keyword
https://read.qxmd.com/read/38511207/baicalin-ameliorates-the-gut-barrier-function-and-intestinal-microbiota-of-broiler-chickens
#1
JOURNAL ARTICLE
Shuangxiu Wan, Linzheng Wang, Zhili Hao, Lin Zhu, Xiaoxia Mao, Hongquan Li, Panpan Sun, Wei Yin, Kuohai Fan, Hailong Zhang, Beibei Li, Wansen Nie, Zongjie Li, Na Sun
The deoxynivalenol (DON)-contaminated feeds can impair chicken gut barrier function, disturb the balance of the intestinal microbiota, decrease chicken growth performance and cause major economic loss. With the aim of investigating the ameliorating effects of baicalin on broiler intestinal barrier damage and gut microbiota dysbiosis induced by DON, a total of 150 Arbor Acres broilers are used in the present study. The morphological damage to the duodenum, jejunum, and ileum caused by DON is reversed by treatment with different doses of baicalin, and the expression of tight junction proteins (ZO-1, claudin-1, and occludin) is also significantly increased in the baicalin-treated groups...
March 21, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38501370/associations-of-early-gut-microbiome-and-metabolome-with-growth-and-body-composition-of-preterm-infants-within-the-first-6-months
#2
JOURNAL ARTICLE
Xinhui Guo, Junyan Han, Luyang Hong, Yihuang Huang, Shujuan Li, Lan Zhang, Weili Yan, Ping Dong, Yi Yang, Yun Cao
Objectives: This study aimed to explore the associations of growth and body composition with gut microbiome and metabolome in preterm infants. Materials and Methods: A prospective cohort study including 73 human milk-fed very preterm infants was conducted. During hospitalization, fecal samples were collected to detect microbes and metabolites using 16S rRNA gene sequencing and liquid chromatography-mass spectrometry. Growth and body composition indices were measured at term equivalent age (TEA) and 6 months of corrected age (CA)...
March 19, 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38472812/high-fat-diet-induced-decreased-circulating-bile-acids-contribute-to-obesity-associated-with-gut-microbiota-in-mice
#3
JOURNAL ARTICLE
Haiying Cai, Junhui Zhang, Chang Liu, Thanh Ninh Le, Yuyun Lu, Fengqin Feng, Minjie Zhao
The altered circulating bile acids (BAs) modulate gut microbiota, energy metabolism and various physiological functions. BA profiles in liver, serum, ileum and feces of HFD-fed mice were analyzed with normal chow diet (NCD)-fed mice after 16-week feeding. Furthermore, gut microbiota was analyzed and its correlation analysis with BA was performed. The result showed that long-term HFD feeding significantly decreased hepatic and serum BA levels, mainly attributed to the inhibition of hepatic BA synthesis and the reduced reabsorption efficiency of BAs in enterohepatic circulation...
February 25, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38332676/repeated-s-ketamine-administration-ameliorates-the-spatial-working-memory-impairment-in-mice-with-chronic-pain-role-of-the-gut-microbiota-brain-axis
#4
JOURNAL ARTICLE
Yubin Jiang, Xingming Wang, Jiawei Chen, Yibao Zhang, Kenji Hashimoto, Jian-Jun Yang, Zhiqiang Zhou
Chronic pain is commonly linked with diminished working memory. This study explores the impact of the anesthetic ( S )-ketamine on spatial working memory in a chronic constriction injury (CCI) mouse model, focusing on gut microbiome. We found that multiple doses of ( S )-ketamine, unlike a single dose, counteracted the reduced spontaneous alteration percentage (%SA) in the Y-maze spatial working memory test, without affecting mechanical or thermal pain sensitivity. Additionally, repeated ( S )-ketamine treatments improved the abnormal composition of the gut microbiome (β-diversity), as indicated by fecal 16S rRNA analysis, and increased levels of butyrate, a key gut - brain axis mediator...
