keyword
https://read.qxmd.com/read/37405128/exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king
#21
Suhail M Saad-Omer, Mustafa Kinaan, Moises Matos, Hanford Yao
The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids. We present a case of Artri King (AK)-induced CS in a 40-year-old woman who presented with an intertrochanteric fracture of her right femur. Laboratory testing revealed suppressed cortisol and adrenocorticotropic hormone, which was consistent with suppression of the hypothalamic-pituitary-adrenal (HPA) axis. Following the cessation of the AK supplement, the patient's HPA axis recovered, and the clinical manifestations of CS improved...
July 2023: Curēus
https://read.qxmd.com/read/37303366/legg-calv%C3%A3-perthes-disease-following-nephrotic-syndrome-with-long-term-steroid-use-in-a-three-year-old-boy-a-case-report
#22
Manami Ueshima, Atsushi Shimasaki, Tadateru Yasu
Nephrotic syndrome (NS) is one of the common pediatric diseases that require glucocorticoid treatment. Patients with NS might receive steroids for a long time if remission is not achieved. Evidence shows that long-term steroid use may induce osteoporosis in adults and children, and steroid use is well known to be related to avascular necrosis of the femoral head (ANFH) in adults. However, no pediatric case of AFNH caused by long-term steroid use due to NS has been reported. In this report, we describe the case of a three-year-old boy with a chief complaint of gait difficulty, who had been treated with glucocorticoid orally for a year because of NS...
May 2023: Curēus
https://read.qxmd.com/read/37171596/bisphosphonate-use-for-glucocorticoid-induced-osteoporosis-in-older-patients-with-immune-thrombocytopenia-a-clinical-perspective
#23
REVIEW
Satoshi Yamasaki
Prednisolone, used as a standard initial treatment for immune thrombocytopenia (ITP), is an important risk factor for osteoporosis. Recently, we found that prescription of bisphosphonate during initial loading of prednisolone may prevent reduction in bone mineral density and development of glucocorticoid-induced osteoporosis (GIO) in older patients with ITP receiving prolonged steroid therapy. In this review, I describe the treatment options for older patients with ITP, and present the best practices for screening, evaluating, and diagnosing ITP...
July 2023: Annals of Hematology
https://read.qxmd.com/read/37082116/glucocorticoid-induced-bone-disorders-in-children-research-progress-in-treatment-mechanisms
#24
REVIEW
Junying Hua, Jianping Huang, Gang Li, Sien Lin, Liao Cui
Long-term or supra-physiological dose of glucocorticoid (GC) application in clinic can lead to impaired bone growth and osteoporosis. The side effects of GC on the skeletal system are particularly serious in growing children, potentially causing growth retardation or even osteoporotic fractures. Children's bone growth is dependent on endochondral ossification of growth plate chondrocytes, and excessive GC can hinder the development of growth plate and longitudinal bone growth. Despite the availability of drugs for treating osteoporosis, they have failed to effectively prevent or treat longitudinal bone growth and development disorders caused by GCs...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37065527/pathological-fractures-of-bilateral-neck-of-femur-in-geriatric-population-our-experience-and-review-of-literature
#25
Harshal Sakale, Sandeep Kumar Yadav, Bikram Keshri Kar, Sharath Kowshik, Alok Chandra Agrawal, Rahul Ranjan
INTRODUCTION: Bilateral neck of femur stress fractures is rare clinical presentation in elderly population. Diagnosis of such fractures when presented can be difficult with inconclusive radiographs and hence their early diagnosis by high index of suspicion and their management can avoid further complications in this age group. In this case series, we report three elderly patients with different predisposing factors for their fractures and treatment options chosen with detailed discussion about the management...
June 2022: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/37038042/the-efficacy-of-dupilumab-in-induction-and-maintenance-of-remission-in-an-adult-patient-with-steroid-dependent-eosinophilic-enteritis-eon
#26
JOURNAL ARTICLE
Sho Watanabe, Hitoshi Uchida, Ryosuke Fujii, Misugi Uga, Tomoyo Machida, Naoki Matsukawa, Masamichi Kurihara, Mariko Negi, Tsunehito Yauchi
Eosinophilic enteritis (EoN) is associated with an eosinophilic infiltrate confined to the small intestine, but treatment options other than diet and corticosteroid therapy are scarce. There is only one report of the use of dupilumab for eosinophilic gastrointestinal disease, involving three pediatric patients. We report a case of successful induction of remission with dupilumab in a 53 year-old female patient with steroid-dependent EoN. The patient presented to the emergency room with uncontrollable abdominal pain and CT revealed a thickened ileal wall and small amount of ascites...
