Laust E R Obling, Rasmus P Beske, Martin A S Meyer, Johannes Grand, Sebastian Wiberg, Benjamin Nyholm, Jakob Josiassen, Frederik T Søndergaard, Thomas Mohr, Anders Damm-Hejmdal, Mette Bjerre, Ruth Frikke-Schmidt, Fredrik Folke, Jacob E Møller, Jesper Kjaergaard, Christian Hassager
PURPOSE: Patients who are successfully resuscitated following out-of-hospital cardiac arrest (OHCA) are still at a high risk of neurological damage and death. Inflammation and brain injury are components of the post-cardiac arrest syndrome, and can be assessed by systemic interleukin 6 (IL-6) and neuron-specific enolase (NSE). Anti-inflammatory treatment with methylprednisolone may dampen inflammation, thereby improving outcome. This study aimed to determine if prehospital high-dose methylprednisolone could reduce IL-6 and NSE in comatose OHCA patients...
November 9, 2023: Intensive Care Medicine