keyword
https://read.qxmd.com/read/38536893/urinary-proteomics-reveals-biological-processes-related-to-acute-kidney-injury-in-bothrops-atrox-envenomings
#1
JOURNAL ARTICLE
Lisele Maria Brasileiro-Martins, Sofia Angiole Cavalcante, Thaís Pinto Nascimento, Alexandre Vilhena Silva-Neto, Marlon Dias Mariano Santos, Amanda C Camillo-Andrade, Juliana de Saldanha da Gama Fischer, Caroline Coelho Ferreira, Lucas Barbosa Oliveira, Marco Aurelio Sartim, Allyson Guimarães Costa, Manuela B Pucca, Fan Hui Wen, Ana Maria Moura-da-Silva, Jacqueline Sachett, Paulo Costa Carvalho, Priscila Ferreira de Aquino, Wuelton M Monteiro
Acute kidney injury (AKI) is a critical systemic complication caused by Bothrops envenoming, a neglected health problem in the Brazilian Amazon. Understanding the underlying mechanisms leading to AKI is crucial for effectively mitigating the burden of this complication. This study aimed to characterize the urinary protein profile of Bothrops atrox snakebite victims who developed AKI. We analyzed three groups of samples collected on admission: healthy subjects (controls, n = 10), snakebite victims who developed AKI (AKI, n = 10), and those who did not evolve to AKI (No-AKI, n = 10)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38534369/potential-utility-of-urinary-follistatin-as-a-non-invasive-indicator-of-acute-tubular-damage-in-patients-with-acute-kidney-injury
#2
JOURNAL ARTICLE
Izumi Nagayama, Kaori Takayanagi, Daisuke Nagata, Hajime Hasegawa, Akito Maeshima
Activin A is known to impede tubular repair following renal ischemia, whereas exogenous follistatin, an activin A antagonist, has been shown to ameliorate kidney damage in rats. Despite these findings, the precise role of endogenous follistatin in the kidney has yet to be elucidated. In this study, we investigated the localization of follistatin in the normal human kidney and its potential utility as a marker for acute kidney injury (AKI). In a total of 118 AKI patients and 16 healthy adults, follistatin levels in serum and urine were quantified using ELISA, and correlations with clinical parameters were analyzed...
March 16, 2024: Cells
https://read.qxmd.com/read/38530359/genome-wide-crispr-screen-identifies-phospholipid-scramblase-3-as-the-biological-target-of-mitoprotective-drug-ss-31
#3
JOURNAL ARTICLE
Josie A Silvaroli, Bijay Bisunke, Ji Young Kim, Amanda Stayton, Laura A Jayne, Shirely A Martinez, Christopher Nguyen, Prisha S Patel, Thitinee Vanichapol, Vivek Verma, Juheb Akhter, Subhashini Bolisetty, Sethu M Madhavan, Cem Kuscu, Christopher C Coss, Diana Zepeda-Orozco, Samir V Parikh, Anjali A Satoskar, Alan J Davidson, James D Eason, Hazel H Szeto, Navjot Singh Pabla, Amandeep Bajwa
BACKGROUND: The synthetic tetra-peptide SS-31 shows promise in alleviating mitochondrial dysfunction associated with common diseases. However, the precise pharmacological basis of its mitoprotective effects remains unknown. METHODS: To uncover the biological targets of SS-31, we performed a genome-scale CRISPR screen in HK-2 cells, a cell culture model where SS-31 mitigates cisplatin-associated cell death and mitochondrial dysfunction. The identified hit candidate gene was functionally validated using knockout cell lines, siRNA mediated downregulation, and tubular epithelial specific conditional knockout mice...
