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https://read.qxmd.com/read/30859734/a-10-lactobionic-acid-containing-moisturizer-reduces-skin-surface-ph-without-irritation-an-in-vivo-in-vitro-study
#1
Marija Tasić-Kostov, Milica Lukić, Snežana Savić
BACKGROUND/OBJECTIVES: Stratum corneum acidification is a newer strategy in management of inflammatory dermatoses; acidifying emollients are normally used for that purpose. However, a decrease in pH of the skin is commonly connected to an increase in irritation. The aim of this study was to investigate whether lactobionic acid (LA), cosmeceutical active and "superacid" belonging to the class of alpha-hydroxy acids (AHAs), could decrease pH of skin surface without irritation...
March 12, 2019: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/30847077/dna-barcoding-of-flowering-plants-in-sumatra-indonesia
#2
Fitri Y Amandita, Katja Rembold, Barbara Vornam, Sri Rahayu, Iskandar Z Siregar, Holger Kreft, Reiner Finkeldey
The rapid conversion of Southeast Asian lowland rainforests into monocultures calls for the development of rapid methods for species identification to support ecological research and sustainable land-use management. Here, we investigated the utilization of DNA barcodes for identifying flowering plants from Sumatra, Indonesia. A total of 1,207 matK barcodes (441 species) and 2,376 rbcL barcodes (750 species) were successfully generated. The barcode effectiveness is assessed using four approaches: (a) comparison between morphological and molecular identification results, (b) best-close match analysis with TaxonDNA, (c) barcoding gap analysis, and (d) formation of monophyletic groups...
February 2019: Ecology and Evolution
https://read.qxmd.com/read/30810171/2oa-phase-ib-ii-study-of-apg-115-in-combination-with-pembrolizumab-in-patients-with-unresectable-or-metastatic-melanomas-or-advanced-solid-tumors
#3
A W Tolcher, D D Fang, Y Li, Y Tang, J Ji, H Wang, R Karim, C Rosas, Y Huang, Y Zhai
No abstract text is available yet for this article.
February 1, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://read.qxmd.com/read/30766439/dissolution-and-bioavailability-improvement-of-bioactive-apigenin-using-solid-dispersions-prepared-by-different-techniques
#4
Sultan M Alshehri, Faiyaz Shakeel, Mohamed A Ibrahim, Ehab M Elzayat, Mohammad Altamimi, Kazi Mohsin, Osaid T Almeanazel, Musaed Alkholief, Abdullah Alshetaili, Bader Alsulays, Fars K Alanazi, Ibrahim A Alsarra
Apigenin (APG) is a poorly soluble bioactive compound/nutraceutical which shows poor bioavailability upon oral administration. Hence, the objective of this research work was to develop APG solid dispersions (SDs) using different techniques with the expectation to obtain improvement in its in vitro dissolution rate and in vivo bioavailability upon oral administration. Different SDs of APG were prepared by microwave, melted and kneaded technology using pluronic-F127 (PL) as a carrier. Prepared SDs were characterized using "thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infra-red (FTIR) spectrometer, powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM)"...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30709382/analysis-on-genie-reveals-novel-recurrent-variants-that-affect-molecular-diagnosis-of-sizable-number-of-cancer-patients
#5
Takahiko Koyama, Kahn Rhrissorrakrai, Laxmi Parida
BACKGROUND: Significant numbers of variants detected in cancer patients are often left labeled only as variants of unknown significance (VUS). In order to expand precision medicine to a wider population, we need to extend our knowledge of pathogenicity and drug response in the context of VUS's. METHODS: In this study, we analyzed variants from AACR Project GENIE Consortium APG (Cancer Discov 7:818-831, 2017) and compared them to the COSMIC database Forbes et al...
February 1, 2019: BMC Cancer
https://read.qxmd.com/read/30671303/extremely-low-levels-of-chloroplast-genome-sequence-variability-in-astelia-pumila-asteliaceae-asparagales
#6
Simon Pfanzelt, Dirk C Albach, K Bernhard von Hagen
Astelia pumila (G.Forst.) Gaudich. (Asteliaceae, Asparagales) is a major element of West Patagonian cushion peat bog vegetation. With the aim to identify appropriate chloroplast markers for the use in a phylogeographic study, the complete chloroplast genomes of five A. pumila accessions from almost the entire geographical range of the species were assembled and screened for variable positions. The chloroplast genome sequence was obtained via a mapping approach, using Eustrephus latifolius (Asparagaceae) as a reference...
