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https://read.qxmd.com/read/30705232/american-medical-society-for-sports-medicine-position-statement-on-concussion-in-sport
#1
Kimberly G Harmon, James R Clugston, Katherine Dec, Brian Hainline, Stanley Herring, Shawn F Kane, Anthony P Kontos, John J Leddy, Michael McCrea, Sourav K Poddar, Margot Putukian, Julie C Wilson, William O Roberts
Sport-related concussion (SRC) is a common injury in recreational and organised sport. Over the past 30 years, there has been significant progress in our scientific understanding of SRC, which in turn has driven the development of clinical guidelines for diagnosis, assessment and management of SRC. In addition to a growing need for knowledgeable healthcare professionals to provide evidence-based care for athletes with SRC, media attention and legislation have created awareness and, in some cases, fear about many issues and unknowns surrounding SRC...
February 2019: British Journal of Sports Medicine
https://read.qxmd.com/read/30586488/provider-owned-insurers-in-the-individual-market
#2
David H Howard, Brad Herring, John Graves, Erin Trish
OBJECTIVES: To describe the number and availability of individual market plans sold by provider-owned insurers and compare differences in premiums between traditional and provider-owned insurers. STUDY DESIGN: Cross-sectional analysis. METHODS: Using the Robert Wood Johnson Foundation's HIX Compare data, we identified insurers selling Affordable Care Act (ACA)-compliant policies in the individual market and identified those insurers owned by health systems by using information on their websites...
December 1, 2018: American Journal of Managed Care
https://read.qxmd.com/read/30565344/gastroparesis-is-associated-with-decreased-foxf1-and-foxf2-in-humans-and-loss-of-foxf1-and-foxf2-results-in-gastroparesis-in-mice
#3
Brian Paul Herring, April M Hoggatt, Anita Gupta, John M Wo
BACKGROUND AND AIMS: The transcription factors FOXF1 and FOXF2 have been implicated in the development of the gastrointestinal tract but their role in adults or in gastrointestinal diseases is poorly understood. We have recently shown that expression of serum response factor (SRF), a transcription factor whose activity is modulated by FOXF proteins, is decreased in the stomach muscularis of patients with gastroparesis. The aim of the current study was to determine whether FOXF expression is decreased in gastroparesis patients and whether loss of FOXF1 and/or FOXF2 from adult smooth muscle is sufficient to impair gastric emptying in mice...
December 19, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/30563834/a-strategy-to-exploit-surrogate-sire-technology-in-livestock-breeding-programs
#4
Paolo Gottardo, Gregor Gorjanc, Mara Battagin, R Chris Gaynor, Janez Jenko, Roger Ros-Freixedes, C Bruce A Whitelaw, Alan J Mileham, William O Herring, John M Hickey
In this work, we performed simulations to develop and test a strategy for exploiting surrogate sire technology in animal breeding programs. Surrogate sire technology allows the creation of males that lack their own germline cells, but have transplanted spermatogonial stem cells from donor males. With this technology, a single elite male donor could give rise to huge numbers of progeny, potentially as much as all the production animals in a particular time period. One hundred replicates of various scenarios were performed...
December 18, 2018: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/30543776/o-glcnac-transferase-links-glucose-metabolism-to-mavs-mediated-antiviral-innate-immunity
#5
Tianliang Li, Xinghui Li, Kuldeep S Attri, Changhong Liu, Lupeng Li, Laura E Herring, John M Asara, Yu L Lei, Pankaj K Singh, Chengjiang Gao, Haitao Wen
Increased glucose metabolism in immune cells not only serves as a hallmark feature of acute inflammation but also profoundly affects disease outcome following bacterial infection and tissue damage. However, the role of individual glucose metabolic pathways during viral infection remains largely unknown. Here we demonstrate an essential function of the hexosamine biosynthesis pathway (HBP)-associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in promoting antiviral innate immunity. Challenge of macrophages with vesicular stomatitis viruses (VSVs) enhances HBP activity and downstream protein O-GlcNAcylation...
December 12, 2018: Cell Host & Microbe
https://read.qxmd.com/read/30517700/novel-strategy-of-ventral-dural-repair-for-idiopathic-thoracic-spinal-cord-herniation-report-of-outcomes-and-review-of-techniques
#6
Eric Z Herring, John H Shin, Sean J Nagel, Ajit A Krishnaney
BACKGROUND: Idiopathic ventral thoracic spinal cord herniation is a rare condition that usually presents with progressive myelopathy or Brown-Séquard syndrome. More than 100 cases have been reported with significant variance in surgical treatment strategies and likewise, significant variance in patient outcomes. Although laminectomy has often been used, to date, there is no consensus regarding the optimal surgical approach or strategy for ventral dural repair. OBJECTIVE: To report and illustrate a novel approach to repair the ventral dural defect with more than 2 yr of clinical follow-up...