March 26, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38526145/hyaluronidase-inhibitor-sha2-75-alleviates-ischemia-reperfusion-induced-acute-kidney-injury
#4
JOURNAL ARTICLE
Yang Zhang, Huajiang Zhao, Jing Zhang
Hyaluronidases (HAases) are enzymes that degrade hyaluronic acid (HA) in the animal kingdom. The HAases-HA system is crucial for HA homeostasis and plays a significant role in biological processes and extracellular matrix (ECM)-related pathophysiological conditions. This study aims to explore the role of inhibiting the HAases-HA system in acute kidney injury (AKI). We selected the potent inhibitor "sHA2.75" to inhibit HAase activity through mixed inhibitory mechanisms. The ischemia-reperfusion mouse model was established using male BALB/c mice (7-9 weeks old), and animals were subjected to subcapsular injection with 50 mg/kg sHA2...
March 25, 2024: Cell Cycle
https://read.qxmd.com/read/38518851/selenium-binding-protein-1-protects-renal-tubular-epithelial-cells-from-ferroptosis-by-upregulating-glutathione-peroxidase-4
#5
JOURNAL ARTICLE
Weihao Zhao, David J Nikolic-Paterson, Ke Li, Yan Li, Yinhong Wang, Xianghui Chen, Zhaoyang Duan, Yuzhan Zhang, Pengfei Liu, Shemin Lu, Rongguo Fu, Lifang Tian
Ferroptosis is a form of programmed cell death involved in various types of acute kidney injury (AKI). It is characterized by inactivation of the selenoprotein, glutathione peroxidase 4 (GPX4), and upregulation of acyl-CoA synthetase long-chain family member 4 (ACSL4). Since urinary selenium binding protein 1 (SBP1/SELENBP1) is a potential biomarker for AKI, this study investigated whether SBP1 plays a role in AKI. First, we showed that SBP1 is expressed in proximal tubular cells in normal human kidney, but is significant downregulated in cases of AKI in association with reduced GPX4 expression and increased ACSL4 expression...
March 20, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38517565/wtap-mediated-n6-methyladenosine-modification-promotes-the-inflammation-mitochondrial-damage-and-ferroptosis-of-kidney-tubular-epithelial-cells-in-acute-kidney-injury-by-regulating-lmnb1-expression-and-activating-nf-%C3%AE%C2%BAb-and-jak2-stat3-pathways
#6
JOURNAL ARTICLE
Fan Huang, Yuchen Wang, XiaoLi Lv, Chenda Huang
Acute kidney injury (AKI) is a serious complication of sepsis patients, but the pathogenic mechanisms underlying AKI are still largely unclear. In this view, the roles of the key component of N6-methyladenosine (m6A)-wilms tumor 1 associated protein (WTAP) in AKI progression were investigated. AKI mice model was established by using cecal ligation and puncture (CLP). AKI cell model was established by treating HK-2 cells with LPS. Cell apoptosis was analyzed by TdT-mediated dUTP Nick-End Labeling (TUNEL) staining and flow cytometry analysis...
March 22, 2024: Journal of Bioenergetics and Biomembranes
https://read.qxmd.com/read/38517396/cordyceps-sinensis-extract-protects-against-acute-kidney-injury-by-inhibiting-perforin-expression-in-nk-cells-via-the-sting-irf3-pathway
#7
JOURNAL ARTICLE
Shuang Li, Wei Pang, Yuzhu Wang, Yiting Zhang
Acute kidney injury (AKI) is associated with immune cell activation and inflammation. However, the putative pathogenic mechanisms of this injury have not been thoroughly investigated. Natural killer (NK) cells play an important role in immune regulation; however, whether NK cells regulate AKI remains unclear. Cordyceps sinensis (CS), a modern Chinese patented medicine preparation, has been widely used in treating patients with chronic kidney disease (CKD) owing to its anti-inflammatory effects and maintenance of immune homeostasis...
