keyword
https://read.qxmd.com/read/38532234/stigma-risks-and-benefits-of-medicinal-cannabis-use-among-australians-with-cancer
#1
JOURNAL ARTICLE
Julia N Morris, Jessica Loyer, Jason Blunt
PURPOSE: People with cancer who use medicinal cannabis do so despite risks associated with limited clinical evidence, legalities, and stigma. This study investigated how Australians with cancer rationalise their medicinal cannabis use despite its risks. METHODS: Ten adults (5 males and 5 females; mean age of 53.3) who used cannabis medicinally for their cancer were interviewed in 2021-2022 about how they used and accessed the substance, attitudes and beliefs underpinning their use, and conversations with others about medicinal cannabis...
March 27, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38521934/efficacy-and-mechanisms-of-cannabis-oil-for-alleviating-side-effects-of-breast-cancer-chemotherapy-cbc2-protocol-for-randomized-controlled-trial
#2
JOURNAL ARTICLE
May Soe Thu, Krit Pongpirul, Mawin Vongsaisuwon, Chanida Vinayanuwattikun, Kamonwan Banchuen, Thunnicha Ondee, Sunchai Payungporn, Phanupong Phutrakool, Preecha Nootim, Pajaree Chariyavilaskul, Sarocha Cherdchom, Kulthanit Wanaratna, Nattiya Hirankarn
BACKGROUND: In a pilot study using both cannabidiol (CBD) and tetrahydrocannabinol (THC) as single agents in advanced cancer patients undergoing palliative care in Thailand, the doses were generally well tolerated, and the outcome measure of total symptom distress scores showed overall symptom benefit. The current study aims to determine the intensity of the symptoms experienced by breast cancer patients, to explore the microbiome profile, cytokines, and bacterial metabolites before and after the treatment with cannabis oil or no cannabis oil, and to study the pharmacokinetics parameters and pharmacogenetics profile of the doses...
March 23, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38477532/medical-cannabis-use-in-oncology-and-associated-outcomes-a-scoping-review
#3
REVIEW
Ana Carolina Valente, Luis Phillipe Nagem Lopes, Maria Eline Matheus
BACKGROUND: Natural and synthetic cannabinoids are being used worldwide to treat various symptoms in cancer patients. This study aims to map the therapeutic benefits and adverse effects associated with the use of cannabis-based drugs in these outcomes. METHODS: Following Joanna Briggs Institute guidelines a scoping review was conducted. The study protocol was available in the Open Science Framework public repository. An extensive search strategy involving databases like Cochrane Library, Embase, CINAHL, Medline/PubMed, Lilacs, Google Scholar, and Open Gray for gray literature analysis was executed by a skilled librarian...
March 13, 2024: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/38397908/therapeutic-potential-of-cannabinoid-profiles-identified-in-cannabis-l-crops-in-peru
#4
JOURNAL ARTICLE
Pedro Wong-Salgado, Fabiano Soares, Jeel Moya-Salazar, José F Ramírez-Méndez, Marcia M Moya-Salazar, Alfonso Apesteguía, Americo Castro
Cannabis is a plant that is cultivated worldwide, and its use is internationally regulated, but some countries have been regulating its medicinal, social, and industrial uses. This plant must have arrived in Peru during the Spanish conquest and remains widely cultivated illicitly or informally to this day. However, new regulations are currently being proposed to allow its legal commercialization for medicinal purposes. Cannabis contains specific metabolites known as cannabinoids, some of which have clinically demonstrated therapeutic effects...
January 29, 2024: Biomedicines
https://read.qxmd.com/read/38247877/cannabidiol-combination-enhances-photodynamic-therapy-effects-on-mcf-7-breast-cancer-cells
#5
JOURNAL ARTICLE
Dimakatso Mokoena, Blassan P George, Heidi Abrahamse
Cannabis sativa is a well-known plant for its psychoactive effects; however, its many derivatives, such as Cannabidiol (CBD), contain several therapeutic applications. Tetrahydrocannabinol (THC) is the main cannabis derivative responsible for psychoactive properties, while CBD is non-psychotropic. For this reason, CBD has been more exploited in the last decade. CBD has been connected to multiple anticancer properties, and when combined with photodynamic therapy (PDT), it is possible to eradicate tumors more effectively...
