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Arterial hypertension and age

Yuli Y Kim, Katherine Awh, Michael Acker, Pavan Atluri, Christian Bermudez, Maria Crespo, Joshua M Diamond, David Drajpuch, Rhondalyn Forde-Mclean, Stephanie Fuller, Lee Goldberg, Jeremy Mazurek, Christopher Mascio, Jonathan N Menachem, Eduardo Rame, Emily Ruckdeschel, Lynda Tobin, Joyce Wald
BACKGROUND: Systemic right ventricular [RV] failure may progress necessitating referral for orthotropic heart transplantation [OHT]. Pulmonary hypertension [PH] frequently coexists in adult congenital heart disease and can complicate the assessment for OHT. METHODS: Single-center case series of six patients [median age 34.9 years (IQR, 31.9-42.4)] with systemic RV physiology with PH referred for OHT evaluation from 2008-2017. RESULTS: One-third (n=6) of 18 patients with systemic RV physiology referred for OHT evaluation had pulmonary arterial hypertension [PAH] defined as mean pulmonary artery pressure [mPAP] > 25 mmHg and pulmonary vascular resistance [PVR] > 3 Wood Units...
February 15, 2019: Clinical Transplantation
Weihang Lu, Wei Guo, Jie Liu, Yangyang Ge, Dan Rong, Bai He, Jianfei Dong, Xin Jia
OBJECTIVE: Successful endovascular repair of thoracic aorta for type B aortic dissection requires correct stent-graft sizing, particularly of distal landing zone which is mainly based on operator experience. The present study aimed to quantitatively define proximal-to-distal tapering of descending thoracic aortic diameter and its consistency. METHODS: The novel parameter HDP (Hundred times Distance accounts for Percentage: distance [from distal end of left subclavian artery to each level along aortic central line] / length [from distal end of left subclavian artery to proximal end of celiac artery along aortic central line] *100) was calculated per 1% unit of descending thoracic aorta based on 3mensio software-derived measurements from 281 consecutive individuals who had undergone enhanced chest computer tomography scanning...
February 12, 2019: Annals of Vascular Surgery
Valeria Gaudieri, Wanda Acampa, Francesco Rozza, Carmela Nappi, Emilia Zampella, Roberta Assante, Teresa Mannarino, Ciro Mainolfi, Mario Petretta, Hein J Verberne, Parthiban Arumugam, Alberto Cuocolo
AIMS: Impaired myocardial perfusion reserve (MPR) may occur earlier than coronary atherosclerosis and it may be an early manifestation of developing coronary artery disease (CAD) in patients with resistant hypertension (RH). We evaluated the relationship between RH and MPR in patients with systemic arterial hypertension after balancing for coronary risk factors. METHODS AND RESULTS: We studied 360 subjects without overt CAD and normal myocardial perfusion at stress-rest 82Rb positron emission tomography/computed tomography...
February 14, 2019: European Heart Journal Cardiovascular Imaging
Edward K Len, Ritesh Akkisetty, Sandia Royal, Maryanne Brooks, Susette Coyle, Rajan Gupta, Matthew Lissauer
BACKGROUND: Hospital over-capacity often forces boarding patients outside of their designated intensive care unit (ICU). Anecdotal evidence suggested medical intensive care unit (MICU) patients boarding in the surgical intensive care unit (SICU) were responsible for increases in healthcare-associated infection (HAI) rates. We studied the effect of ICU boarding on rates of SICU HAIs. METHODS: This single-center, retrospective two-year database study compared primary SICU patients (Home) to MICU patients boarding in the SICU (Boarders)...
February 15, 2019: Surgical Infections
Jennifer J DuPont, Rachel M Kenney, Ayan R Patel, Iris Z Jaffe
Arterial stiffness progressively increases with ageing and is an independent predictor of cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the time course of aging-related arterial stiffness and the associated CVD risk which increases disproportionately in postmenopausal women. The association between arterial stiffness and mortality is almost 2 fold higher in women versus men. The differential clinical characteristics of the development of arterial stiffness between men and women indicate the involvement of sex-specific mechanisms...
