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JOURNAL ARTICLE
Melissa A Hite, Tonna McCutcheon, Michael P Feng, Molly M Ford, Timothy M Geiger, M Benjamin Hopkins, Roberta L Muldoon, Rebecca Irlmeier, Andrea Fa, Fei Ye, Alexander T Hawkins
INTRODUCTION: The opioid epidemic has resulted in close examination of postsurgical prescribing patterns. Little is known about postoperative opioid use in outpatient anorectal procedures. This study evaluated patient opioid use and created prescribing recommendations for these procedures. METHODS: One hundred and four patients undergoing outpatient anorectal procedures from January to May 2018 were surveyed on opioid consumption, surgical experience, and pain satisfaction...
June 22, 2023: Journal of Surgical Research
#42
JOURNAL ARTICLE
Philip Young-Woo Sun, Jonathon Fanning, Anna Peeler, Benjamin Shou, John Lindsley, Giorgio Caturegli, Glenn Whitman, Stephanie Cha, Bo Soo Kim, Sung-Min Cho
BACKGROUND: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) has been used in patients with COVID-19 acute respiratory distress syndrome (ARDS). We aim to assess the characteristics of delirium and describe its association with sedation and in-hospital mortality. METHODS: We retrospectively reviewed adult patients on VV-ECMO for severe COVID-19 ARDS in the Johns Hopkins Hospital ECMO registry in 2020-2021. Delirium was assessed by the Confusion Assessment Method for the ICU (CAM-ICU) when patients scored-3 or above on the Richmond Agitation-Sedation Scale (RASS)...
2023: Frontiers in Medicine
#43
JOURNAL ARTICLE
Kate Sellen, Benjamin Markowitz, Janet A Parsons, Pamela Leece, Curtis Handford, Nick Goso, Shaun Hopkins, Michelle Klaiman, Rita Shahin, Geoffrey Milos, Amy Wright, Mercy Charles, Laurie Morrison, Carol Strike, Aaron Orkin
INTRODUCTION: Opioid overdose epidemic is a public health crisis that is impacting communities around the world. Overdose education and naloxone distribution programs equip and train lay people to respond in the event of an overdose. We aimed to understand factors to consider for the design of naloxone distribution programs in point-of-care settings from the point of view of community stakeholders. METHODS: We hosted a multi-stakeholder co-design workshop to elicit suggestions for a naloxone distribution program...
May 15, 2023: BMC Public Health
#44
JOURNAL ARTICLE
Jonathan Dallas, Talia A Wenger, Kristie Q Liu, Li Ding, Benjamin S Hopkins, Frank J Attenello, William J Mack
OBJECTIVES: Multiple prior studies have shown a relationship between COVID-19 and strokes; further, COVID-19 has been shown to influence both time-to-thrombectomy and overall thrombectomy rates. Using large-scale, recently released national data, we assessed the association between COVID-19 diagnosis and patient outcomes following mechanical thrombectomy. MATERIALS AND METHODS: Patients in this study were identified from the 2020 National Inpatient Sample. All patients with arterial strokes undergoing mechanical thrombectomy were identified using ICD-10 coding criteria...
May 4, 2023: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#45
JOURNAL ARTICLE
Henry T Shu, Sung-Min Cho, Andrew B Harris, Meghana Jami, Benjamin L Shou, Matthew J Griffee, Akram M Zaaqoq, Christopher J Wilcox, Marc Anders, Peter Rycus, Glenn Whitman, Bo Soo Kim, Babar Shafiq
Our primary objective was to identify if fasciotomy was associated with increased mortality in patients who developed acute compartment syndrome (ACS) on extracorporeal cardiopulmonary resuscitation (ECPR). Additionally, we sought to identify any additional risk factors for mortality in these patients and report the amputation-free survival following fasciotomy. We retrospectively reviewed adult ECPR patients from the Extracorporeal Life Support Organization registry who were diagnosed with ACS between 2013 and 2021...
May 15, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#46
JOURNAL ARTICLE
Benjamin W B Holman, Stephanie M Fowler, Kristy L Bailes, Richard G Meyer, David L Hopkins, Edward H Clayton
This study compared the fatty acid and mineral concentrations of lamb meat that was prepared to different levels of cooking doneness. Ten m. longissimus lumborum were each sectioned into 4 slices that were randomly assigned to be uncooked or grilled to an internal end-point temperature of 60 °C (rare), 71 °C (medium), or 77 °C (well done). It was found that cooking loss increased as the level of cooking doneness increased. The proportion of most major fatty acids were not altered by cooking...
