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https://read.qxmd.com/read/30770574/allergen-immunotherapy-for-ige-mediated-food-allergy-there-is-a-measure-in-everything-to-a-proper-proportion-of-therapy
#1
Giovanni Battista Pajno, Riccardo Castagnoli, Muraro Antonella, Montserrat Alvaro-Lozano, Cezmi A Akdis, Műbeccel Akdis, Stefania Arasi
IgE-mediated food allergy (FA) is a potentially life-threatening condition with a negative impact on quality of life and an increasing prevalence in westernized countries in the recent two decades. A strict avoidance of the triggering food(s) represents the current standard approach. However, an elimination diet may be difficult and frustrating, in particular for common foods, (e.g. milk, egg, and peanut). Food allergy immunotherapy (FA-AIT) may provide an active treatment that enables to increase the amount of food that the patient can intake without reaction during treatment (i...
February 15, 2019: Pediatric Allergy and Immunology
https://read.qxmd.com/read/30732197/association-between-food-allergy-and-ankylosing-spondylitis-an-observational-study
#2
Qian Niu, Wei Wei, Zhuochun Huang, Junlong Zhang, Bin Yang, Lanlan Wang
Food allergies can alter the gut microbiome composition, increasing the risk of conditions such as ankylosing spondylitis (AS).To identify the association between specific allergens and AS, we investigated the differences in the serum levels of 14 food antigen-specific immunoglobulin (Ig) G between AS patients and healthy participants. The association between the levels of these antibodies and disease activity was assessed by measuring the inflammatory marker C-reactive protein (CRP).We enrolled 75 AS patients and 78 healthy controls who had undergone antigen-specific IgG tests in West China Hospital between January 2015 and October 2017, and performed enzyme-linked immunosorbent assays for specific IgG against 14 food allergens: rice, egg, mushroom, milk, pork, chicken, beef, crab, codfish, corn, soybean, tomato, shrimp, and wheat...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30714219/food-avoidance-strategies-in-eosinophilic-oesophagitis
#3
Antonella Cianferoni, Michelle Shuker, Terri Brown-Whitehorn, Hannah Hunter, Carina Venter, Jonathan M Spergel
EoE is a chronic disease associated with significant morbidity that can result in permanent fibrosis and stricture formation. Given the complexity a multidisciplinary approach is recommended to manage these patients. In the majority of children with EoE not responsive to proton pump inhibitors (PPI), inflammation is driven by sensitivity to foods and treatment with an elimination diet can be effective. Foods most commonly identified to trigger EoE in children are milk and wheat, but egg, soy, meats and grains can also be triggers...
February 3, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30656696/food-protein-induced-enterocolitis-syndrome-guidelines-summary-and-practice-recommendations
#4
REVIEW
Sam Mehr, Dianne E Campbell
Food protein-induced enterocolitis syndrome (FPIES) is a poorly understood non-IgE gastrointestinal-mediated food allergy that predominantly affects infants and young children. Cells of the innate immune system appear to be activated during an FPIES reaction. Acute FPIES typically presents between one and 4 hours after ingestion of the trigger food, with the principal symptom being profuse vomiting, and is often accompanied by pallor and lethargy. Additional features can include hypotension, hypothermia, diarrhoea, neutrophilia and thrombocytosis...
January 18, 2019: Medical Journal of Australia
https://read.qxmd.com/read/30643099/associations-between-metal-levels-in-whole-blood-and-ige-concentrations-in-pregnant-women-based-on-data-from-the-japan-environment-and-children-s-study
#5
Mayumi Tsuji, Chihaya Koriyama, Yasuhiro Ishihara, Megumi Yamamoto, Kiwako Yamamoto-Hanada, Kumiko Kanatani, Yu Ait Bamai, Kazunari Onishi, Ayako Senju, Shunsuke Araki, Eiji Shibata, Seiichi Morokuma, Masafumi Sanefuji, Hiroshi Kitazawa, Mayako Saito, Masakazu Umezawa, Atsuto Onoda, Koichi Kusuhara, Rie Tanaka, Toshihiro Kawamoto
BACKGROUND: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children. METHODS: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children's Study...