February 14, 2019: British Journal of Pharmacology
Fabrice Carrat, Hélène Fontaine, Céline Dorival, Mélanie Simony, Alpha Diallo, Christophe Hezode, Victor De Ledinghen, Dominique Larrey, Georges Haour, Jean-Pierre Bronowicki, Fabien Zoulim, Tarik Asselah, Patrick Marcellin, Dominique Thabut, Vincent Leroy, Albert Tran, François Habersetzer, Didier Samuel, Dominique Guyader, Olivier Chazouilleres, Philippe Mathurin, Sophie Metivier, Laurent Alric, Ghassan Riachi, Jérôme Gournay, Armand Abergel, Paul Cales, Nathalie Ganne, Véronique Loustaud-Ratti, Louis D'Alteroche, Xavier Causse, Claire Geist, Anne Minello, Isabelle Rosa, Moana Gelu-Simeon, Isabelle Portal, François Raffi, Marc Bourliere, Stanislas Pol
BACKGROUND: Although direct-acting antivirals have been used extensively to treat patients with chronic hepatitis C virus (HCV) infection, their clinical effectiveness has not been well reported. We compared the incidence of death, hepatocellular carcinoma, and decompensated cirrhosis between patients treated with direct-acting antivirals and those untreated, in the French ANRS CO22 Hepather cohort. METHODS: We did a prospective study in adult patients with chronic HCV infection enrolled from 32 expert hepatology centres in France...
February 11, 2019: Lancet
Byeoung-Hoon Chung, Seon-Hee Heo, Yang-Jin Park, Young-Wook Kim, Shin-Young Woo, Dong-Ik Kim
BACKGROUND: Primary closure (PC) and patch angioplasty (PA) during carotid endarterectomy (CEA) have been disputed in many studies. Some studies announced that PC is associated with a higher restenosis rate. The aim of this study was to evaluate the outcomes of PC and PA using propensity score matching (PSM). METHODS: Between November 1994 and October 2016, 1044 patients underwent primary CEA procedures at our institution and were retrospectively analyzed. The study endpoints included rates of ipsilateral stroke, any clinical stroke, cranial nerve palsy, hematoma, bleeding warranting repeat surgery within 30 postoperative days...
February 11, 2019: Annals of Vascular Surgery
Veerle A B van den Bogaard, Peter van Luijk, Yoran M Hummel, Peter van der Meer, E Schuit, Liselotte M Boerman, Saskia W M C Maass, Jan F Nauta, Lars C Steggink, Jourik A Gietema, Geertruida H de Bock, Annette J Berendsen, Wilma G J M Smit, Nanna M Sijtsema, Roel G J Kierkels, Johannes A Langendijk, Anne P G Crijns, John H Maduro
PURPOSE: The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiotherapy (RT). METHODS AND MATERIALS: We conducted a cross-sectional study consisting of 109 BC survivors treated with RT between 2005 and 2011. The endpoint was cardiac function, assessed by echocardiography. Systolic function was assessed with the left ventricle ejection fraction (LVEF) (n=107) and the global longitudinal strain (GLS) of the left ventricle (LV) (n=52)...
February 11, 2019: International Journal of Radiation Oncology, Biology, Physics
K M Pencina, T G Travison, S Bhasin, Z Li, N Nigam, W J Manning, R S Vasan, U Hoffmann, C J O'Donnell, S Basaria
BACKGROUND: The relation between endogenous testosterone concentrations and myocardial mass and function remains incompletely understood. OBJECTIVES: To determine the cross-sectional association between endogenous hormone levels with cardiac magnetic resonance measures of myocardial mass, structure, and function in community-dwelling men across a wide age range. METHODS: A total of 720 men from the Framingham Heart Study Offspring Cohort (age range 37-82, mean = 59...
