keyword
https://read.qxmd.com/read/38529801/precision-allergy-molecular-diagnosis-applications-in-food-allergy
#1
JOURNAL ARTICLE
Sakura Sato, Motohiro Ebisawa
PURPOSE OF THE REVIEW: Precision medicine has become important in the diagnosis and management of food allergies. This review summarizes the latest information regarding molecular allergology, an essential component of food allergy managements. RECENT FINDINGS: Component-resolved diagnostics (CRD) can be used to investigate sensitization to allergens based on symptoms and to reveal co-sensitization and/or cross-sensitization in patients with allergies. The following allergen components are known to be associated with symptoms: ovomucoid from eggs, omega-5 gliadin from wheat, and many storage proteins (Gly m 8 from soy, Ara h 2 from peanut, Cor a 14 from hazelnut, Ana o 3 from cashew nut, Jug r 1 from walnut, and Ses i 1 from sesame)...
March 27, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38528385/predicting-the-outcome-of-pediatric-oral-food-challenges-for-determining-tolerance-development
#2
JOURNAL ARTICLE
Hamin Kim, Kyunguk Jeong, Mireu Park, Yun Young Roh, Jae Hwa Jung, Soo Yeon Kim, Jong Deok Kim, Min Jung Kim, Yoon Hee Kim, Myung Hyun Sohn, Sooyoung Lee, Kyung Won Kim
PURPOSE: Despite the risk of anaphylaxis, oral food challenges (OFCs) are performed clinically for various indications, particularly to confirm tolerance development. This study aimed to assess OFCs by relevant indications and build an outcome prediction model to help determine when to perform OFCs in children who are likely to have developed immune tolerance. METHODS: In total, 432 pediatric OFCs were retrospectively analyzed according to indications. Clinical characteristics, serum total immunoglobulin (Ig) E, blood eosinophils, and specific IgE and IgG4 levels for food allergens were noted and compared...
March 2024: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/38523669/the-clinical-burden-of-food-allergies-insights-from-the-food-allergy-research-education-fare-patient-registry
#3
JOURNAL ARTICLE
Christopher Warren, Ruchi Gupta, Arpamas Seetasith, Robert Schuldt, Rongrong Wang, Ahmar Iqbal, Sachin Gupta, Thomas B Casale
BACKGROUND: Food allergies are serious and potentially life-threatening, and often place a large burden on patients and their caregivers, including impacts on quality of life. OBJECTIVE: To assess the real-world patient burden of food allergies, using self-reported data available from the Food Allergy Research & Education (FARE) Patient Registry (NCT04653324). METHODS: The FARE Patient Registry is voluntary and captures real-world experiences of adults and pediatric patients in the United States, and their caregivers, through a series of surveys assessing patient health and experiences with food allergies...
March 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38506873/-food-desensitization
#4
JOURNAL ARTICLE
Pedro Piraino Sosa, Giovanni Ojeda Soley
In recent times, the primary approach to treating food allergies involved strict avoidance of the triggering allergen. Many considered this approach as lacking true treatment, leaving patients vulnerable to even small amounts or hidden sources of the allergenic food. Desensitization or Oral Tolerance Induction (OTI) is a studied method aiming for a lasting tolerance to the allergen. The ultimate goal is permanent tolerance, where allergic reactions won't reoccur after new exposure to the triggering allergen, following a period of abstinence...
December 31, 2023: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://read.qxmd.com/read/38506860/-classification-of-food-allergy-generalities
#5
JOURNAL ARTICLE
Jorge Cesar Martínez, Jorge Lavrut, Pablo Slullitel
The prevalence of food allergy has increased in some regions of the world, and with it the incidence, according to geographical variability, in the phenotype and clinical manifestations. Food allergy arises from the specific immune response induced by exposure to the proteins of a certain food. Food intolerance refers to non-immune reactions, caused by unique physiological characteristics of the individual, including metabolic, toxic, pharmacological and undefined mechanisms. Adverse reactions to foods are classified as: IgE-mediated: Type I Hypersensitivity, non-IgE-mediated: Type IV Hypersensitivity, mixed: Types I and IV Hypersensitivity Non-Allergic; toxic, pharmacological, metabolic, intolerances...
