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JOURNAL ARTICLE
Heather Prendergast, Ryan Stratton, Nia Butler, Nasima Mannan, Shaveta Khosla
The purpose of this study was to examine barriers and facilitators to compliance for cancer care in patients utilizing an emergency department (ED)-based assessment. Adult ED patients who either had active cancer or a history of cancer were enrolled between August 2020 and Jan 2022 for this prospective cohort study. We piloted the National Comprehensive Cancer Network (NCCN) Distress Thermometer. Multivariable regression analyses were used to assess the predictors of high distress. Of the 152 patients enrolled, 73% were Black patients, 11% were non-Hispanic White, and 16% included patients from other racial and ethnic groups (including 10...
April 15, 2024: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
#2
JOURNAL ARTICLE
Yorihide Yanagita, Shinichi Arizono, Yuichi Tawara, Masaki Oomagari, Hikaru Machiguchi, Masayuki Tanahashi, Norimasa Katagiri, Yuki Iida, Ryo Kozu
BACKGROUND: Lung resection is the standard of care for patients with clinical stage I/II non-small cell lung cancer. This surgery reduces both the duration and quality of patients' daily ambulatory activities 1 month after surgery. However, little is known about physical activity after lung resection in patients with lung cancer. To evaluate the recovery process of physical activity with pulmonary rehabilitation in patients after lung resection and examine whether physical activity is affected by age...
April 13, 2024: Clinical Biomechanics
#3
JOURNAL ARTICLE
Charly Barbe, Frédéric Chorin
It has now been established that preoperative physical activity plays an essential role in minimizing postoperative complications. Patients who have undergone physical preparation recover their preoperative abilities more quickly. However, only about a third of those with access to such preparation report an improvement in their physical abilities. The modalities of intervention and follow-up, such as the training load and the generic format of the proposed sessions, seem to hinder patient participation in these programs, thus explaining the mixed results...
April 2024: Soins; la Revue de Référence Infirmière
#4
JOURNAL ARTICLE
Eva Ester Molina Beltran, Cindy Neuzillet, Frédéric Chorin
The maintenance and optimization of functional capacities before, during, and after treatment are major challenges for frailty persons as cancer's patients. It is now known that physical activity in prehabilitation plays a crucial role in limiting, among other things, post-operative complications. The benefits have already been demonstrated in various studies, including a decrease in hospitalization duration, an increase in cardiorespiratory endurance, improvement in quality of life, and better fatigue management...
April 2024: Soins; la Revue de Référence Infirmière
#5
JOURNAL ARTICLE
Dan Lin, Cheryl L Thompson, Alaina Demalis, Rebecca Derbes, Laila Al-Shaar, Emma S Spielfogel, Kathleen M Sturgeon
PURPOSE: Studies have reported inverse associations of pre-diagnosis recreational physical activity (RPA) level with all-cause and breast cancer (BCa)-specific mortality among BCa patients. However, the association between pre-diagnosis RPA level and BCa recurrence is unclear. We investigated the association between pre-diagnosis RPA level and risk of BCa recurrence in the California Teachers Study (CTS). METHODS: Stage I-IIIb BCa survivors (n = 6,479) were followed with median of 7...
April 13, 2024: Cancer Causes & Control: CCC
#6
JOURNAL ARTICLE
Seungpil Jeong, Yean-Jung Choi
Cancer screening is pivotal for early detection and improved survival rates. While socio-ecological factors are known to influence screening uptake, the role of lifestyle, dietary habits, and general health in shaping these decisions remains underexplored. Utilizing the 2019 Korea National Health and Nutrition Examination Survey (KNHANES), this study examined the myriad of factors impacting cancer screening utilization. Data from 274,872 adults aged 40 years or older were scrutinized, highlighting demographics, income, lifestyle behaviors, health-related variables, nutrient intake, and dietary quality...
