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PD Adequacy

Qingyu Niu, Huiping Zhao, Bei Wu, Shihming Tsai, Jian Wu, Meng Zhang, Lixia Lu, Jie Qiao, Chuncui Men, Li Zuo, Mei Wang
OBJECTIVE: To investigate the occurrence of vascular calcification (VC) in different types of arteries in patients with maintenance peritoneal dialysis (PD) patients and its influencing factors. METHODS: This study enrolled PD patients with stable status who has received PD treatment for more than 6 months in Peking University People's Hospital. We used plain X-ray films of abdomen, pelvis, and hands to quantitatively evaluate VC of large artery (abdominal aorta, iliac artery), medium artery (femoral artery, radial artery), and small artery (finger arteries)...
January 30, 2019: Blood Purification
Ken Yamashita, Shiro Oka, Shinji Tanaka, Shinji Nagata, Toshio Kuwai, Akira Furudoi, Tadamasa Tamura, Masaki Kunihiro, Hideharu Okanobu, Koichi Nakadoi, Hiroyuki Kanao, Makoto Higashiyama, Koji Arihiro, Kazuya Kuraoka, Fumio Shimamoto, Kazuaki Chayama
PURPOSE: Long-term prognosis of T1 laterally spreading tumors (LSTs) after treatment have not been clarified. This study compared clinicopathological characteristics and long-term prognosis of T1 LSTs. METHODS: We retrospectively assessed 169 patients with 169 T1 LSTs between January 1992 and December 2008 by ten hospitals. Patients who did not meet the Japanese Society for Cancer of the Colon and Rectum (JSCCR) 2016 guidelines for the treatment of colorectal carcinoma (CRC) criteria were defined as non-endoscopically curable...
January 3, 2019: International Journal of Colorectal Disease
Shuchita Sharma, Siddhartha Kattamanchi, Mary Grace Gonzales, James A Sloand, Jaime Uribarri
BACKGROUND: AMIA cycler is a new automated peritoneal dialysis (APD) system, which was approved by FDA in 2015, which is more patient centric due to its features of voice guidance and touch screen. We retrospectively studied if these patient-centric features translated into better patient outcomes. METHODS: We compared 18 patients on AMIA cycler to 18 patients on conventional APD system. Data regarding training duration, dialysis adequacy, laboratory data, and peritonitis incidence were obtained using chart review and compared between the 2 groups...
January 2, 2019: Blood Purification
Kamonwan Tangvoraphonkchai, Andrew Davenport
BACKGROUND: Increased vascular stiffness is associated with low bone mineral density (BMD) in the general population, and both are risk factors for mortality. We wished to determine whether vascular stiffness is associated with BMD in peritoneal dialysis (PD) patients. METHODS: We measured vascular stiffness by aortic pulse wave velocity (aPWV), BMD by dual electron absorptiometry (DXA) scanning, and body composition using bioimpedance. RESULTS: We reviewed DXA scans in 125 PD patients, 56...
December 10, 2018: Journal of Nephrology
Xue-Ying Cao, Ya-Ni He, Jian-Hui Zhou, Shi-Ren Sun, Li-Ning Miao, Wen Chen, Jing-Ai Fang, Ming Wang, Nian-Song Wang, Hong-Li Lin, Jian Liu, Zhao-Hui Ni, Wen-Hu Liu, Yu Na, Jiu-Yang Zhao, Zhi-Yong Guo, Hong-Guang Zheng, Wei Shi, Geng-Ru Jiang, Guang-Yan Cai, Xiang-Mei Chen
Background: Automated peritoneal dialysis (APD) can cater to individual needs, provide treatment while asleep, take into account the adequacy of dialysis, and improve the quality of life. Currently, independent research and development of APD machines made in China are more conducive to patients. A randomized, multicenter, crossover study was conducted by comparing an APD machine made in China with an imported machine. The safety, effectiveness, and manipulability of the two machines were compared...
December 5, 2018: Chinese Medical Journal
Sylwia Małgorzewicz, Zbigniew Heleniak, Monika Lichodziejewska-Niemierko, Rutkowski Rutkowski, Ewa Aleksandrowicz-Wrona, Alicja Dębska-Ślizień
Cardiovascular (CVS) morbidity and mortality in the peritoneal dialysis patients (PD) is 10-30-fold higher than in the general population. A relatively low level of adiponectin and a higher level of leptin are important predictors of vascular complications as well as CVS events in PD patients. The asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is an important risk factor of CVS morbidity and mortality. It is very important to establish all CVS risk factors in the PD patients to prevent CVS morbidity and mortality in this population...
