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https://read.qxmd.com/read/30772299/feasibility-of-qualitative-testing-of-bcr-abl-and-jak2-v617f-in-suspected-myeloproliperative-neoplasm-mpn-using-rt-pcr-reversed-dot-blot-hybridization-rt-pcr-rdb
#1
Najmiatul Masykura, Ummu Habibah, Siti Fatimah Selasih, Soegiarto Gani, Cosphiadi Irawan, Sugiyono Somoastro, Ahmad Rusdan Handoyo Utomo
BACKGROUND: Defining the presence of BCR-ABL transcript in suspected myeloproliferative neoplasm is essential in establishing chronic myeloid leukemia. In the absence of BCR-ABL, the conventional diagnostic algorithm recommends JAK2 V617F mutation testing to support diagnosis of other MPN diseases such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis. In certain cases of thrombocythemia, simultaneous upfront testing of both BCR-ABL and JAK2 may be desirable. We wanted to test the feasibility of multiplex detection of BCR-ABL transcript variants and JAK2 V617F mutation simultaneously using the reverse transcriptase polymerase chain reaction (RT-PCR)-based reverse dot-blot hybridization (RDB) method...
January 19, 2019: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/30770929/myd88-dependent-signaling-in-non-parenchymal-cells-promotes-liver-carcinogenesis
#2
Antje Mohs, Nadine Kuttkat, Tobias Otto, Sameh A Youssef, Alain De Bruin, Christian Trautwein
In Western countries, a rising incidence of obesity and type 2 diabetes correlates with an increase of non-alcoholic steatohepatitis (NASH)-a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). NASH is associated with chronic liver injury, triggering hepatocyte death and enhanced translocation of intestinal bacteria, leading to persistent liver inflammation through activation of Toll-like receptors and their adapter protein myeloid differentiation factor 88 (MyD88). Therefore, we investigated the role of MyD88 during progression from NASH to HCC using a mouse model of chronic liver injury (hepatocyte-specific deletion of nuclear factor κB essential modulator, Nemo; NemoΔhepa)...
February 13, 2019: Carcinogenesis
https://read.qxmd.com/read/30767712/population-pharmacokinetic-and-pharmacogenetics-of-imatinib-in-chinese-patients-with-chronic-myeloid-leukemia
#3
Qing Wang, Zhi-Ping Jiang, Er-Qian Yu, Jing Zeng, Yan Zhu, Hua-Lin Cai, Miao Yan, Da-Xiong Xiang, Xie-Lan Zhao, Ping Xu, Zheng Jiao, Hoan Linh Banh
AIM: This study aimed to establish a population pharmacokinetic (PPK) model in Chinese patients with chronic myeloid leukemia, and to quantify the effects of pharmacogenetics on pharmacokinetic parameters of imatinib. METHODS: A total of 229 plasma concentrations from 170 patients were analyzed. Nonlinear mixed effect model was used to establish the PPK model. RESULTS: A one-compartment model with first-order absorption and first-order elimination adequately describes imatinib pharmacokinetics...
February 15, 2019: Pharmacogenomics
https://read.qxmd.com/read/30765830/impacts-of-post-transplantation-cyclophosphamide-treatment-after-allogeneic-hematopoietic-stem-cell-transplantation-in-acute-myeloid-leukemia
#4
Sinem Namdaroglu, Ali Hakan Kaya, Hikmettullah Batgi, Omur Kayikci, Mehmet Sinan Dal, Dicle Iskender, Merih Kizil Cakar, Emre Tekgunduz, Fevzi Altuntas
Post-transplant cyclophosphamide has become a promising medical option after allogeneic HSCT. In this study we aimed to evaluate the efficacy of cyclophosphamide and cyclosporine combination in acute and chronic graft-versus-host disease (GvHD) prophylaxis in acute myeloid leukemia (AML) cases scheduled for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Retrospective analysis of data from 40 cases who underwent allogeneic HSCT under GvHD prophylaxis with cyclophosphamide and cyclosporine combination between April 2016 and August 2017 was made...
