Beili Wang, Wenjing Yang, Yexin Tong, Mingjun Sun, Sheng Quan, Jing Zhu, Qianwen Zhang, Zhaoyu Qin, Yanxia Ni, Ying Zhao, Kouqiong Wang, Chunyan Zhang, Yichi Zhang, Zhenxin Wang, Zhenju Song, Huafen Liu, Hao Fang, Ziqing Kong, Chen Ding, Wei Guo
Since its outbreak in late 2021, the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been widely reported to be able to evade neutralizing antibodies, becoming more transmissible while causing milder symptoms than previous SARS-CoV-2 strains. Understanding the underlying molecular changes of Omicron SARS-CoV-2 infection and corresponding host responses are important to the control of Omicron COVID-19 pandemic. In this study, we report an integrative proteomics and metabolomics investigation of serum samples from 80 COVID-19 patients infected with Omicron SARS-CoV-2, as well as 160 control serum samples from 80 healthy individuals and 80 patients who had flu-like symptoms but were negative for SARS-CoV-2 infection...
November 2023: Journal of Medical Virology