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JOURNAL ARTICLE
Thomas Barrett Sullivan, Tracey P Bastrom, Carrie E Bartley, Lori A Dolan, Stuart L Weinstein, Peter O Newton
STUDY DESIGN: Retrospective. OBJECTIVES: Utilize three-dimensional (3D) measurements to assess the relationship between thoracic scoliosis severity and thoracic kyphosis in a large, multicenter cohort, and determine impact of 3D measurements on adolescent idiopathic scoliosis (AIS) curve classification. Research has demonstrated differences in two-dimensional (2D) and 3D assessment of the sagittal plane deformity in AIS. A prior smaller, single-institution study demonstrated an association between scoliosis severity and loss of 3D thoracic kyphosis...
December 2020: Spine Deformity
#22
JOURNAL ARTICLE
Pawin Gajaseni, Luca Labianca, Piyush Kalakoti, Andrew J Pugely, Stuart L Weinstein
PURPOSE: Surgical correction for AIS has evolved from all hooks to hybrids or all screw constructs. Limited literature exists reporting outcomes using PHDS for posterior spinal fusion (PSF). This is the largest series in evaluating results of PHDS technique. METHODS: A retrospective review of consecutive AIS patients undergoing PSF by a single surgeon between 2006 and 2015 was performed. All eligible patients met a minimum 2-year follow-up. Patient demographics and radiographical parameters (radiographic shoulder height (RSH), T1 tilt, clavicle angle) at baseline, 6-week and 2-year post-operation were recorded...
March 2021: European Spine Journal
#23
RANDOMIZED CONTROLLED TRIAL
Lori A Dolan, Sabrina Donzelli, Fabio Zaina, Stuart L Weinstein, Stefano Negrini
STUDY DESIGN: Comparative effectiveness study OBJECTIVE.: To evaluate factors leading to higher percentage of brace failures in a cohort of North American patients with adolescent idiopathic scoliosis relative to their peers in Italy. SUMMARY OF BACKGROUND DATA: Studies of bracing in United States have shown worse outcomes than studies from European centers, possibly due to sample characteristics or treatment approaches. METHODS: Sample: Braced patients, aged 10 to 15, Risser <3, Cobb 20°- to 40°, observed to Cobb ≥40° and/or ≥Risser 4 selected from prospective databases...
September 1, 2020: Spine
#24
REVIEW
Benjamin D Roye, Matthew E Simhon, Hiroko Matsumoto, Prachi Bakarania, Hagit Berdishevsky, Lori A Dolan, Kelly Grimes, Theodoros B Grivas, Michael T Hresko, Lori A Karol, Baron S Lonner, Michael Mendelow, Stefano Negrini, Peter O Newton, Eric C Parent, Manuel Rigo, Luke Strikeleather, John Tunney, Stuart L Weinstein, Grant Wood, Michael G Vitale
STUDY DESIGN: Survey. OBJECTIVES: Bracing is the mainstay of conservative treatment in Adolescent Idiopathic Scoliosis (AIS). The purpose of this study was to establish best practice guidelines (BPG) among a multidisciplinary group of international bracing experts including surgeons, physiatrists, physical therapists, and orthotists utilizing formal consensus building techniques. Currently, there is significant variability in the practice of brace treatment for AIS and, therefore, there is a strong need to develop BPG for bracing in AIS...
August 2020: Spine Deformity
#25
JOURNAL ARTICLE
Lori A Dolan, Stuart L Weinstein, Mark F Abel, Patrick P Bosch, Matthew B Dobbs, Tyler O Farber, Matthew F Halsey, M Timothy Hresko, Walter F Krengel, Charles T Mehlman, James O Sanders, Richard M Schwend, Suken A Shah, Kushagra Verma
STUDY DESIGN: Prognostic study and validation using prospective clinical trial data. OBJECTIVE: To derive and validate a model predicting curve progression to ≥45° before skeletal maturity in untreated patients with adolescent idiopathic scoliosis (AIS). Studies have linked the natural history of AIS with characteristics such as sex, skeletal maturity, curve magnitude, and pattern. The Simplified Skeletal Maturity Scoring System may be of particular prognostic utility for the study of curve progression...