March 21, 2024: Aging
https://read.qxmd.com/read/38517242/heparin-binding-protein-levels-predict-unfavorable-outcome-in-covid-19-pneumonia-a-post-hoc-analysis-of-the-save-trial
#8
JOURNAL ARTICLE
Evdoxia Kyriazopoulou, George N Dalekos, Symeon Metallidis, Garyphalia Poulakou, Ilias C Papanikolaou, Vasiliki Tzavara, Katerina Argyraki, Zoi Alexiou, Periklis Panagopoulos, Michael Samarkos, George Chrysos, Aikaterini Tseliou, Haralampos Milionis, Styliani Sympardi, Anil Vasishta, Evangelos J Giamarellos-Bourboulis
We aimed to evaluate heparin-binding protein (HBP) as a marker of prognosis of unfavorable outcome in COVID-19 pneumonia. This was a post-hoc analysis of the SAVE clinical trial investigating anakinra treatment, guided by suPAR (soluble urokinase plasminogen activator receptor) levels ≥6 ng/ml, for the prevention of severe respiratory failure (SRF) in hospitalized patients with COVID-19 pneumonia. Baseline HBP plasma levels were measured in 534 patients by fluorescence dry quantitative immunoassay using the Jet-iStar 800 analyzer...
January 19, 2024: Shock
https://read.qxmd.com/read/38513239/landscape-of-driver-mutations-and-their-clinical-effects-on-down-syndrome-related-myeloid-neoplasms
#9
JOURNAL ARTICLE
Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko Moriya Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito
Transient abnormal myelopoiesis (TAM) is a common complication in newborns with Down syndrome (DS). It commonly progresses to myeloid leukemia (ML-DS) after spontaneous regression. In contrast to the favorable prognosis of primary ML-DS, patients with refractory/relapsed ML-DS have poor outcomes. However, the molecular basis for refractoriness and relapse, and the full spectrum of driver mutations in ML-DS remain largely unknown. We conducted a genomic profiling study of 143 TAM, 204 ML-DS, and 34 non-DS acute megakaryoblastic leukemia cases, including 39 ML-DS cases analyzed by exome sequencing...
March 21, 2024: Blood
https://read.qxmd.com/read/38512776/diagnostic-accuracy-of-thermal-hydration-and-heart-rate-assessments-in-discriminating-positive-acute-kidney-injury-risk-following-physical-work-in-the-heat
#10
JOURNAL ARTICLE
Christopher L Chapman, Blair D Johnson, David P Hostler, Zachary J Schlader
Occupational heat stress increases the risk of acute kidney injury (AKI). This study presents a secondary analysis to generate novel hypotheses for future studies by investigating the diagnostic accuracy of thermal, hydration, and heart rate assessments in discriminating positive AKI risk following physical work in the heat in unacclimatized individuals. Unacclimatized participants ( n  = 13, 3 women, age: ∼23 years) completed four trials involving 2 h of exercise in a 39...
March 21, 2024: Journal of Occupational and Environmental Hygiene
https://read.qxmd.com/read/38508544/a-comprehensive-review-on-role-of-aurora-kinase-inhibitors-akis-in-cancer-therapeutics
#11
REVIEW
Deepali Gupta, Mukesh Kumar, Sana Saifi, Shivani Rawat, A S Ethayathulla, Punit Kaur
Aurora kinases (AURKs) are a family of serine /threonine protein kinases that have a crucial role in cell cycle process mainly in the event of chromosomal segregation, centrosome maturation and cytokinesis. The family consists of three members including Aurora kinase A (AURK-A), Aurora kinase B (AURK-B) and Aurora kinase C (AURK-C). All AURKs contain a conserved kinase domain for their activity but differ in their cellular localization and functions. AURK-A and AURK-B is expressed mainly in somatic cells while the expression of AURK-C is limited to germ cells...
