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https://read.qxmd.com/read/30763644/discovery-of-a-new-class-of-type-1-methionine-aminopeptidases-that-have-relaxed-substrate-specificity
#1
Sandeep Chowdary Bala, Neshatul Haque, Vijaykumar Pillalamarri, Ravikumar Reddi, Rajnandani Kashyap, Anil Kumar Marapaka, Anthony Addlagatta
Methionine aminopeptidases (MetAPs) are a class of enzymes evolved to cleave initiator methionine in 60-70% of the total cellular proteins in all living cells. Based on their sequence differences, they are classified into Type 1 and Type 2. Type 1 is further divided into Type 1a, 1a', 1b, 1c and 1d. Irrespective of various classifications, all MetAPs reported till date displayed hydrolytic activity against peptides that contain only methionine on the N-terminus. A cysteine at the top of the active site in all the Type 1 structures is reported to be critical for the specificity...
February 11, 2019: International Journal of Biological Macromolecules
https://read.qxmd.com/read/30763215/role-of-noncoding-rnas-in-the-pathogenesis-of-abdominal-aortic-aneurysm
#2
Sandeep Kumar, Reinier A Boon, Lars Maegdefessel, Stefanie Dimmeler, Hanjoong Jo
Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall and is among the most challenging cardiovascular diseases as without urgent surgical intervention, ruptured AAA has a mortality rate of >80%. Most patients present acutely after aneurysm rupture or dissection from a previously asymptomatic condition and are managed by either surgery or endovascular repair. Patients usually are old and have other concurrent diseases and conditions, such as diabetes mellitus, obesity, and hypercholesterolemia making surgical intervention more difficult...
February 15, 2019: Circulation Research
https://read.qxmd.com/read/30760325/neutrophilic-proteolysis-in-the-cystic-fibrosis-lung-correlates-with-a-pathogenic-microbiome
#3
Robert A Quinn, Sandeep Adem, Robert H Mills, William Comstock, Lindsay DeRight Goldasich, Gregory Humphrey, Alexander A Aksenov, Alexei V Melnik, Ricardo da Silva, Gail Ackermann, Nuno Bandeira, David J Gonzalez, Doug Conrad, Anthony J O'Donoghue, Rob Knight, Pieter C Dorrestein
BACKGROUND: Studies of the cystic fibrosis (CF) lung microbiome have consistently shown that lung function decline is associated with decreased microbial diversity due to the dominance of opportunistic pathogens. However, how this phenomenon is reflected in the metabolites and chemical environment of lung secretions remains poorly understood. METHODS: Here we investigated the microbial and molecular composition of CF sputum samples using 16S rRNA gene amplicon sequencing and untargeted tandem mass spectrometry to determine their interrelationships and associations with clinical measures of disease severity...
February 13, 2019: Microbiome
https://read.qxmd.com/read/30759730/il-10-could-play-a-role-in-the-interrelation-between-diabetes-mellitus-and-osteoarthritis
#4
Sandeep Silawal, Maximilian Willauschus, Gundula Schulze-Tanzil, Clemens Gögele, Markus Geßlein, Silke Schwarz
The association between osteoarthritis (OA), obesity and metabolic syndrome suggests an interrelation between OA and diabetes mellitus (DM). Little is known about the role of anti-inflammatory cytokine interleukin (IL)-10 in the interrelation between OA and DM. Hence, the effects of IL-10 under hyperglycemia (HG) and hyperinsulinemia (HI) in human articular chondrocytes (hAC) and chondrosarcoma cell line Okayama University Medical School (OUMS)-27 were examined. HAC and OUMS-27, cultured in normoglycemic (NG) and HG conditions were stimulated with insulin and/or IL-10...
February 12, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30757997/pla2r-antibody-positive-membranous-glomerulonephropathy-associated-with-psoriasis-vulgaris
#5
Sandeep Arora, Anantharam Jairam, S Radhakrishnan, Niyor Das, Mahesha Vankalakunti
No abstract text is available yet for this article.
February 12, 2019: Indian Journal of Dermatology, Venereology and Leprology
https://read.qxmd.com/read/30753202/stress-response-behavior-and-development-are-shaped-by-transposable-element-induced-mutations-in-drosophila
#6
Gabriel E Rech, María Bogaerts-Márquez, Maite G Barrón, Miriam Merenciano, José Luis Villanueva-Cañas, Vivien Horváth, Anna-Sophie Fiston-Lavier, Isabelle Luyten, Sandeep Venkataram, Hadi Quesneville, Dmitri A Petrov, Josefa González
Most of the current knowledge on the genetic basis of adaptive evolution is based on the analysis of single nucleotide polymorphisms (SNPs). Despite increasing evidence for their causal role, the contribution of structural variants to adaptive evolution remains largely unexplored. In this work, we analyzed the population frequencies of 1,615 Transposable Element (TE) insertions annotated in the reference genome of Drosophila melanogaster, in 91 samples from 60 worldwide natural populations. We identified a set of 300 polymorphic TEs that are present at high population frequencies, and located in genomic regions with high recombination rate, where the efficiency of natural selection is high...