November 2019: Spine Deformity
#26
COMPARATIVE STUDY
Lori A Dolan, Stuart L Weinstein, Mark F Abel, Patrick P Bosch, Matthew B Dobbs, Tyler O Farber, Matthew F Halsey, M Timothy Hresko, Walter F Krengel, Charles T Mehlman, James O Sanders, Richard M Schwend, Suken A Shah, Kushagra Verma
STUDY DESIGN: Prognostic study and validation using prospective clinical trial data. OBJECTIVE: To derive and validate a model predicting curve progression to ≥45° before skeletal maturity in untreated patients with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Studies have linked the natural history of AIS with characteristics such as sex, skeletal maturity, curve magnitude, and pattern. The Simplified Skeletal Maturity Scoring System may be of particular prognostic utility for the study of curve progression...
November 2019: Spine Deformity
#27
Luca Labianca, Cosma Calderaro, Stuart L Weinstein
Background: Although most cases of scoliosis are idiopathic, scoliosis may also be congenital or associated with other diseases. Herniated Nucleus Pulposus (HNP) has been reported as a potential cause of non-structural scoliosis. HNP is unusual in adolescents and the clinical features are typically different from those in adults. Case Presentation: An 18-year-old Caucasian male was referred to our ambulatory service for evaluation of scoliosis after orthopedic evaluation at another center...
2019: Iowa Orthopaedic Journal
#28
REVIEW
Cosma Calderaro, Jocelyn T Compton, Jessica M Hanley, Luca Labianca, Kazuta Yamashita, Stuart L Weinstein
Background: Vertebral fracture after posterior arthrodesis and instrumentation for idiopathic scoliosis is a rare occurrence with limited reported cases in the literature. Case Presentation: A 16-year-old female patient surgically treated for adolescent idiopathic scoliosis with T2-L1 posterior spinal fusion was in a low-energy fall resulting in fracture of L1 and new kyphosis and scoliosis of the thoracolumbar spine at the distal aspect of the fusion. The fracture was initially managed conservatively, however pain persisted and thus she was indicated for extension of the fusion and correction of the post-traumatic kyphosis...
2019: Iowa Orthopaedic Journal
#29
JOURNAL ARTICLE
Thomas Meirick, Apurva S Shah, Lori A Dolan, Stuart L Weinstein
Background: Adolescent idiopathic scoliosis (AIS) has been associated with unnecessary referrals, but the provider and patient costs associated with these referrals remain unknown. The purpose of this study was to determine the prevalence and associated costs of unnecessary referrals for AIS in a university hospital-based orthopaedic clinic. These data are required to estimate the cost-efficacy of scoliosis screening programs. Methods: We accessed the electronic medical records of all patients referred during 2013-2014 with suspected AIS...
2019: Iowa Orthopaedic Journal
#30
JOURNAL ARTICLE
Stuart L Weinstein
INTRODUCTION: Adolescent idiopathic Scoliosis (AIS) affects 2% to 3% of the population of which only 0.3% to 0.5% of affected patients will have a curvature of >20 degrees, the curve magnitude at which treatment is generally recommended. For AIS the current natural history data is limited and most of the information comes from a small body of literature from the University of Iowa. METHODS: The Iowa natural history studies began as retrospective reviews but beginning in 1976, the cohort was followed prospectively...
July 2019: Journal of Pediatric Orthopedics
#31
JOURNAL ARTICLE
Stuart L Weinstein
In a traditional view, the natural history of a condition or a disease tells us of the adult consequences of that entity, be it benign or otherwise. This knowledge then provides guidance as to who needs treatment, and allows us to assess whether our treatments alter an otherwise adverse natural history in a positive way without introducing iatrogenic complications. However, in the new paradigm for health care delivery of value-based care, we need to be able to express natural history in additional terms of burden of disease...