February 14, 2019: Scientific Reports
https://read.qxmd.com/read/30764894/high-circ_100053-predicts-a-poor-outcome-for-chronic-myeloid-leukemia-and-is-involved-in-imatinib-resistance
#5
Lei Ping, Chen Jian-Jun, Liao Chu-Shu, Liu Guang-Hua, Zhou Ming
Chronic myeloid leukemia (CML) is a rare clonal myeloproliferative malignancy, which is caused by a reciprocal translocation between chromosomes 9 and 22 t(9;22) (q34;q11). Altered circle RNAs (circRNAs) could contribute to leukemogenesis. In this study, we aimed to investigate the expression profiling of circRNAs in CML. We performed circRNA-sequencing to identify differentially expressed circRNAs in CML cells. Furthermore, we found that circ_100053 was significantly upregulated in peripheral blood mononuclear cells (PBMC) and serum samples from CML compared with healthy controls...
February 14, 2019: Oncology Research
https://read.qxmd.com/read/30764661/investigation-of-phytochemical-constituents-of-anti-leukemic-herbal-drugs-used-by-the-traditional-healers-of-purulia-birbhum-and-bankura-districts-of-west-bengal
#6
Monaj Kumar Sarkar, Vellingiri Vadivel, Mamilla R Charan Raja, Santanu Kar Mahapatra
In the present work, 16 different plant drugs used by traditional healers from West Bengal were screened through in vitro cell line model. Herbal drugs used by traditional tribal healers in Purulia, Birbhum and Bankura districts of West Bengal were collected and screening against acute myeloid leukemia (AML) cell line (HL-60). Among 16 plant extracts, bark of Flacourtia indica (66.67%), leaf of Madhuca longifolia (69.17%), and leaf of Prosopis cineraria (68.08%) showed better cytotoxicity results than other herbals...
February 15, 2019: Natural Product Research
https://read.qxmd.com/read/30764482/inflammation-and-pancreatic-cancer-focus-on-metabolism-cytokines-and-immunity
#7
REVIEW
Andrea Padoan, Mario Plebani, Daniela Basso
Systemic and local chronic inflammation might enhance the risk of pancreatic ductal adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor microenvironment concurs in enhancing tumor growth and metastasis. Inflammation is closely correlated with immunity, the same immune cell populations contributing to both inflammation and immune response. In the PDAC microenvironment, the inflammatory cell infiltrate is unbalanced towards an immunosuppressive phenotype, with a prevalence of myeloid derived suppressor cells (MDSC), M2 polarized macrophages, and Treg , over M1 macrophages, dendritic cells, and effector CD4⁺ and CD8⁺ T lymphocytes...
February 5, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30762219/efficacy-and-safety-of-tyrosine-kinase-inhibitors-for-newly-diagnosed-chronic-phase-chronic-myeloid-leukemia-over-a-5-year-period-results-from-the-japanese-registry-obtained-by-the-new-target-system
#8
Masahiro Kizaki, Naoto Takahashi, Noriyoshi Iriyama, Shinichiro Okamoto, Takaaki Ono, Noriko Usui, Koiti Inokuchi, Chiaki Nakaseko, Mineo Kurokawa, Masahiko Sumi, Fumihiko Nakamura, Tatsuya Kawaguchi, Ritsuro Suzuki, Kazuhito Yamamoto, Kazunori Ohnishi, Itaru Matsumura, Tomoki Naoe
We report the results of a multicenter observational study using the New TARGET system, in which the effectiveness and safety of tyrosine kinase inhibitors (TKIs) were evaluated in newly diagnosed chronic-phase chronic myeloid leukemia (CML) patients. A total of 506 patients were enrolled between April 2010 and March 2013. Median age was 56 (range 18-92) years; 35% of patients were females. As the first-line therapy, 139 (27.9%), 169 (33.9%) and 144 (28.9%) patients were treated with imatinib, nilotinib, and dasatinib, respectively...
