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H Salehi, M Momeni, M Ebrahimi, M J Fatemi, H Rahbar, F Ranjpoor, A Salehi, F Moosavizadeh
Wound care quality and speed of burn healing are important factors that affect the treatment, prognosis and complications of burns. Burn care is challenging, and the ideal method controversial. The aim of this study was to compare the effects of a new dressing (ColActive dressing) in the treatment of superficial second-degree burns versus traditional dressing including Vaseline and Nitrofurazone. This was a randomized clinical trial study involving 25 cases. A superficial second-degree burn area was divided into two parts in each patient; randomly, traditional dressing was used on one area, and ColActive plus Ag dressing on the other...
September 30, 2018: Annals of Burns and Fire Disasters
Ranadip Goswami, Shyama Charan Mandal, Biswarup Pathak, Subhadip Neogi
Luminescent metal-organic frameworks (LMOFs) are promising functional materials for sustainable applications, where analyte induced multiresponsive system with good recyclability is beneficial for detecting numerous lethal pollutants. We designedly built the dual functionalized, three-dimensional Zn(II)-framework [Zn3 ( bpg)1.5 ( azdc)3 ]∙(DMF)5.9 ∙(H2 O)1.05 (CSMCRI-1) using -OH group integrated bpg linker, and -N═N- moiety containing H2 azdc ligand, which functions as unique tetra-sensoric fluorescent probe...
February 5, 2019: ACS Applied Materials & Interfaces
Shan Xu, Jing-Jing Shi, Bo Ding, Zheng-Yu Liu, Xiu-Guang Wang, Xiao-Jun Zhao, En-Cui Yang
The detection of nitrofuran antibiotics and toxic inorganic anions is currently necessary and challenging because their abuse and/or residuals have caused severe environmental pollution and illness. A heterometallic two-dimensional (2D) layered complex, {[Eu2Na(Hpddb)(pddb)2(CH3COO)2]·2.5(DMA)}n (1), was solvothermally synthesized and structurally and photophysically characterized. Pairs of acetate aggregated {Eu2Na(CH3COO)2} chains are periodically interconnected by V-shaped 4,4'-(pyridine-2,6-diyl)dibenzolate (pddb) linkers...
January 16, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
F G Menezes, L Corrêa, J O Medina-Pestana, W F Aguiar, L F A Camargo
BACKGROUND: Urinary tract infections are frequent complications early after kidney transplantation, and the use of antimicrobial coated catheters in settings other than transplantation has shown promising results for infection prevention. The purpose of this study was to compare the efficacy of Nitrofurazone-coated silicone urinary catheters with non-impregnated silicone urinary catheters in reducing bacteriuria and urinary tract infections in kidney transplant recipients. METHODS: This single-center study, randomized controlled trial at the Hospital do Rim, a tertiary referral center in kidney transplantation, located in São Paulo, Brazil...
November 19, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Wenhao Su, Wei Shi, Yu Han, Yuan Hu, Aiying Ke, Hongxi Wu, Guangxu Liu
The current knowledge about the effect of pCO2 -driven ocean acidification on the bioaccumulation of pollutants in marine species is still scarce, as only limited types of pollutants have been investigated. Therefore, to obtain a better understanding of the effect of ocean acidification on the process of bioaccumulation and subsequent food safety, the accumulation of benzo[a]pyrene (B[a]P), chloramphenicol (CAP), and nitrofurazone (NFZ) in an edible bivalve species, Tegillarca granosa, under present and near-future ocean acidification scenarios was investigated in the present study...
February 10, 2019: Science of the Total Environment
Cauê B Scarim, Cleverton R de Andrade, João A da Rosa, Jean L Dos Santos, Chung M Chin
Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in mice with a Y strain of Trypanosoma cruzi and analysed the histopathological data about the effects of NFOH and BZN on different tissues, including the heart, skeletal muscle, liver, kidney, colon, spleen and brain...
October 15, 2018: International Journal of Experimental Pathology
Oguz Eroglu, Turgut Deniz, Ucler Kisa, Faruk Metin Comu, Sedat Kaygusuz, Orhan Murat Kocak
OBJECTIVE: To investigate the effects of treatments of 'mad honey', blossom honey and nitrofurazone on infected wound healing. METHOD: Male albino Wistar rats were randomly divided into four groups: 'mad honey' (MH), blossom honey (BH), nitrofurazone (N) and control (C). All rats were anaesthetised intraperitoneally. A circular skin incision was made to the back regions. Grafts containing slime-producing Staphylococcus epidermidis were placed on the incision area and then sutured to the skin...