April 3, 2024: Nutrients
#7
JOURNAL ARTICLE
Anna Seller, Christian M Tegeler, Jonas Mauermann, Tatjana Schreiber, Ilona Hagelstein, Kai Liebel, André Koch, Jonas S Heitmann, Sarah M Greiner, Clara Hayn, Dominik Dannehl, Tobias Engler, Andreas D Hartkopf, Markus Hahn, Sara Y Brucker, Helmut R Salih, Melanie Märklin
Ligands of the natural killer group 2D (NKG2DL) family are expressed on malignant cells and are usually absent from healthy tissues. Recognition of NKG2DLs such as MICA/B and ULBP1-3 by the activating immunoreceptor NKG2D, expressed by NK and cytotoxic T cells, stimulates anti-tumor immunity in breast cancer. Upregulation of membrane-bound NKG2DLs in breast cancer has been demonstrated by immunohistochemistry. Tumor cells release NKG2DLs via proteolytic cleavage as soluble (s)NKG2DLs, which allows for effective immune escape and is associated with poor prognosis...
April 8, 2024: International Journal of Molecular Sciences
#8
JOURNAL ARTICLE
Juan Pablo Rigalli, Anna Gagliardi, Klara Diester, Gzona Bajraktari-Sylejmani, Antje Blank, Jürgen Burhenne, Alexander Lenard, Lars Werntz, Andrea Huppertz, Lena Münch, Janica Margrit Wendt, Max Sauter, Walter Emil Haefeli, Johanna Weiss
Drug efflux transporters of the ATP-binding-cassette superfamily play a major role in the availability and concentration of drugs at their site of action. ABCC2 (MRP2) and ABCG2 (BCRP) are among the most important drug transporters that determine the pharmacokinetics of many drugs and whose overexpression is associated with cancer chemoresistance. ABCC2 and ABCG2 expression is frequently altered during treatment, thus influencing efficacy and toxicity. Currently, there are no routine approaches available to closely monitor transporter expression...
April 8, 2024: International Journal of Molecular Sciences
#9
REVIEW
Maya R MacLean, Olivia L Walker, Raj Pranap Arun, Wasundara Fernando, Paola Marcato
Cancer stem cells (CSCs) represent a subpopulation within tumors that promote cancer progression, metastasis, and recurrence due to their self-renewal capacity and resistance to conventional therapies. CSC-specific markers and signaling pathways highly active in CSCs have emerged as a promising strategy for improving patient outcomes. This review provides a comprehensive overview of the therapeutic targets associated with CSCs of solid tumors across various cancer types, including key molecular markers aldehyde dehydrogenases, CD44, epithelial cellular adhesion molecule, and CD133 and signaling pathways such as Wnt/β-catenin, Notch, and Sonic Hedgehog...
April 7, 2024: International Journal of Molecular Sciences
#10
REVIEW
Svetlana N Aleksakhina, Alexander O Ivantsov, Evgeny N Imyanitov
Many tumors have well-defined vulnerabilities, thus potentially allowing highly specific and effective treatment. There is a spectrum of actionable genetic alterations which are shared across various tumor types and, therefore, can be targeted by a given drug irrespective of tumor histology. Several agnostic drug-target matches have already been approved for clinical use, e.g., immune therapy for tumors with microsatellite instability (MSI) and/or high tumor mutation burden (TMB), NTRK1-3 and RET inhibitors for cancers carrying rearrangements in these kinases, and dabrafenib plus trametinib for BRAF V600E mutated malignancies...
April 7, 2024: International Journal of Molecular Sciences
#11
JOURNAL ARTICLE
Seidy Y Aguilar-Martínez, Gabriela E Campos-Viguri, Selma E Medina-García, Ricardo J García-Flores, Jessica Deas, Claudia Gómez-Cerón, Abraham Pedroza-Torres, Elizabeth Bautista-Rodríguez, Gloria Fernández-Tilapa, Mauricio Rodríguez-Dorantes, Carlos Pérez-Plasencia, Oscar Peralta-Zaragoza
Expression of miR-21 has been found to be altered in almost all types of cancers, and it has been classified as an oncogenic microRNA. In addition, the expression of tumor suppressor gene RECK is associated with miR-21 overexpression in high-grade cervical lesions. In the present study, we analyze the role of miR-21 in RECK gene regulation in cervical cancer cells. To identify the downstream cellular target genes of upstream miR-21, we silenced endogenous miR-21 expression using siRNAs. We analyzed the expression of miR-21 and RECK, as well as functional effects on cell proliferation and migration...