February 14, 2019: International Journal of Hematology
https://read.qxmd.com/read/30761815/current-perspectives-for-the-treatment-of-chronic-myeloid-leukemia
#9
Elifcan Aladağ, İbrahim Celalettin Haznedaroğlu
With an annual incidence of 1-2 in a million, Ph*(+) chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disease that makes myeloid neoplastic cells breed out of control. This BCR-ABL(+) myeloproliferative disease makes up about 15%-20% of all leukemia cases in adults. CML is seen more in males than females, with a rate of three to two. However, it does not show differences in prevalence in terms of age. CML consists of three clinical phases. The first one is the chronic phase, defined by rising white blood cell levels and also by myeloid proliferation and bone marrow maturation...
February 11, 2019: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/30761547/frequency-and-implications-of-myeloid-derived-suppressor-cells-and-lymphocyte-subsets-in-egyptian-patients-with-hepatitis-c-virus-related-hepatocellular-carcinoma
#10
Helal F Hetta, Asmaa M Zahran, Shima G Mansor, Mohamed O Abdel-Malek, Mohamed A Mekky, Wael A Abbas
BACKGROUND AND AIM: Myeloid-derived suppressor cells (MDSCs) play a pivotal role in tumor immunity and induction of immune tolerance to a variety of antitumor effectors, including T-lymphocytes. Herein, we tried to evaluate the frequency and clinical significance of MDSCs and different lymphocyte subsets in HCV- related hepatocellular carcinoma (HCC). METHODS: Four groups were enrolled; chronic HCV (CHC, n=40), HCV related liver cirrhosis (HCV-LC, n= 40), HCV related HCC (HCV-HCC, n=75) and healthy control group (n=20)...
February 13, 2019: Journal of Medical Virology
https://read.qxmd.com/read/30755436/c-ebp%C3%AE-is-a-critical-mediator-of-ifn-%C3%AE-induced-exhaustion-of-chronic-myeloid-leukemia-stem-cells
#11
Asumi Yokota, Hideyo Hirai, Ryuichi Sato, Hiroko Adachi, Fumiko Sato, Yoshihiro Hayashi, Atsushi Sato, Naoka Kamio, Yasuo Miura, Masakazu Nakano, Daniel G Tenen, Shinya Kimura, Kei Tashiro, Taira Maekawa
Even in the era of ABL tyrosine kinase inhibitors, eradication of chronic myeloid leukemia (CML) stem cells is necessary for complete cure of the disease. Interferon-α (IFN-α) has long been used for the treatment of chronic-phase CML, but its mechanisms of action against CML stem cells remain unclear. We found that IFN-α upregulated CCAAT/enhancer binding protein β (C/EBPβ) in BCR-ABL-expressing mouse cells by activating STAT1 and STAT5, which were recruited to a newly identified 3' distal enhancer of Cebpb that contains tandemly aligned IFN-γ-activated site elements...
February 12, 2019: Blood Advances
https://read.qxmd.com/read/30753563/long-term-risk-of-hospitalization-among-five-year-survivors-of-childhood-leukemia-in-the-nordic-countries
#12
Gitte Vrelits Sørensen, Jeanette Falck Winther, Sofie de Fine Licht, Klaus Kaa Andersen, Anna Sällfors Holmqvist, Laura Madanat-Harjuoja, Laufey Tryggvadottir, Andrea Bautz, Timothy L Lash, Henrik Hasle
Background: Adverse effects from childhood leukemia treatment may persist or present years after cure from cancer. We provide a comprehensive evaluation of subsequent hospitalization in five-year survivors of childhood acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). Methods: In the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study we identified 4,003 five-year survivors diagnosed with childhood leukemia 1970-2008 in Denmark, Sweden, Iceland, and Finland...