2024: Gut Microbes
https://read.qxmd.com/read/38160211/characterization-of-priestia-megaterium-s1-a-polymer-degrading-gut-microbe-isolated-from-the-gut-of-tenebrio-molitor-larvae-fed-on-styrofoam
#5
JOURNAL ARTICLE
Krishnamoorthi Akash, Rengasamy Parthasarathi, Rajavel Elango, Subramanian Bragadeeswaran
This study reveals that Tenebrio molitor larvae are fed with two different feeds i.e., barley bran along with Styrofoam, and barley bran without Styrofoam, the survival percentage of mealworms shows 86 and 89%, respectively. Five isolates namely S1, S2, S3, S4, and S5 were isolated from the gut of Styrofoam-feeding Tenebrio molitor larvae and tested for Hydrophobicity percentage, clear zone assay and turbidity measurement. S1 isolate showed best (turbidity percentage of 19.65%, 13.54% hydrophobicity percentage, and 37% zone of clearance) when compared to other isolates, respectively...
December 30, 2023: Archives of Microbiology
https://read.qxmd.com/read/38138044/modulation-of-zebrafish-danio-rerio-intestinal-mucosal-barrier-function-fed-different-postbiotics-and-a-probiotic-from-lactobacilli
#6
JOURNAL ARTICLE
Mark Rawling, Marion Schiavone, Amélie Mugnier, Eric Leclercq, Daniel Merrifield, Andrew Foey, Emmanuelle Apper
It is generally accepted that microbes play a critical role in maintaining gut barrier function, making them ideal to target in order to mitigate the effects of intestinal diseases such as inflammatory bowel disease with specialist supplementations such as probiotic or postbiotic preparations. In this study, specific strains of Lactobacillus helvictus both live and inactivated and Lactobacillus plantarum inactivated were fed to zebrafish at an inclusion level of 6 × 106 cells/g in order to assess the effects on gut barrier function and protection...
November 30, 2023: Microorganisms
https://read.qxmd.com/read/38123761/association-between-erythrocyte-membrane-fatty-acids-and-gut-bacteria-in-obesity-related-cognitive-dysfunction
#7
JOURNAL ARTICLE
Tong Zhao, Hongying Huang, Jinchen Li, Jingyi Shen, Cui Zhou, Rong Xiao, Weiwei Ma
Obesity increases the risk of cognitive impairment and dementia, and the gut microbiota can affect brain cognitive function and obesity through a variety of pathways such as the gut-brain axis. This study aimed to discover how fatty acid affect cognitive function by regulating intestinal flora in obesity. Obese subjects were recruited for cognitive function assessment, and participants were divided into obese group with cognitive impairment (MCI, n = 49) and obese cognitively normal group (Non_MCI, n = 55)...
December 20, 2023: AMB Express
https://read.qxmd.com/read/38062857/gut-microbiota-derived-12-ketolithocholic-acid-suppresses-the-il-17a-secretion-from-colonic-group-3-innate-lymphoid-cells-to-prevent-the-acute-exacerbation-of-ulcerative-colitis
#8
JOURNAL ARTICLE
Na Li, Peiguang Ma, Yalan Li, Xuekai Shang, Xinmei Nan, Lei Shi, Xiao Han, Jiajing Liu, Yanfei Hong, Qiuyi Li, Jiaqi Cui, Junxiang Li, Guiying Peng
Intestinal microbiota dysbiosis and metabolic disruption are well-known as the primary triggers of ulcerative colitis (UC). However, their role in regulating the group 3 innate lymphoid cells (ILC3s), which are essential for intestinal health, remains unexplored during the development of disease severity. Here, our results showed that the microbiota structure of patients with severe UC (SUCs) differed from those with mild UC (MiUCs), moderate UC (MoUCs), and healthy controls (HCs). Microbes producing secondary bile acids (SBAs) and SBAs decreased with the aggravation of UC, and a strong positive correlation existed between them...