December 4, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/30346513/patterns-in-reduction-or-cessation-of-drinking-in-australia-2001-2013-and-motivation-for-change
#7
Amy Pennay, Sarah Callinan, Michael Livingston, Daniel I Lubman, John Holmes, Sarah MacLean, Rachel Herring, Paul Dietze
Aims: This paper examines: (a) change over time (2001-2013) in recently reducing or ceasing drinking in the Australian population and (b) the reasons given for reducing or ceasing drinking in the most recent survey (2013); stratified by sex and age group. Short summary: Rates of reducing and ceasing drinking increased between 2001 and 2013 in Australia. Young people were more likely to modify drinking due to lifestyle and enjoyment reasons; older groups were more likely to report health reasons...
October 20, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://read.qxmd.com/read/30306788/refractory-spontaneous-hypoglycaemia-a-diagnostic-conundrum
#8
Seong Keat Cheah, David Halsall, Peter Barker, John Grant, Abraham Mathews, Shyam Seshadri, Singhan Krishnan
A frail 79-year-old lady with dementia presented with a 2-year history of frequent falls. Recurrent hypoglycaemic episodes were diagnosed and treated with continuous glucose infusion in multiple hospital admissions. Hypoadrenalism and hypothyroidism were ruled out. Whilst hypoglycaemic (blood glucose 1.6 mmol/L), both plasma C-peptide and proinsulin concentrations, were inappropriately elevated at 4210 pmol/L (174–960) and >200 pmol/L (0–7) respectively with plasma insulin suppressed at 12 pmol/L (0–180)...
September 24, 2018: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/30278007/vertebral-tethering-for-scoliosis-management-commentary-on-an-article-by-peter-o-newton-md-et-al-anterior-spinal-growth-tethering-for-skeletally-immature-patients-with-scoliosis-a-retrospective-look-two-to-four-years-postoperatively
#9
https://read.qxmd.com/read/30193325/diagnosis-and-management-of-mild-traumatic-brain-injury-in-children-a-systematic-review
#10
Angela Lumba-Brown, Keith Owen Yeates, Kelly Sarmiento, Matthew J Breiding, Tamara M Haegerich, Gerard A Gioia, Michael Turner, Edward C Benzel, Stacy J Suskauer, Christopher C Giza, Madeline Joseph, Catherine Broomand, Barbara Weissman, Wayne Gordon, David W Wright, Rosemarie Scolaro Moser, Karen McAvoy, Linda Ewing-Cobbs, Ann-Christine Duhaime, Margot Putukian, Barbara Holshouser, David Paulk, Shari L Wade, Stanley A Herring, Mark Halstead, Heather T Keenan, Meeryo Choe, Cindy W Christian, Kevin Guskiewicz, P B Raksin, Andrew Gregory, Anne Mucha, H Gerry Taylor, James M Callahan, John DeWitt, Michael W Collins, Michael W Kirkwood, John Ragheb, Richard G Ellenbogen, T J Spinks, Theodore G Ganiats, Linda J Sabelhaus, Katrina Altenhofen, Rosanne Hoffman, Tom Getchius, Gary Gronseth, Zoe Donnell, Robert E O'Connor, Shelly D Timmons
Importance: In recent years, there has been an exponential increase in the research guiding pediatric mild traumatic brain injury (mTBI) clinical management, in large part because of heightened concerns about the consequences of mTBI, also known as concussion, in children. The CDC National Center for Injury Prevention and Control's (NCIPC) Board of Scientific Counselors (BSC), a federal advisory committee, established the Pediatric Mild TBI Guideline workgroup to complete this systematic review summarizing the first 25 years of literature in this field of study...