February 13, 2019: Andrology
Mai Kimura, Takashi Kohno, Takashi Kawakami, Masaharu Kataoka, Takahiro Hiraide, Hidenori Moriyama, Sarasa Isobe, Toshimitsu Tsugu, Yuji Itabashi, Mitsushige Murata, Shinsuke Yuasa, Keiichi Fukuda
BACKGROUND: There is no consensus on the length of hospital stay (LOHS) and post-interventional management after balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). We examined temporal trends with respect to LOHS and requirement for intensive care for BPA and their relationship with the incidence of BPA-related complications. METHODS: From November 2012 to September 2017, a total of 123 consecutive patients with CTEPH who underwent BPA were enrolled (age: 66...
February 2019: Canadian Journal of Cardiology
Oscar Calvillo-Argüelles, Husam Abdel-Qadir, Maria Michalowska, Filio Billia, Sivisan Suntheralingam, Eitan Amir, Paaladinesh Thavendiranathan
BACKGROUND: Statins can reduce the risk of anthracycline-induced cardiotoxicity. Whether such cardioprotective effects can be seen in trastuzumab-treated patients has not been explored. METHODS: Consecutive women with HER2+ breast cancer who received trastuzumab with or without anthracyclines were identified retrospectively. Patients receiving statins before and during cancer treatment were matched with 2 patients of the same age (± 2 years) and anthracycline exposure status but without statin treatment...
February 2019: Canadian Journal of Cardiology
Sarah G Običan, Linda Odibo, Methodius G Tuuli, Alejandro Rodriguez, Anthony O Odibo
OBJECTIVE: To test the hypothesis that third-trimester uterine artery Doppler (UAD) predicts adverse pregnancy and neonatal outcomes in a high-risk population. STUDY DESIGN: This is a nested case control study of women with singleton gestations referred for a fetal growth ultrasound between 24 and 36 weeks. Third-trimester UAD was performed if estimated fetal weight (Hadlock's chart) was <20th percentile as these patients were considered high risk for poor pregnancy outcomes...
February 13, 2019: Journal of Maternal-fetal & Neonatal Medicine
Fady M Kaldas, Islam M Korayem, Tara A Russell, Vatche G Agopian, Antony Aziz, Joseph DiNorcia, Douglas G Farmer, Hasan Yersiz, Jonathan R Hiatt, Ronald W Busuttil
Importance: Anastomotic biliary complications (ABCs) constitute the most common technical complications in liver transplant (LT). Given the ever-increasing acuity of LT, identification of factors contributing to ABCs is essential to minimize morbidity and optimize outcomes. A detailed analysis in a patient population undergoing high-acuity LT is lacking. Objective: To evaluate the rate of, risk factors for, and outcomes of ABCs and acuity level in LT recipients...
February 13, 2019: JAMA Surgery
Ewa Konduracka, Grażyna Cieślik, Maciej T Małecki, Grzegorz Gajos, Aleksander Siniarski, Krzysztof P Malinowski, Magdalena Kostkiewicz, Lucyna Mastalerz, Jadwiga Nessler, Wiesława Piwowarska
INTRODUCTION It is widely believed that patients with diabetes are at increased risk of severe and premature coronary artery disease (CAD) when compared to non-diabetic individuals. OBJECTIVES To evaluate the prevalence, 7-year incidence, predictors, and outcomes of obstructive and non-obstructive CAD in patients with long-lasting type 1 diabetes. PATIENTS AND METHODS We enrolled 2330 patients at a median age of 50 years with a median diabetes duration of 32 years. All study participants underwent diagnostic work-up for CAD with an exercise treadmill test (ETT) and/or single-photon emission computed tomography (SPECT)...
February 13, 2019: Polish Archives of Internal Medicine
Marta Rojek, Marek W Rajzer, Wiktoria Wojciechowska, Tomasz Drożdż, Paweł Skalski, Tomasz Pizoń, Andrzej Januszewicz, Danuta Czarnecka
OBJECTIVE: To assess the impact of long-term exposure to aircraft noise on blood pressure (BP), prevalence of arterial hypertension, and indices of asymptomatic organ damage. METHODS: Using acoustic maps, we selected and further compared people living (average 35 years) in areas exposed to high, more than 60 dB (n = 101), and low aircraft noise, less than 55 dB (n = 100). Medical history taking, office BP measurement, ambulatory BP monitoring, and echocardiographic and arterial stiffness measurements were performed...
