Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Jonathan J H Bray, Marco Coronelli, Sam G C Scott, John A Henry, Liam S Couch, Mahmood Ahmad, Julian Ormerod, James Gamble, Timothy R Betts, Andrew Lewis, Oliver J Rider, Peregrine G Green, Neil Herring
AIMS: The trials upon which recommendations for the use of cardiac resynchronization therapy (CRT) in heart failure used optimal medical therapy (OMT) before sodium-glucose co-transporter 2 inhibitors (SGLT2i). Moreover, the SGLT2i heart failure trials included only a small proportion of participants with CRT, and therefore, it remains uncertain whether SGLT2i should be considered part of OMT prior to CRT. METHODS AND RESULTS: We compared electrocardiogram (ECG) and echocardiographic responses to CRT as well as hospitalization and mortality rates in consecutive patients undergoing implantation at a large tertiary centre between January 2019 to June 2022 with and without SGLT2i treatment...
April 22, 2024: ESC Heart Failure
#2
JOURNAL ARTICLE
Jacob D Meyer, Seana L Perkins, John M Gidley, Julianna M Kuzniar, L Alison Phillips, Jeni L Lansing, Nathaniel G Wade, Matthew P Herring, Wesley K Lefferts
UNLABELLED: Many adults with major depressive disorder (MDD) do not receive effective treatment. The potential benefits of resistance exercise training (RET) are understudied and may be mechanistically related to cerebral blood flow changes. PURPOSE: To assess feasibility, acceptability, and preliminary efficacy of a 16-week, theory-informed RET trial for the treatment of MDD and explore changes in cerebral blood flow. METHODS: Ten adults with DSM-5-diagnosed MDD were enrolled in a single-arm, 16-week, twice-weekly, whole-body RET intervention, consistent with US and WHO Physical Activity resistance exercise guidelines...
April 12, 2024: Psychology of Sport and Exercise
#3
JOURNAL ARTICLE
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Alvaro Curiel-Garcia, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert H Vonderheide, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Broad-spectrum RAS inhibition holds the potential to benefit roughly a quarter of human cancer patients whose tumors are driven by RAS mutations1,2 . RMC-7977 is a highly selective inhibitor of the active GTP-bound forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants (RAS(ON) multi-selective)3 . As >90% of human pancreatic ductal adenocarcinoma (PDAC) cases are driven by activating mutations in KRAS4 , we assessed the therapeutic potential of the RAS(ON) multi-selective inhibitor RMC-7977 in a comprehensive range of PDAC models...
April 8, 2024: Nature
#4
JOURNAL ARTICLE
Francis van Oordt, Antonio Cuba, Emily S Choy, John E Elliott, Kyle H Elliott
Hutchison's niche theory suggests that coexisting competing species occupy non-overlapping hypervolumes, which are theoretical spaces encompassing more than three dimensions, within an n-dimensional space. The analysis of multiple stable isotopes can be used to test these ideas where each isotope can be considered a dimension of niche space. These hypervolumes may change over time in response to variation in behaviour or habitat, within or among species, consequently changing the niche space itself. Here, we use isotopic values of carbon and nitrogen of ten amino acids, as well as sulphur isotopic values, to produce multi-isotope models to examine niche segregation among an assemblage of five coexisting seabird species (ancient murrelet Synthliboramphus antiquus, double-crested cormorant Phalacrocorax auritus, Leach's storm-petrel Oceanodrama leucorhoa, rhinoceros auklet Cerorhinca monocerata, pelagic cormorant Phalacrocorax pelagicus) that inhabit coastal British Columbia...
April 3, 2024: Scientific Reports
#5
Eric M Merten, John D Sears, Tina M Leisner, Paul B Hardy, Anirban Ghoshal, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Peter J Brown, Michael A Stashko, Laura E Herring, Angie L Mordant, Thomas S Webb, Christine A Mills, Natalie K Barker, Jamie J Arnold, Craig E Cameron, Daniel N Streblow, Nathaniel J Moorman, Mark Heise, Timothy M Willson, Konstantin I Popov, Kenneth H Pearce
UNLABELLED: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has been responsible for numerous large-scale outbreaks in the last twenty years. Currently, there are no FDA-approved therapeutics for any alphavirus infection. CHIKV non-structural protein 2 (nsP2), which contains a cysteine protease domain, is essential for viral replication, making it an attractive target for a drug discovery campaign. Here, we optimized a CHIKV nsP2 protease (nsP2pro) biochemical assay for the screening of a 6,120-compound cysteine-directed covalent fragment library...
