Rama Malaviya, Jaclynn Meshanni, Vasanthi R Sunil, Alessandro Venosa, Changjiang Guo, Elena V Abramova, Kinal N Vayas, Chenghui Jiang, Jessica A Cervelli, Andrew J Gow, Jeffrey D Laskin, Debra L Laskin
Nitrogen mustard (NM) is a toxic vesicant that causes acute injury to the respiratory tract. This is accompanied by an accumulation of activated macrophages in the lung and oxidative stress which have been implicated in tissue injury. In these studies, we analyzed the effects of N-acetylcysteine (NAC), an inhibitor of oxidative stress and inflammation on NM-induced lung injury, macrophage activation and bioenergetics. Treatment of rats with NAC (150 mg/kg, i.p., daily) beginning 30 min after administration of NM (0...
March 19, 2024: Toxicology and Applied Pharmacology