December 31, 2023: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://read.qxmd.com/read/38505000/evaluation-of-anti-fel-d-1-igy-ingredient-for-pet-food-on-growth-performance-in-kittens
#6
JOURNAL ARTICLE
Erik D Hedrick, Ray A Matulka, Lisa Conboy-Schmidt, Kimberly A May
INTRODUCTION: The domestic cat (Felis catus) is one of the most common pets. Worldwide, approximately one in five adults are sensitive to cat allergens. The major cat allergen is the secretoglobulin Fel d 1, which is primarily produced in the salivary and sebaceous glands. Chickens produce IgY antibodies, which are similar in structure to mammalian IgG. When chickens are exposed to Fel d 1, anti-Fel d 1-specific IgY (AFD1) is produced and is naturally concentrated in egg yolk. The aim of this study was to evaluate the tolerability, effects on growth and food consumption, and potential adverse effects of a chicken egg product ingredient containing AFD1 in kittens...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38492666/food-aversion-and-anxiety-represent-primary-patient-barriers-to-food-oral-immunotherapy
#7
JOURNAL ARTICLE
Jordan Trevisonno, Carina Venter, Kaci Pickett-Nairne, Philippe Bégin, Scott B Cameron, Edmond S Chan, Victoria E Cook, Jeffrey M Factor, Marion Groetch, Mariam A Hanna, Douglas H Jones, Richard L Wasserman, Douglas Paul Mack
While oral immunotherapy (OIT) for food allergy is a reasonable treatment option, barriers to this procedure's implementation have not been extensively evaluated from a patient perspective OBJECTIVE: We evaluated the barriers patients face during OIT administration, including anxiety and taste aversion, and evaluated the role of healthcare professionals, especially dietitians METHODS: A survey in Canada and the US involved families currently enrolled in food OIT programmes RESULTS: Of responses from 379 participants, fear of reaction was the most common barrier to OIT initiation, with 45...
March 14, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38490160/characterisation-of-protective-vaccine-antigens-from-the-thiol-containing-components-of-excretory-secretory-material-of-ostertagia-ostertagi
#8
JOURNAL ARTICLE
Daniel R G Price, Philip Steele, David Frew, Kevin McLean, Dorota Androscuk, Peter Geldhof, Jimmy Borloo, Javier Palarea Albaladejo, Alasdair J Nisbet, Tom N McNeilly
Previous vaccination trials have demonstrated that thiol proteins affinity purified from Ostertagia ostertagi excretory-secretory products (O. ostertagi ES-thiol) are protective against homologous challenge. Here we have shown that protection induced by this vaccine was consistent across four independent vaccine-challenge experiments. Protection is associated with reduced cumulative faecal egg counts across the duration of the trials, relative to control animals. To better understand the diversity of antigens in O...
March 1, 2024: Veterinary Parasitology
https://read.qxmd.com/read/38477961/mobile-app-web-platform-for-monitoring-food-oral-immunotherapy-in-children-longitudinal-clinical-validation-study
#9
JOURNAL ARTICLE
Sergio Sánchez-Fernández, Eva María Lasa, Soledad Terrados, Francisco Javier Sola-Martínez, Sara Martínez-Molina, Marta López de Calle, Paula Cabrera-Freitag, María José Goikoetxea
BACKGROUND: Milk and egg allergies significantly impact the quality of life, particularly in children. In this regard, food oral immunotherapy (OIT) has emerged as an effective treatment option; however, the occurrence of frequent adverse reactions poses a challenge, necessitating close monitoring during treatment. OBJECTIVE: This study aims to evaluate the ability of a new mobile/web app called OITcontrol to monitor milk and egg OIT. METHODS: Patients undergoing milk or egg OIT were recruited and divided into 2 groups: the active group used the OITcontrol app in conjunction with standard written monitoring methods, whereas the control group relied solely on written diaries...
March 13, 2024: JMIR Pediatrics and Parenting
https://read.qxmd.com/read/38462795/disparities-in-pediatric-anaphylaxis-triggers-and-management-across-asia
#10
JOURNAL ARTICLE
Agnes Sze Yin Leung, Elizabeth Huiwen Tham, Punchama Pacharn, Yuhan Xing, Hoang Kim Tu Trinh, Sooyoung Lee, Kangmo Ahn, Pantipa Chatchatee, Sakura Sato, Motohiro Ebisawa, Bee Wah Lee, Gary Wing Kin Wong
BACKGROUND: The epidemiology and management of anaphylaxis are not well-reported in Asia. METHODS: A regional pediatric anaphylaxis registry was established by the Asia-Pacific Research Network for Anaphylaxis (APRA), using standardized protocols for prospective data collection, to evaluate the triggers and management of anaphylaxis in the Asia-Pacific region. Pediatric patients below 18 years presenting with anaphylaxis across four Asian countries/cities (Thailand, Singapore, Hong Kong (HK), and Qingdao) were included...
