolving into necrotic ulcers, with a central gray-black eschar. It is a rare skin condition, usually occurring in immunocompromised patients suffering from bacterial sepsis caused by Pseudomonas aeruginosa. However, seemingly healthy children have been diagnosed with this skin disease as well. OBJECTIVES: We report the work-up of a case of vulvar EG caused by Pseudomonas aeruginosa in a toddler, which led to a diagnosis of an underlying neutropenia...
January 11, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Essohana Padaro, Hèzouwè Magnang, Yao Layibo, Koffi Mawussi, Irénée Messanh Kuéviakoé, Kossi Agbétiafa, Ahoéfa Vovor
This study aims to describe the different bcr-abl gene transcript variants in order to determine their frequency and to study their influence on CBC diagnostic test. We conducted a cross-sectional study of 34 patients with chronic myeloid leukemia in Togo. The search for fusion transcripts was performed in the laboratory of biological haematology at the Henri Mondor Hospital, Créteil (France). The average age of patients was 42,32±14,87 years ranging between 9 and 65 years. Most patients were male, with a sex- ratio of 1...
2018: Pan African Medical Journal
David McCartney, Brian Shine, Deborah Hay, Daniel S Lasserson
Background: Anaemia is common in older people and the identification of potentially reversible haematinic deficiencies relies on appropriate investigation, often undertaken in primary care. Aim: To determine the laboratory prevalence of anaemia, the types of anaemia observed, and the biochemical and haematological investigations undertaken to characterise any associated haematinic abnormality in older primary care patients. Design & setting: A retrospective primary care based study of patients aged >65 years undergoing a full blood count in Oxfordshire, UK between 1 January 2012 and 31 December 2013...
January 2018: BJGP open
Chiara Tani, Elena Elefante, Miguel Martin-Cascón, Meriem Belhocine, Cristina Lavilla Olleros, Roberta Vagelli, Chiara Stagnaro, Nathalie Costedoat-Chalumeau, Guillermo Ruiz-Irastorza, Marta Mosca
Objectives: To analyse the real-life practice on the use of Tacrolimus (TAC) in patients with systemic lupus erythematosus (SLE) from three European SLE referral centres. Methods: Adult patients with SLE regularly followed at three European referral centres were included. Demographics, cumulative organ involvement, treatment history, Systemic Lupus Disease Activity Index (SLEDAI), laboratory features and physician's judgement were collected at baseline and at 3-6-12 months after starting TAC...
2018: Lupus Science & Medicine
Helene Bohnert, Max Maurer, Philip C Calder, Johann Pratschke, Paul Thul, Verena Müller
BACKGROUND: Data on the use of lipid emulsions containing fish-oil (FO) derived n-3 polyunsaturated fatty acids (n-3 PUFAs) in addition to medium- and long-chain triglycerides (MCT/LCT) for long-term home parenteral nutrition (HPN) are limited. This study aimed to compare HPN regimens containing either MCT/LCT/FO-derived n-3 PUFAs (test group) or MCT/LCT (control group) with respect to efficacy and safety during 8 weeks of HPN using a non-inferiority trial design with change of body mass index (BMI) as primary endpoint...
November 30, 2018: Nutrition Journal
Francois Kiemde, Massa Dit Achille Bonko, Marc Christian Tahita, Palpouguini Lompo, Halidou Tinto, Petra F Mens, Henk D F H Schallig, Michael Boele van Hensbroek
BACKGROUND: Infectious diseases in children living in resource-limited settings are often presumptively managed on the basis of clinical signs and symptoms. Malaria is an exception. However, the interpretation of clinical signs and symptoms in relation to bacterial infections is often challenging, which may lead to an over prescription of antibiotics when a malaria infection is excluded. The present study aims to determine the association between clinical signs and symptoms and basic hematology data, with laboratory confirmed bacterial infections...
November 27, 2018: BMC Pediatrics
Anna Yordanova, Paula Linden, Stefan Hauser, Michael Meisenheimer, Stefan Kürpig, Georg Feldmann, Florian C Gaertner, Markus Essler, Hojjat Ahmadzadehfar
BACKGROUND: Data are sparse regarding the feasibility of radioligand therapy (RLT) with [177 Lu]Lu-PSMA-617 as a retreatment. We aimed to assess the outcome and safety of rechallenge PSMA-RLT in patients with progressive prostatic cancer who previously benefited from this therapy. MATERIALS AND METHODS: Patients who received rechallenge therapy at our department from January 2015 to March 2018 were assessed. Non-haematological and haematological adverse events were evaluated from laboratory data and clinical reports and were graded according to the Common Terminology Criteria for Adverse Events (CTCAE v...
November 24, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Tim M Reynolds, Anthony S Wierzbicki
BACKGROUND: Increasing demand for laboratory testing at weekends is common but little is known about its appropriateness. METHODS: An audit was conducted in a large district hospital of routine haematology and clinical biochemistry requests ordered over 2 weekends. Appropriateness was assessed by review of ordered tests compared with clinical records by a qualified chemical pathologist. RESULTS: Profiles requested on phlebotomy included full blood count (76%), renal profile (91%), C-Reactive protein (41%), liver function tests (18%) and another test in 18%...
November 25, 2018: International Journal of Clinical Practice
Julie Makani, Furahini Tluway, Abel Makubi, Deogratius Soka, Siana Nkya, Raphael Sangeda, Josephine Mgaya, Stella Rwezaula, Fenella J Kirkham, Christina Kindole, Elisha Osati, Elineema Meda, Robert W Snow, Charles R Newton, David Roberts, Muhsin Aboud, Swee Lay Thein, Sharon E Cox, Lucio Luzzatto, Bruno P Mmbando
Background: Africa has the highest burden of Sickle cell disease (SCD) but there are few large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania, with 11,000 SCD births annually, established the Muhimbili Sickle Cell program aiming to improve understanding of SCD in Africa. We report the profile of SCD seen in the first 10 years at Muhimbili National Hospital (MNH). Methods: Individuals seen at MNH known or suspected to have SCD were enrolled at clinic and laboratory testing for SCD, haematological and biochemical analyses done...
2018: BMC Hematology
Lyn Awad, Hani Tamim, Dania Abdallah, Mohammad Salameh, Anas Mugharbil, Tamima Jisr, Kamal Zahran, Nabila Droubi, Ahmad Ibrahim, Rima Moghnieh
BACKGROUND: In recent years, there has been a significant increase in the incidence of fungal infections attributed to Candida species worldwide, with a major shift toward non-albicans Candida (NAC). In this study, we have described the distribution of Candida species among different hospital departments and calculated the antifungal consumption in our facility. We also correlated the consumption of certain antifungals and the prevalence of specific Candida species. METHODS: This was a retrospective review of all the Candida isolates recovered from the computerised microbiology laboratory database of Makassed General Hospital, a tertiary care centre in Beirut, Lebanon, between January 2010 and December 2015...
November 20, 2018: BMC Infectious Diseases
Nicolas Laing, Henry Tufton, Emmanuel Ochola, Ojok Godfrey P'Kingston, Mala K Maini, Nicholas Easom
Background: Chronic hepatitis B infection affects 240 million people, with the highest prevalence in Africa and Asia, and results in 700 000 deaths annually. Access to diagnostics, particularly for hepatitis B virus viral load quantification (HBV DNA), is a major barrier to treatment. We aimed to test World Health Organization guidelines for hepatitis B management in resource-limited settings. Methods: We compared treatment allocation with and without the use of HBV DNA in a cohort in Uganda...
November 17, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
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