December 3, 2018: Acta Biochimica Polonica
B L King-Kallimanis, B Kanapuru, G M Blumenthal, M R Theoret, P G Kluetz
BACKGROUND: Older adults with lung cancer often have comorbidities that may increase risk of symptomatic adverse events (AEs) and physical function decline. The objective of this study was to examine age-related differences in patient-reported symptoms and functional domains in patients with advanced lung cancer receiving immunotherapy drugs. METHODS: Three randomized controlled trials of anti-programmed death receptor-1/programmed death-ligand 1 therapy in patients with advanced non-small cell lung cancer that included patient-reported outcomes (PROs) were identified...
October 25, 2018: Seminars in Oncology
Susie Q Lew
Urea kinetics (weekly Kt/V) greater than 1.7 generally define adequate peritoneal dialysis (PD). Adequacy of PD depends on residual renal function and PD clearance. Preserving residual renal function and peritoneal membrane characteristics helps to maintain PD adequacy.The dose of PD can be augmented by increasing the total dialysate volume. Greater volume can be achieved by increasing either the fill volume per exchange or the number of exchanges. Increased time on dialysis can be achieved by keeping PD fluid in the peritoneal cavity at all times...
November 2018: Advances in Peritoneal Dialysis
María-José Giménez, Lorenzo Aguilar, Juan José Granizo
Fifteen years after its licensure, this revision assesses the role of cefditoren facing the current pharmacoepidemiology of resistances in respiratory human-adapted pathogens ( Streptococcus pneumoniae , Streptococcus pyogenes , Haemophilus influenzae and Moraxella catarrhalis ). In the era of post- pneumococcal conjugate vaccines and in an environment of increasing diffusion of the fts I gene among H. influenzae isolates, published studies on the cefditoren in vitro microbiological activity, pharmacokinetic/pharmcodynamic (PK/PD) activity and clinical efficacy are reviewed...
2018: Multidisciplinary Respiratory Medicine
Qi Zhang, Xueying Cao, Jianhui Zhou, Rui Ding, Jing Huang, Guangyan Cai, Xiangmei Chen
It has been verified that the red blood cell distribution width (RDW) is related to renal function. This study aimed to investigate the association of RDW with the residual renal function in peritoneal dialysis (PD) patients. The patients were categorized into three groups according to the quartiles of their baseline RDWs. The correlations between RDW and clinical parameters, dialysis adequacy, and residual renal function were analyzed. The clinical data, PD prescription and dialysis adequacy of 54 uremic patients on continuous ambulatory PD were collected...
September 2018: Saudi Journal of Kidney Diseases and Transplantation
Myriam Benomar, Clement Vachey, Thierry Lobbedez, Julie Henriques, Didier Ducloux, Dewi Vernerey, Cécile Courivaud
Background: Failed kidney transplant is becoming a frequent cause of dialysis initiation. Although studies have shown no difference between peritoneal dialysis (PD) and haemodialysis (HD) in terms of patients and technique survival, PD remains quite rarely used in this condition. Studies in larger multicentre matched cohorts are missing. Methods: We conducted a retrospective study about 328 patients registered in the French Language Peritoneal Dialysis Registry (RDPLF) who started PD after kidney transplant failure (Tx group) between January 2002 and December 2012 who were compared with 656 matched never-transplanted patients having started PD during the same period (control group)...
October 24, 2018: Nephrology, Dialysis, Transplantation
Ben-Chung Cheng, Nai-Wen Tsai, Yun-Ru Lai, Chin-Cheng Huang, Cheng-Hsien Lu
Background: Peritoneal dialysis (PD) is an increasingly popular therapeutic option for patients with advanced renal failure. However, intra-abdominal adhesions (IAA) represent a major unsolved problem in adequate PD performance. In this study, we investigated the role of previous abdominal surgery on the presence of subsequent IAA as well as outcomes in those patients with PD who had subsequent IAA. Methods: Two hundred and two patients who received continuous ambulatory peritoneal dialysis were prospectively enrolled in this study...
2018: BioMed Research International
Ferga C Gleeson, Michael J Levy, Anja C Roden, Lisa A Boardman, Frank A Sinicrope, Robert R McWilliams, Lizhi Zhang
Background and study aims  The US FDA recently approved a cancer treatment with pembrolizumab based upon the tumor biomarker status of deficient mismatch repair (dMMR) rather than a specific disease-based approach. We sought to determine if endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) could determine dMMR and quantification of PD-L1 expression to potentially guide the delivery of tumor agnostic immunotherapy. Patients and methods  Immunohistochemistry was performed on archived pancreas core biopsy specimens...
October 2018: Endoscopy International Open
Tao Zhang, Yitian Dou, Xuejun Wang, Jing Li, Shili Cao
BACKGROUND/AIMS: Mounting clinical experience and evidence from scale observational studies have suggested that polycystic kidney disease (PKD) was not a contraindication for peritoneal dialysis (PD). Recent studies have reported that PD may be associated with a better prognosis in PKD than that of non-PKD patients. To solve the problem, we performed a systematic review and comprehensive meta-analysis to compare the outcomes between PKD and non-PKD patients on PD and the all-cause mortality between patients with PKD on PD and hemodialysis (HD)...