2019: PeerJ
https://read.qxmd.com/read/30665641/effect-of-an-eco-friendly-o-w-emulsion-stabilized-with-amphiphilic-sodium-alginate-derivatives-on-lambda-cyhalothrin-adsorption-desorption-on-natural-soil-minerals
#7
Yang Peng, Dunchao Xiao, Gaobo Yu, Yuhong Feng, Jiacheng Li, Xinyu Zhao, Yiyuan Tang, Longzheng Wang, Quan Zhang
The effects of amphiphilic O/W emulsions, stabilized by the alkyl polyglycoside (APG) or cholesterol-grafted sodium alginate (CSAD)/APG systems, on lambda-cyhalothrin adsorption/desorption mechanisms on natural soil minerals (i.e., illite and kaolinite) were investigated. Sorption and desorption of lambda-cyhalothrin onto soil minerals was studied via batch equilibration to give insight into the adsorption equilibrium, kinetics, and thermodynamics of lambda-cyhalothrin adsorption onto minerals. The results indicate the following: (i) The adsorption processes for the APG system and CSAD/APG system include: rapid adsorption, slow adsorption, and adsorption equilibrium...
April 2019: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/30649865/crystalline-ammonium-peroxogermanate-as-a-waste-free-fully-recyclable-versatile-precursor-for-germanium-compounds
#8
Dmitry A Grishanov, Andrei V Churakov, Alexander G Medvedev, Alexey A Mikhaylov, Ovadia Lev, Petr V Prikhodchenko
High, nearly 100%, yield synthesis of ammonium peroxogermanate (APG), (NH4 )6 [Ge6 (μ-OO)6 (μ-O)6 (OH)6 ]·6H2 O, is presented, and its crystal structure is determined by single crystal X-ray study. It comprises centrosymmetric hexanuclear peroxogermanate anions [Ge6 (μ-OO)6 (μ-O)6 (OH)6 ]6- with six μ-oxo- and six μ-peroxo groups forming negatively charged layers. The space between these layers is filled by ammonium cations and water molecules, forming a highly stable structure due to hydrogen bonding...
January 16, 2019: Inorganic Chemistry
https://read.qxmd.com/read/30601504/development-of-anti-photo-and-anti-thermal-high-internal-phase-emulsions-stabilized-by-biomass-lignin-as-a-nutraceutical-delivery-system
#9
Kai Chen, Lei Lei, Yong Qian, Dongjie Yang, Xueqing Qiu
Herein, oil-in-water high internal phase emulsions (HIPEs) were stabilized by lignin from different technical resources with the assistance of alkyl polyglycoside (APG) using an ultrasonic cavitation method. The results showed that the amphiphilicity of lignin determined the formation of HIPEs. Microscopic and rheological characterization indicated that the molecular weight and concentration of lignin, the APG dosage and the oil/water ratio had important influences on the microstructure and stability of the HIPEs...
January 2, 2019: Food & Function
https://read.qxmd.com/read/30503709/calibration-and-characterization-of-intracellular-asante-potassium-green-probes-apg-2-and-apg-4
#10
Priyanka S Rana, Brandon A Gibbons, Alexey A Vereninov, Valentina E Yurinskaya, Robert J Clements, Timothy A Model, Michael A Model
The response of fluorescent ion probes to ions is affected by intracellular environment. To properly calibrate them, intracellular and extracellular concentrations of the measured ion must be made equal. In the first, computational, part of this work, we show, using the example of potassium, that the two requirements for ion equilibration are complete dissipation of membrane potential and high membrane permeability for both potassium and sodium. In the second part, we tested the ability of various ionophores to achieve potassium equilibration in Jurkat and U937 cells and found a combination of valinomycin, nigericin, gramicidin and ouabain to be the most effective...