April 6, 2024: International Journal of Molecular Sciences
#12
JOURNAL ARTICLE
Sahar Sarmasti Emami, Anni Ge, Derek Zhang, Yawei Hao, Min Ling, Rachel Rubino, Christopher J B Nicol, Wenqi Wang, Xiaolong Yang
The Hippo pathway plays crucial roles in governing various biological processes during tumorigenesis and metastasis. Within this pathway, upstream signaling stimuli activate a core kinase cascade, involving MST1/2 and LATS1/2, that subsequently phosphorylates and inhibits the transcriptional co-activators YAP and its paralog TAZ. This inhibition modulates the transcriptional regulation of downstream target genes, impacting cell proliferation, migration, and death. Despite the acknowledged significance of protein kinases in the Hippo pathway, the regulatory influence of protein phosphatases remains largely unexplored...
April 5, 2024: International Journal of Molecular Sciences
#13
JOURNAL ARTICLE
Contrast Agents Based on Human Serum Albumin and Nitroxides for 1 H-MRI and Overhauser-Enhanced MRI.
Dmitry Mitin, Friedemann Bullinger, Sergey Dobrynin, Jörn Engelmann, Klaus Scheffler, Mikhail Kolokolov, Olesya Krumkacheva, Kai Buckenmaier, Igor Kirilyuk, Alexey Chubarov
In cancer diagnostics, magnetic resonance imaging (MRI) uses contrast agents to enhance the distinction between the target tissue and background. Several promising approaches have been developed to increase MRI sensitivity, one of which is Overhauser dynamic nuclear polarization (ODNP)-enhanced MRI (OMRI). In this study, a macromolecular construct based on human serum albumin and nitroxyl radicals (HSA-NIT) was developed using a new synthesis method that significantly increased the modification to 21 nitroxide residues per protein...
April 5, 2024: International Journal of Molecular Sciences
#14
JOURNAL ARTICLE
Daria A Bogdanova, Ekaterina D Kolosova, Tamara V Pukhalskaia, Ksenia A Levchuk, Oleg N Demidov, Ekaterina V Belotserkovskaya
The tumor microenvironment (TME) plays an essential role in tumor progression and in modulating tumor response to anticancer therapy. Cellular senescence leads to a switch in the cell secretome, characterized by the senescence-associated secretory phenotype (SASP), which may regulate tumorigenesis. Senolytic therapy is considered a novel anticancer strategy that eliminates the deleterious effects of senescent cells in the TME. Here, we show that two different types of senolytic drugs, despite efficiently depleting senescent cells, have opposite effects on cancer-associated fibroblasts (CAFs) and their ability to regulate epithelial-mesenchymal transition (EMT)...
April 4, 2024: International Journal of Molecular Sciences
#15
REVIEW
Dominik Kľoc, Slavomír Kurhajec, Mykhailo Huniadi, Ján Sýkora, Tomáš Guman, Marek Šarišský
The signaling lymphocytic activation molecule (SLAM) receptor family (SLAMF) consists of nine glycoproteins that belong to the CD2 superfamily of immunoglobulin (Ig) domain-containing molecules. SLAMF receptors modulate the differentiation and activation of a wide range of immune cells. Individual SLAMF receptors are expressed on the surface of hematopoietic stem cells, hematopoietic progenitor cells, B cells, T cells, NK cells, NKT cells, monocytes, macrophages, dendritic cells, neutrophils, and platelets...
April 4, 2024: International Journal of Molecular Sciences
#16
JOURNAL ARTICLE
Oliver Illini, Felix Carl Saalfeld, Petros Christopoulos, Michaël Duruisseaux, Anders Vikström, Nir Peled, Ingel Demedts, Elizabeth Dudnik, Anna Eisert, Sayed M S Hashemi, Urska Janzic, Waleed Kian, Katja Mohorcic, Saara Mohammed, Maria Silvoniemi, Sacha I Rothschild, Christian Schulz, Claas Wesseler, Alfredo Addeo, Karin Armster, Malinda Itchins, Marija Ivanović, Diego Kauffmann-Guerrero, Jussi Koivunen, Jonas Kuon, Nick Pavlakis, Berber Piet, Martin Sebastian, Janna-Lisa Velthaus-Rusik, Luciano Wannesson, Marcel Wiesweg, Robert Wurm, Corinna Albers-Leischner, Daniela E Aust, Melanie Janning, Hannah Fabikan, Sylvia Herold, Anna Klimova, Sonja Loges, Yana Sharapova, Maret Schütz, Christoph Weinlinger, Arschang Valipour, Tobias Raphael Overbeck, Frank Griesinger, Marko Jakopovic, Maximilian J Hochmair, Martin Wermke
EGFR exon 20 (EGFR Ex20) insertion mutations in non-small cell lung cancer (NSCLC) are insensitive to traditional EGFR tyrosine kinase inhibitors (TKIs). Mobocertinib is the only approved TKI specifically designed to target EGFR Ex20. We performed an international, real-world safety and efficacy analysis on patients with EGFR Ex20-positive NSCLC enrolled in a mobocertinib early access program. We explored the mechanisms of resistance by analyzing postprogression biopsies, as well as cross-resistance to amivantamab...