July 2019: Journal of Pediatric Orthopedics
#32
JOURNAL ARTICLE
Alan G Shamrock, Morgan L Bertsch, Heather R Kowalski, Stuart L Weinstein
BACKGROUND: Knee pain has a variety of etiologies in the pediatric population, including septic arthritis, osteomyelitis, fracture, ligamentous injury, and neoplasms. Extrinsic sources of knee pain may also be intra-abdominal, although abdominal pathology is much more likely to manifest as hip or proximal thigh musculature pain. CASE REPORT: A 5-year-old healthy male presented with atraumatic right knee pain, discomfort with weightbearing, fever, and elevated inflammatory laboratory markers...
July 2019: Journal of Emergency Medicine
#33
JOURNAL ARTICLE
Stuart A Archer, Ahtasham Raza, Fabian Dröge, Craig Robertson, Alexander J Auty, Dimitri Chekulaev, Julia A Weinstein, Theo Keane, Anthony J H M Meijer, John W Haycock, Sheila MacNeil, James A Thomas
With the aim of developing a sensitizer for photodynamic therapy, a previously reported luminescent dinuclear complex that functions as a DNA probe in live cells was modified to produce a new iso-structural derivative containing RuII (TAP)2 fragments (TAP = 1,4,5,8-tetraazaphenanthrene). The structure of the new complex has been confirmed by a variety of techniques including single crystal X-ray analysis. Unlike its parent, the new complex displays Ru → L-based 3 MLCT emission in both MeCN and water. Results from electrochemical studies and emission quenching experiments involving guanosine monophosphate are consistent with an excited state located on a TAP moiety...
March 28, 2019: Chemical Science
#34
JOURNAL ARTICLE
Luca Labianca, Stuart L Weinstein
This study describes a new procedure for a safer and easier access for the intrathecal injection of the recently approved nusinersen therapy in spinal muscular atrophy. This therapy changed the natural history of the disease, but, to date, scoliosis surgery was an excluding criteria for nusinersen therapy. The bone mass, due to the posterior spinal fusion of the scoliosis surgery, prevents the needle for the Nusinersen administration from intervertebral access This is a single-center, single-surgeon case series descriptive study...
March 29, 2019: Journal of Pediatric Orthopedics. Part B
#35
RANDOMIZED CONTROLLED TRIAL
Cindy Weinstein, Karin Jordan, Stuart A Green, Elber Camacho, Saleem Khanani, Elizabeth Beckford-Brathwaite, Annpey Pong, Stephen J Noga, Bernardo L Rapoport
PURPOSE: Fosaprepitant improved prevention of chemotherapy-induced nausea and vomiting (CINV) in a randomized, double-blind phase III trial (PN031). This post hoc analysis explored factors that may have influenced response. METHODS: Adult subjects (N = 1000) scheduled to receive non-anthracycline and cyclophosphamide (AC) moderately emetogenic chemotherapy (MEC) on day 1 were randomly assigned 1:1 to a single-dose, 150-mg intravenous fosaprepitant regimen or a control regimen...
November 2018: Supportive Care in Cancer
#36
COMPARATIVE STUDY
William E Trick, Stephen J Sokalski, Stuart Johnson, Kristen L Bunnell, Joseph Levato, Michael J Ray, Robert A Weinstein
OBJECTIVETo evaluate probiotics for the primary prevention of Clostridium difficile infection (CDI) among hospital inpatients.DESIGNA before-and-after quality improvement intervention comparing 12-month baseline and intervention periods.SETTINGA 694-bed teaching hospital.INTERVENTIONWe administered a multispecies probiotic comprising L. acidophilus (CL1285), L. casei (LBC80R), and L. rhamnosus (CLR2) to eligible antibiotic recipients within 12 hours of initial antibiotic receipt through 5 days after final dose...