December 2023: Gut Microbes
https://read.qxmd.com/read/38021696/microbiota-as-a-new-target-in-cancer-pathogenesis-and-treatment
#9
REVIEW
Abeer S Algrafi, Aisha A Jamal, Dana M Ismaeel
The microbial ecosystem of humans is an integral part of human health and disease. A significant percentage of tumors worldwide are thought to be microbially induced. The relationship between cancer and microbes is complex. In this article review, we aim to give an overview of human microbiota and its role in carcinogenesis, emphasize the relation between microbiota and cancer immunity, and highlight its role in the future of cancer therapy. The term microbiota refers to the collection of microorganisms that are located in an individual, whereas the total genome of these microorganisms is referred to as the microbiome...
October 2023: Curēus
https://read.qxmd.com/read/37689649/comparison-of-the-effect-of-autoclaved-and-non-autoclaved-live-soil-exposure-on-the-mouse-immune-system-effect-of-soil-exposure-on-immune-system
#10
JOURNAL ARTICLE
Laura Kummola, Martín I González-Rodríguez, Pertti Marnila, Noora Nurminen, Tanja Salomaa, Lotta Hiihtola, Iida Mäkelä, Olli H Laitinen, Heikki Hyöty, Aki Sinkkonen, Ilkka S Junttila
BACKGROUND: . Lack of exposure to the natural microbial diversity of the environment has been linked to dysregulation of the immune system and numerous noncommunicable diseases, such as allergies and autoimmune disorders. Our previous studies suggest that contact with soil material, rich in naturally occurring microbes, could have a beneficial immunoregulatory impact on the immune system in mice and humans. However, differences in the immunomodulatory properties of autoclaved, sterile soil material and non-autoclaved, live soil material have not been compared earlier...
September 9, 2023: BMC Immunology
https://read.qxmd.com/read/37475479/transplantation-of-gut-microbiota-from-old-mice-into-young-healthy-mice-reduces-lean-mass-but-not-bone-mass
#11
JOURNAL ARTICLE
Lina Lawenius, Carrie Cowardin, Louise Grahnemo, Julia M Scheffler, Karin Horkeby, Cecilia Engdahl, Jianyao Wu, Liesbeth Vandenput, Antti Koskela, Juha Tukkanen, Eivind Coward, Kristian Hveem, Arnulf Langhammer, Sanna Abrahamsson, Jeffrey I Gordon, Klara Sjögren, Claes Ohlsson
Aging is associated with low bone and lean mass as well as alterations in the gut microbiota (GM). In this study, we determined whether the reduced bone mass and relative lean mass observed in old mice could be transferred to healthy young mice by GM transplantation (GMT). GM from old (21-month-old) and young adult (5-month-old) donors was used to colonize germ-free (GF) mice in three separate studies involving still growing 5- or 11-week-old recipients and 17-week-old recipients with minimal bone growth. The GM of the recipient mice was similar to that of the donors, demonstrating successful GMT...
2023: Gut Microbes
https://read.qxmd.com/read/37406441/age-associated-changes-in-the-growth-development-of-abdominal-fat-and-their-correlations-with-cecal-gut-microbiota-in-broiler-chickens
#12
JOURNAL ARTICLE
Xiaoying Liu, Chenxu Wang, Yumeng Wang, Chaohui Wang, Xi Sun, Yufei Zhu, Xiaojun Yang, Lixin Zhang, Yanli Liu
Excess abdominal fat is a common phenomenon in broiler chickens. Gut microbiota could regulate lipid metabolism through their effects on short-chain fatty acids (SCFAs) production. This study was conducted to investigate the potential relationship between abdominal fat development and cecal microorganism populations. Abdominal fat and cecum contents were collected at 3, 7, 14, 21, 28, 35, and 42 d of age. The results showed that abdominal fat weight increased with age. The abdominal fat percentage was higher between 7 and 21 d of age than at 3 d (P < 0...
