Kim Phung, Laura McAdam, Jinhui Ma, Hugh J McMillan, Stefan Jackowski, Maya Scharke, Mary-Ann Matzinger, Nazih Shenouda, Khaldoun Koujok, Jacob L Jaremko, Kevin Smit, Scott Walker, Colleen Hartigan, Nasrin Khan, Victor N Konji, Lynn MacLeay, Marika Page, Elizabeth Sykes, Marie-Eve Robinson, Nathalie Alos, Elizabeth A Cummings, Josephine Ho, Anne Marie Sbrocchi, Robert Stein, David Saleh, B Catharine Craven, Utkarsh J Dang, Kerry Siminoski, Frank Rauch, Leanne M Ward
Patients with Duchenne muscular dystrophy (DMD) have a high fracture burden due to progressive myopathy and steroid-induced osteoporosis. This study in males with DMD showed that markers of systemic glucocorticoid exposure including shorter stature, greater bone age delay, and lower lumbar spine bone mineral density were associated with spine fragility. INTRODUCTION: Fragility fractures are frequent in DMD. The purpose of this study was to identify clinical factors associated with prevalent vertebral fractures (VF) in boys, teens/young adults with Duchenne muscular dystrophy (DMD)...
November 7, 2022: Osteoporosis International