April 10, 2023: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/37026113/potential-targets-and-mechanisms-of-jiedu-quyu-ziyin-decoction-for-treating-sle-giop-based-on-network-pharmacology-and-molecular-docking
#27
JOURNAL ARTICLE
Jie Li, Run-Yu Chang, Lin-Feng Chen, Su-Hai Qian, Rong-Yun Wang, Ji-le Lan, Lin Huang, Xing-Hong Ding
BACKGROUND: Systemic lupus erythematosus (SLE) is characterized by poor regulation of the immune response leading to chronic inflammation and multiple organ dysfunction. Glucocorticoid (GC) is currently one of the main treatments. However, a high dose or prolonged use of GC may result in glucocorticoid-induced osteoporosis (GIOP). Jiedu Quyu Ziyin decoction (JP) is effective in treating SLE and previous clinical studies have proved that JP can prevent and treat SLE steroid osteoporosis (SLE-GIOP)...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37001571/diosgenin-reduces-bone-loss-through-the-regulation-of-gut-microbiota-in-ovariectomized-rats
#28
JOURNAL ARTICLE
Changheng Song, Yujie Ma, Yuhan Wang, Pei Li, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Diosgenin (DIO) is an aglycone of steroid saponins acquired from plants, including Dioscorea alata, Smilax China, and Trigonella foenum graecum, acting as an anti-osteoporosis, anti-diabetic, anti-hyperlipidemic, anti-inflammatory. Recent studies have demonstrated that DIO reduces bone loss. This study aimed to investigate the effects of DIO on the gut microbiota (GM) of ovariectomized (OVX) osteoporotic rats. Female Sprague-Dawley rats were randomly divided into sham operation (sham + vehicle group) or ovariectomy...
March 29, 2023: Gene
https://read.qxmd.com/read/37001370/a-case-report-of-effective-intra-articular-elcatonin-administration-in-a-patient-with-osteonecrosis-of-the-lunate
#29
Takashi Nagai, Kazunari Tomita, Kazutoshi Kubo, Jun Ikeda, Keikichi Kawasaki, Katsunori Inagaki
INTRODUCTION AND IMPORTANCE: Although corticosteroids are effective for bronchial asthma, they are associated with various side effects, such as osteonecrosis of the femoral head and tibial condyle and osteoporosis. Here, we report a patient who was on corticosteroids for a long period of time due to severe asthma, which was thought to have led to lunate osteonecrosis of both wrist joints. Calcitonin (elcatonin), an osteoporosis drug, was administered to the wrist joint. CASE PRESENTATION: Allergy to anesthetics and various non-steroidal anti-inflammatory drugs (NSAIDs) made surgical treatment not possible and pain control difficult...
March 27, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/36966936/periplocin-targets-low-density-lipoprotein-receptor-related-protein-4-to-attenuate-osteoclastogenesis-and-protect-against-osteoporosis
#30
JOURNAL ARTICLE
Xiaodi Zhang, Zhengfang Sun, Ying Zhang, Liuzhu Pan, Wei Jiang, Hui Dong, Zhengxin Jin, Jianning Kang, Ronghan Liu, Bin Ning
Osteoporosis is a common inflammaging-related condition, where long-term accumulation of pro-inflammatory cytokines causes massive bone loss. Periplocin, a cardiotonic steroid isolated from Periploca forrestii, has been proved to reduce inflammation in several inflammatory diseases, such as rheumatoid arthritis. However, its effect and mechanism of inflammation in osteoporosis, in which pro-inflammatory factors accelerate bone loss, has not been well demonstrated. In this study, periplocin attenuated receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation of bone marrow-derived macrophages (BMMs) and RAW264...