February 11, 2019: Journal of the National Cancer Institute
https://read.qxmd.com/read/30753547/batf2-prevents-t-cell-mediated-intestinal-inflammation-through-regulation-of-the-il-23-il-17-pathway
#13
Hisako Kayama, Haruka Tani, Shoko Kitada, Anunya Opasawatchai, Ryu Okumura, Daisuke Motooka, Shota Nakamura, Kiyoshi Takeda
Inappropriate activation of the interleukin (IL)-23 signaling pathway causes chronic inflammation through the induction of immunopathological Th17 cells in several tissues including the intestine, whereas adequate Th17 responses are essential for host defense against harmful organisms. In the intestinal lamina propria, IL-23 is primarily produced by innate myeloid cells including dendritic cells (DCs) and macrophages (Ms). However, the molecular mechanisms underlying the regulation of IL-23 production by these cells remains poorly understood...
February 12, 2019: International Immunology
https://read.qxmd.com/read/30753270/body-size-and-obesity-during-adulthood-and-risk-of-lympho-hematopoietic-cancers-an-update-of-the-wcrf-aicr-systematic-review-of-published-prospective-studies
#14
L Abar, J G Sobiecki, M Cariolou, N Nanu, A R Vieira, C Stevens, D Aune, D C Greenwood, D S M Chan, T Norat
Background: To summarise the evidence on the associations between body mass index (BMI) and BMI in early adulthood, height, waist circumference (WC) and waist to hip ratio (WHR), and risk of lympho-hematopoietic cancers. Method: We conducted a meta-analysis of prospective studies and identified relevant studies published up to December 2017 by searching PubMed. A random effects model was used to calculate dose-response summary relative risks (RRs). Results: Our findings showed BMI, and BMI in early adulthood (aged 18-21 years) is associated with the risk of Hodgkin's and Non-Hodgkin's lymphoma (HL and NHL), Diffuse Large Beta Cell Lymphoma (DLBCL), Leukaemia including Acute and Chronic Myeloid Lymphoma (AML and CML), and Chronic Lymphocytic Leukaemia (CLL) and Multiple Myeloma...
February 7, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://read.qxmd.com/read/30747340/cognitive-behavioral-therapy-for-treatment-related-fatigue-in-chronic-myeloid-leukemia-patients-on-tyrosine-kinase-inhibitors-a-mixed-method-study
#15
Hanneke Poort, Patrick Onghena, Harriët J G Abrahams, Heather S L Jim, Paul B Jacobsen, Nicole M A Blijlevens, Hans Knoop
Treatment-related fatigue significantly limits quality of life among chronic myeloid leukemia (CML) patients receiving tyrosine kinase inhibitors (TKIs), yet no interventions to reduce this symptom have been studied. We examined preliminary feasibility and efficacy of cognitive behavioral therapy for TKI treatment-related fatigue in patients with CML. We used a mixed methods convergent design and collected quantitative data through randomized single-case experiments. We included CML patients receiving TKIs and reporting severe fatigue...
February 12, 2019: Journal of Clinical Psychology in Medical Settings
https://read.qxmd.com/read/30747249/comparison-of-the-safety-and-efficacy-of-prophylactic-donor-lymphocyte-infusion-after-haploidentical-versus-matched-sibling-pbsct-in-very-high-risk-acute-myeloid-leukemia
#16
Xiao-Ning Gao, Ji Lin, Li-Jun Wang, Fei Li, Hong-Hua Li, Shu-Hong Wang, Wen-Rong Huang, Chun-Ji Gao, Li Yu, Dai-Hong Liu
Donor lymphocyte infusion (DLI) might be used prophylactically to reduce relapse after allogeneic hematopoietic stem cell transplantation for very high-risk leukemia/lymphoma without effective targeted therapy. To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective analysis in a cohort of 21 HID-SCT and 13 MSD-SCT recipients, displaying similar baseline characteristics except for donor's gender distribution...