October 1, 2018: Journal of Wound Care
Mohammad Nazmol Hasan, Zobaer Akond, Md Jahangir Alam, Anjuman Ara Begum, Moizur Rahman, Md Nurul Haque Mollah
The aim of toxicogenomic studies is to optimize the toxic dose levels of chemical compounds (CCs) and their regulated biomarker genes. This is also crucial in drug discovery and development. There are popular online computational tools such as ToxDB and Toxygates to identify toxicogenomic biomarkers using t-test. However, they are not suitable for the identification of biomarker gene regulatory dose of corresponding CCs. Hence, we describe a one-way ANOVA model together with Tukey's HSD test for the identification of toxicogenomic biomarker genes and their influencing CC dose with improved efficiency...
2018: Bioinformation
Jun Yang, Jing Bai, Mingbo Qu, Bo Xie, Qing Yang
A nitroreductase-encoded gene from an efficient nitro-reducing bacterium Streptomyces mirabilis DUT001, named snr, was cloned and heterogeneously expressed in Escherichia coli. The purified Streptomyces nitroreductase SNR was a homodimer with an apparent subunit molecular weight of 24 kDa and preferred NADH to NADPH as a cofactor. By enzyme incubation and isothermal calorimetry experiments, flavin mononucleotide (FMN) was found to be the preferred flavin cofactor; the binding process was exothermic and primarily enthalpy driven...
September 19, 2018: Biotechnology and Applied Biochemistry
Shao-Hua Chiu, Ya-Ling Su, Anh V T Le, Shu-Hua Cheng
The toxicity of nitrofuran drugs has attracted great attention, and the reported electroanalytical methods suffered limited sensitivity. In this work, a sensitive electrochemical assay in the cathodic region is developed to determine four nitrofuran derivatives, including nitrofurantoin (NFT), nitrofurazone (NFZ), furaltadone (FTD), and furazolidone (FZD). The screen-printed carbon electrode (SPCE) was used as the electrode substrate, and the sensing surface was composed of multi-walled carbon nanotube (MWCNT) and conducting poly(melamine) (PME)...
October 2018: Analytical and Bioanalytical Chemistry
Sreekanth Thota, Daniel A Rodrigues, Pedro de Sena Murteira Pinheiro, Lídia M Lima, Carlos A M Fraga, Eliezer J Barreiro
Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile and promising motif in drug design and medicinal chemistry. Herein, we discuss the current and future challenges in the emergence of bioactive NAH-based scaffolds and to developing strategies to overcome the failures in drug discovery. The NAH-related approved drugs nitrofurazone, nitrofurantoin, carbazochrome, testosterone 17-enanthate 3-benzilic acid hydrazine, nifuroxazide, dantrolene, and azumolene are already used as therapeutics in various countries...
September 15, 2018: Bioorganic & Medicinal Chemistry Letters
Wubante Demilew, Getnet Mequanint Adinew, Seyfe Asrade
Background: Medicinal plants play indispensable roles to treat various ailments. Acanthus polystachyus is one of the medicinal plants used traditionally for treatment of wounds. However, there were no scientific reports documented so far on the wound healing activities of this plant. Thus, the present study provides a scientific evaluation for the wound healing potential of the crude extract of A. polystachyus leaves. Methods: The crude extraction was carried out using 80% methanol...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Sarva Mangala Praveena, Siti Norashikin Mohamad Shaifuddin, Syazwani Sukiman, Fauzan Adzima Mohd Nasir, Zanjabila Hanafi, Norizah Kamarudin, Tengku Hanidza Tengku Ismail, Ahmad Zaharin Aris
This study investigated the occurrence of nine pharmaceuticals (amoxicillin, caffeine, chloramphenicol, ciprofloxacin, dexamethasone, diclofenac, nitrofurazone, sulfamethoxazole, and triclosan) and to evaluate potential risks (human health and ecotoxicological) in Lui, Gombak and Selangor (Malaysia) rivers using commercial competitive Enzyme-Linked Immunosorbent Assay (ELISA) kit assays. Physicochemical properties of these rivers showed the surface samples belong to Class II of Malaysian National Water Quality Standards which requires conventional treatment before consumption...