March 22, 2024: bioRxiv
#6
JOURNAL ARTICLE
Karina Amani Zapata, Donald Virostek, Yuhan Ma, Anne-Marie Datcu, McKenzie R Gunselman, John A Herring, Megan E Johnson
BACKGROUND: This study determined brace wear adherence for patients treated with nighttime braces and evaluated the effect of brace adherence on curve progression. METHODS: One hundred twenty-two patients with AIS ages 10-16 years, Risser stages 0-2, major curves 20°-40° treated with Providence nighttime braces prescribed to be worn at least 8 h per night were prospectively enrolled and followed until skeletal maturity or surgery. Brace adherence was measured using iButton temperature sensors after 3 months of brace initiation and at brace discharge...
March 8, 2024: Spine Deformity
#7
JOURNAL ARTICLE
Elise A Chong, Kingsley Gideon Kumashie, Emeline R Chong, Joseph Fabrizio, Aditi Gupta, Jakub Svoboda, Stefan K Barta, Kristy M Walsh, Ellen B Napier, Rachel K Lundberg, Sunita D Nasta, James N Gerson, Daniel J Landsburg, Joyce Gonzalez, Andrew Gaano, Madison E Weirick, Christopher M McAllister, Moses Awofolaju, Gavin N John, Shane C Kammerman, Josef Novaceck, Raymone Pajarillo, Kendall A Lundgreen, Nicole Tanenbaum, Sigrid Gouma, Elizabeth M Drapeau, Sharon Adamski, Kurt D'Andrea, Ajinkya Pattekar, Amanda Hicks, Scott Korte, Harsh Sharma, Sarah Herring, Justine C Williams, Jacob T Hamilton, Paul Bates, Scott E Hensley, Eline T Luning Prak, Allison R Greenplate, E John Wherry, Stephen J Schuster, Marco Ruella, Laura A Vella
Patients with B-cell lymphomas have altered cellular components of vaccine responses due to malignancy and therapy, and the optimal timing of vaccination relative to therapy remains unknown. SARS-CoV-2 vaccines created an opportunity for new insights in vaccine timing because patients were challenged with a novel antigen across multiple phases of treatment. We studied serologic mRNA vaccine response in retrospective and prospective cohorts with lymphoma and CLL, paired with clinical and research immune parameters...
March 4, 2024: Journal of Infectious Diseases
#8
JOURNAL ARTICLE
David B Rein, Carolina Franco, Nicholas S Reed, Evan R Herring-Nathan, Phoebe A Lamuda, Katelin M Alfaro Hudak, Wen Hu, Alex J Hartzman, Karl R White, John S Wittenborn
BACKGROUND: The goal of this study was to re-estimate rates of bilateral hearing loss Nationally, and create new estimates of hearing loss prevalence at the U.S. State and County levels. METHODS: We developed small area estimation models of mild, and moderate or worse bilateral hearing loss in the U.S. using data from the National Health and Nutrition Examination Survey (2001-2012, 2015-2018), the American Community Survey (2019), Census County Business Patterns (2019); Social Security Administration Data (2019); Medicare Fee-for-Service and Advantage claims data (2019); the Area Health Resources File (2019), and other sources...
February 2024: Lancet Reg Health Am
#9
JOURNAL ARTICLE
Andrew A Herring, Allison D Rosen, Elizabeth A Samuels, Chunqing Lin, Melissa Speener, John Kaleekal, Steven J Shoptaw, Aimee K Moulin, Arianna Campbell, Erik Anderson, Mariah M Kalmin
IMPORTANCE: Although substantial evidence supports buprenorphine for treatment of opioid use disorder (OUD) in controlled trials, prospective study of patient outcomes in clinical implementation of emergency department (ED) buprenorphine treatment is lacking. OBJECTIVE: To examine the association between buprenorphine treatment in the ED and follow-up engagement in OUD treatment 1 month later. DESIGN, SETTING, AND PARTICIPANTS: This multisite cohort study was conducted in 7 California EDs participating in a statewide implementation project to improve access to buprenorphine treatment...
