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Physical Activity + Cancer

Tessa De Vrieze, Lore Vos, Nick Gebruers, An De Groef, Lore Dams, Elien Van der Gucht, Ines Nevelsteen, Nele Devoogdt
BACKGROUND: Lymphedema is associated with significant physical and psychosocial problems. The Lymphedema Functioning, Disability and Health questionnaire for upper limb lymphedema is a valid and reliable tool quantifying the amount of problems in functioning in patients with breast cancer-related lymphedema. Patients suggested a revision of the scoring system to facilitate completion of the questionnaire. Therefore, adjustment of the questionnaire was carried out by implementing a numeric rating scale instead of the existing visual analog scale...
February 13, 2019: Lymphatic Research and Biology
Byung Joo Lee, Yong Hyun Park, Ji Youl Lee, Soo Jin Kim, Yongjun Jang, Jong In Lee
BACKGROUND: Recently, the application of smartphone in medical field has received great attention. INTRODUCTION: The objective of this study was to compare the effectiveness of smartphone-based and conventional pedometer-based exercise monitoring systems in promoting home exercise among prostate cancer patients. METHODS: Prostate cancer patients who have undergone surgery or androgen deprivation therapy were recruited. All participants were provided with physical activity goals based on their activities and were advised to achieve these goals during their home exercise period...
February 13, 2019: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Maria C Ramello, Ismahène Benzaïd, Brent M Kuenzi, Maritza Lienlaf-Moreno, Wendy M Kandell, Daniel N Santiago, Mibel Pabón-Saldaña, Lancia Darville, Bin Fang, Uwe Rix, Sean Yoder, Anders Berglund, John M Koomen, Eric B Haura, Daniel Abate-Daga
Adoptive transfer of T cells that express a chimeric antigen receptor (CAR) is an approved immunotherapy that may be curative for some hematological cancers. To better understand the therapeutic mechanism of action, we systematically analyzed CAR signaling in human primary T cells by mass spectrometry. When we compared the interactomes and the signaling pathways activated by distinct CAR-T cells that shared the same antigen-binding domain but differed in their intracellular domains and their in vivo antitumor efficacy, we found that only second-generation CARs induced the expression of a constitutively phosphorylated form of CD3ζ that resembled the endogenous species...
February 12, 2019: Science Signaling
Muhannad Abu-Remaileh, Monther Abu-Remaileh, Rania Akkawi, Ibrahim Knani, Shiran Udi, Micheal E Pacold, Joseph Tam, Rami I Aqeilan
OBJECTIVE: WWOX, a well-established tumor suppressor, is frequently lost in cancer and plays important roles in DNA damage response and cellular metabolism. METHODS: We re-analyzed several genome-wide association studies (GWAS) using the Type 2 Diabetes Knowledge Portal website to uncover WWOX's association with metabolic syndrome (MetS). Using several engineered mouse models, we studied the effect of somatic WWOX loss on glucose homeostasis. RESULTS: Several WWOX variants were found to be strongly associated with MetS disorders...
January 31, 2019: Molecular Metabolism
Sandra A S van den Heuvel, Jonne Doorduin, Monique A Steegers, Ewald M Bronkhorst, Sandra A Radema, Kris C Vissers, Selina E van der Wal, Nens van Alfen
OBJECTIVES: Oxaliplatin-induced neurotoxicity can be a dose-limiting side effect to effective chemotherapy. Acute hyperexcitability causes cold-evoked sensory and motor symptoms, which resemble neuromyotonia. An accessible and non-invasive technique for early detection could help select patients for potential treatments. We assessed the use of a simple surface electromyography (sEMG) in patients directly after oxaliplatin infusion. METHODS: In patients with colorectal cancer, acute neurotoxicity was evaluated by means of a physical examination, a questionnaire, and sEMG directly after the second and fourth cycle of oxaliplatin...
February 9, 2019: Neuroscience Letters
Glenn Choon Lim Wong, Vipin Narang, Yanxia Lu, Xavier Camous, Ma Shwe Zin Nyunt, Christophe Carre, Chrystal Tan, Chin Hui Xian, Joni Chong, Michelle Chua, Wilson How, Esther Mok, Paul Tambyah, Michael Poidinger, Brian Abel, Nicolas Burdin, Laurence Quemeneur, Nabil Bosco, Tze Pin Ng, Anis Larbi
Physical inactivity is one of the leading contributors to worldwide morbidity and mortality. The elderly are particularly susceptible since the features of physical inactivity overlap with the outcomes of natural aging - including the propensity to develop cardiovascular diseases, cancer, diabetes mellitus, sarcopenia and cognitive impairment. The age-dependent loss of immune function, or immunosenescence, refers to the progressive depletion of primary immune resources and is linked to the development of many of these conditions...