February 12, 2019: Annals of Hematology
https://read.qxmd.com/read/30746327/transcatheter-aortic-valve-replacement-and-cardiac-resynchronization-therapy-in-cancer-related-cardiotoxicity
#17
Enrico Melillo, Luigi Ascione, Giuseppe Palmiero, Valentina Maria Caso, Pio Caso
Cardiotoxicity related to antineoplastic agents is a rising and growing issue, therefore early recognition and prompt management can impact on the overall prognosis of cancer patients. We report the case of a 70-year-old woman without cardiovascular risk factors, with a medical history of non-Hodgkin lymphoma and chronic myeloid leukemia treated with chemotherapy and radiotherapy, who underwent transcatheter aortic valve replacement for severe aortic stenosis and cardiac resynchronization therapy for further development of complete left bundle branch block, with a significant improvement of her functional status and left ventricle systolic function in a long-term follow-up...
October 2018: Journal of Cardiovascular Echography
https://read.qxmd.com/read/30744447/chronic-myeloid-leukaemia-in-pregnancy-call-for-guidelines
#18
Pallavee P, Rupal Samal, Seetesh Ghose
Although the incidence of chronic myeloid leukaemia (CML) in pregnancy is low, it is progressively rising. The management strategies for CML patients during pregnancy include tyrosine kinase inhibitors, interferon alpha, leukapheresis and hydroxyurea, each of which has their own deleterious effects on the mother and foetus. There are virtually no accepted guidelines on the therapeutic options for these patients. We report two cases of CML which were reported to us during pregnancy, on imatinib, with different ultimate pregnancy outcomes...
February 11, 2019: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/30742098/targeting-syk-signaling-in-myeloid-cells-protects-against-liver-fibrosis-and-hepatocarcinogenesis
#19
Alejandro Torres-Hernandez, Wei Wang, Yuri Nikiforov, Karla Tejada, Luisana Torres, Aleksandr Kalabin, Yue Wu, Muhammad Israr Ul Haq, Mohammed Y Khan, Zhen Zhao, Wenyu Su, Jimmy Camargo, Mautin Hundeyin, Brian Diskin, Salma Adam, Juan A Kochen Rossi, Emma Kurz, Berk Aykut, Sorin A A Shadaloey, Joshua Leinwand, George Miller
Liver fibrosis and fibrosis-associated hepatocarcinogenesis are driven by chronic inflammation and are leading causes of morbidity and death worldwide. SYK signaling regulates critical processes in innate and adaptive immunity, as well as parenchymal cells. We discovered high SYK expression in the parenchymal hepatocyte, hepatic stellate cell (HSC), and the inflammatory compartments in the fibrotic liver. We postulated that targeting SYK would mitigate hepatic fibrosis and oncogenic progression. We found that inhibition of SYK with the selective small molecule inhibitors Piceatannol and PRT062607 markedly protected against toxin-induced hepatic fibrosis, associated hepatocellular injury and intra-hepatic inflammation, and hepatocarcinogenesis...
February 11, 2019: Oncogene
https://read.qxmd.com/read/30739087/bilateral-adrenal-myelolipomas-presenting-as-acute-adrenal-insufficiency-in-an-adult-with-congenital-adrenal-hyperplasia
#20
Sakolwan Suchartlikitwong, Rahul Jasti, Joaquin Lado-Abeal, Ana Marcella Rivas Mejia
Adrenal myelolipomas are relatively rare tumours composed of adipocytes and myeloid cells that arise in response to chronic adrenocorticotropic hormone stimulation. We present the case of bilateral adrenal myelolipomas in a 39-year-old man with untreated congenital adrenal hyperplasia (CAH) presenting with acute adrenal insufficiency and severe virilisation. Phenotypically, he is a man of short stature and has hyperpigmentation of the skin, gingiva and nail beds. Genital examination revealed micropenis and no palpable testes...
February 9, 2019: BMJ Case Reports
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