January 2, 2024: JAMA Network Open
#10
JOURNAL ARTICLE
Hao Yu, Anas M Khanshour, Aki Ushiki, Nao Otomo, Yoshinao Koike, Elisabet Einarsdottir, Yanhui Fan, Lilian Antunes, Yared H Kidane, Reuel Cornelia, Rory R Sheng, Yichi Zhang, Jimin Pei, Nick V Grishin, Bret M Evers, Jason Pui Yin Cheung, John A Herring, Chikashi Terao, You-Qiang Song, Christina A Gurnett, Paul Gerdhem, Shiro Ikegawa, Jonathan J Rios, Nadav Ahituv, Carol A Wise
Adolescent idiopathic scoliosis (AIS) is a common and progressive spinal deformity in children that exhibits striking sexual dimorphism, with girls at more than fivefold greater risk of severe disease compared to boys. Despite its medical impact, the molecular mechanisms that drive AIS are largely unknown. We previously defined a female-specific AIS genetic risk locus in an enhancer near the PAX1 gene. Here, we sought to define the roles of PAX1 and newly identified AIS-associated genes in the developmental mechanism of AIS...
January 26, 2024: ELife
#11
REVIEW
Matthew A Stults-Kolehmainen, Dale S Bond, Laura A Richardson, Louisa Y Herring, Bethany Mulone, Carol Ewing Garber, John Morton, Saber Ghiassi, Andrew J Duffy, Ethan Balk, Charles J Abolt, Matt C Howard, Garrett I Ash, Susannah Williamson, Emilian Rejane Marcon, Melissa De Los Santos, Samantha Bond, Janet Huehls, Osama Alowaish, Nina Brojan Heyman, Bruno Gualano
BACKGROUND: Physical activity (PA) is important for the long-term health and weight management of patients who undergo metabolic and bariatric surgery (MBS). However, the roles of exercise professionals in MBS settings have not been systematically determined. OBJECTIVES: To investigate: (1) who are the professionals implementing PA programming in MBS clinical settings; and (2) what patient-centric tasks do they perform? SETTING: Clinical and academic exercise settings worldwide...
January 2024: Surgery for Obesity and Related Diseases
#12
JOURNAL ARTICLE
Lisa Jo Melnyk, James M Lazorchak, Daniel H Kusnierz, Gary D Perlman, John Lin, Raghuraman Venkatapathy, Devi Sundaravadivelu, Jonathan Thorn, James Durant, Katherine Pugh, Michael A Stover
BACKGROUND: Restoration efforts have led to the return of anadromous fish, potential source of food for the Penobscot Indian Nation, to the previously dammed Penobscot River, Maine. OBJECTIVE: U.S. Environmental Protection Agency (EPA), Penobscot Indian Nation's Department of Natural Resources (PINDNR), and Agency for Toxic Substances and Disease Registry (ATSDR), measured contaminants in six species of anadromous fish. Fish tissue concentrations were then used, along with exposure parameters, to evaluate potential human and aquatic-dependent wildlife risk...
December 15, 2023: Journal of Exposure Science & Environmental Epidemiology
#13
JOURNAL ARTICLE
T Spelman, W L Herring, C Acosta, R Hyde, V G Jokubaitis, E Pucci, A Lugaresi, G Laureys, E K Havrdova, D Horakova, G Izquierdo, S Eichau, S Ozakbas, R Alroughani, T Kalincik, P Duquette, M Girard, T Petersen, F Patti, T Csepany, F Granella, F Grand'Maison, D Ferraro, R Karabudak, M Jose Sa, M Trojano, V van Pesch, B Van Wijmeersch, E Cartechini, P McCombe, O Gerlach, D Spitaleri, C Rozsa, S Hodgkinson, R Bergamaschi, R Gouider, A Soysal, Castillo-Triviño, J Prevost, J Garber, K de Gans, R Ampapa, M Simo, J L Sanchez-Menoyo, G Iuliano, A Sas, A van der Walt, N John, O Gray, S Hughes, G De Luca, M Onofrj, K Buzzard, O Skibina, M Terzi, M Slee, C Solaro, Oreja-Guevara, C Ramo-Tello, Y Fragoso, V Shaygannejad, F Moore, C Rajda, E Aguera Morales, H Butzkueven
AIM: To evaluate the real-world comparative effectiveness and the cost-effectiveness, from a UK National Health Service perspective, of natalizumab versus fingolimod in patients with rapidly evolving severe relapsing-remitting multiple sclerosis (RES-RRMS). METHODS: Real-world data from the MSBase Registry were obtained for patients with RES-RRMS who were previously either naive to disease-modifying therapies or had been treated with interferon-based therapies, glatiramer acetate, dimethyl fumarate, or teriflunomide (collectively known as BRACETD)...