March 24, 2023: Biochemical Pharmacology
https://read.qxmd.com/read/36933598/development-of-triamcinolone-acetonide-hyaluronic-acid-conjugates-with-selective-targeting-and-less-osteoporosis-effect-for-rheumatoid-arthritis-treatments
#31
JOURNAL ARTICLE
Tzu-Yang Chen, Neng-Yu Lin, Chih-Hao Wen, Chih-An Lin, Parthiban Venkatesan, Prasanna Wijerathna, Chung-Yu Lin, Ping-Shan Lai
Rheumatoid arthritis (RA) is a common systemic autoimmune disease in developed countries. In clinical treatment, steroids have been used as bridging and adjunctive therapy after disease-modifying anti-rheumatic drug administration. However, the severe side effects caused by the nonspecific targeting of organs followed by long-term administration have limited their usage in RA. In this study, poorly water-soluble triamcinolone acetonide (TA), a highly potent corticosteroid for intra-articular injection, is conjugated on hyaluronic acid (HA) for intravenous purposes with increased specific drug accumulation in inflamed parts for RA...
March 16, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/36835062/a-proteomic-screen-to-unravel-the-molecular-pathways-associated-with-warfarin-induced-or-tnap-inhibited-arterial-calcification-in-rats
#32
JOURNAL ARTICLE
Britt Opdebeeck, Ellen Neven, Stuart Maudsley, Hanne Leysen, Deborah Walter, Hilde Geryl, Patrick C D'Haese, Anja Verhulst
Arterial media calcification refers to the pathological deposition of calcium phosphate crystals in the arterial wall. This pathology is a common and life-threatening complication in chronic kidney disease, diabetes and osteoporosis patients. Recently, we reported that the use of a TNAP inhibitor, SBI-425, attenuated arterial media calcification in a warfarin rat model. Employing a high-dimensionality unbiased proteomic approach, we also investigated the molecular signaling events associated with blocking arterial calcification through SBI-425 dosing...
February 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36804257/obacunone-inhibits-rankl-m-csf-mediated-osteoclastogenesis-by-suppressing-integrin-fak-src-signaling
#33
JOURNAL ARTICLE
Huimin Hu, Xiaodong Wang, Yansheng Huang, Baorong He, Jinwen Zhu, Kai Sun, Chaoyang Deng, Yunshan Guo, Dingjun Hao, Bin Jian
Disrupted osteoblastogenesis or aberrant activation of osteoclastogenesis usually results in the break of bone homeostasis thus causing bone-associated diseases like osteoporosis. Obacunone, as a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. However, the role of obacunone in regulating osteoclastogenesis has not been elucidated so far. Here, using in vitro cell models of RANKL (Receptor activator of nuclear factor-kB ligand) and M-CSF (Macrophage-colony-stimulating factor)-induced osteoclastogenesis, we showed that obacunone inhibited osteoclast differentiation in RAW264...
February 15, 2023: Cytokine
https://read.qxmd.com/read/36627860/metabolic-bone-health-considerations-in-giant-cell-arteritis-and-polymyalgia-rheumatica
#34
REVIEW
Candice Low, Richard Conway
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two common systemic inflammatory conditions with a combined lifetime risk of approximately 3.5% in women and 1.5% in men. They are intimately associated with the aging process, virtually never occurring prior to 50 years of age and becoming more common over time. The reasons for this are unclear, but likely relate in part to factors related to aging of the immune system. The treatment of both GCA and PMR is traditionally based on glucocorticoids, frequently requiring a prolonged treatment course over long periods of time...
2023: Women's Health
https://read.qxmd.com/read/36514507/chronic-steroid-use-an-overlooked-impact-on-patients-with-inflammatory-bowel-disease
#35
JOURNAL ARTICLE
Kristen L Farraj, James R Pellegrini, Rezwan F Munshi, Jose Russe-Russe, Aboud Kaliounji, Muhammad S Tiwana, Pranay Srivastava, Krishnayer Subramani
BACKGROUND AND AIM: Steroids have long been used in inducing remission of inflammatory bowel disease (IBD). Chronic use, defined as therapy greater than 3 months, has been implicated in complications including increased hospital length of stay (LOS), infections, and even death. In our retrospective study, we aim to identify the complications of chronic steroid use in patients with IBD. METHODS: The fourth quarter of 2015-2019 National Inpatient Sample (NIS) was used in this study...