April 8, 2023: Meat Science
#47
MULTICENTER STUDY
Rachel L Choron, Amanda L Teichman, Christopher G Bargoud, Jason D Sciarretta, Randi N Smith, Dustin S Hanos, Iman N Afif, Jessica H Beard, Navpreet K Dhillon, Ashling Zhang, Mira Ghneim, Rebekah J Devasahayam, Oliver L Gunter, Alison A Smith, Brandi L Sun, Chloe S Cao, Jessica K Reynolds, Lauren A Hilt, Daniel N Holena, Grace Chang, Meghan Jonikas, Karla Echeverria, Nathaniel S Fung, Aaron Anderson, Caitlin A Fitzgerald, Ryan P Dumas, Jeremy H Levin, Christine T Trankiem, JaeHee Jane Yoon, Jacqueline Blank, Joshua Hazelton, Christopher J McLaughlin, Rami Al-Aref, Jordan M Kirsch, Daniel S Howard, Dane R Scantling, Kate Dellonte, Michael Vella, Brent Hopkins, Chloe H Shell, Pascal O Udekwu, Evan G Wong, Bellal A Joseph, Howard Lieberman, Walter Ramsey, Collin Stewart, Claudia Alvarez, John D Berne, Jeffry Nahmias, Ivan Puente, Joe H Patton, Ilya Rakitin, Lindsey L Perea, Odessa R Pulido, Hashim Ahmed, Jane Keating, Lisa M Kodadek, Jason Wade, Reynold Henry, Martin A Schreiber, Andrew J Benjamin, Abid Khan, Laura K Mann, Caleb J Mentzer, Vasileios Mousafeiris, Francesk Mulita, Shari Reid-Gruner, Erica Sais, Joshua Marks, Christopher Foote, Carlos H Palacio, Dias Argandykov, Haytham Kaafarani, Susette Coyle, Marie Macor, Michelle T Bover Manderski, Mayur Narayan, Mark J Seamon
BACKGROUND: Duodenal leak is a feared complication of repair, and innovative complex repairs with adjunctive measures (CRAM) were developed to decrease both leak occurrence and severity when leaks occur. Data on the association of CRAM and duodenal leak are sparse, and its impact on duodenal leak outcomes is nonexistent. We hypothesized that primary repair alone (PRA) would be associated with decreased duodenal leak rates; however, CRAM would be associated with improved recovery and outcomes when leaks do occur...
July 1, 2023: Journal of Trauma and Acute Care Surgery
#48
JOURNAL ARTICLE
Benjamin S Hopkins, Michael B Cloney, Pavlos Texakalidis, Constantine L Karras, Najib El Tecle, Kevin Swong, Aruna Ganju, Geoffrey Stricsek, Jean-Paul Wolinksy, Matthew B Potts, Babak S Jahromi, Tyler Koski, Nader S Dahdaleh
OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic has necessitated the use of telehealth visits (THVs). The effects on neurosurgical practice have not been well characterized, especially concerning new-patient THVs. Therefore, the authors of this study reviewed their institution's experience with outpatient clinic visits and THVs from before the COVID-19 pandemic to the present to focus on clinical metrics, rates of surgery, and the effects of implementing THVs in order to better understand their implications for clinical practice as more data emerge over time...
April 14, 2023: Journal of Neurosurgery
#49
Royce W Zhou, Jia Xu, Tiphaine C Martin, Alexis L Zachem, John He, Sait Ozturk, Deniz Demircioglu, Ankita Bansal, Andrew P Trotta, Bruno Giotti, Berkley Gryder, Yao Shen, Xuewei Wu, Saul Carcamo, Kaitlyn Bosch, Benjamin Hopkins, Alexander Tsankov, Randolph Steinhagen, Drew R Jones, John Asara, Jerry E Chipuk, Rachel Brody, Steven Itzkowitz, Iok In Christine Chio, Dan Hasson, Emily Bernstein, Ramon E Parsons
No abstract text is available yet for this article.
April 6, 2023: Nature Communications
#50
JOURNAL ARTICLE
Benjamin S Hopkins, Vincent N Nguyen, Jonathan Dallas, Pavlos Texakalidis, Max Yang, Alex Renn, Gage Guerra, Zain Kashif, Stephanie Cheok, Gabriel Zada, William J Mack
No abstract text is available yet for this article.