2024: Journal of Medical Economics
#14
JOURNAL ARTICLE
Eric Z Herring, Emily L Graczyk, William D Memberg, Robert Adams, Gaudalupe Fernandez Baca-Vaca, Brianna C Hutchison, John T Krall, Benjamin J Alexander, Emily C Conlan, Kenya E Alfaro, Preethisiri Bhat, Aaron B Ketting-Olivier, Chase A Haddix, Dawn M Taylor, Dustin J Tyler, Jennifer A Sweet, Robert F Kirsch, A Bolu Ajiboye, Jonathan P Miller
BACKGROUND AND OBJECTIVES: Paralysis after spinal cord injury involves damage to pathways that connect neurons in the brain to peripheral nerves in the limbs. Re-establishing this communication using neural interfaces has the potential to bridge the gap and restore upper extremity function to people with high tetraplegia. We report a novel approach for restoring upper extremity function using selective peripheral nerve stimulation controlled by intracortical microelectrode recordings from sensorimotor networks, along with restoration of tactile sensation of the hand using intracortical microstimulation...
November 20, 2023: Neurosurgery
#15
JOURNAL ARTICLE
John P Incardona, Tiffany L Linbo, James R Cameron, Barbara L French, Jennie L Bolton, Jacob L Gregg, Carey E Donald, Paul K Hershberger, Nathaniel L Scholz
Pacific herring ( Clupea pallasii ), a cornerstone of marine food webs, generally spawn on marine macroalgae in shallow nearshore areas that are disproportionately at risk from oil spills. Herring embryos are also highly susceptible to toxicity from chemicals leaching from oil stranded in intertidal and subtidal zones. The water-soluble components of crude oil trigger an adverse outcome pathway that involves disruption of the physiological functions of cardiomyocytes in the embryonic herring heart. In previous studies, impaired ionoregulation (calcium and potassium cycling) in response to specific polycyclic aromatic hydrocarbons (PAHs) corresponds to lethal embryolarval heart failure or subtle chamber malformations at the high and low ends of the PAH exposure range, respectively...
November 14, 2023: Environmental Science & Technology
#16
JOURNAL ARTICLE
Kirsty McDowell, Carly Adamson, Colette Jackson, Ross Campbell, Paul Welsh, Mark C Petrie, John J V McMurray, Pardeep S Jhund, Neil Herring
BACKGROUND AND AIMS: Neuropeptide Y (NPY) is the most abundant neuropeptide found in the heart and is released alongside norepinephrine following prolonged sympathetic activation, a process that is implicated in the pathophysiology of heart failure (HF). In patients with severely impaired left ventricular ejection fraction (LVEF) undergoing cardiac resynchronization therapy (CRT), higher levels of NPY measured in coronary sinus blood, are associated with poorer outcome. The aim was to examine the association of peripheral venous NPY levels and outcomes in a HF population with a range of LVEF, using a highly sensitive and specific assay...
November 8, 2023: European Journal of Heart Failure
#17
JOURNAL ARTICLE
Sangeeta Bhatia, Kris V Parag, Jack Wardle, Rebecca K Nash, Natsuko Imai, Sabine L Van Elsland, Britta Lassmann, John S Brownstein, Angel Desai, Mark Herringer, Kara Sewalk, Sarah Claire Loeb, John Ramatowski, Gina Cuomo-Dannenburg, Elita Jauneikaite, H Juliette T Unwin, Steven Riley, Neil Ferguson, Christl A Donnelly, Anne Cori, Pierre Nouvellet
Since 8th March 2020 up to the time of writing, we have been producing near real-time weekly estimates of SARS-CoV-2 transmissibility and forecasts of deaths due to COVID-19 for all countries with evidence of sustained transmission, shared online. We also developed a novel heuristic to combine weekly estimates of transmissibility to produce forecasts over a 4-week horizon. Here we present a retrospective evaluation of the forecasts produced between 8th March to 29th November 2020 for 81 countries. We evaluated the robustness of the forecasts produced in real-time using relative error, coverage probability, and comparisons with null models...