January 12, 2019: Journal of Epidemiology
https://read.qxmd.com/read/30615406/infectious-disease-bedbugs-lice-and-mites
#6
Mark K Huntington, Jay R Allison, Amy L Hogue, Charles W Shafer
Bedbugs, mites, and scabies are ectoparasites that commonly affect humans. Bedbugs ( Cimex species) were once rare in the United States but are now common. They cause intensely pruritic lesions on areas of exposed skin. The bites are highly allergenic and can cause asthma exacerbations or anaphylaxis. Management of bedbug bites involves symptomatic relief of itching and dealing with patient anxiety. Identification and elimination of infestation are most important. Another ectoparasite of concern is lice ( Pediculus and Pthirus species), which causes head, body, and pubic infestations...
January 2019: FP Essentials
https://read.qxmd.com/read/30582501/a-cross-sectional-study-of-the-prevalence-of-food-allergies-among-children-younger-than-ages-14-years-in-a-beijing-urban-region
#7
Li Sha, Mingjun Shao, Chuanhe Liu, Yongning Wu, Yuzhi Chen
Background: The prevalence of food allergies has increased over the past several decades, but little is known about this issue in Beijing. Objective: The objectives of this study were to assess the prevalence of food allergies in the Beijing urban area and to summarize the clinical features and common food allergens in children <14 years of age. Methods: We conducted a cross-sectional study of children ages 0-14 years who were recruited from 10 kindergartens and 20 primary and middle schools in two communities in the central region (Xicheng district)...
January 1, 2019: Allergy and Asthma Proceedings:
https://read.qxmd.com/read/30540712/pediatric-eosinophilic-esophagitis-results-of-the-european-retrospective-pediatric-eosinophilic-esophagitis-registry-retropeer
#8
Assaf Hoofien, Jorge A Dias, Monica Malamisura, Francesca Rea, Sonny Chong, Johanna Oudshoorn, Danielle Nijenhuis-Hendriks, Sebastian Otte, Alexandra Papadopoulou, Claudio Romano, Frederic Gottrand, Victor V Miravet, Rok Orel, Salvatore Oliva, Carolina G Junquera, Andrzej Załęski, Vaidotas Urbonas, Roger Garcia-Puig, Maria J M Gomez, Gloria Dominguez-Ortega, Marcus K-H Auth, Michal Kori, Amir Ben Tov, Nicolas Kalach, Saskia V Velde, Mark Furman, Erasmo Miele, Luba Marderfeld, Eleftheria Roma, Noam Zevit
OBJECTIVES: Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists diagnosing and treating EoE and to identify the triggering allergens in European children. METHODS: Retrospective anonymized data were collected from 26 European pediatric gastroenterology centers in 13 countries. Inclusion criteria were patients diagnosis with EoE, completed investigations prescribed by the treating physician, and were on stable medical or dietary interventions...
December 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/30535420/feeding-high-oleic-peanuts-to-layer-hens-enhances-egg-yolk-color-and-oleic-fatty-acid-content-in-shell-eggs
#9
Ondulla T Toomer, Amanda M Hulse-Kemp, Lisa L Dean, Deborah L Boykin, Ramon Malheiros, Kenneth E Anderson
Previous studies have identified normal-oleic peanuts as a suitable and economical broiler feed ingredient. However, no studies to date have examined the use of high-oleic (HO) peanut cultivars as a feed ingredient for laying hens and determined the impact of feeding HO peanuts on performance and egg nutritive qualities. This project aimed to examine the use of HO peanuts as a feed ingredient for layer hens to determine the effect on performance, egg lipid chemistry, and quality of the eggs produced. Forty-eight 40-wk-old layer hens were fed a conventional soybean meal + corn control diet or a HO peanut + corn diet for 10 wk in conventional battery cages...
December 11, 2018: Poultry Science
https://read.qxmd.com/read/30517849/a-light-initiated-chemiluminescent-assay-for-rapid-quantitation-of-allergen-specific-igg-4-in-clinical-samples
#10
Junpu Li, Shaoshen Li, Lunhui Huang, Yaqiong Cui, Tiantian She, Ying Bian, Huiqiang Li
BACKGROUND: An increase in allergen-specific IgG4 (sIgG4 ), which serves as a blocking antibody, is associated with acquisition of immune tolerance after immunotherapy. In this study, we developed a rapid, sensitive, and homogeneous immunoassay based on the light-initiated chemiluminescent assay (LICA) technology for quantifying allergen sIgG4 in serum samples. METHODS: Allergen sIgG4 was measured in vitro by incubating the sample with biotinylated allergens and chemiluminescent beads coated with anti-human IgG4 antibody, followed by the addition of streptavidin-coated sensitizer beads...