February 2019: PLoS Genetics
https://read.qxmd.com/read/30747191/heterogeneous-hydrosilylation-reaction-catalysed-by-platinum-complexes-immobilized-on-bipyridine-periodic-mesoporous-organosilicas
#7
Yuki Naganawa, Yoshifumi Maegawa, Haiqing Guo, Sandeep Suryabhan Gholap, Shinji Tanaka, Kazuhiko Sato, Shinji Inagaki, Yumiko Nakajima
The utility of a bipyridine periodic mesoporous organosilica, BPy-PMO, as a support material of a hydrosilylation catalyst was investigated in the hydrosilylation of phenylacetylene with trimethoxysilane. [PtMe2(BPy-PMO)] (1) exhibited a moderate catalytic activity, whereas the reaction was successfully catalysed by [PtMe2(BPy-PMO-TMS)] (2) bearing end-capped TMS groups on the surface. Spectroscopic analyses of 2 revealed that the porous structure of BPy-PMO-TMS remained almost unchanged through the reaction...
February 12, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/30745705/clinical-practice-guidelines-for-the-management-of-obsessive-compulsive-disorder-in-children-and-adolescents
#8
Ajit Avasthi, Akhilesh Sharma, Sandeep Grover
No abstract text is available yet for this article.
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745703/clinical-practice-guidelines-for-the-management-of-schizophrenia-in-children-and-adolescents
#9
Sandeep Grover, Ajit Avasthi
No abstract text is available yet for this article.
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745698/clinical-practice-guidelines-for-the-management-of-depression-in-children-and-adolescents
#10
Sandeep Grover, Ajit Avasthi
No abstract text is available yet for this article.
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745695/clinical-practice-guidelines-for-the-assessment-and-management-of-attention-deficit-hyperactivity-disorder
#11
Ruchita Shah, Sandeep Grover, Ajit Avasthi
No abstract text is available yet for this article.
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745693/inpatient-care-and-use-of-electroconvulsive-therapy-in-children-and-adolescents-aligning-with-mental-health-care-act-2017
#12
Sandeep Grover, Ajit Avasthi, Shiv Gautam
No abstract text is available yet for this article.
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745692/preamble-for-clinical-practice-guidelines-for-child-and-adolescent-psychiatric-disorders
#13
Shiv Gautam, Ajit Avasthi, Sandeep Grover
No abstract text is available yet for this article.
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745649/indian-guidelines-on-neurosurgical-interventions-in-psychiatric-disorders
#14
REVIEW
Paresh K Doshi, Shyam S Arumugham, Ajit Bhide, Sandeep Vaishya, Amit Desai, Om Prakash Singh, Suresh B Math, Shiv Gautam, T S Satyanarayana Rao, E Mohandas, Dwarkanath Srinivas, Ajit Avasthi, Sandeep Grover, Y C Janardhan Reddy
Neurosurgery for psychiatric disorders (NPD) has been practiced for >80 years. However, the interests have waxed and waned, from 1000s of surgeries in 1940-1950s to handful of surgery in 60-80s. This changed with the application of deep brain stimulation surgery, a surgery, considered to be "reversible" there has been a resurgence in interest. The Indian society for stereotactic and functional neurosurgery (ISSFN) and the world society for stereotactic and functional neurosurgery took the note of the past experiences and decided to form the guidelines for NPD...
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30745611/comparison-of-weight-based-and-pinna-size-based-selection-of-proseal-laryngeal-mask-airway-in-paediatric-population-a-prospective-exploratory-trial
#15
Ramya Ravi, V K Mohan, Ashok Shankar Badhe, Sandeep Kumar Mishra, Prasanna Udupi Bidkar
Background and Aims: Weight-based selection of ProSeal laryngeal mask airway (PLMA) size may be unreliable in some situations. The aim of this study was to compare the ventilation parameters using PLMA during controlled ventilation between weight-based size selection and pinna size-based selection in children. Methods: A total of 204 patients were randomised to receive either pinna size-based (Group P) or weight-based (Group W) size selection of PLMA. We tested the hypothesis that pinna size-based selection of PLMA was better than weight-based selection of PLMA in paediatric patients during controlled ventilation under general anaesthesia in terms of oropharyngeal sealing pressure (the primary end-point) and Brimacombe score...