June 28, 2023: Poultry Science
https://read.qxmd.com/read/37381634/a-comparative-study-of-the-gut-microbiome-in-indian-children-with-type-1-diabetes-and-healthy-controls
#13
JOURNAL ARTICLE
Vaishali Tamahane, Shivang Bhanushali, Nikhil Shah, Abhishek Gupta, Vaman Khadilkar, Ketan Gondhalekar, Anuradha Khadilkar, Yogesh Souche
INTRODUCTION: Type 1 diabetes mellitus (T1DM) occurs in genetically susceptible individuals due to certain environmental triggers causing destruction of insulin secreting beta cells. One of the environmental triggers studied recently in the pathogenesis and progression of T1DM is the role of gut microbiome. OBJECTIVES: (1) To compare the gut microbiome profile of T1DM children with healthy age, gender, and body mass index (BMI) matched controls. (2) To assess the relationship of abundance of genera with glycemic control in children with T1DM...
June 28, 2023: Journal of Diabetes
https://read.qxmd.com/read/36856122/-agave-fructans-enhance-the-effects-of-fermented-milk-products-on-obesity-biomarkers-a-randomised-trial
#14
RANDOMIZED CONTROLLED TRIAL
M Vega-Cárdenas, F Martínez-Gutierrez, E E Lara-Ramírez, E Reynaga-Hernandez, L Yañez-Estrada, S Ratering, S Schnell, C I Godínez-Hernández, J M Vargas-Morales, D P Portales-Pérez
Dysbiosis has been implicated in childhood obesity. Oral intake of fermented milk containing Lacticaseibacillus casei strain Shirota preserves gut microbiota (GM) diversity in children and adults. This study was a double-blind trial involving 37 overweight or obese children aged 6-10 years. Children were followed over a 6-week intervention period in which they received different fermented milk products containing L. casei Shirota: 10 in the first group received just L. casei Shirota; 13 received L. casei Shirota with 3 g/day of inulin ( L...
April 18, 2023: Beneficial Microbes
https://read.qxmd.com/read/36815493/probiotic-educated-tregs-are-more-potent-than-na%C3%A3-ve-tregs-for-immune-tolerance-in-stressed-new-born-mice
#15
JOURNAL ARTICLE
Y Liu, T K Hoang, E S Park, J Freeborn, B Okeugo, D Q Tran, J M Rhoads
When new-born mice are subjected to acute maternal separation stress, cow-milk based formula feeding, and brief recurrent hypoxia with cold stress, they develop gut inflammation similar to the phenotype of neonatal necrotizing enterocolitis, characterised by an increase in gut mucosal effector T (Teffs) and reduced Foxp3+ regulatory T (Tregs) cells. The imbalance can be prevented by probiotic Limosilactobacillus reuteri DSM 17938 (LR 17938). We hypothesised that LR 17938 could potentiate a tolerogenic function of Tregs...
February 23, 2023: Beneficial Microbes
https://read.qxmd.com/read/36587078/extraction-purification-and-chemical-degradation-of-lps-from-gut-microbiota-strains
#16
JOURNAL ARTICLE
Molly Dorothy Pither, Alba Silipo, Antonio Molinaro, Flaviana Di Lorenzo
It is estimated that more than 500 different bacterial species colonize the human gut, and they are collectively known as the gut microbiota. Such a massive bacterial presence is now considered an additional organ of the human body, thus becoming the object of an intense and daily growing research activity. Gram-negative bacteria represent a large percentage of the gut microbiota strains. The main constituent of the outer membrane of Gram-negatives is the lipopolysaccharide (LPS). Since its first discovery, LPS has been extensively studied for its structure-dependent capability to elicit a potent immune inflammatory reaction when perceived by specific immune receptors present in our body...