December 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/30484638/single-laboratory-validation-of-the-multiplex-xmap-food-allergen-detection-assay-xmap-fada-with-incurred-food-samples
#11
William L Nowatzke, Kerry G Oliver, Chung Y Cho, Prasad Rallabhandi, Eric A E Garber
An xMAP Food Allergen Detection Assay (xMAP FADA) was developed to meet analytical needs when responding to complaints by individuals with multiple food allergies and to address potential ambiguities associated with cross-reactive proteins. A Single Laboratory Validation (SLV) was conducted to examine the reliability of the xMAP FADA to detect 15 analytes individually, or as part of a mixture, at ≥6 concentrations, in four foods. The xMAP FADA reliably detected the analytes despite the incurred dark chocolate and incurred baked muffins displaying recoveries of 10-20% and <60%, respectively...
November 28, 2018: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/30479743/early-aggressive-intervention-for-infantile-atopic-dermatitis-to-prevent-development-of-food-allergy-a-multicenter-investigator-blinded-randomized-parallel-group-controlled-trial-paci-study-protocol-for-a-randomized-controlled-trial
#12
Kiwako Yamamoto-Hanada, Tohru Kobayashi, Hywel C Williams, Masashi Mikami, Mayako Saito-Abe, Kumiko Morita, Osamu Natsume, Miori Sato, Motoko Iwama, Yumiko Miyaji, Makiko Miyata, Shinichiro Inagaki, Fukuie Tatsuki, Narita Masami, Shoji F Nakayama, Hiroshi Kido, Hirohisa Saito, Yukihiro Ohya
Background: Atopic dermatitis is the first clinical manifestation of the atopic march, with the highest incidence in the first year of life. Those affected often go on to develop other allergic diseases including food allergy, asthma, and allergic rhinitis. Recent evidence suggests that sensitization to foods may occur through a defective skin barrier which is common in atopic dermatitis in early life. We hypothesize that therapeutic aggressive intervention to treat new onset atopic dermatitis may prevent the development of later allergen sensitization, and associated food allergy, asthma, and allergic rhinitis...
2018: Clinical and Translational Allergy
https://read.qxmd.com/read/30473111/selection-of-egg-peptide-biomarkers-in-processed-food-products-by-high-resolution-mass-spectrometry
#13
M Gavage, K Van Vlierberghe, C Van Poucke, M De Loose, K Gevaert, M Dieu, P Renard, T Arnould, N Gillard
Food allergy is a growing health problem worldwide; thus, there is an urgent need for robust, specific, and sensitive analytical methods for detecting allergens. Mass spectrometry is an alternative to the existing methods, and it can overcome their limitations. One of the first steps in the development of any analytical method is the identification of the analytes to be further studied. In the case of allergen detection by mass spectrometry, the analytes are peptides. In this study, a strategy was developed for identifying potential peptide biomarkers in processed food products...
November 20, 2018: Journal of Chromatography. A
https://read.qxmd.com/read/30467437/component-resolved-diagnosis-crd-of-food-anaphylaxis
#14
Małgorzata Bulanda, Magdalena Leśniak, Judyta Szałkowska, Weronika Madej, Agata Wojtyna, Maria Czarnobilska, Daniel Bulanda, Ewa Czarnobilska
Anaphylaxis is an increasing problem in public health. The food allergens (mainly milk, eggs, and peanuts) are the most frequent cause of anaphylaxis in children and youth. In order to define the cause of anaphylaxis, skin tests, the determination of the concentration of specific IgE in the blood and basophil activation test are conducted. In vitro tests are preferred due to the risk of allergic response during in vivo tests. Component-resolved diagnosis (CRD) is an additional tool in allergology, recommended in the third level of diagnostics when there are diagnostic doubts after the above mentioned tests have been carried out...
2018: Folia Medica Cracoviensia
https://read.qxmd.com/read/30453619/solid-food-introduction-and-the-development-of-food-allergies
#15
REVIEW
Carlo Caffarelli, Dora Di Mauro, Carla Mastrorilli, Paolo Bottau, Francesca Cipriani, Giampaolo Ricci
The rise of food allergy in childhood, particularly among developed countries, has a significant weight on public health and involves serious implications for patients' quality of life. Even if the mechanisms of food tolerance and the complex interactions between the immune system and environmental factors are still mainly unknown, pediatricians have worldwide implemented preventive measures against allergic diseases. In the last few decades, the prevention of food allergy has tracked various strategies of complementary feeding with a modification of international guidelines from delayed introduction to early weaning...