2018: Kidney & Blood Pressure Research
Lana M Chahine, Thomas G Beach, Nicholas Seedorff, Chelsea Caspell-Garcia, Christopher S Coffey, Michael Brumm, Charles H Adler, Geidy E Serrano, Carly Linder, Sherri Mosovsky, Tatiana Foroud, Holly Riss, Dixie Ecklund, John Seibyl, Danna Jennings, Vanessa Arnedo, Lindsey Riley, K D Dave, Brit Mollenhauer
BACKGROUND: α-synuclein is a lead Parkinson's disease (PD) biomarker. There are conflicting reports regarding accuracy of α-synuclein in different tissues and biofluids as a PD biomarker, and the within-subject anatomical distribution of α-synuclein is not well described. The Systemic Synuclein Sampling Study (S4) aims to address these gaps in knowledge. The S4 is a multicenter, cross-sectional, observational study evaluating α-synuclein in multiple tissues and biofluids in PD and healthy controls (HC)...
2018: Journal of Parkinson's Disease
Constantinos Kormas, Ioannis Zalonis, Ioannis Evdokimidis, Constantin Potagas
In this study, we examined the performance of patients with Parkinson's disease (PD) with different cognitive profiles on the Face-Name Associative Memory Examination (FNAME). We evaluated 71 patients with a comprehensive neuropsychological battery. The results revealed that the group with executive and additional visuospatial deficits demonstrated significantly lower scores on FNAME. This finding indicates the possible clinical utility of FNAME for screening patients with PD with distinct cognitive profiles...
September 12, 2018: Neurological Sciences
Gilbert Bigras, Simon Mairs, Paul E Swanson, Didier Morel, Raymond Lai, Iyare Izevbaye
Pembrolizumab is an FDA-approved immune-checkpoint (IC) inhibitor that targets programmed cell death protein PD-1, and recent phase III trials have demonstrated its superiority over chemotherapy in the treatment of patients with advanced non-small cell lung cancer (NSCLC). Eligibility for treatment with Pembrolizumab is based on demonstration of PD-L1 expression on tumoral cells using the approved companion test 22C3 PharmDx (Dako). Access to the drug depends on a tumor proportion score (TPS) expressing the PD-L1 protein above predetermined cutoffs...
August 8, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
Gonzalo Labarca, Erik Folch, Michael Jantz, Hiren J Mehta, Adnan Majid, Sebastian Fernandez-Bussy
RATIONALE: Endobronchial ultrasound and transbronchial needle aspiration (EBUS-TBNA) are commonly used for the diagnosis and mediastinal staging of lung cancer. Molecular markers are becoming increasingly important in patients with lung cancer to define targetable mutations suitable for personalized therapy, such as epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), reactive oxygen species proto-oncogene (ROS1), and programmed death-ligand 1 (PD-L1). OBJECTIVES: To evaluate the adequacy of EBUS-TBNA-derived tissue for molecular analysis...
October 2018: Annals of the American Thoracic Society
Lucas de Francisco Carvalho, Catarina Possenti Sette, Fabiano Koich Miguel
OBJECTIVE: To investigate the clinical functioning of the criticism avoidance dimension from the Dimensional Clinical Personality Inventory 2 (Inventário Dimensional Clínico da Personalidade 2 [IDCP-2]), establishing a clinically relevant cut-off for the typical traits of avoidant personality disorder (AvPD) for screening purposes. METHODS: We administered the IDCP-2 to a sample of 2,276 subjects aged 18 to 90 years (mean = 26.95, standard deviation = 9.71). Of the total sample, 1,650 were women (67%) and most were college students (72...
2018: Trends in Psychiatry and Psychotherapy
Silvio Borrelli, Vincenzo La Milia, Luca De Nicola, Gianfranca Cabiddu, Roberto Russo, Michele Provenzano, Roberto Minutolo, Giuseppe Conte, Carlo Garofalo
Achievement of sodium and fluid balance is considered a major determinant of dialysis adequacy in peritoneal dialysis (PD). However, the contribution of different PD modalities to dialytic sodium removal (DSR) remains ill-defined. We performed a systematic review and meta-analysis to compare DSR by manual (continuous ambulatory PD, CAPD) versus automated PD (APD). Alternative PD strategies to remove sodium were also analyzed. Seven cohort studies, including 683 patients, 406 in CAPD and 277 in APD, were meta-analyzed out of the 30 studies selected based on DSR data availability...
July 5, 2018: Journal of Nephrology
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