2023: Methods in Molecular Biology
https://read.qxmd.com/read/36557597/associations-between-changes-in-fat-free-mass-fecal-microbe-diversity-and-mood-disturbance-in-young-adults-after-10-weeks-of-resistance-training
#17
JOURNAL ARTICLE
Kristen S Smith, Molly M Morris, Casey D Morrow, Josh R Novak, Michael D Roberts, Andrew Dandridge Frugé
BACKGROUND: The gut microbiome contributes to numerous physiological processes in humans, and diet and exercise are known to alter both microbial composition and mood. We sought to explore the effect of a 10-week resistance training (RT) regimen with or without peanut protein supplementation (PPS) in untrained young adults on fecal microbiota and mood disturbance (MD). METHODS: Participants were randomized into PPS (n = 25) and control (CTL [no supplement]; n = 24) groups and engaged in supervised, full-body RT twice a week...
November 26, 2022: Microorganisms
https://read.qxmd.com/read/36539168/dietary-supplementation-of-synbiotic-leuconostoc-mesenteroide-b4-and-dextran-improves-immune-regulation-and-disease-resistance-of-penaeus-vannamei-against-vibrio-parahaemolyticus
#18
JOURNAL ARTICLE
Mei-Ying Huang, Lo Chia-Yi, Cheng-Yu Lai, Jong-Ding Yu, Po-Tsang Lee
White shrimp (Penaeus vannamei) is an important culture species in Taiwan but often encounters disease infection by Vibrio parahaemolyticus that cause acute hepatopancreatic necrosis disease (AHPND). This study investigates the effects of dietary supplementation of Leuconostoc mesenteroide B4 and its fermentate (dextran) on the immune response, intestinal morphology, disease resistance, and immune-related gene expression in white shrimp. In comparison to the control group, the shrimp fed with a diet containing B4+dextran (107 CFU B4/g feed and 0...
December 17, 2022: Fish & Shellfish Immunology
https://read.qxmd.com/read/36518262/multi-omics-analyses-reveal-that-the-gut-microbiome-and-its-metabolites-promote-milk-fat-synthesis-in-zhongdian-yak-cows
#19
JOURNAL ARTICLE
Lily Liu, Peifu Wu, Fenfen Chen, Jielong Zhou, Aiwei Guo, Kerong Shi, Qin Zhang
BACKGROUND: Yak cows produce higher quality milk with higher concentrations of milk fat than dairy cows. Recently, studies have found the yak milk yield and milk fat percentage have decreased significantly over the past decade, highlighting the urgency for yak milk improvement. Therefore, we aimed to analyze how the gut microbiome impacts milk fat synthesis in Zhongdian yak cows. METHODS: We collected milk samples from Zhongdian yak cows and analyzed the milk fat percentage, selecting five Zhongdian yak cows with a very high milk fat percentage (>7%, 8...
2022: PeerJ
https://read.qxmd.com/read/36349343/the-intestinal-microbiota-and-short-chain-fatty-acids-in-association-with-advanced-metrics-of-glycemia-and-adiposity-among-young-adults-with-type-1-diabetes-and-overweight-or-obesity
#20
JOURNAL ARTICLE
Daria Igudesman, Jamie Crandell, Karen D Corbin, Franklin Muntis, Dessi P Zaharieva, Anna Casu, Joan M Thomas, Cynthia M Bulik, Ian M Carroll, Brian W Pence, Richard E Pratley, Michael R Kosorok, David M Maahs, Elizabeth J Mayer-Davis
Background: Comanagement of glycemia and adiposity is the cornerstone of cardiometabolic risk reduction in type 1 diabetes (T1D), but targets are often not met. The intestinal microbiota and microbiota-derived short-chain fatty acids (SCFAs) influence glycemia and adiposity but have not been sufficiently investigated in longstanding T1D. Objectives: We evaluated the hypothesis that an increased abundance of SCFA-producing gut microbes, fecal SCFAs, and intestinal microbial diversity were associated with improved glycemia but increased adiposity in young adults with longstanding T1D...
November 2022: Current Developments in Nutrition
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