November 15, 2018: Science of the Total Environment
Binqiang Tian, Lujie Song, Tao Liang, Zuowei Li, Xuxiao Ye, Qiang Fu, Yonghui Li
The aim of the present study was to determine whether it was possible to repair urethral defects with a material of adipose mesenchymal stem cells (ADMSCs)‑porous silk fibroin (SF). A total of 39 male New Zealand white rabbits were randomly divided into a control group, an SF group and a bromodeoxyuridine (BrdU)‑labeled ADMSCs‑SF group (SSF group; n=13/group). Defects were made by resecting the posterior urethral wall. The defects in the SF and SSF groups were repaired using SF and BrdU‑labeled ADMSCs‑SF materials respectively...
July 2018: Molecular Medicine Reports
Cui-Ping Gong, Shou-Cun Li, Rong-Ye Wang
Silver nanoparticles (AgNPs) have been emerged as significant wound healing agents because of their improved mechanical properties. However, the green synthesized silver nanoparticleshave reported significant wound healing action in Albino rats which was validated by the measurement of wound closure rate. Silver nanoparticles were efficiently synthesized using Euphorbia milii leaf extract. The UV-visible spectra recorded the effect of the reaction time on AgNPs synthesis and was indentified that the peak became shaper with an increase in time, which corresponds to increase in the number of nanoparticles formed from the reduction of silver ions present in the aqueous solution...
June 2018: Journal of Photochemistry and Photobiology. B, Biology
Sheng-Li Hou, Jie Dong, Xiao-Lei Jiang, Zhuo-Hao Jiao, Chu-Ming Wang, Bin Zhao
Two novel anionic In-MOFs V101 and V102 were synthesized and structurally characterized. The structrual transformation from 2-fold interpenetration to noninterpenetration was completed by changing solvent from DMF to DEF. Luminescence investigations reveal that only V102 not V101 can sensitively and selectively detect traces of antibiotics nitrofurazone in water solution via an environmentally friendly manner, and the detection limit can reach to 0.2 ppm. The luminescent difference between V101 and V102 mainly originates from the divergence of interpenetration structures...
February 6, 2018: Analytical Chemistry
Didem Kart, Ayşe Semra Kustimur, Meral Sağıroğlu, Ayşe Kalkancı
BACKGROUND: Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa and Candida albicans biofilms are major causes of catheter-associated urinary tract infections. Antimicrobial-coated or impregnated urinary catheters are seen as a possible way to prevent these infections. AIMS: To determine the biofilm-forming ability of 89 E. faecalis isolates from urinary tract infections and to compare several urinary catheters for antimicrobial durability and the inhibitory effects on biofilm formation of different laboratory strains and clinical isolates of E...
December 1, 2017: Balkan Medical Journal
Esen Özkaya, Sıla Kılıç
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmetic products. They are potential contact sensitizers, including low molecular weight PEGs in nitrofurazone preparations that are still widely used in Turkey. OBJECTIVES: To investigate the prevalence of allergic contact dermatitis caused by PEG and PG in a relatively large group of patients in Turkey. METHODS: In this retrospective, cross-sectional, single-centre study, 836 patients patch tested with PEG and PG between 1996 and 2015 were reviewed...
March 2018: Contact Dermatitis
Łukasz Popiołek, Anna Biernasiuk
In this research we synthesized and tested for in vitro antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of1 H NMR and13 C NMR spectroscopy. The in vitro screening of antimicrobial properties of synthesized compounds revealed a wide spectrum of antimicrobial activity. Compounds 28 , 29 , 32 - 43 , and 45 - 48 showed very high bactericidal effect towards Staphylococcus spp. ATTC and Bacillus spp. ATTC (MIC = 0.002-7.81 µg/ml and MBC = 0.002-31.25 µg/ml)...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Weiwei Bian, Zhen Liu, Gang Lian, Le Wang, Qilong Wang, Jinhua Zhan
That intense demand for both high sensitivity and high reliability has been a key factor strengthening the surface enhanced Raman spectroscopy (SERS) in the analytical application, particular in the hyphenation with pre-concentration technique. Credible data acquisition and processing is very dependent on the stable and uniform performance of SERS-active substrate. Here, a reliable and uniform ultrathin-layer Au was proposed for protecting the porous Ag fiber (porous Ag@Au) and applied in the solid phase microextraction coupled with SERS...
November 22, 2017: Analytica Chimica Acta
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