November 29, 2018: Analytical Biochemistry
https://read.qxmd.com/read/30459627/the-smac-mimetic-apg-1387-sensitizes-immune-mediated-cell-apoptosis-in-hepatocellular-carcinoma
#11
Zide Chen, Jiehua Chen, Hongyan Liu, Wei Dong, Xuan Huang, Dajun Yang, Jinlin Hou, Xiaoyong Zhang
The inhibitor of apoptosis protein ( IAP ) genes are frequently overexpressed in malignancies. Second mitochondria-derived activator of caspase (SMAC) mimetics, which target IAPs, have potential to trigger cancer cell death and sensitize tumor cells to cytotoxic therapy. The aim of this study was to investigate the anti-tumor potential of a novel bivalent SMAC mimetic, APG-1387, in hepatocellular carcinoma (HCC). The mRNA and protein expressions of IAPs, including cellular IAPs (cIAP1 and cIAP2) and X chromosome-linked IAP (XIAP), were increased in HCC tumors compared with normal liver tissue...
2018: Frontiers in Pharmacology
https://read.qxmd.com/read/30447640/integrated-approach-to-enhance-the-anaerobic-biodegradation-of-benz-%C3%AE-anthracene-a-high-molecule-weight-polycyclic-aromatic-hydrocarbon-in-sludge-by-simultaneously-improving-the-bioavailability-and-microbial-activity
#12
Jingyang Luo, Lijuan Wu, Yinguang Chen, Leiyu Feng, Jiashun Cao
The biodegradation of benz[α]anthracene (BaA), which was a high-molecule-weight PAH, was enhanced via a combination of alkaline and alkyl polyglucosides (APG) treatment during waste activated sludge (WAS) anaerobic fermentation. The biodegradation efficiency of BaA was increased from 14.1% in the control to 30.2 and 47.8% in pH 10 and pH 10 & APG reactors, respectively. Mechanism investigations found that the alkaline and APG treatments stimulated the processes of BaA desorption from sludge and transfer/entry into microorganisms, and ultimately improved the BaA bioavailability...
November 6, 2018: Journal of Hazardous Materials
https://read.qxmd.com/read/30441369/carotid-local-pulse-wave-velocity-measurement-using-dual-element-accelerometric-patch-probe
#13
R Arathy, P M Nabeel, Jayaraj Joseph, Mohanasankar Sivaprakasam
In this work, we demonstrate an accelerometric patch probe with two microelectromechanical accelerometer sensors for local pulse wave velocity (PWV) measurement from the carotid artery. Dual acceleration plethysmogram (APG) signals were acquired from a small section of the artery by keeping the sensors at 32 mm apart. A custom analog front-end circuit (inter-channel delay $< 0.15$ ms) was used for reliable signal acquisition. Simultaneously acquired dual APG signals were processed in real-time and local PWV was evaluated in a beat-by-beat manner...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/30368139/alkyl-polyglycoside-and-earthworm-eisenia-fetida-enhance-biodegradation-of-green-waste-and-its-use-for-growing-vegetables
#14
Xiaoqiang Gong, Suyan Li, Scott X Chang, Qian Wu, Linlin Cai, Xiangyang Sun
Managing municipal green waste is a challenge to municipalities, partly because of the slow rate of decomposition of green waste during composting due to its high lignin and cellulose contents. Hence, this study evaluated the effect of alkyl polyglycoside (APG), a biosurfactant, and the earthworm Eisenia fetida on the composting process. Addition of APG and E. fetida significantly increased total bacteria, cellulolytic fungi, phosphate solubilizing bacteria and nitrogen fixing bacteria populations, and the activities of cellulase, urease and alkaline phosphatase in composts as compared with the control...
October 24, 2018: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/30298859/microhardness-of-bovine-enamel-after-different-fluoride-application-protocols
#15
Marcia Regina Cabral Oliveira, Pedro Henrique Cabral Oliveira, Luiz Henrique Cabral Oliveira, Anna Carolina Ratto Tempestini Horliana, Paulo Francisco César, Sandra Kiss Moura, Sandra Kalil Bussadori
The aim of the present study was to evaluate microhardness, mineral recovery and the enamel surface after the application of topical fluoride to artificial dental caries. Twenty-five bovine enamel blocks were prepared for artificial caries-like lesions and randomly divided into five groups (n=5): untreated (C control), 1.23% acidulated phosphate fluoride gel (APG), 2% neutral fluoride gel (NFG), 1.23% acidulated fluoride mousse (AFM) and fluoride varnish (5% Duraphat, DFV). Knoop microhardness (KHN) was evaluated after 7 and 14 days of treatment as well as 1 week after 28 days of treatment...