March 10, 2024: Allergy
https://read.qxmd.com/read/38459888/primary-secondary-and-tertiary-prevention-of-food-allergy-current-practices-and-future-directions
#11
REVIEW
Caoimhe Cronin, Noah Salzberg, Yuxin Woon, Juan Trujillo Wurttele
The incidence of food allergies has risen around the globe, and experts have been exploring methods of preventing such allergies in young children to ease the burden of disease and reduce the morbidity and mortality caused by anaphylaxis to food allergens. Such preventative measures can be categorised as primary, secondary and tertiary prevention, which are discussed in detail in this review. Primary prevention is defined as the prevention of becoming sensitised towards specific allergens. The evidence suggests that avoiding common allergenic foods during pregnancy and breastfeeding is not protective against food allergies, and guidelines recommend weaning from 4 to 6 months of age, with recent studies supporting the early introduction of peanuts at 4 months to prevent peanut allergy...
2024: Allergologia et Immunopathologia
https://read.qxmd.com/read/38458433/noveos%C3%A2-and-immunocap%C3%A2-have-similar-performances-for-diagnosing-food-allergies
#12
JOURNAL ARTICLE
Benjamin Trouche-Estival, Joana Vitte, Audrey Martin-Blondel, Marine Michelet, Vianney Gruzelle, Alain Didier, Laurent Guilleminault, Claire Mailhol, Silvia Martinez Rivera, Anaïs De Lima Correia, Camille Taurus, Antoine Blancher, Julien Goret, Caroline Klingebiel, Pol André Apoil
BACKGROUND: The clinical interest of newly available platforms for specific IgE measurement must be evaluated. However, data are lacking for NOVEOS™ (Hycor), in particular for food allergens. OBJECTIVE: We compared technical and clinical performance of two platforms (ImmunoCAP™ and NOVEOS™) for the measurement of specific IgE to 10 food allergens. METHODS: Sera from 289 clinically-characterized patients were tested for IgE specific for six food allergen extracts (egg white, cow's milk, peanut, hazelnut, fish, shrimp) and four molecular allergens (Gal d 1, Bos d 8, Ara h 2, Cor a 14)...
March 6, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38441821/a-review-of-shared-decision-making-published-protocols-and-post-desensitization-strategies-in-oral-immunotherapy-oit
#13
REVIEW
Susan Laubach, Edwin H Kim, Matthew Greenhawt, Sally Bailey, Aikaterini Anagnostou
PURPOSE OF REVIEW: The aim of this review is to highlight key published oral immunotherapy (OIT) protocols and post-desensitization strategies for the major food allergens and to cover important concepts to consider when evaluating OIT for food-allergic patients. Shared decision-making should help identify patient and family values which will help influence the type of evidence-based protocol and maintenance strategy to use. RECENT FINDINGS: With food OIT emerging as a treatment option, there is a pressing need for patients, physicians, and other providers to have a nuanced understanding of the management choices available to them...
March 5, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38407394/omalizumab-for-the-treatment-of-multiple-food-allergies
#14
JOURNAL ARTICLE
Robert A Wood, Alkis Togias, Scott H Sicherer, Wayne G Shreffler, Edwin H Kim, Stacie M Jones, Donald Y M Leung, Brian P Vickery, J Andrew Bird, Jonathan M Spergel, Ahmar Iqbal, Julie Olsson, Monica Ligueros-Saylan, Alkaz Uddin, Agustin Calatroni, Charmaine Marquis Huckabee, Nicole H Rogers, Nancy Yovetich, Jennifer Dantzer, Kim Mudd, Julie Wang, Marion Groetch, David Pyle, Corinne A Keet, Michael Kulis, Sayantani B Sindher, Andrew Long, Amy M Scurlock, Bruce J Lanser, Tricia Lee, Christopher Parrish, Terri Brown-Whitehorn, Amanda K Rudman Spergel, Maria Veri, Sanaz Daneshfar Hamrah, Erica Brittain, Julian Poyser, Lisa M Wheatley, R Sharon Chinthrajah
BACKGROUND: Food allergies are common and are associated with substantial morbidity; the only approved treatment is oral immunotherapy for peanut allergy. METHODS: In this trial, we assessed whether omalizumab, a monoclonal anti-IgE antibody, would be effective and safe as monotherapy in patients with multiple food allergies. Persons 1 to 55 years of age who were allergic to peanuts and at least two other trial-specified foods (cashew, milk, egg, walnut, wheat, and hazelnut) were screened...
February 25, 2024: New England Journal of Medicine
https://read.qxmd.com/read/38380907/a-novel-bartonella-like-bacterium-forms-an-interdependent-mutualistic-symbiosis-with-its-host-the-stored-product-mite-tyrophagus-putrescentiae
#15
JOURNAL ARTICLE
Qing Xiong, Bruno Sopko, Pavel B Klimov, Jan Hubert
A novel Bartonella -like symbiont (BLS) of Tyrophagus putrescentiae was characterized. BLS formed a separate cluster from the Bartonella clade together with an ant symbiont. BLS was present in mite bodies (103 16S DNA copies/mite) and feces but was absent in eggs. This indicated the presence of the BLS in mite guts. The BLS showed a reduction in genome size (1.6 Mb) and indicates gene loss compared to Bartonella apis . The BLS can be interacted with its host by using host metabolic pathways (e.g., the histidine and arginine metabolic pathways) as well as by providing its own metabolic pathways (pantothenate and lipoic acid) to the host, suggesting the existence of a mutualistic association...
