Yan Wang, Hanwen Zhang, Wen Sun, Siyu Wang, Shuting Zhang, Linlin Zhu, Yali Chen, Lizhe Xie, Zongyang Sun, Bin Yan
Clinical evidence has suggested that surgical corticotomy of the alveolar bone can accelerate local orthodontic tooth movement (OTM), but the underlying cell and molecular mechanisms remain largely unclear. The present study examined the role of macrophages played in corticotomy-assisted OTM. Orthodontic nickel-titanium springs were applied to the left maxillary first molars of rats or mice to induce OTM with or without corticotomy. Corticotomy enhanced OTM distance by accelerating movement through induction of local osteoclastogenesis and macrophage infiltration during OTM...
November 14, 2018: Scientific Reports