November 17, 2018: Nutrients
https://read.qxmd.com/read/30408639/food-allergy-is-associated-with-depression-and-psychological-distress-a-web-based-study-in-11-876-japanese
#16
Shinsuke Hidese, Shun Nogawa, Kenji Saito, Hiroshi Kunugi
BACKGROUND: Although some studies suggest a possible association between food allergy (FA) and depression/psychological distress, empirical data are still scarce. We aimed to examine whether this association exists in a large sample of the Japanese population. METHODS: This web-based cross-sectional survey included 1000 individuals with self-reported lifetime history of clinical depression (mean age: 41.4 years, 501 men), and the remaining 10,876 subjects served as controls (mean age: 45...
October 26, 2018: Journal of Affective Disorders
https://read.qxmd.com/read/30401008/the-potential-anti-inflammatory-role-of-adiponectin-in-food-allergy-a-case-control-study-on-children
#17
Mahshid Sirjani, Raheleh Shokouhi Shoormasti, Nastaran Sabetkish, Maryam Ayazi, Nazanin Khodayari Namini, Behnoosh Tayebi, Zahra Pourpak
We aimed to assess the possible relationship between food allergy and two key adipokines - leptin and adiponectin - in children with food allergy. A total of forty patients with definite diagnosis of food allergy according to clinical history and specific IgE (sIgE) for food allergens (group I) were enrolled in this pilot study. The control group (group II) included thirty children with no evidence of allergic symptoms. Serum levels of leptin and adiponectin were measured by ELISA. Meanwhile, sIgE was measured for the eight most common food allergens by the immunoblot method in all participants...
November 2018: British Journal of Nutrition
https://read.qxmd.com/read/30400704/-the-analysis-of-serum-allergen-spectrum-in-0%C3%AF-12-years-old-children-with-allergic-diseases-in-liaoning-province
#18
H Y Wang, Z W Cai
Objective: To explore the distribution and characteristics of allergens in children aged 0-12 years old in liaoning province. Method: 46 620 children with suspected allergic diseases were grouped according to age, sex and detection time. Then allergen detections were conducted. The distribution of allergen in different groups was analyzed. Result: Most children were sensitized to single allergen, followed by a double positive. 98.08% children showed sensitivities to up to five kinds of allergen. The allergen spectrum of patients in different age groups was slightly different...
October 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://read.qxmd.com/read/30375892/comparison-of-allergen-specific-ige-levels-between-immulite-2000-and-immunocap-systems-against-six-inhalant-allergens-and-ten-food-allergens
#19
Jinyoung Yang, Hyeyoung Lee, Ae Ran Choi, Ki Hyun Park, Ji Hyeong Ryu, Eun-Jee Oh
In vitro allergen-specific immunoglobulin E (sIgE) measurement has been used as an important diagnostic tool for allergic diseases. Currently, quantitative sIgE levels are detected mainly by using ImmunoCAP and Immulite 2000 assay system. These two systems have the same calibration scale at 0-100 kUA/L, but they differ in used allergens, detection methods and automation systems. We compared 1600 paired sIgE results for 204 allergic patients, including 100 paired sIgE assay results for each of 16 allergens (Alternaria alternata, birch-alder mix, cat dander, D...
October 30, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/30373020/absolute-quantification-of-targeted-meat-and-allergenic-protein-additive-peptide-markers-in-meat-products
#20
Magdalena Montowska, Emilia Fornal
We present an implementation of the absolute quantification (AQUA) method for monitoring of peptide abundance in complex mixtures of processed proteins. Specific peptide markers from meats (chicken, duck, goose, pork and beef) and common protein allergenic additives (soy, milk and egg white preparations) were chosen and synthesised with stable isotopes (13 C and 15 N) for use as internal standards. A wide range of food samples, from cooked or raw meat to sterilised pâté, was analysed by a triggered multiple reaction monitoring mode experiment and triple quadrupole mass spectrometry for the direct measure of tryptic peptides representing the amounts of specific proteins...
February 15, 2019: Food Chemistry
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