December 2022: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/36479151/selective-androgen-receptor-modulators-an-emerging-liver-toxin
#36
REVIEW
Haseeb Mohideen, Hafsa Hussain, Dushyant Singh Dahiya, Hisham Wehbe
Selective androgen receptor modulators (SARMs) are a class of nonsteroidal drugs that are favored over anabolic androgenic steroids (AASs) for their tissue-selectivity and improved side-effect profile. These drugs have been evaluated for treatment of various diseases including muscle-wasting disorders, osteoporosis, and breast cancer. Despite lacking approval for therapeutic use, SARMs are widely used recreationally as performance enhancing drugs by bodybuilders and athletes. In recent years, cases of drug-induced liver injury (DILI) secondary to SARMs have begun to emerge, but little is known regarding their hepatotoxicity...
February 28, 2023: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/36427218/intracardiac-thrombosis-following-intravenous-zoledronate-treatment-in-a-child-with-steroid-induced-osteoporosis
#37
Samantha J Case, Rebecca J Moon, Tara Bharucha, Justin H Davies
OBJECTIVES: Bisphosphonates are used in childhood osteoporosis but can cause an acute phase reaction (APR) and hypocalcemia. We present a child with cardiac thrombosis following zoledronate, a previously unreported complication. CASE PRESENTATION: An 11-year-old with Duchenne muscular dystrophy and steroid-induced osteoporosis presented 48 h after first zoledronate infusion with fever, tachycardia, tachypnoea and hypoglycaemia. This was managed as acute adrenal crisis and possible sepsis...
November 28, 2022: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/36342539/risk-factors-associated-with-prevalent-vertebral-fractures-in-duchenne-muscular-dystrophy
#38
JOURNAL ARTICLE
Kim Phung, Laura McAdam, Jinhui Ma, Hugh J McMillan, Stefan Jackowski, Maya Scharke, Mary-Ann Matzinger, Nazih Shenouda, Khaldoun Koujok, Jacob L Jaremko, Kevin Smit, Scott Walker, Colleen Hartigan, Nasrin Khan, Victor N Konji, Lynn MacLeay, Marika Page, Elizabeth Sykes, Marie-Eve Robinson, Nathalie Alos, Elizabeth A Cummings, Josephine Ho, Anne Marie Sbrocchi, Robert Stein, David Saleh, B Catharine Craven, Utkarsh J Dang, Kerry Siminoski, Frank Rauch, Leanne M Ward
Patients with Duchenne muscular dystrophy (DMD) have a high fracture burden due to progressive myopathy and steroid-induced osteoporosis. This study in males with DMD showed that markers of systemic glucocorticoid exposure including shorter stature, greater bone age delay, and lower lumbar spine bone mineral density were associated with spine fragility. INTRODUCTION: Fragility  fractures are frequent in DMD. The purpose of this study was to identify clinical factors associated with prevalent vertebral fractures (VF) in boys, teens/young adults with Duchenne muscular dystrophy (DMD)...
November 7, 2022: Osteoporosis International
https://read.qxmd.com/read/36339402/necroptosis-a-new-target-for-prevention-of-osteoporosis
#39
REVIEW
Xinli Hu, Zheng Wang, Chao Kong, Yu Wang, Weiguo Zhu, Wei Wang, Yongjin Li, Wei Wang, Shibao Lu
Multiple causes may contribute to osteoporosis, characterized by a loss in bone mass and density as a consequence of the degradation of bone microstructure and a resultant rise in bone fragility. Recently, increasing attention has been paid to the role of necroptosis in the development of osteoporosis. Necroptosis is orchestrated by a set of proteins known as receptor-interacting protein kinase (RIPK)1, RIPK3, and mixed lineage kinase domain-like protein (MLKL). A necrosome is formed by MLKL, RIPK1, RIPK3, and RIPK3-RIPK3...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/36315414/the-impact-of-glucocorticoids-on-bone-health-and-growth-endocrine-and-non-endocrine-effects-in-children-and-young-patients
#40
JOURNAL ARTICLE
Clelia Cipolla, Giorgio Sodero, Ignazio Cammisa, Arianna Turriziani Colonna, Sara Giuliano, Inbal D Amar, Ronny Ram Biton, Giovanni Scambia, Paola Villa
Glucocorticoids have numerous applications in short and/or long-term therapy both in pediatric and young adults, based on their significant anti-inflammatory and immunosuppressive effects. Different routes of administration can be provided including topical, inhalatory and oral. Topical treatments are the first choice for many dermatologic conditions. The inhalatory form is widely used in asthma management while systemic pathologies often require oral administration. The risks for adverse effects are related to the dose and duration of therapy as well as the specific agent used...
October 31, 2022: Minerva pediatrics
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