keyword
https://read.qxmd.com/read/38497634/a-passive-ankle-dorsiflexion-testing-system-for-an-in-vivo-model-of-overuse-induced-tendinopathy
#1
JOURNAL ARTICLE
Pooja H Chainani, Patrick M Williamson, Diana Yeritsyan, Kaveh Momenzadeh, Nadim Kheir, Joseph P DeAngelis, Arun J Ramappa, Ara Nazarian
Tendinopathy is a chronic tendon condition that results in pain and loss of function and is caused by repeated overload of the tendon and limited recovery time. This protocol describes a testing system that cyclically applies mechanical loads via passive dorsiflexion to the rat Achilles tendon. The custom-written code consists of pre- and post-cyclic loading measurements to assess the effects of the loading protocol along with the feedback control-based cyclic fatigue loading regimen. We used 25 Sprague-Dawley rats for this study, with 5 rats per group receiving either 500, 1,000, 2,000, 3,600, or 7,200 cycles of fatigue loads...
March 1, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38487305/safety-tolerability-and-pharmacokinetics-of-aildenafil-citrate-tablets-a-novel-oral-pde5-inhibitor-in-healthy-chinese-volunteers-after-multiple-dose-administration
#2
JOURNAL ARTICLE
Ran Xie, Bo Jia, Lu Cheng, Nan Zhao, Xu He, Xia Wang, Xia Zhao, Yimin Cui
BACKGROUND: Aildenafil citrate is a potent and selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5, developed for the treatment of erectile dysfunction (ED). AIM: This study aimed to assess the pharmacokinetics, safety, and tolerability of aildenafil citrate tablets after multiple doses in healthy Chinese males. METHODS: Twenty participants were divided into 2 groups, 10 participants each. Participants were administered multiple doses of aildenafil citrate tablets at 30 and 60 mg...
February 2024: Sexual Medicine
https://read.qxmd.com/read/38484144/towards-the-improvement-of-the-mechanical-and-tribological-properties-of-braided-ligament-for-acl-reconstruction-a-carrot-and-stick-strategy
#3
JOURNAL ARTICLE
Shenglin Li, Shuhan Wang, Jiasheng Shao, Jiali Wang, Wenliang Liu, Linxin Chen, Zeng Li, Chao Zhang, Jian Song
Bone tunnel enlargement has been troubling the clinical adoption of braided artificial ligaments for decades, to which mechanical and tribological performance promotion shall be an effective and promising approach. Herein, a "carrot and stick" strategy has been introduced with two types of polyethylene terephthalate (PET) fibers to fabricate hybrid textures, which is expected to advance fatigue and tribological performance without yielding essential mechanical strength and biocompatibility. Owing to advancements in such a "carrot and stick" strategy, the obtained grafts present three promising properties: i) enhancement of mechanical strength; ii) COF reduction of 25% at the greatest extent, thus lowering the risk of bone tunnel enlargement; iii) final displacement shrinkage of graft length after cyclic loadings, favored in the clinic for isometric reconstruction...
March 14, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38475263/lap-shear-strength-and-fatigue-analysis-of-continuous-carbon-fibre-reinforced-3d-printed-thermoplastic-composites-by-varying-the-load-and-fibre-content
#4
JOURNAL ARTICLE
Khalid Saeed, Alistair Mcilhagger, Thomas Dooher, Jawad Ullah, Faisal Manzoor, Xavier Velay, Edward Archer
This study focuses on evaluating the fatigue life performance of 3D-printed polymer composites produced through the fused deposition modelling (FDM) technique. Fatigue life assessment is essential in designing components for industries like aerospace, medical, and automotive, as it provides an estimate of the component's safe service life during operation. While there is a lack of detailed research on the fatigue behaviour of 3D-printed polymer composites, this paper aims to fill that gap. Fatigue tests were conducted on the 3D-printed polymer composites under various loading conditions, and static (tensile) tests were performed to determine their ultimate tensile strength...
February 21, 2024: Polymers
https://read.qxmd.com/read/38473684/finite-element-analysis-and-fatigue-test-of-integra-dental-implant-system
#5
JOURNAL ARTICLE
Rafał Zieliński, Sebastian Lipa, Martyna Piechaczek, Jerzy Sowiński, Agata Kołkowska, Wojciech Simka
The study involved numerical FEA (finite element analysis) of dental implants. Based on this, fatigue tests were conducted according to the PN-EN 14801 standard required for the certification of dental products. Thanks to the research methodology developed by the authors, it was possible to conduct a thorough analysis of the impact of external and internal factors such as material, geometry, loading, and assembly of the dental system on the achieved value of fatigue strength limit in the examined object. For this purpose, FEM studies were based on identifying potential sites of fatigue crack initiation in reference to the results of the test conducted on a real model...