July 2018: Infection Control and Hospital Epidemiology
#37
JOURNAL ARTICLE
Joshua D Campbell, Christina Yau, Reanne Bowlby, Yuexin Liu, Kevin Brennan, Huihui Fan, Alison M Taylor, Chen Wang, Vonn Walter, Rehan Akbani, Lauren Averett Byers, Chad J Creighton, Cristian Coarfa, Juliann Shih, Andrew D Cherniack, Olivier Gevaert, Marcos Prunello, Hui Shen, Pavana Anur, Jianhong Chen, Hui Cheng, D Neil Hayes, Susan Bullman, Chandra Sekhar Pedamallu, Akinyemi I Ojesina, Sara Sadeghi, Karen L Mungall, A Gordon Robertson, Christopher Benz, Andre Schultz, Rupa S Kanchi, Carl M Gay, Apurva Hegde, Lixia Diao, Jing Wang, Wencai Ma, Pavel Sumazin, Hua-Sheng Chiu, Ting-Wen Chen, Preethi Gunaratne, Larry Donehower, Janet S Rader, Rosemary Zuna, Hikmat Al-Ahmadie, Alexander J Lazar, Elsa R Flores, Kenneth Y Tsai, Jane H Zhou, Anil K Rustgi, Esther Drill, Ronglei Shen, Christopher K Wong, Joshua M Stuart, Peter W Laird, Katherine A Hoadley, John N Weinstein, Myron Peto, Curtis R Pickering, Zhong Chen, Carter Van Waes
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations, and/or aberrant methylation of genes and microRNAs, which are correlated with the expression of multi-gene programs linked to squamous cell stemness, epithelial-to-mesenchymal differentiation, growth, genomic integrity, oxidative damage, death, and inflammation...
April 3, 2018: Cell Reports
#38
JOURNAL ARTICLE
Stuart L Weinstein, Lori A Dolan, Jose A Morcuende
This review summarizes evidence developed at the University of Iowa concerning the management and outcomes of developmental dysplasia of the hip beginning with the observations and analyses of Dr Arthur Steindler in the early 1900s. The strong evidence-based practice tradition established by Steindler 100 years ago continues as we critically evaluate our procedures and patient outcomes, only altering approaches when warranted by strong personal and research evidence. Our practice continues to be conservative in that we strive to produce the best environment possible for the hip to develop on its own and operate only when less invasive methods have failed...
May 2018: Clinical Orthopaedics and related Research
#39
JOURNAL ARTICLE
Joan E Bechtold, Benjamin R Williams, Stuart L Weinstein, David W Polly, Andrew J Pugely, Joseph A Buckwalter, Stephen A Albanese, Kevin J Bozic, Brian D Snyder
Research is a foundational component of an orthopaedic residency. It fosters intellectual curiosity and pursuit of excellence, while teaching discipline and the scientific method. These are the key principles for careers in both community-based practice and academia. Currently, no consensus exists on how to best engage residents and support their research endeavors. In 2014, the American Academy of Orthopaedic Surgeons Board of Specialty Societies Research and Quality Committee convened a Clinician-Scientist Collaboration Workgroup...
November 15, 2017: Journal of Bone and Joint Surgery. American Volume
#40
JOURNAL ARTICLE
Joshua B Holt, Lori A Dolan, Stuart L Weinstein
BACKGROUND: Spinal muscular atrophy (SMA) is a progressive neuromuscular disease commonly including progressive scoliosis resulting in severe deformity and negatively affecting pulmonary function. Surgical correction and stabilization of this progressive deformity is generally recommended; however, the timing and method of surgical fixation remains controversial. METHODS: Retrospective review of clinical, radiographic, and pulmonary function data from 16 children with SMA and surgically treated scoliosis between 1985 and 2013...
December 2017: Journal of Pediatric Orthopedics
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