January 18, 2024: Cells
https://read.qxmd.com/read/38203245/cannabinoids-in-treating-chemotherapy-induced-nausea-and-vomiting-cancer-associated-pain-and-tumor-growth
#6
REVIEW
Pavana P Bathula, M Bruce Maciver
Cannabis has been used as an herbal remedy for thousands of years, and recent research indicates promising new uses in medicine. So far, some studies have shown cannabinoids to be safe in helping mitigate some cancer-associated complications, including chemotherapy-induced nausea and vomiting, cancer-associated pain, and tumor growth. Researchers have been particularly interested in the potential uses of cannabinoids in treating cancer due to their ability to regulate cancer-related cell cycle pathways, prompting many beneficial effects, such as tumor growth prevention, cell cycle obstruction, and cell death...
December 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38004513/investigation-of-cannabinoid-acid-cyclodextrin-inclusion-complex-for-improving-physicochemical-and-biological-performance
#7
JOURNAL ARTICLE
Chulhun Park, Jieyu Zuo, Myung-Chul Gil, Raimar Löbenberg, Beom-Jin Lee
This study aimed to investigate the enhancement of cannabinoid acid solubility and stability through the formation of a cannabinoid acid/cyclodextrin (CD) inclusion complex. Two cannabinoid acids, tetrahydro-cannabinolic acid (THCA) and cannabidiolic acid (CBDA), were selected as a model drug along with five types of CD: α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), and methylated-β-cyclodextrin (M-β-CD)...
October 26, 2023: Pharmaceutics
https://read.qxmd.com/read/37947877/does-cannabis-elevate-cancer-risk-evidence-from-mendelian-randomization
#8
JOURNAL ARTICLE
Dong Niu, Chenchen Li, Haoran Qu, Yuling Zheng
BACKGROUND: Cannabis use is increasing annually but the relationship between cannabis use and cancer incidence is not uniform because of confounding factors. We aimed to assess the effect of cannabis use on cancer risk using a two-sample Mendelian randomization (MR) approach. METHODS: Secondary data analyses were performed on pooled data based on Genome-Wide Association Study (GWAS), selecting data from the ICC and UK-Biobank and 23andMeInc lifetime cannabis use and cannabis use disorder related to the substance use disorders working group from the Psychiatric Genomics Consortium, then selecting highly correlated SNPs as instrumental variables...
November 10, 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37786222/cannabis-use-patterns-among-patients-with-early-stage-breast-cancer-in-a-large-multicenter-cohort-from-a-state-with-legalized-adult-non-medical-cannabis
#9
JOURNAL ARTICLE
M M Cousins, M P Dykstra, K Griffith, M Mietzel, D Kendrick, E Trumpower, D Dusseau, M M Dominello, T P Boike, J A Hayman, E M Walker, S Jolly, M L Mierzwa, R Jagsi, F A Vicini, L J Pierce
PURPOSE/OBJECTIVE(S): Cannabis use among patients with cancer is an area of great interest given its widespread acceptance despite the lack of supporting clinical data. The absence of data limits the understanding of potential clinical benefits of cannabis and the ability of providers to deliver evidence-based recommendations for patient care. We explored cannabis use patterns in patients with early-stage breast cancer in a large multicenter cohort in a state with legalized adult non-medical cannabis...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37625625/cannabinoids-and-standardized-cannabis-extracts-inhibit-migration-invasion-and-induce-apoptosis-in-mcf-7-cells-through-fak-mapk-akt-nf-%C3%AE%C2%BAb-signaling
#10
JOURNAL ARTICLE
Wiwit Suttithumsatid, Wanida Sukketsiri, Pharkphoom Panichayupakaranant
BACKGROUND: Breast cancer is the highest incidence of all types of cancer in women, and the cancer metastasis process accounts for a majority of cancer deaths. Two major cannabinoids, Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), from Cannabis sativa are expected to have anti-cancer activity. This study aimed to investigate the effects of THC, CBD, and standardized cannabis extracts (F1, F2, and F3) on migration, invasion, and apoptosis of human breast cancer (MCF-7) cells...