March 6, 2024: Materials
https://read.qxmd.com/read/38473604/study-on-fatigue-life-of-aluminum-alloy-6061-t6-based-on-random-defect-characteristics
#6
JOURNAL ARTICLE
Lei Lu, Hao Chen, Mingming Ren, Sha Xu, Yongfang Li, Tianjun Zhou, Yali Yang
A certain number of hole-like defects will occur in aluminum alloys under cyclic loading. The internal holes will reduce the strength of the material and cause stress concentration, which will aggravate the development of fatigue damage. A classification method of defect features based on X-ray CT damage data is proposed. The random hole distribution model is established through the linear congruence method and the region division method. The hole parameter is introduced as the intermediate variable of the 3D reconstruction model of internal defects...
February 29, 2024: Materials
https://read.qxmd.com/read/38463467/revolutionizing-endodontics-advancements-in-nickel-titanium-instrument-surfaces
#7
REVIEW
Paridhi Rajesh Agrawal, Manoj Chandak, Pradnya Prashant Nikhade, Aditya Satyawansingh Patel, Jay Kailas Bhopatkar
Nickel-titanium (NiTi) instruments have become the backbone of endodontics due to their exceptional properties, superelasticity, and shape memory. However, challenges such as unexpected breakage, poor cutting efficiency, and corrosion have prompted researchers to explore innovative surface modifications to enhance their performance. This comprehensive review discusses the latest advancements in NiTi metallurgy and their impact on rotary NiTi file systems. Various surface treatment techniques, including ion implantation, cryogenic treatment (CT), thermal nitridation, electropolishing, and physical or chemical vapor deposition, have been investigated to minimize defects, boost surface hardness, and improve cyclic fatigue resistance...
February 2024: J Conserv Dent Endod
https://read.qxmd.com/read/38460898/developing-effective-strategies-to-optimize-physical-activity-and-cardiorespiratory-fitness-in-the-long-covid-population-the-need-for-caution-and-objective-assessment
#8
REVIEW
Mark A Faghy, Rae Duncan, Emily Hume, Lewis Gough, Clare Roscoe, Deepika Laddu, Ross Arena, Ruth E M Asthon, Caroline Dalton
The Post Covid-19 Condition (commonly known as Long Covid) has been defined by the World Health Organisation as occurring in individuals with a history of probable or confirmed SARS CoV 2 infection, usually within 3 months from the onset of acute Covid-19 infection with symptoms that last for at least two months which cannot be explained by an alternative diagnosis. Long Covid is associated with over two hundred recognised symptoms and affects tens of millions of people worldwide. Widely reported reductions in quality of life(QoL) and functional status are caused by extremely sensitive and cyclical symptom profiles that are augmented following exposure to physical, emotional, orthostatic, and cognitive stimuli...
March 8, 2024: Progress in Cardiovascular Diseases
https://read.qxmd.com/read/38418282/comparison-of-subcritical-growth-parameters-of-a-y-tzp-obtained-via-cyclic-or-dynamic-fatigue-tests
#9
JOURNAL ARTICLE
Karen Akemi Fukushima, Abdulaziz Alhotan, Sahar Ganz Riman, Gaurav Joshi, Yuanyuan Duan, Jason A Griggs, Paulo Francisco Cesar
OBJECTIVE: The objective of this study was to 1) compare the stress corrosion coefficient (n) of a Y-TZP obtained by two fatigue tests: cyclic and dynamic and 2) evaluate the effect of frequency in the characteristic lifetime and the existence of interaction between the cyclic fatigue and slow crack growth. METHODS: A total of 145 Y-TZP specimens were produced in accordance with the manufacturer's instructions. These specimens, measuring 4.0 × 3.0 × 25...