2023: PloS One
#18
Matthew A Stults-Kolehmainen, Dale S Bond, Laura A Richardson, Louisa Y Herring, Bethany Mulone, Carol Ewing Garber, John Morton, Saber Ghiassi, Andrew J Duffy, Ethan Balk, Charles J Abolt, Matt C Howard, Garrett I Ash, Susannah Williamson, Emilian Rejane Marcon, Melissa De Los Santos, Samantha Bond, Janet Huehls, Osama Alowaish, Nina Brojan Heyman, Bruno Gualano
BACKGROUND: Physical activity (PA) is important for the long-term health and weight management of patients who undergo metabolic and bariatric surgery (MBS). However, the roles of exercise professionals in MBS settings have not been systematically determined. OBJECTIVES: To investigate: (1) who are the professionals implementing PA programming in MBS clinical settings; and (2) what patient-centric tasks do they perform? SETTING: Clinical and academic exercise settings worldwide...
August 18, 2023: medRxiv
#19
JOURNAL ARTICLE
Sungbong Jang, Roger Ros-Freixedes, John M Hickey, Ching-Yi Chen, Justin Holl, William O Herring, Ignacy Misztal, Daniela Lourenco
BACKGROUND: Whole-genome sequence (WGS) data harbor causative variants that may not be present in standard single nucleotide polymorphism (SNP) chip data. The objective of this study was to investigate the impact of using preselected variants from WGS for single-step genomic predictions in maternal and terminal pig lines with up to 1.8k sequenced and 104k sequence imputed animals per line. METHODS: Two maternal and four terminal lines were investigated for eight and seven traits, respectively...
July 26, 2023: Genetics, Selection, Evolution: GSE
#20
JOURNAL ARTICLE
Nao Otomo, Anas M Khanshour, Masaru Koido, Kazuki Takeda, Yukihide Momozawa, Michiaki Kubo, Yoichiro Kamatani, John A Herring, Yoji Ogura, Yohei Takahashi, Shohei Minami, Koki Uno, Noriaki Kawakami, Manabu Ito, Tatsuya Sato, Kei Watanabe, Takashi Kaito, Haruhisa Yanagida, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Hideki Shigematsu, Takahiro Iida, Satoru Demura, Ryo Sugawara, Nobuyuki Fujita, Mitsuru Yagi, Eijiro Okada, Naobumi Hosogane, Katsuki Kono, Masaya Nakamura, Kazuhiro Chiba, Toshiaki Kotani, Tsuyoshi Sakuma, Tsutomu Akazawa, Teppei Suzuki, Kotaro Nishida, Kenichiro Kakutani, Taichi Tsuji, Hideki Sudo, Akira Iwata, Satoshi Inami, Carol A Wise, Yuta Kochi, Morio Matsumoto, Shiro Ikegawa, Kota Watanabe, Chikashi Terao
INTRODUCTION: Adolescent idiopathic scoliosis (AIS) is a disorder with a three-dimensional spinal deformity and is a common disease affecting 1-5% of adolescents. AIS is also known as a complex disease involved in environmental and genetic factors. A relation between AIS and body mass index (BMI) has been epidemiologically and genetically suggested. However, the causal relationship between AIS and BMI remains to be elucidated. MATERIAL AND METHODS: Mendelian randomization (MR) analysis was performed using summary statistics from genome-wide association studies (GWASs) of AIS (Japanese cohort, 5,327 cases, 73,884 controls; US cohort: 1,468 cases, 20,158 controls) and BMI (Biobank Japan: 173430 individual; meta-analysis of genetic investigation of anthropometric traits and UK Biobank: 806334 individuals; European Children cohort: 39620 individuals; Population Architecture using Genomics and Epidemiology: 49335 individuals)...
2023: Frontiers in Endocrinology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