February 21, 2024: MSystems
https://read.qxmd.com/read/38374627/variation-in-the-allergenicity-of-scrambled-boiled-short-baked-and-long-baked-egg-white-proteins
#16
JOURNAL ARTICLE
Purevsan Gantulga, Jeongmin Lee, Kyunguk Jeong, Se-Ah Jeon, Sooyoung Lee
BACKGROUND: Hen's egg white (HEW) is the most common cause of food allergy in children which induces mild to fatal reactions. The consultation for a proper restriction is important in HEW allergy. We aimed to identify the changes in HEW allergenicity using diverse cooking methods commonly used in Korean dishes. METHODS: Crude extract of raw and 4 types of cooked HEW extracts were produced and used for sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE), enzyme-linked immunosorbent assay (ELISA), and ELISA inhibition assays using 45 serum samples from HEW allergic and tolerant children...
February 19, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38349368/management-of-food-allergies-and-food-related-anaphylaxis
#17
JOURNAL ARTICLE
Edward G A Iglesia, Mildred Kwan, Yamini V Virkud, Onyinye I Iweala
IMPORTANCE: An estimated 7.6% of children and 10.8% of adults have IgE-mediated food-protein allergies in the US. IgE-mediated food allergies may cause anaphylaxis and death. A delayed, IgE-mediated allergic response to the food-carbohydrate galactose-α-1,3-galactose (alpha-gal) in mammalian meat affects an estimated 96 000 to 450 000 individuals in the US and is currently a leading cause of food-related anaphylaxis in adults. OBSERVATIONS: In the US, 9 foods account for more than 90% of IgE-mediated food allergies-crustacean shellfish, dairy, peanut, tree nuts, fin fish, egg, wheat, soy, and sesame...
February 13, 2024: JAMA
https://read.qxmd.com/read/38348623/why-is-pet-cat-dog-allergen-immunotherapy-ait-such-a-controversial-topic-current-perspectives-and-future-directions
#18
REVIEW
G Liccardi, M Martini, M B Bilò, L Cecchi, M Milanese, L Brussino, E Motta, P Rogliani
Dogs and cats are the most common pets worldwide. In Italy, the prevalence of allergic sensitization to cats and dogs is 16% and 9% respectively. The limited standardization of allergenic extracts, especially for dogs, emphasizes the importance of Component Resolved Diagnosis (CRD) for accurate diagnosis and subsequent prescription of allergen immunotherapy (AIT). However, this low standardization is the main factor contributing to the unsatisfactory clinical efficacy of traditional AIT, AIT with modified allergens, and intralymphatic allergen-specific immunotherapy (ILAIT)...
February 13, 2024: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/38338542/comprehensive-epitope-analysis-of-monoclonal-antibodies-binding-to-hen-egg-ovalbumin-using-a-peptide-array
#19
JOURNAL ARTICLE
Yuko Terada, Masanobu Akimoto, Hirofumi Sakoda, Shunsuke Yamamoto, Mayuka Kubota, Tomoharu Motoyama, Yo Imanaka, Shogo Nakano, Sohei Ito, Shigeki Kato, Keisuke Ito
Food allergies are a significant health issue worldwide. In many countries, labeling of primary allergens in food products has been made mandatory to ensure consumer safety. In food manufacturing settings, the lateral flow immunoassay (LFI)-based on antigen-antibody reactions-is a rapid and accurate method for allergen testing and is widely used. Peptide arrays are tools that enable the synthesis of peptides of any sequence on a substrate and high-throughput analysis of their interactions with chemicals. This study aimed to investigate a new application of peptide arrays in the field of food technology, particularly in the development of antibodies for food allergen testing...
January 26, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38336145/age-specific-metabolomic-profiles-in-children-with-food-allergy
#20
JOURNAL ARTICLE
E Crestani, M Benamar, W Phipatanakul, R Rachid, T A Chatila
BACKGROUND: Food allergy (FA) in young children is often associated with eczema, frequently directed to egg/cow milk allergens and has a higher chance of resolution, while FA that persists in older children has less chance of resolution and is less clearly associated with atopy. METHODS: Children with FA (n = 62) and healthy controls (n = 28) were categorized into "younger" (≤5 years) and "older" (>5 years). Mass spectrometry-based untargeted metabolomic profiling as wells as cytokine profiling were performed on plasma samples in FA children in each age group...
February 7, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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