February 27, 2024: Dental Materials
https://read.qxmd.com/read/38406139/effect-of-temperature-on-the-cyclic-fatigue-resistance-and-phase-transformation-behavior-of-three-different-niti-endodontic-instruments
#10
JOURNAL ARTICLE
Esra İrem Yi Ği T, İrem Çetinkaya
Background This study aims to analyze the phase transformation behavior and evaluate the effect of different temperatures on the fracture strength of files. Methodology A total of 108 files were used, and cyclic fatigue tests were performed on HyFlex EDM, VDW.ROTATE, and TruNatomy at three different temperatures (+4°C, +35°C, and +60°C) The time to fracture of files was measured, and the number of cycles was calculated. In addition, the fractured fragment lengths were measured. The Kruskal-Wallis test was used to compare the data that were not normally distributed according to groups...
January 2024: Curēus
https://read.qxmd.com/read/38404784/optimization-of-3d-printing-parameters-in-polylactic-acid-bio-metamaterial-under-cyclic-bending-loading-considering-fracture-features
#11
JOURNAL ARTICLE
Ali Dadashi, Mohammad Azadi
3D printing has become a crucial additive manufacturing technique with the applications in various industries. Fused deposition modeling (FDM) is a common additive manufacturing process that offers considerable flexibility in the component fabrication through multiple parameters, which strongly influence the properties of the produced parts. This study focused on the impact of different printing parameters on the fatigue behavior of polylactic acid (PLA). The standard samples were 3D-printed with varying speed (5, 10, and 15 mm/s), print temperature (180, 210, and 240 °C), and nozzle diameter (0...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38400267/mechanical-properties-and-fatigue-life-analysis-of-motion-cables-in-sensors-under-cyclic-loading
#12
JOURNAL ARTICLE
Weizhe Liang, Wei Guan, Ying Ding, Chunjin Hang, Yan Zhou, Xiaojing Zou, Shenghai Yue
Motion cables, which are widely used in aero-engine sensors, are critical components that determine sensor stability. Because motion cables have unique motion characteristics, the study of their mechanical properties and reliability is very important. In addition, motion cables are complex in structure and cannot be applied to conventional fixed cable research methods. In this study, a new approach is proposed to introduce the theory of anisotropic composites into a simplified cable model, so that the cable is both physically conditioned and has good mechanical properties...
February 8, 2024: Sensors
https://read.qxmd.com/read/38399841/mode-i-fatigue-and-fracture-assessment-of-polyimide-epoxy-and-silicon-epoxy-interfaces-in-chip-package-components
#13
JOURNAL ARTICLE
Pedro Morais, Alireza Akhavan-Safar, Ricardo J C Carbas, Eduardo A S Marques, Bala Karunamurthy, Lucas F M da Silva
Semiconductor advancements demand greater integrated circuit density, structural miniaturization, and complex material combinations, resulting in stress concentrations from property mismatches. This study investigates the failure in two types of interfaces found in chip packages: silicon-epoxy mold compound (EMC) and polyimide-EMC. These interfaces were subjected to quasi-static and fatigue loading conditions. Employing a compliance-based beam method, the tests determined interfacial critical fracture energy values, (GIC), of 0...
February 7, 2024: Polymers
https://read.qxmd.com/read/38399077/cyclic-fatigue-of-different-reciprocating-endodontic-instruments-using-matching-artificial-root-canals-at-body-temperature-in-vitro
#14
JOURNAL ARTICLE
Sebastian Bürklein, Paul Maßmann, Edgar Schäfer, David Donnermeyer
Reciprocating motion expands the lifetime of endodontic instruments during the preparation of severely curved root canals. This study aimed to investigate the time to fracture (TTF) and number of cycles to failure (NCF) of different reciprocating instruments ( n = 20 in each group) at body temperature using a dynamic testing model (amplitude = 3 mm). Reciproc Blue (RPB), size 25/.08, WaveOne Gold (WOG) 25/.07, Procodile (Proc) 25/.06, R-Motion (RM_06) 25/.06 and R-Motion (RM_04) 30/.04 instruments were tested in their specific reciprocating motion in artificial matching root canals (size of the instrument ± 0...
February 8, 2024: Materials
https://read.qxmd.com/read/38395248/influence-of-microarchitecture-on-stressed-volume-and-mechanical-fatigue-behaviour-of-equine-subchondral-bone
#15
JOURNAL ARTICLE
Andrew Koshyk, Andrew J Pohl, Yuji Takahashi, W Michael Scott, Holly D Sparks, W Brent Edwards
Fractures of the equine metacarpophalangeal (MCP) joint are among the most common and fatal injuries experienced by racehorses. These bone injuries are a direct result of repetitive, high intensity loading of the skeleton during racing and training and there is consensus that they represent a mechanical fatigue phenomenon. Existing work has found the fatigue life of bone to be strongly determined by bone microarchitecture and the resulting stressed volume (i.e., the volume of bone stressed above assumed yield)...