February 8, 2019: Journal of Hypertension
Matthew R Lammi, Lesley Ann Saketkoo, Samuel C Okpechi, Mohamed A Ghonim, Dorota Wyczechowska, Natalie Bauer, Kusma Pyakurel, Saito Saito, Bennett P deBoisblanc, A Hamid Boulares
BACKGROUND AND OBJECTIVE: Endothelial microparticles (EMP) are submicron vesicles released from endothelial cells. We aimed to determine the utility of EMP as biomarkers of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) patients and the pathogenic role of microparticles (MP) in vascular inflammation. METHODS: Levels of EMP (CD144+, CD31+, CD62E+ and CD143+) were compared between three groups (10 SSc patients with PAH, 10 SSc patients without pulmonary hypertension (no-PH) and 10 healthy age- and sex-matched controls)...
February 12, 2019: Respirology: Official Journal of the Asian Pacific Society of Respirology
William R Miranda, Donald J Hagler, Guy S Reeder, Carole A Warnes, Heidi M Connolly, Alexander C Egbe, Nathaniel W Taggart
OBJECTIVE: To review our experience with balloon testing prior to atrial septal defect (ASD) closure in adults with left ventricular (LV) diastolic dysfunction. BACKGROUND: ASD closure in patients with LV diastolic dysfunction may precipitate LV failure. Temporary ASD occlusion has been used in this scenario but data are limited. METHODS: Retrospective review of 27 patients age ≥ 50 years undergoing temporary ASD balloon occlusion between 2000 and 2018 for suspected LV diastolic dysfunction or elevated LV end-diastolic pressure (LVEDP)...
February 12, 2019: Catheterization and Cardiovascular Interventions
Martino Deidda, Christian Cadeddu Dessalvi, Selina Campus, Francesco Ortu, Paolo Piano, Pier Paolo Bassareo, Giuseppe Mercuro
Objective: Human immunodeficiency virus (HIV) infection may also be associated with cardiac dysfunction, thus negatively affecting patients' morbidity and mortality. This preliminary study aimed at evaluating whether bi-and three-dimensional (3D) strain echocardiographic facilities were able to identify alterations in the right ventricular (RV) function in highly selected - because free from cardiovascular risk factors and other comorbidities - HIV patients. Materials and Methods: Eight of these specific HIV patients (age: 32...
October 2018: Journal of Cardiovascular Echography
Hadil Ak Al Otair, Majdy M Idrees, Sarfraz A Saleemi, Ahmed M Eltoukhy, Ali A Alhijji, Waleed A Al Habeeb, Mohammed A Omair
BACKGROUND: Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality in patients with systemic sclerosis (SSc). The objective of this study is to describe the clinical characteristics, mortality, and predictors of SSc-PAH in Saudi patients. METHODS: Retrospective chart review study of SSc patients who were followed for at least 1 year in three tertiary care centers in Saudi Arabia was conducted. Clinical information, echocardiographic findings, and right heart catheterization (RHC) results were collected...
January 2019: Annals of Thoracic Medicine
Sarah Geisbüsch, Andreas Kuehnl, Michael Salvermoser, Benedikt Reutersberg, Matthias Trenner, Hans-Henning Eckstein
OBJECTIVE: Hospital incidence, treatment modality, and in hospital mortality after surgery are reported for thoraco-abdominal aortic aneurysms (TAAAs) treated by endovascular or open means in Germany from 2005 to 2014. METHODS: Data were extracted from diagnosis related group statistics from the German Federal Statistical Office. All inpatient cases with a diagnosis of ruptured and non-ruptured TAAA (ICD-10 I71.5 and I71.6) and procedure codes for fenestrated or branched endovascular aortic repair (f/bEVAR 5-38a...
February 7, 2019: European Journal of Vascular and Endovascular Surgery
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