Eric Rogier, Nastassia Battle, Catherine Bakari, Misago D Seth, Douglas Nace, Camelia Herman, Achut Barakoti, Rashid A Madebe, Celine I Mandara, Beatus M Lyimo, David J Giesbrecht, Zachary R Popkin-Hall, Filbert Francis, Daniel Mbwambo, Issa Garimo, Sijenunu Aaron, Abdallah Lusasi, Fabrizio Molteni, Ritha Njau, Jane A Cunningham, Samwel Lazaro, Ally Mohamed, Jonathan J Juliano, Jeffrey A Bailey, Venkatachalam Udhayakumar, Deus S Ishengoma
Plasmodium falciparum with the histidine rich protein 2 gene (pfhrp2) deleted from its genome can escape diagnosis by HRP2-based rapid diagnostic tests (HRP2-RDTs). The World Health Organization (WHO) recommends switching to a non-HRP2 RDT for P. falciparum clinical case diagnosis when pfhrp2 deletion prevalence causes ≥ 5% of RDTs to return false negative results. Tanzania is a country of heterogenous P. falciparum transmission, with some regions approaching elimination and others at varying levels of control...
April 8, 2024: Scientific Reports