March 24, 2023: Journal of Neurosurgery
#51
JOURNAL ARTICLE
Ross MacKenzie, Benjamin Hawkins, Daniel Eisenkraft Klein, Mustafa Ahmad, Amanda Keys Norman, Adam D Koon
The opioid crisis in the United States has resulted in more than 500,000 deaths since 1999, and recent estimates suggest that attributable deaths could reach 842,000 by 2032. While heroin and synthetic products such as fentanyl now account for the majority of opioid overdoses, the prescription opioid crisis that emerged in the mid-1990s was the primary antecedent to the current situation. Recent settlements in litigation against opioid producers, suppliers and retailers has resulted in the release of almost 2...
April 2023: International Journal on Drug Policy
#52
JOURNAL ARTICLE
Chrissie K Lim, Youjia Zhong, Richard Hopkins, Wei-Xiang Sin, Bijin Veonice Au, Sriram Narayanan, Chiung-Hui Huang, Colin Yc Lee, Ming Liang Oon, Avisha Chowdhury, Benjamin Wong, Frances Yeap, Mariflor Villegas, Julien Pompon, Patricia Pl Ng, Siok-Bian Ng, Thuan Chong T Quah, Poh-Lin Tan, Keh-Chuang Chin, John E Connolly
Severe mosquito bite allergy (SMBA) is a manifestation of chronic active Epstein-Barr virus (CAEBV) infection defined by necrotic ulceration of the stings. CAEBV with SMBA has a high mortality rate as most patients eventually develop fulminant and refractory hemophagocytic lymphohistiocytosis (HLH). However, how self-resolving SMBA escalates to systemic lethal HLH remains unclear. Through comprehensive immune profiling of a SMBA patient with CAEBV and her healthy monozygotic twin, we found that both twins were seropositive for EBV but showed high discordance in their circulating natural killer (NK) cells...
March 6, 2023: Blood
#53
JOURNAL ARTICLE
Jacob R Hopkins, Jean M Huffman, Neil J Jones, William J Platt, Benjamin A Sikes
AbstractFire-plant feedbacks engineer recurrent fires in pyrophilic ecosystems like savannas. The mechanisms sustaining these feedbacks may be related to plant adaptations that trigger rapid responses to fire's effects on soil. Plants adapted for high fire frequencies should quickly regrow, flower, and produce seeds that mature rapidly and disperse postfire. We hypothesized that the offspring of such plants would germinate and grow rapidly, responding to fire-generated changes in soil nutrients and biota. We conducted an experiment using longleaf pine savanna plants that were paired on the basis of differences in reproduction and survival under annual ("more" pyrophilic) versus less frequent ("less" pyrophilic) fire regimes...
March 2023: American Naturalist
#54
JOURNAL ARTICLE
Priya Bhardwaj, Neil M Iyengar, Heba Zahid, Katharine M Carter, Dong Jun Byun, Man Ho Choi, Qi Sun, Oleksandr Savenkov, Charalambia Louka, Catherine Liu, Phoebe Piloco, Monica Acosta, Rohan Bareja, Olivier Elemento, Miguel Foronda, Lukas E Dow, Sofya Oshchepkova, Dilip D Giri, Michael Pollak, Xi Kathy Zhou, Benjamin D Hopkins, Ashley M Laughney, Melissa K Frey, Lora Hedrick Ellenson, Monica Morrow, Jason A Spector, Lewis C Cantley, Kristy A Brown
Obesity, defined as a body mass index (BMI) ≥ 30, is an established risk factor for breast cancer among women in the general population after menopause. Whether elevated BMI is a risk factor for women with a germline mutation in BRCA1 or BRCA2 is less clear because of inconsistent findings from epidemiological studies and a lack of mechanistic studies in this population. Here, we show that DNA damage in normal breast epithelia of women carrying a BRCA mutation is positively correlated with BMI and with biomarkers of metabolic dysfunction...
February 22, 2023: Science Translational Medicine
#55
JOURNAL ARTICLE
Risha Irvin, Maya Venkataramani, Panagis Galiatsatos, Jeanne D Hitchcock, Nondie Hemphill, Margaret Dearey, Benjamin F Bigelow, Lisa A Cooper, Nancy Edwards Molello, Katie J O'Conor, Kathleen R Page, Sherita H Golden
COVID-19 vaccines offer hope to end the COVID-19 pandemic. In this article, we document key lessons learned as we continue to confront COVID-19 variants and work to adapt our vaccine outreach strategies to best serve our community. In the fall of 2020, the Office of Diversity, Inclusion and Health Equity at Johns Hopkins Medicine, in collaboration with the Office of Government and Community Affairs for Johns Hopkins University and Medicine, established the COVID-19 Vaccine Equity Community Education and Outreach Initiative in partnership with faith and community leaders, local and state government representatives, and community-based organizations...