January 2019: Indian Journal of Anaesthesia
https://read.qxmd.com/read/30745396/activity-of-a-long-acting-injectable-bedaquiline-formulation-in-a-paucibacillary-mouse-model-of-latent-tuberculosis-infection
#16
Amit Kaushik, Nicole C Ammerman, Sandeep Tyagi, Vikram Saini, Iwan Vervoort, Sophie Lachau-Durand, Eric Nuermberger, Koen Andries
The potent anti-tuberculosis activity and long half-life of bedaquiline make it an attractive candidate for long-acting/extended release formulations for treatment of latent tuberculosis infection (LTBI). Our objective was to evaluate a long-acting injectable (LAI) bedaquiline formulation in a validated paucibacillary mouse model of LTBI. Following immunization with Mycobacterium bovis rBCG30, BALB/c mice were challenged by aerosol infection with M. tuberculosis H37Rv. Treatment began 13 weeks after challenge infection with one of the following regimens: untreated negative control; positive controls of daily rifampin (10 mg/kg), once-weekly rifapentine (15 mg/kg) and isoniazid (50 mg/kg), or daily bedaquiline (25 mg/kg); test regimens of one, two, or three monthly doses of LAI bedaquiline at 160 mg/dose (BLAI-160 ); and test regimens of daily bedaquiline at 2...
February 11, 2019: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/30745225/chemistry-manufacturing-and-controls-for-gene-modified-hematopoietic-stem-cells
#17
Sandeep Soni, Donald B Kohn
Gene modification of hematopoietic stem cells is increasingly becoming popular as a therapeutic approach, given the recent approvals and the number of new applications for clinical trials targeting monogenetic and immunodeficiency disorders. Technological advances in stem cell selection, culture, transduction and gene editing now allow for efficient ex vivo genetic manipulation of stem cells. Gene-addition techniques using viral vectors (mainly retrovirus- and lentivirus-based) and gene editing using various targeted nuclease platforms (e...
February 8, 2019: Cytotherapy
https://read.qxmd.com/read/30743123/pmt-new-analytical-framework-for-automated-evaluation-of-geo-environmental-modelling-approaches
#18
Omid Rahmati, Aiding Kornejady, Mahmood Samadi, Ravinesh C Deo, Christian Conoscenti, Luigi Lombardo, Kavina Dayal, Ruhollah Taghizadeh-Mehrjardi, Hamid Reza Pourghasemi, Sandeep Kumar, Dieu Tien Bui
Geospatial computation, data transformation to a relevant statistical software, and step-wise quantitative performance assessment can be cumbersome, especially when considering that the entire modelling procedure is repeatedly interrupted by several input/output steps, and the self-consistency and self-adaptive response to the modelled data and the features therein are lost while handling the data from different kinds of working environments. To date, an automated and a comprehensive validation system, which includes both the cutoff-dependent and -independent evaluation criteria for spatial modelling approaches, has not yet been developed for GIS based methodologies...
February 2, 2019: Science of the Total Environment
https://read.qxmd.com/read/30740330/extra-cardiac-comorbidities-or-complications-in-adults-with-congenital-heart-disease-a-nationwide-inpatient-experience-in-the-united-states
#19
Sandeep Singh, Rupak Desai, Hee Kong Fong, Ashish Sadolikar, Suparn Samani, Hemant Goyal
With a great interest, we read the article by Neidenbach et al. on non-cardiac comorbidities in German adults with congenital heart disease (ACHD). ACHD always bear an increased risk of developing concomitant non-cardiac comorbidities and complications and impose a great healthcare burden. Limited large-scale data from the United States (US) on this focus incited us to write this brief report. Gilboa et al. estimated nearly 2.4 million people living with CHD (1.4 million adults, 1 million children) in the US in 2010...
December 2018: Cardiovascular Diagnosis and Therapy
https://read.qxmd.com/read/30739904/recurrent-metastatic-eccrine-porocarcinoma-a-case-report-and-review-of-the-literature
#20
Misbahuddin Khaja, Umair Ashraf, Shehriyar Mehershahi, Puvanalingam Ayyadurai, Sandeep Malik
BACKGROUND Eccrine porocarcinoma, or malignant eccrine poroma, is a rare primary skin tumor that develops in the sixth and seventh decades of life, and can present as a painless and solitary nodule. Histopathology is required to confirm the diagnosis. A rare case is presented of metastatic eccrine porocarcinoma, occurring four years after surgical excision of the primary scalp tumor, and includes a review of the literature. CASE REPORT A 67-year-old man initially presented with a scalp lesion that was non-painful, exophytic, and pigmented...
February 11, 2019: American Journal of Case Reports
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