2019: Exercise Immunology Review
Nicole Kiss, Brenton James Baguley, Kylie Ball, Robin M Daly, Steve F Fraser, Catherine L Granger, Anna Ugalde
BACKGROUND: Nutrition and physical activity interventions are important components of cancer care. With an increasing demand for services, there is a need to consider flexible, easily accessible, and tailored models of care while maintaining optimal outcomes. OBJECTIVE: This systematic review describes and appraises the efficacy of technology-supported self-guided nutrition and physical activity interventions for people with cancer. METHODS: A systematic search of multiple databases from 1973 to July 2018 was conducted for randomized and nonrandomized trials investigating technology-supported self-guided nutrition and physical activity interventions...
February 12, 2019: JMIR MHealth and UHealth
Hui-Ling Lai, Chun-I Chen, Chu-Yun Lu, Yu-Chun Yao, Chiung-Yu Huang
BACKGROUND: Theory has suggested that personality plays an important role related to health behavior and results in health outcomes, but inconsistent with the findings exist. Moreover, limited research has focused on style of coping with personality traits and health-related quality of life (HRQOL) for patients with breast cancer. We tested how ways of coping and personality traits are associated with HRQOL in patients with breast cancer, after controlling for age, education, disease severity, and sleep disorders...
February 12, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Cátia Reis, Sara Dias, Ana Maria Rodrigues, Rute Dinis Sousa, Maria João Gregório, Jaime Branco, Helena Canhão, Teresa Paiva
Background: Adequate sleep is essential for health. Both, short and long sleep durations are associated to worse quality of life and poor health outcomes. Portugal represents a specific population model, since according to European statistics it has high rates of chronic diseases like depression, hypertension, diabetes and stroke; and low quality of life as well as low index of physical activity, while in parallel it has some other good health indicators such as: low age-standardized mortality for both genders, nutrition in terms of energy and fruit consumption, smoking and alcohol, obesity and overweight prevalence...
July 2018: Sleep Science
Hikaru Ihira, Norie Sawada, Taiki Yamaji, Atsushi Goto, Taichi Shimazu, Manami Inoue, Motoki Iwasaki, Shoichiro Tsugane
BACKGROUND: Although physical activity has been reported as a protective factor for kidney and bladder cancer in epidemiological studies, it is not clear. METHODS: In a population-based prospective study of 76,795 Japanese aged 45-74 years, participants were evaluated physical activity by self-administered questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) of the risk of urological cancer were calculated by the Cox proportional hazards models...
February 12, 2019: British Journal of Cancer
Sandra Pinho, Paul S Frenette
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal, differentiation and migration of HSCs and progenitor cells at steady state and in response to emergencies and injury. Improved methods for HSC isolation, driven by advances in single-cell and molecular technologies, have led to a better understanding of their behaviour, heterogeneity and lineage fate and of the niche cells and signals that regulate their function...
February 11, 2019: Nature Reviews. Molecular Cell Biology
Erik Wibowo, Richard J Wassersug, John W Robinson, Andrew Matthew, Deborah McLeod, Lauren M Walker
BACKGROUND: Androgen deprivation therapy (ADT) for prostate cancer has numerous side effects. Clinical guidelines for side effect management exist; however, these are not always integrated into routine practice. What remains undocumented and therefore the objective of this study, is to describe patients' willingness to employ established strategies. PATIENTS AND METHODS: Study participants were 91 men who had attended an educational program (ie, attend a class plus read a book), designed to prepare patients for managing ADT side effects...
December 20, 2018: Clinical Genitourinary Cancer
Olga D'Almeida, Omar Mothar, Esther Apraku Bondzie, Yolande Lieumo, Laure Tagne, Sumeet Gupta, Thomas Volkert, Stuart Levine, Jean-Bosco Tagne
BACKGROUND: MicroRNAs are noncoding RNA molecules of ~ 22 nucleotides with diagnostic and therapeutic action [Curr Drug Targets, 2015. 16(12): p. 1381-403], affecting the expression of mRNAs involved in invasion, migration, and development [Oncotarget, 2015. 6(9): p. 6472-98, Cancer Manag Res, 2014. 6: p. 205-16]. miR-200c is part of the miR-200c/141 cluster on chromosome 12p13. Its mechanism of action when encapsulated is critical in lung cancer when patients express changes in miRNAs...