April 3, 2024: International Journal of Molecular Sciences
#17
JOURNAL ARTICLE
Leonardo Donati, Debora Casagrande Pierantoni, Angela Conti, Eleonora Calzoni, Laura Corte, Claudio Santi, Ornelio Rosati, Gianluigi Cardinali, Carla Emiliani
The evolution of regulatory perspectives regarding the health and nutritional properties of industrial hemp-based products ( Cannabis sativa L.) has pushed research to focus on the development of new methods for both the extraction and formulation of the bioactive compounds present in hemp extracts. While the psychoactive and medicinal properties of hemp-derived cannabinoid extracts are well known, much less has been investigated on the functional and antimicrobial properties of hemp extracts. Within the hemp value chain, various agricultural wastes and by-products are generated...
April 3, 2024: International Journal of Molecular Sciences
#18
JOURNAL ARTICLE
Kirill A Kulagin, Elizaveta S Starodubova, Pamila J Osipova, Anastasia V Lipatova, Igor A Cherdantsev, Svetlana V Poddubko, Vadim L Karpov, Dmitry S Karpov
Proteasome inhibitors are used in the therapy of several cancers, and clinical trials are underway for their use in the treatment of glioblastoma (GBM). However, GBM becomes resistant to chemotherapy relatively rapidly. Recently, the overexpression of ribonucleotide reductase (RNR) genes was found to mediate therapy resistance in GBM. The use of combinations of chemotherapeutic agents is considered a promising direction in cancer therapy. The present work aimed to evaluate the efficacy of the combination of proteasome and RNR inhibitors in yeast and GBM cell models...
April 3, 2024: International Journal of Molecular Sciences
#19
JOURNAL ARTICLE
Ryan Incrocci, Rosalinda Monroy Del Toro, Grace Devitt, Melody Salimian, Kamaljit Braich, Michelle Swanson-Mungerson
Epstein-Barr Virus (EBV) exists in a latent state in 90% of the world's population and is linked to numerous cancers, such as Burkitt's Lymphoma, Hodgkin's, and non-Hodgkin's Lymphoma. One EBV latency protein, latency membrane protein 2A (LMP2A), is expressed in multiple latency phenotypes. LMP2A signaling has been extensively studied and one target of LMP2A is the mammalian target of rapamycin (mTOR). Since mTOR has been linked to reprogramming tumor metabolism and increasing levels of hypoxia-inducible factor 1 α (HIF-1α), we hypothesized that LMP2A would increase HIF-1α levels to enhance ATP generation in B lymphoma cell lines...
April 2, 2024: International Journal of Molecular Sciences
#20
JOURNAL ARTICLE
Emma Franco-Mateos, Virginia Souza-Egipsy, Laura García-Estévez, José Pérez-García, María Gion, Laia Garrigós, Patricia Cortez, Cristina Saavedra, Patricia Gómez, Carolina Ortiz, Víctor L Cruz, Javier Ramos, Javier Cortés, Juan F Vega
The binding activity of various trastuzumab biosimilars versus the branded trastuzumab towards the glycosylated extracellular domain of the human epidermal growth factor receptor 2 (HER2) target in the presence of pertuzumab was investigated. We employed size exclusion chromatography with tetra-detection methodology to simultaneously determine absolute molecular weight, concentration, molecular size, and intrinsic viscosity. All trastuzumab molecules in solution exhibit analogous behavior in their binary action towards HER2 regardless of the order of addition of trastuzumab/pertuzumab...
April 1, 2024: International Journal of Molecular Sciences
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