August 23, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/37489337/cannabis-and-substance-related-carcinogenesis-in-europe-a-lagged-causal-inferential-panel-regression-study
#11
JOURNAL ARTICLE
Albert Stuart Reece, Kellie Bennett, Gary Kenneth Hulse
Recent European data facilitate an epidemiological investigation of the controversial cannabis-cancer relationship. Of particular concern were prior findings associating high-dose cannabis use with reproductive problems and potential genetic impacts. Cancer incidence data age-standardised to the world population was obtained from the European Cancer Information System 2000-2020 and many European national cancer registries. Drug use data were obtained from the European Monitoring Centre for Drugs and Drug Addiction...
July 18, 2023: Journal of Xenobiotics
https://read.qxmd.com/read/37215911/-cannabis-sativa-l-modulates-altered-metabolic-pathways-involved-in-key-metabolisms-in-human-breast-cancer-mcf-7-cells-a-metabolomics-study
#12
JOURNAL ARTICLE
Ochuko L Erukainure, Omolola R Oyenihi, James F Amaku, Chika I Chukwuma, Adeline Lum Nde, Veronica F Salau, Motlalepula G Matsabisa
The present study investigated the ability of Cannabis sativa leaves infusion (CSI) to modulate major metabolisms implicated in cancer cells survival, as well as to induce cell death in human breast cancer (MCF-7) cells. MCF-7 cell lines were treated with CSI for 48 h, doxorubicin served as the standard anticancer drug, while untreated MCF-7 cells served as the control. CSI caused 21.2% inhibition of cell growth at the highest dose. Liquid chromatography-mass spectroscopy (LC-MS) profiling of the control cells revealed the presence of carbohydrate, vitamins, oxidative, lipids, nucleotides, and amino acids metabolites...
May 2023: Heliyon
https://read.qxmd.com/read/37176831/study-of-cannabis-oils-obtained-from-three-varieties-of-c-sativa-and-by-two-different-extraction-methods-phytochemical-characterization-and-biological-activities
#13
JOURNAL ARTICLE
Sebastián Pino, Luis Espinoza, Carlos Jara-Gutiérrez, Joan Villena, Andrés F Olea, Katy Díaz
Currently, much effort is being placed into obtaining extracts and/or essential oils from Cannabis sativa L. for specific therapeutic purposes or pharmacological compositions. These potential applications depend mainly on the phytochemical composition of the oils, which in turn are determined by the type of C. sativ a and the extraction method used to obtain the oils. In this work, we have evaluated the contents of secondary metabolites, delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD), in addition to the total phenolic, flavonoids, and anthraquinone content in oils obtained using solid-liquid extraction (SLE) and supercritical fluid extraction (SCF)...
April 26, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37128337/repositioning-cannabinoids-and-terpenes-as-novel-egfr-tkis-candidates-for-targeted-therapy-against-cancer-a-virtual-screening-model-using-cadd-and-biophysical-simulations
#14
JOURNAL ARTICLE
Ossama Daoui, Suraj N Mali, Kaouakeb Elkhattabi, Souad Elkhattabi, Samir Chtita
This study examines the potential of Cannabis sativa L. plants to be repurposed as therapeutic agents for cancer treatment through designing of hybrid Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). A set of 50 phytochemicals was taken from Cannabinoids and Terpenes and subjected for screening using Semi-flexible and Flexible Molecular Docking methods, MM-GBSA free binding energy computations, and pharmacokinetic/pharmacodynamic (ADME-Tox) predictions. Nine promising phytochemicals, Cannabidiolic acid (CBDA), Cannabidiol (CBD), Tetrahydrocannabivarin (THCV), Dronabinol (Δ-9-THC), Delta-8-Tetrahydrocannabinol (Δ-8-THC), Cannabicyclol (CBL), Delta9-tetrahydrocannabinolic acid (THCA), Beta-Caryophyllene (BCP), and Gamma-Elemene (γ-Ele) were identified as potential EGFR-TKIs natural product candidates for cancer therapy...