November 1, 2018: JAMA Pediatrics
https://read.qxmd.com/read/30193284/centers-for-disease-control-and-prevention-guideline-on-the-diagnosis-and-management-of-mild-traumatic-brain-injury-among-children
#11
Angela Lumba-Brown, Keith Owen Yeates, Kelly Sarmiento, Matthew J Breiding, Tamara M Haegerich, Gerard A Gioia, Michael Turner, Edward C Benzel, Stacy J Suskauer, Christopher C Giza, Madeline Joseph, Catherine Broomand, Barbara Weissman, Wayne Gordon, David W Wright, Rosemarie Scolaro Moser, Karen McAvoy, Linda Ewing-Cobbs, Ann-Christine Duhaime, Margot Putukian, Barbara Holshouser, David Paulk, Shari L Wade, Stanley A Herring, Mark Halstead, Heather T Keenan, Meeryo Choe, Cindy W Christian, Kevin Guskiewicz, P B Raksin, Andrew Gregory, Anne Mucha, H Gerry Taylor, James M Callahan, John DeWitt, Michael W Collins, Michael W Kirkwood, John Ragheb, Richard G Ellenbogen, Theodore J Spinks, Theodore G Ganiats, Linda J Sabelhaus, Katrina Altenhofen, Rosanne Hoffman, Tom Getchius, Gary Gronseth, Zoe Donnell, Robert E O'Connor, Shelly D Timmons
Importance: Mild traumatic brain injury (mTBI), or concussion, in children is a rapidly growing public health concern because epidemiologic data indicate a marked increase in the number of emergency department visits for mTBI over the past decade. However, no evidence-based clinical guidelines have been developed to date for diagnosing and managing pediatric mTBI in the United States. Objective: To provide a guideline based on a previous systematic review of the literature to obtain and assess evidence toward developing clinical recommendations for health care professionals related to the diagnosis, prognosis, and management/treatment of pediatric mTBI...
November 1, 2018: JAMA Pediatrics
https://read.qxmd.com/read/29933283/injectable-corticosteroids-in-sport
#12
Nathan P Olafsen, Stanley A Herring, John W Orchard
OBJECTIVE: To review the literature guiding all aspects of the use of injectable corticosteroids for painful musculoskeletal conditions, with a focus on the treatment of athletes. DATA SOURCES: An extensive search of the literature was completed including search terms of corticosteroid, steroid, athlete, and injection, among others. Additional articles were used after being identified from previously reviewed articles. MAIN RESULTS: Injections of corticosteroids for a variety of painful conditions of the extremities and the axial spine have been described...
September 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://read.qxmd.com/read/29787605/correction-evaluating-signals-of-oil-spill-impacts-climate-and-species-interactions-in-pacific-herring-and-pacific-salmon-populations-in-prince-william-sound-and-copper-river-alaska
#13
Eric J Ward, Milo Adkison, Jessica Couture, Sherri C Dressel, Michael A Litzow, Steve Moffitt, Tammy Hoem Neher, John Trochta, Rich Brenner
[This corrects the article DOI: 10.1371/journal.pone.0172898.].
2018: PloS One
https://read.qxmd.com/read/29751308/the-influence-of-avian-biovectors-on-mercury-speciation-in-a-bog-ecosystem
#14
Jocelyn C Kickbush, Mark L Mallory, John D Murimboh, Jennie Rand, Sara J Klapstein, Amanda L Loder, Nicholas M Hill, Nelson J O'Driscoll
Methylmercury (MeHg) is a neurotoxin and endocrine disruptor that bioaccumulates and biomagnifies through trophic levels, resulting in potentially hazardous concentrations. Although wetlands are known hotspots for mercury (Hg) methylation, the effects of avian biovectors on these processes are poorly understood. We examined Hg speciation and distribution in shallow groundwater and surface water from a raised-bog with over 30years of avian biovector (herring gulls Larus argentatus and great black-backed gulls Larus marinus) colonization and guano input...
October 1, 2018: Science of the Total Environment
https://read.qxmd.com/read/29748991/marginalized-zero-inflated-poisson-models-with-missing-covariates
#15
Habtamu K Benecha, John S Preisser, Kimon Divaris, Amy H Herring, Kalyan Das
Unlike zero-inflated Poisson regression, marginalized zero-inflated Poisson (MZIP) models for counts with excess zeros provide estimates with direct interpretations for the overall effects of covariates on the marginal mean. In the presence of missing covariates, MZIP and many other count data models are ordinarily fitted using complete case analysis methods due to lack of appropriate statistical methods and software. This article presents an estimation method for MZIP models with missing covariates. The method, which is applicable to other missing data problems, is illustrated and compared with complete case analysis by using simulations and dental data on the caries preventive effects of a school-based fluoride mouthrinse program...