February 21, 2024: Bone
https://read.qxmd.com/read/38395100/biodegradation-affected-fatigue-behavior-of-extrusion-based-additively-manufactured-porous-iron-manganese-scaffolds
#16
JOURNAL ARTICLE
Niko E Putra, Vahid Moosabeiki, Marius A Leeflang, Jie Zhou, Amir A Zadpoor
Additively manufactured (AM) biodegradable porous iron-manganese (FeMn) alloys have recently been developed as promising bone-substituting biomaterials. However, their corrosion fatigue behavior has not yet been studied. Here, we present the first study on the corrosion fatigue behavior of an extrusion-based AM porous Fe35Mn alloy under cyclic loading in air and in the revised simulated body fluid (r-SBF), including the fatigue crack morphology and distribution in the porous structure. We hypothesized that the fatigue behavior of the architected AM Fe35Mn alloy would be strongly affected by the simultaneous biodegradation process...
February 21, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38394767/biomechanical-behavior-of-molars-restored-with-direct-and-indirect-restorations-in-combination-with-deep-margin-elevation
#17
JOURNAL ARTICLE
Rijkje A Bresser, Marco A Carvalho, Lucas Z Naves, H Melma, Marco S Cune, Marco M M Gresnigt
STATEMENT OF PROBLEM: The existing knowledge is insufficient for comprehending the fatigue survival and fracture resistance of molars that have deep approximal direct and indirect restorations, whether with or without deep margin elevation (DME). PURPOSE: The aim of this laboratory and in silico study is to investigate the fatigue survival, fracture strength, failure pattern and tooth deformation of molars restored with DME in combination with a direct or indirect restoration...
February 12, 2024: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/38391881/mechanical-properties-and-corrosion-rate-of-znag3-as-a-novel-bioabsorbable-material-for-osteosynthesis
#18
JOURNAL ARTICLE
Maria Roesner, Sergej Zankovic, Adalbert Kovacs, Moritz Benner, Roland Barkhoff, Michael Seidenstuecker
Osteosynthesis in fracture treatment typically uses hardware that remains in the patient's body, which brings a permanent risk of negative side effects such as foreign body reactions or chronic inflammation. Bioabsorbable materials, however, can degrade and slowly be replaced by autologous bone tissue. A suitable material is requested to offer great biocompatibility alongside excellent mechanical properties and a reasonable corrosion rate. Zinc-silver alloys provide these characteristics, which makes them a promising candidate for research...
January 25, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38390927/acute-effects-of-30-g-cyclodextrin-intake-during-crossfit-%C3%A2-training-on-performance-and-fatigue
#19
JOURNAL ARTICLE
Franscisco Javier Grijota, Víctor Toro-Román, Ignacio Bartolomé, Elías Cordero-Román, Cristian Sánchez López, Jose Miguel Jiménez, Ismael Martínez-Guardado
The main objective of this study was to investigate the influence of carbohydrate intake (cyclodextrin) on performance during the performance of two consecutive workouts of the day (WODs) lasting 20 min each. Twenty-one male CrossFit (CF) athletes (29.5 ± 4.3 years; 72.81 ± 12.85 kg; 1.74 ± 0.06 m; 3.41 ± 1.21 years of experiences) participated in a crossover, randomized, and double-blind study. The effect of supplementation with 30 g of cyclodextrin (SG) (Cluster Dextrin® ) or placebo (PG) (Bolero Advanced Hydration® ) was evaluated on the performance of two specific WOD...
January 30, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38389862/fatigue-analysis-of-canine-tracheal-stents-using-the-finite-element-method
#20
JOURNAL ARTICLE
Hun-Young Yoon, Jin-Young Choi
This study aimed to evaluate fatigue of three stent designs when various forces are applied and perform a comparative analyses. A computer simulation using the finite element method was performed. In particular, we constructed a three-dimensional finite element model of nitinol stents with three designs (S6: single-woven wire, wire diameter: 0.006 inch; D6: double-woven wire, wire diameter: 0.006 inch, and D7: double-woven wire, wire diameter: 0.007 inch) that are used to treat canine tracheal collapse (TC)...
March 2024: Veterinary and Animal Science
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