April 2023: Heliyon
https://read.qxmd.com/read/37116158/factors-associated-with-demand-for-medical-cannabis-use-among-breast-cancer-patients-in-northern-thailand-a-cross-sectional-study
#15
JOURNAL ARTICLE
Alongkorn Sukrueangkul, Petcherut Sirisuwan, Pariyakorn Sanguankittiphan, Tiwakron Prachaiboon, Kanlayawee Anonjarn, Sumonthip Boonkerd, Yiam Khongruangrat
OBJECTIVE: Breast cancer is the leading cause of death among women worldwide. Although modern treatments are recognized as effective, they often cause side effects. In Thailand, medical cannabis (MC) was legalized in 2019 with limited research on demand for its use. Therefore, this study aimed to identify factors associated with demand for MC among breast cancer patients in the North of Thailand as a target group. METHODS: This cross-sectional analytical study administered multistage random sampling to recruit 432 breast cancer patients in northern Thailand...
April 1, 2023: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/37099198/causal-relationship-between-cannabis-use-and-cancer-a-genetically-informed-perspective
#16
JOURNAL ARTICLE
Peng Huang, Peng Fei Zhang, Qiu Li
PURPOSE: Cannabis use is increasing legally worldwide, while its impact on cancer risk is unclear. This study was performed to investigate the relationship between cannabis use and the risk of several types of cancer. METHODS: We conducted a two-sample Mendelian randomization (MR) study to explore the causality of cannabis use on 9 site-specific types of cancer including breast cancer, cervical cancer, melanoma, colorectal cancer, laryngeal cancer, oral cancer, oropharyngeal cancer, esophageal cancer, and glioma...
September 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37074337/increasing-cancer-in-adolescents-and-young-adults-cancer-types-and-causation-implications
#17
JOURNAL ARTICLE
Archie Bleyer
Purpose: This study aimed to identify cancer incidence trends in the United States and globally in adolescents and young adults (AYAs) 15-39 years of age, by sex, and to speculate on causes for trend changes. Methods : For the United States, SEER*Stat was used to obtain average annual percent change (AAPC) trends in cancer incidence during the period 2000-2019 among 395,163 AYAs. For global data, the source was the Institute of Health Metrics and Evaluation and its sociodemographic index (SDI) classification system...
April 19, 2023: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/36913466/dietary-supplement-use-in-women-diagnosed-with-breast-cancer
#18
JOURNAL ARTICLE
Meg Hauer, Anthony M Rossi, Betsy C Wertheim, Hilary B Kleppel, Jennifer W Bea, Janet L Funk
BACKGROUND: Vitamins, minerals, and natural product (NP)-derived dietary supplements are commonly used among women with breast cancer, where interactions with treatments and the disease are possible, emphasizing the importance for health care providers to be aware of supplement use. OBJECTIVES: The study aimed to investigate current vitamin/mineral (VM) and NP supplement use among those diagnosed with breast cancer, including usage based on tumor type or concurrent breast cancer treatments and primary information sources for specific supplements...
January 2023: Journal of Nutrition
https://read.qxmd.com/read/36854495/phytocannabinoids-in-triple-negative-breast-cancer-treatment-current-knowledge-and-future-insights
#19
REVIEW
Sabrina Bimonte, Giuseppe Palma, Marco Cascella, Arturo Cuomo
Triple negative breast cancer (TNBC) represents an aggressive subtype of breast cancer, which is deficient in estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Thus, TNBC cells are unable to respond to the conventional hormonal therapies, making chemotherapy the only therapeutic choice. Patients with TNBC develop metastasis and recurrence over time and have reduced survival compared to patients with other subtypes of breast cancer. Therefore, there is a need for innovative therapies...
March 2023: Anticancer Research
https://read.qxmd.com/read/36641008/medical-cannabis-for-insomnia-in-a-patient-with-advanced-breast-cancer
#20
JOURNAL ARTICLE
Saba Jafri, Eric Hansen, Ryan Fuenmayor, Amy A Case
No abstract text is available yet for this article.
January 11, 2023: Journal of Pain and Symptom Management
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