February 15, 2023: Health Security
#56
JOURNAL ARTICLE
Connie C W Hsia, Jason H T Bates, Bastiaan Driehuys, Sean B Fain, Jonathan G Goldin, Eric A Hoffman, James C Hogg, David L Levin, David A Lynch, Matthias Ochs, Grace Parraga, G Kim Prisk, Benjamin M Smith, Merryn Tawhai, Marcos F Vidal Melo, Jason C Woods, Susan R Hopkins
Multiple thoracic imaging modalities have been developed to link structure to function in the diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders three-dimensional maps of lung structures and may be combined with positron emission tomography (PET) to obtain dynamic physiological data. Magnetic resonance imaging (MRI) using ultrashort-echo time (UTE) sequences has improved signal detection from lung parenchyma; contrast agents are used to deduce airway function, ventilation-perfusion-diffusion, and mechanics...
February 2023: Annals of the American Thoracic Society
#57
JOURNAL ARTICLE
Sarah E Rowan, Jason Haukoos, Kevin F Kamis, Emily Hopkins, Stephanie Gravitz, Carolynn Lyle, Alia A Al-Tayyib, Edward M Gardner, James W Galbraith, Yu-Hsiang Hsieh, Michael S Lyons, Richard E Rothman, Douglas A E White, Jake R Morgan, Benjamin P Linas, Allison L Sabel, David L Wyles
BACKGROUND: Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departments (EDs) serve as an important clinical setting for HCV screening, although optimal methods of linkage-to-care for HCV-diagnosed individuals remain unknown. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial...
January 27, 2023: Trials
#58
JOURNAL ARTICLE
Laura Winchester, Imelda Barber, Michael Lawton, Jessica Ash, Benjamine Liu, Samuel Evetts, Lucinda Hopkins-Jones, Suppalak Lewis, Catherine Bresner, Ana Belen Malpartida, Nigel Williams, Steve Gentlemen, Richard Wade-Martins, Brent Ryan, Alejo Holgado-Nevado, Michele Hu, Yoav Ben-Shlomo, Donald Grosset, Simon Lovestone
Biomarkers to aid diagnosis and delineate the progression of Parkinson's disease are vital for targeting treatment in the early phases of the disease. Here, we aim to discover a multi-protein panel representative of Parkinson's and make mechanistic inferences from protein expression profiles within the broader objective of finding novel biomarkers. We used aptamer-based technology (SomaLogic®) to measure proteins in 1599 serum samples, 85 cerebrospinal fluid samples and 37 brain tissue samples collected from two observational longitudinal cohorts (the Oxford Parkinson's Disease Centre and Tracking Parkinson's) and the Parkinson's Disease Brain Bank, respectively...
2023: Brain communications
#59
JOURNAL ARTICLE
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus D Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Michael B Yaffe, Lewis C Cantley
Protein phosphorylation is one of the most widespread post-translational modifications in biology1,2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and several thousand have been associated with human diseases and biological processes3,4 . For the vast majority of phosphorylation events, it is not yet known which of the more than 300 protein serine/threonine (Ser/Thr) kinases encoded in the human genome are responsible3 ...
January 2023: Nature
#60
JOURNAL ARTICLE
Shiva T Radhakrishnan, Kate I Gallagher, Benjamin H Mullish, Jose I Serrano-Contreras, James L Alexander, Jesus Miguens Blanco, Nathan P Danckert, Maria Valdivia-Garcia, Billy J Hopkins, Anik Ghai, Azad Ayub, Jia V Li, Julian R Marchesi, Horace R T Williams
Faecal or biopsy samples are frequently used to analyse the gut microbiota, but issues remain with the provision and collection of such samples. Rectal swabs are widely-utilised in clinical practice and previous data demonstrate their potential role in microbiota analyses; however, studies to date have been heterogenous, and there are a particular lack of data concerning the utility of swabs for the analysis of the microbiota's functionality and metabolome. We compared paired stool and rectal swab samples from healthy individuals to investigate whether rectal swabs are a reliable proxy for faecal sampling...
January 10, 2023: Scientific Reports
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