March 18, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38503767/renal-biopsies-from-donors-with-acute-kidney-injury-show-different-molecular-patterns-according-to-the-post-transplant-function
#12
JOURNAL ARTICLE
Flavia Neri, Maria Letizia Lo Faro, Maria Kaisar, Ka Ho Tam, Martyna Borak, Jan Lindeman, Annalisa Angelini, Marny Fedrigo, Jesper Kers, James Hunter, Rutger Ploeg
The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was to identify protein mediators implicated in either recovery or failure of these organs. Forty kidney biopsies from donors with (20) and without AKI (20) were selected and then subdivided according to the post-transplant outcome defined as a threshold of 45 ml/min for the eGFR at 1 year from transplantation. Tissue homogenates were analysed by western blot to assess how the levels of 17 pre-selected proteins varied across the four groups...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38501417/-chlorogenic-acid-alleviates-acute-kidney-injury-in-septic-mice-by-inhibiting-nlrp3-inflammasomes-and-the-caspase-1-canonical-pyroptosis-pathway
#13
JOURNAL ARTICLE
S Fang, R Sun, H Su, K Zhai, Y Xiang, Y Gao, W Guo
OBJECTIVE: To investigate the role of caspase-1-medicated canonical pyroptosis pathway in chlorogenic acid (CGA) treatment of acute kidney injury (AKI) in mice. METHOD: Twenty-four C57Bl/6J mice were randomized into sham-operated group, cecal ligation and puncture (CLP) group, CLP+dexamethasone group (CLP+DXM group), and CLP+CGA group ( n =6) and subjected to either sham operation (laparotomy only) or CLP. After modeling the mice received intravenous infusion of 10 mg/kg normal saline (in sham and CLP groups), 1 μg/kg dexamethasone or 15 mg/kg of chlorogenic acid for 6 h delivered using an intravenous pump...
February 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/38497110/timp2-protects-against-sepsis-associated-acute-kidney-injury-by-camp-nlrp3-axis-mediated-pyroptosis
#14
JOURNAL ARTICLE
Dongxue Xu, Jun Jiang, Ye Liu, Jingjing Pang, Jinmeng Suo, Yiming Li, Zhiyong Peng
The tissue inhibitor of metalloproteinases 2 (TIMP2) has emerged as a promising biomarker for predicting the risk of sepsis-associated acute kidney injury (SA-AKI). However, its exact role in SA-AKI and the underlying mechanism remains unclear. In this study, we investigated the impact of kidney tubule-specific Timp2 knockout mice on kidney injury and inflammation. Our findings demonstrated that Timp2-knockout mice exhibited more severe kidney injury than wild-type mice, along with elevated levels of pyroptosis markers NLRP3, Caspase1, and GSDMD in the early stage of SA-AKI...
March 18, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38485717/sting-contributes-to-lipopolysaccharide-induced-tubular-cell-inflammation-and-pyroptosis-by-activating-endoplasmic-reticulum-stress-in-acute-kidney-injury
#15
JOURNAL ARTICLE
Yun Cao, Xinghua Chen, Zijing Zhu, Zilv Luo, Yiqun Hao, Xueyan Yang, Jun Feng, Zongwei Zhang, Jijia Hu, Yonghong Jian, Jiefu Zhu, Wei Liang, Zhaowei Chen
Recently, innate immunity and inflammation were recognized as the key factors for acute kidney injury (AKI) caused by sepsis, which is closely related to high mortality. Stimulator of interferon genes (STING) has emerged as a critical component of innate immune and inflammatory responses. However, the role of STING in the pathogenesis of septic AKI remains unclear. This study demonstrated that the STING was significantly activated in tubular cells induced by lipopolysaccharide (LPS) in vivo and in vitro. Tubule-specific STING knockout attenuated LPS-induced renal dysfunction and pathological changes...
March 14, 2024: Cell Death & Disease
https://read.qxmd.com/read/38482886/tak-242-improves-sepsis-associated-acute-kidney-injury-in-rats-by-inhibiting-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#16
JOURNAL ARTICLE
Yan-Mei Xia, Yu-Qian Guan, Ji-Fang Liang, Wei-Dong Wu
OBJECTIVE: This study was designed to observe the effect of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway activity on sepsis-associated acute kidney injury (SA-AKI), thereby providing new considerations for the prevention and treatment of SA-AKI. METHODS: The rats were divided into Sham, cecal ligation and puncture (CLP), CLP + vehicle, and CLP + TAK-242 groups. Except the Sham group, a model of CLP-induced sepsis was established in other groups...