July 2018: Biometrical Journal. Biometrische Zeitschrift
https://read.qxmd.com/read/29656941/submucosal-gland-myoepithelial-cells-are-reserve-stem-cells-that-can-regenerate-mouse-tracheal-epithelium
#16
Thomas J Lynch, Preston J Anderson, Pavana G Rotti, Scott R Tyler, Adrianne K Crooke, Soon H Choi, Daniel T Montoro, Carolyn L Silverman, Weam Shahin, Rui Zhao, Chandler W Jensen-Cody, Andrea Adamcakova-Dodd, T Idil Apak Evans, Weiliang Xie, Yulong Zhang, Hongmei Mou, B Paul Herring, Peter S Thorne, Jayaraj Rajagopal, Charles Yeaman, Kalpaj R Parekh, John F Engelhardt
The mouse trachea is thought to contain two distinct stem cell compartments that contribute to airway repair-basal cells in the surface airway epithelium (SAE) and an unknown submucosal gland (SMG) cell type. Whether a lineage relationship exists between these two stem cell compartments remains unclear. Using lineage tracing of glandular myoepithelial cells (MECs), we demonstrate that MECs can give rise to seven cell types of the SAE and SMGs following severe airway injury. MECs progressively adopted a basal cell phenotype on the SAE and established lasting progenitors capable of further regeneration following reinjury...
May 3, 2018: Cell Stem Cell
https://read.qxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#17
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://read.qxmd.com/read/29291125/jellyfish-on-the-menu-mtdna-assay-reveals-scyphozoan-predation-in-the-irish-sea
#18
Philip D Lamb, Ewan Hunter, John K Pinnegar, Simon Creer, Richard G Davies, Martin I Taylor
Localized outbreaks of jellyfish, known as blooms, cause a variety of adverse ecological and economic effects. However, fundamental aspects of their ecology remain unknown. Notably, there is scant information on the role jellyfish occupy in food webs: in many ecosystems, few or no predators are known. To identify jellyfish consumers in the Irish Sea, we conducted a molecular gut content assessment of 50 potential predators using cnidarian-specific mtDNA primers and sequencing. We show that jellyfish predation may be more common than previously acknowledged: uncovering many previously unknown jellyfish predators...
November 2017: Royal Society Open Science
https://read.qxmd.com/read/29097735/mammalian-%C3%AE-2-ampk-regulates-intrinsic-heart-rate
#19
Arash Yavari, Mohamed Bellahcene, Annalisa Bucchi, Syevda Sirenko, Katalin Pinter, Neil Herring, Julia J Jung, Kirill V Tarasov, Emily J Sharpe, Markus Wolfien, Gabor Czibik, Violetta Steeples, Sahar Ghaffari, Chinh Nguyen, Alexander Stockenhuber, Joshua R St Clair, Christian Rimmbach, Yosuke Okamoto, Dongmei Yang, Mingyi Wang, Bruce D Ziman, Jack M Moen, Daniel R Riordon, Christopher Ramirez, Manuel Paina, Joonho Lee, Jing Zhang, Ismayil Ahmet, Michael G Matt, Yelena S Tarasova, Dilair Baban, Natasha Sahgal, Helen Lockstone, Rathi Puliyadi, Joseph de Bono, Owen M Siggs, John Gomes, Hannah Muskett, Mahon L Maguire, Youlia Beglov, Matthew Kelly, Pedro P N Dos Santos, Nicola J Bright, Angela Woods, Katja Gehmlich, Henrik Isackson, Gillian Douglas, David J P Ferguson, Jürgen E Schneider, Andrew Tinker, Olaf Wolkenhauer, Keith M Channon, Richard J Cornall, Eduardo B Sternick, David J Paterson, Charles S Redwood, David Carling, Catherine Proenza, Robert David, Mirko Baruscotti, Dario DiFrancesco, Edward G Lakatta, Hugh Watkins, Houman Ashrafian
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding adenine nucleotides. Humans bearing activating mutations in the γ2 subunit exhibit a phenotype including unexplained slowing of heart rate (bradycardia). Here, we show that γ2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate, including sarcolemmal hyperpolarization-activated current (I f ) and ryanodine receptor-derived diastolic local subsarcolemmal Ca2+ release...
November 2, 2017: Nature Communications
https://read.qxmd.com/read/28899991/infographic-consensus-statement-on-concussion-in-sport
#20
EDITORIAL
Paul McCrory, Willem Meeuwisse, Jiri Dvorak, Mark Aubry, Julian Bailes, Steven Broglio, Robert C Cantu, David Cassidy, Ruben J Echemendia, Rudy J Castellani, Gavin A Davis, Richard Ellenbogen, Carolyn Emery, Lars Engebretsen, Nina Feddermann-Demont, Christopher C Giza, Kevin M Guskiewicz, Stanley Herring, Grant L Iverson, Karen M Johnston, James Kissick, Jeffrey Kutcher, John J Leddy, David Maddocks, Michael Makdissi, Geoff Manley, Michael McCrea, William P Meehan, Shinji Nagahiro, Jon Patricios, Margot Putukian, Kathryn J Schneider, Allen Sills, Charles H Tator, Michael Turner, Pieter E Vos
No abstract text is available yet for this article.
November 2017: British Journal of Sports Medicine
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