February 11, 2019: BMC Cancer
N B Zhu, M Zhou, C Q Yu, Y Guo, Z Bian, Y L Tan, P Pei, J S Chen, Z M Chen, J Lyu, L M Li
Objective: To examine the prevalence of 'healthy lifestyle' from data extracted from the China Kadoorie Biobank (CKB) of 0.5 million adults from ten areas across China. Methods: After excluding participants with self-reported histories of coronary heart disease, stroke or cancer, a total of 487 198 participants at baseline (2004-2008) and 22 604 participants at second survey (2013- 2014), were included for analysis. 'Healthy lifestyle' was defined as haing the following characteristics: a) never smoking or having stopped smoking for reasons other than illness; b) alcohol drinking <25 g/day (men)/<15 g/day (women); c) diet rich in vegetables, fruits, legumes and fish, but low in red meat; d) upper quarter of the physical activity level; e) body mass index of 18...
February 10, 2019: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Carolyn J Peddle-McIntyre, Favil Singh, Rajesh Thomas, Robert U Newton, Daniel A Galvão, Vinicius Cavalheri
BACKGROUND: Patients with advanced lung cancer have a high symptom burden, which is often complicated by coexisting conditions. These issues, combined with the indirect effects of cancer treatment, can cumulatively lead patients to continued deconditioning and low exercise capacity. This is a concern as exercise capacity is considered a measure of whole body health, and is critical in a patient's ability to participate in life activities and tolerate difficult treatments. There is evidence that exercise training improves exercise capacity and other outcomes, such as muscle force and health-related quality of life (HRQoL), in cancer survivors...
February 11, 2019: Cochrane Database of Systematic Reviews
Jun-Yu Li, Zhi-Qiang Luo
Lung cancer is one of the most common cancers and has been the most common cause of cancer deaths for several decades. Recently, lung cancer-associated lncRNA 1 (LCAL1) has been identified to be overexpressed in lung cancer tissues, while inhibiting LCAL1 expression has shown potential to inhibiting lung cancer growth. However, the molecular mechanism between LCAL1 and lung cancer cell survival remains poorly understood. In the present study, we provided the first evidence that LCAL1 may support lung cancer survival via inhibiting the activity of AMP-activated protein kinase (AMPK)...
February 11, 2019: Molecular and Cellular Biochemistry
Laurie Grealish, Melissa K Hyde, Melissa Legg, Mark Lazenby, Joanne F Aitken, Jeff Dunn, Suzanne K Chambers
OBJECTIVE: To prospectively explore predictors of hope in people with colorectal cancer at 24 months post-diagnosis. METHODS: The present study is a secondary analysis of two waves within a longitudinal survey of patients newly diagnosed with colorectal cancer in Queensland, Australia. Baseline predictors (sociodemographic, disease, lifestyle characteristics, cancer threat appraisal and quality of life domains) were measured via mailed surveys and telephone interviews at 6 months post-diagnosis...
February 10, 2019: European Journal of Cancer Care
Anja Funch, Naja Benigna Kruse, Karen la Cour, Hanne Peoples, Eva Ejlersen Waehrens, Åse Brandt
OBJECTIVE: To explore whether people with advanced cancer who had assistive devices had higher or lower ADL ability and/or HRQoL than people with advanced cancer who did not have assistive devices. METHODS: A cross-sectional study of 164 participants with advanced cancer. Self-reported ADL ability and HRQoL were assessed using the ADL-Interview and the EORTC QLQ-C30. Data regarding assistive devices were collected using a study-specific questionnaire. Data were analysed using multiple linear regression...
February 10, 2019: European Journal of Cancer Care
Weike Wang, Teresa T Fung, Molin Wang, Stephanie A Smith-Warner, Edward L Giovannucci, Fred K Tabung
Background: We examined the role of the insulinemic potential of diet and lifestyle in the development of cancers of the digestive system, using two plasma C-peptide-based indices: the empirical dietary index for hyperinsulinemia (EDIH) and empirical lifestyle index for hyperinsulinemia (ELIH). Methods: We used Cox regression to analyze data on 45 816 men (Health Professionals Follow-up Study, 1986-2012) and 74 191 women (Nurses' Health Study, 1984-2012) to examine associations between EDIH and ELIH scores and digestive system cancers...
November 2018: JNCI cancer spectrum
Long H Nguyen, Po-Hong Liu, Xiaobin Zheng, NaNa Keum, Xiaoyu Zong, Xiao Li, Kana Wu, Charles S Fuchs, Shuji Ogino, Kimmie Ng, Walter C Willett, Andrew T Chan, Edward L Giovannucci, Yin Cao
Background: Colorectal cancer (CRC) diagnosed before age 50 years, or young-onset CRC, is increasing globally with undefined etiology. A sedentary lifestyle is an emerging risk factor for CRC after age 50 years, but its role in young-onset CRC is unknown. Methods: We prospectively evaluated sedentary behaviors, primarily time watching television (TV), and risk of young-onset CRC among 89 278 women in the Nurses' Health Study II ages 25-42 years at recruitment (1991-2011)...
November 2018: JNCI cancer spectrum
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