December 2024: Renal Failure
https://read.qxmd.com/read/38482555/tnik-depletion-induces-inflammation-and-apoptosis-ininjured-renal-proximal-tubule-epithelial-cells
#17
JOURNAL ARTICLE
Shayna T J Bradford, Haojia Wu, Yuhei Kirita, Changfeng Chen, Nicole P Malvin, Yasuhiro Yoshimura, Yoshiharu Muto, Benjamin D Humphreys
In the aftermath of acute kidney injury (AKI), surviving proximal tubule epithelia repopulate injured tubules to promote repair. However, a portion of cells fail to repair (termed Failed Repair Proximal Tubule Cells, FR-PTCs) and exert ongoing proinflammatory and profibrotic effects. To better understand the molecular drivers of the FR-PTC state, we reanalyzed a mouse ischemia-reperfusion injury single nucleus RNA-sequencing (snRNA-seq) atlas to identify Traf2 and Nck Interacting Kinase, Tnik, to be exclusively expressed in FR-PTCs, but not in healthy or acutely injured proximal tubules post AKI (2 and 6 weeks) in mice...
March 14, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38479859/longitudinal-relationship-between-screen-based-sedentary-behavior-and-nutrient-intake-in-japanese-children-an-observational-epidemiological-cohort-study
#18
JOURNAL ARTICLE
Hiromasa Tsujiguchi, Yuriko Sakamoto, Akinori Hara, Keita Suzuki, Sakae Miyagi, Masaharu Nakamura, Chie Takazawa, Kim Oanh Pham, Thao Thi Thu Nguyen, Yasuhiro Kambayashi, Yukari Shimizu, Hirohito Tsuboi, Yasuki Ono, Toshio Hamagishi, Aki Shibata, Koichi Hayashi, Tadashi Konoshita, Hiroyuki Nakamura
BACKGROUND: Concerns regarding the impact of screen-based sedentary behavior on health have been increasing. Therefore, the present study investigated the longitudinal relationship between multiple screen time and nutrient intake in children and adolescents. METHODS: The present study was conducted utilizing 3 years longitudinal data. Study subjects were 740 Japanese children aged between 6 and 12 years at baseline and between 9 and 15 years in the follow-up. Screen-based sedentary behavior was assessed using screen time, including television (TV) viewing, personal computer (PC) use, and mobile phone (MP) use...
2024: Environmental Health and Preventive Medicine
https://read.qxmd.com/read/38478853/andrographolide-attenuates-sepsis-induced-acute-kidney-injury-by-inhibiting-ferroptosis-through-the-nrf2-fsp1-pathway
#19
JOURNAL ARTICLE
Yixin Zhang, Youcheng Zeng, Ming Huang, Guodong Cao, Liang Lin, Xiaoyue Wang, Qinghong Cheng
Sepsis is a systemic inflammatory response syndrome caused by infection, which causes renal dysfunction known as sepsis-associated acute kidney injury (S-AKI). Ferroptosis is a form of lipid peroxidation dependent on iron and reactive oxygen species that differs from other forms of programmed cell death at the morphological and biochemical levels. Andrographolide (AG), a natural diterpenoid lactone compound extracted from Andrographis paniculata , has been shown to have therapeutic effects in kidney disease...
March 13, 2024: Free Radical Research
https://read.qxmd.com/read/38476861/prognostic-biomarkers-and-aki-potential-to-enhance-the-identification-of-post-operative-patients-at-risk-of-loss-of-renal-function
#20
REVIEW
Rishabh Singh, James C Watchorn, Alexander Zarbock, Lui G Forni
Acute kidney injury (AKI) is a common complication after surgery and the more complex the surgery, the greater the risk. During surgery, patients are exposed to a combination of factors all of which are associated with the development of AKI. These include hypotension and hypovolaemia, sepsis, systemic inflammation, the use of nephrotoxic agents, tissue injury, the infusion of blood or blood products, ischaemia, oxidative stress and reperfusion injury. Given the risks of AKI, it would seem logical to conclude that early identification of patients at risk of AKI would translate into benefit...
2024: Research and Reports in Urology
keyword
keyword
167209
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.