October 5, 2018: Dental Materials Journal
https://read.qxmd.com/read/30289052/management-and-prognosis-of-cancers-in-the-accessory-parotid-gland
#16
Xiaoxue Han, Xifeng Zhang, Yuqin Gao, Pai Pang, Fayu Liu, Changfu Sun
Objective This study was performed to analyze the clinical management of accessory parotid gland (APG) cancer and possible risk factors for disease-related death. Methods Patients diagnosed with primary APG cancers in the largest medical center in Northeast China were enrolled from January 1990 to December 2016. Results All 43 patients underwent resection of the tumors and superficial parotid gland by a standard Blair incision. Seven (16.3%) patients also required selective neck dissection. The most common lesion was mucoepidermoid carcinoma...
October 5, 2018: Journal of International Medical Research
https://read.qxmd.com/read/30281452/graph-based-joint-dequantization-and-contrast-enhancement-of-poorly-lit-jpeg-images
#17
Xianming Liu, Gene Cheung, Xiangyang Ji, Debin Zhao, Wen Gao
JPEG images captured in poor lighting conditions suffer from both low luminance contrast and coarse quantization artifacts due to lossy compression. Performing dequantization and contrast enhancement in separate back-to-back steps would amplify the residual compression artifacts, resulting in low visual quality. Leveraging on recent development in graph signal processing (GSP), we propose to jointly dequantize and contrast-enhance such images in a single graph-signal restoration framework. Specifically, we separate each observed pixel patch into illumination and reflectance via Retinex theory, where we define generalized smoothness prior and signed graph smoothness prior according to their respective unique signal characteristics...
March 2019: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://read.qxmd.com/read/30219740/agricultural-adjuvants-may-impair-leaf-transpiration-and-photosynthetic-activity
#18
Anna Räsch, Mauricio Hunsche, Matthias Mail, Jürgen Burkhardt, Georg Noga, Shyam Pariyar
Adjuvants such as surfactants are commonly incorporated into agrochemical formulations to enhance the biological efficiency of foliar sprays by improving the wetting behavior of the spray and/or the penetration of the active ingredients into the leaf tissues. Penetration accelerating adjuvants are known to increase the cuticular permeability and may alter the cuticular barrier to water loss. However, none or very little emphasis has been given to the impacts of adjuvants on crop water balance or drought tolerance, a very important factor affecting crop performance under water scarcity...
November 2018: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/30211195/autologous-platelet-rich-gel-combined-with-in-vitro-amplification-of-bone-marrow-mesenchymal-stem-cell-transplantation-to-treat-the-diabetic-foot-ulcer-a-case-report
#19
Qinan Wu, Xiaotian Lei, Liu Chen, Yanling Zheng, Hongmei Huang, Cheng Qian, Ziwen Liang
The diabetic foot ulcer (DFU) is the leading cause of the high mortality and morbidity rates of diabetes patients, and the DFU accounts for approximately 15% of all diagnosed diabetes cases in China. Traditional treatment is typically ineffective for DFUs. Here, we present a case of DFU that was successfully treated with an autologous platelet-rich gel (APG) and in vitro amplification of bone marrow mesenchymal stem cell (BMMSC) transplantation. A 54-year-old woman initially presented with a right foot diabetic ulcer at the hospital...
August 2018: Annals of Translational Medicine
https://read.qxmd.com/read/30182534/autologous-platelet-rich-gel-treatment-for-diabetic-chronic-cutaneous-ulcers-a-meta-analysis-of-randomized-controlled-trials
#20
Yan Li, Yunyi Gao, Yun Gao, Dawei Chen, Chun Wang, Guanjian Liu, Xin Yang, Xingwu Ran
BACKGROUND: Recent years, many studies have reported that autologous platelet-rich gel (APG) is an effective adjunctive method to promote chronic cutaneous ulcers in diabetics. The aim of the present study was to explore the efficacy and safety of APG for the topical treatment of diabetic chronic cutaneous ulcers. METHODS: The Chinese CBM, CNKI, VIP, Wanfang databases, Cochrane Library databases, EBSCOhost, Embase and PubMed on October 18, 2017 were systematically searched...
September 5, 2018: Journal of Diabetes
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